DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-2871796)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001187	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0001187	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0002529	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0004948	PLCG2	P16885	3.1.4.11	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome R-HSA-202407 ( R-HSA-202433 ) R-HSA-202407 Reaction Name: PLC-gamma1 hydrolyses PIP2 See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2396606 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2396606 Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730840 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730841 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730841 Reaction Name: Phosphorylation and activation of VAV See in Reactome R-HSA-2730847 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730856 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730858 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-2730889 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-2730892 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730892 Reaction Name: Recruitment of VAV to p-SLP-76 See in Reactome R-HSA-429497 ( R-HSA-114604 ) R-HSA-429497 Reaction Name: SLP-76 stimulates PLC gamma 2 See in Reactome R-HSA-5607735 ( R-HSA-5607764 ) R-HSA-5607735 Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2 See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5607755 ( R-HSA-5607764 ) R-HSA-5607755 Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-9027373 ( R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-9027425 ( R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9032478 ( R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9606894 ( R-HSA-983695 ) R-HSA-9606894 Reaction Name: p-DAPP1 (p-BAM32) binds PLCG2 See in Reactome
MONDO:0005012	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005012	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0005233	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005292	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0005335	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005575	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0005578	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0006547	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0007154	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0007256	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0007265	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0007648	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0008093	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0008097	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0008097	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0008097	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0008566	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0008566	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0009026	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0009327	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0009578	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0009693	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0010150	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0010854	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0011908	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0011908	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0012371	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0013186	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0013410	MAP3K1	Q13233	2.7.11.25	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome	R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System	R-HSA-166869 ( R-HSA-166058; R-HSA-975138; R-HSA-975871 ) R-HSA-166869 Reaction Name: TRAF6 binds MEKK1 See in Reactome R-HSA-2730868 ( R-HSA-2871796 ) R-HSA-2730868 Reaction Name: Phosphorylation of MEK7 by MEKK1 See in Reactome R-HSA-2730887 ( R-HSA-2871796 ) R-HSA-2730887 Reaction Name: Autophosphorylation and activation of MEKK1 See in Reactome R-HSA-2730896 ( R-HSA-2871796 ) R-HSA-2730896 Reaction Name: Phosphorylation of MEK4 by MEKK1 See in Reactome R-HSA-933528 ( R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome
MONDO:0013766	PLCG2	P16885	3.1.4.11	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome R-HSA-202407 ( R-HSA-202433 ) R-HSA-202407 Reaction Name: PLC-gamma1 hydrolyses PIP2 See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2396606 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2396606 Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730840 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730841 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730841 Reaction Name: Phosphorylation and activation of VAV See in Reactome R-HSA-2730847 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730856 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730858 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-2730889 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-2730892 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730892 Reaction Name: Recruitment of VAV to p-SLP-76 See in Reactome R-HSA-429497 ( R-HSA-114604 ) R-HSA-429497 Reaction Name: SLP-76 stimulates PLC gamma 2 See in Reactome R-HSA-5607735 ( R-HSA-5607764 ) R-HSA-5607735 Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2 See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5607755 ( R-HSA-5607764 ) R-HSA-5607755 Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-9027373 ( R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-9027425 ( R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9032478 ( R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9606894 ( R-HSA-983695 ) R-HSA-9606894 Reaction Name: p-DAPP1 (p-BAM32) binds PLCG2 See in Reactome
MONDO:0013767	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0013767	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0013944	PLCG2	P16885	3.1.4.11	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome R-HSA-202407 ( R-HSA-202433 ) R-HSA-202407 Reaction Name: PLC-gamma1 hydrolyses PIP2 See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2396606 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2396606 Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730840 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730841 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730841 Reaction Name: Phosphorylation and activation of VAV See in Reactome R-HSA-2730847 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730856 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730858 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-2730889 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-2730892 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730892 Reaction Name: Recruitment of VAV to p-SLP-76 See in Reactome R-HSA-429497 ( R-HSA-114604 ) R-HSA-429497 Reaction Name: SLP-76 stimulates PLC gamma 2 See in Reactome R-HSA-5607735 ( R-HSA-5607764 ) R-HSA-5607735 Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2 See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5607755 ( R-HSA-5607764 ) R-HSA-5607755 Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-9027373 ( R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-9027425 ( R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9032478 ( R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9606894 ( R-HSA-983695 ) R-HSA-9606894 Reaction Name: p-DAPP1 (p-BAM32) binds PLCG2 See in Reactome
MONDO:0014112	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0015278	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0015447	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0016225	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0016419	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0016692	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0016982	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0017317	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0018874	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0019086	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0019311	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0019438	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0021094	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9607240; R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0030913	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0032568	PAK1	Q13153	2.7.11.1	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-8964616 R-HSA-8964616 Reactome Name: G beta:gamma signalling through CDC42 See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Muscle contraction Immune System Developmental Biology Signal Transduction	R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029460 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029460 Reaction Name: PAK1 phosphorylates LIMK1 See in Reactome R-HSA-2730856 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730887 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730887 Reaction Name: Autophosphorylation and activation of MEKK1 See in Reactome R-HSA-2730889 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-428531 ( R-HSA-428540 ) R-HSA-428531 Reaction Name: Recruitment of PAK to NCK See in Reactome R-HSA-430183 ( R-HSA-202433 ) R-HSA-430183 Reaction Name: NCK binds PAK See in Reactome R-HSA-442832 ( R-HSA-5627123 ) R-HSA-442832 Reaction Name: PAK phosphorylates cortactin See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-445797 ( R-HSA-445355; R-HSA-5627123 ) R-HSA-445797 Reaction Name: MYLK (MLCK) Active Calmodulin Binding See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357477 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357477 Reaction Name: PAK1-3 phosphorylates VE-cadherin See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668984 ( R-HSA-5627123 ) R-HSA-5668984 Reaction Name: PAK1 or PAK2 phosphorylates MYLK See in Reactome R-HSA-5669158 ( R-HSA-5627123 ) R-HSA-5669158 Reaction Name: NF2 binds PAK1 See in Reactome R-HSA-5669240 ( R-HSA-5627123 ) R-HSA-5669240 Reaction Name: FLNA binds PAK1 See in Reactome R-HSA-5669250 ( R-HSA-5627123 ) R-HSA-5669250 Reaction Name: PAK1 phosphorylates FLNA See in Reactome R-HSA-5687086 ( R-HSA-5687128 ) R-HSA-5687086 Reaction Name: PAK1,2,3 phosphorylates MAPK6,4 See in Reactome R-HSA-8964599 ( R-HSA-8964616 ) R-HSA-8964599 Reaction Name: Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex See in Reactome R-HSA-8964604 ( R-HSA-8964616 ) R-HSA-8964604 Reaction Name: CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated See in Reactome R-HSA-8964605 ( R-HSA-8964616 ) R-HSA-8964605 Reaction Name: PAK1:ARHGEF6 complex binds G-protein beta-gamma complex See in Reactome R-HSA-8964614 ( R-HSA-8964616 ) R-HSA-8964614 Reaction Name: PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated See in Reactome R-HSA-8964619 ( R-HSA-8964616 ) R-HSA-8964619 Reaction Name: PAK1 binds ARHGEF6 See in Reactome R-HSA-8964634 ( R-HSA-8964616 ) R-HSA-8964634 Reaction Name: CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9017507 ( R-HSA-9013409 ) R-HSA-9017507 Reaction Name: RHOJ binds effectors at the plasma membrane See in Reactome R-HSA-9018746 ( R-HSA-9013406 ) R-HSA-9018746 Reaction Name: RHOQ binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome
MONDO:0033669	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0044792	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0044792	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392; R-HSA-881907 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2454202; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome

