DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-264876)

Number of enzymes:	2
Number of disease:	2
Number of reactomes:	8
Number of reactions:	10

Search results (Reactome ID: R-HSA-264876)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010961	PCSK1	P29120	3.4.21.93	R-HSA-264876 R-HSA-264876 Reactome Name: Insulin processing See in Reactome R-HSA-422085 R-HSA-422085 Reactome Name: Synthesis, secretion, and deacylation of Ghrelin See in Reactome R-HSA-381771 R-HSA-381771 Reactome Name: Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) See in Reactome R-HSA-400511 R-HSA-400511 Reactome Name: Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) See in Reactome R-HSA-209952 R-HSA-209952 Reactome Name: Peptide hormone biosynthesis See in Reactome	R-HSA-400508 R-HSA-400508 Reactome Name: Incretin synthesis, secretion, and inactivation See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-265301 ( R-HSA-209952 ) R-HSA-265301 Reaction Name: Corticotropin cleavage from POMC See in Reactome R-HSA-381798 ( R-HSA-381771 ) R-HSA-381798 Reaction Name: PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1 See in Reactome R-HSA-400492 ( R-HSA-400511 ) R-HSA-400492 Reaction Name: PCSK1 hydrolyzes proGIP to GIP See in Reactome R-HSA-422021 ( R-HSA-422085 ) R-HSA-422021 Reaction Name: PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin See in Reactome R-HSA-9023196 ( R-HSA-264876 ) R-HSA-9023196 Reaction Name: PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) See in Reactome
MONDO:0011872	RAB27A	P51159	3.6.5.2	R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-264876 R-HSA-264876 Reactome Name: Insulin processing See in Reactome R-HSA-8873719 R-HSA-8873719 Reactome Name: RAB geranylgeranylation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism of proteins Vesicle-mediated transport	R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome R-HSA-8870466 ( R-HSA-8873719 ) R-HSA-8870466 Reaction Name: RGGT:CHM binds RABs See in Reactome R-HSA-8870469 ( R-HSA-8873719 ) R-HSA-8870469 Reaction Name: RGGT geranylgeranylates RAB proteins See in Reactome R-HSA-8877308 ( R-HSA-8876198 ) R-HSA-8877308 Reaction Name: MADD exchanges GTP for GDP on RAB27 See in Reactome R-HSA-9023171 ( R-HSA-264876 ) R-HSA-9023171 Reaction Name: Insulin secretory granule translocates across the cortical actin network See in Reactome