Number of enzymes:	9
Number of disease:	47
Number of reactomes:	148
Number of reactions:	373

Search summary (Reactome ID: R-HSA-2871796)

Search results (Reactome ID: R-HSA-2871796)

MONDO:0001187

R-HSA-171007

R-HSA-2871796

R-HSA-9634635

R-HSA-1963640

R-HSA-5674135

R-HSA-9027284

R-HSA-9607240

R-HSA-8849471

R-HSA-186763

R-HSA-442982

R-HSA-5673000

R-HSA-5673001

R-HSA-9648002

R-HSA-9026519

R-HSA-5654688

R-HSA-9028731

R-HSA-5654700

R-HSA-5654712

R-HSA-5654706

R-HSA-5654704

R-HSA-1169092

R-HSA-74751

R-HSA-9034864

R-HSA-1433557

R-HSA-375165

R-HSA-167044

R-HSA-2428933

R-HSA-2424491

R-HSA-180336

R-HSA-5654693

R-HSA-5675221

R-HSA-5658442

R-HSA-179812

R-HSA-1250347

R-HSA-8851805

R-HSA-3928662

R-HSA-5621575

R-HSA-112412

R-HSA-210993

R-HSA-1250196

R-HSA-2179392

R-HSA-5654719

R-HSA-5218921

R-HSA-5654699

R-HSA-186797

R-HSA-8848021

R-HSA-2404192

R-HSA-168256

R-HSA-983705

R-HSA-202733

R-HSA-9006927

R-HSA-2428924

R-HSA-438064

R-HSA-2428928

R-HSA-1236394

R-HSA-112399

R-HSA-74752

R-HSA-442742

R-HSA-1266738

R-HSA-5654687

R-HSA-5683057

R-HSA-166520

R-HSA-194138

R-HSA-5684996

R-HSA-881907

R-HSA-9675108

R-HSA-177929

R-HSA-1168372

R-HSA-112316

R-HSA-5654708

R-HSA-112315

R-HSA-5654743

R-HSA-5654741

R-HSA-5621481

R-HSA-4420097

R-HSA-9006335

R-HSA-190236