DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2408522)

Number of enzymes:	8
Number of disease:	15
Number of reactomes:	4
Number of reactions:	13

Search results (Reactome ID: R-HSA-2408522)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002135	KARS1	Q15046	6.1.1.6 2.7.7.-	R-HSA-379726 R-HSA-379726 Reactome Name: Mitochondrial tRNA aminoacylation See in Reactome R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome R-HSA-380233 ( R-HSA-379726 ) R-HSA-380233 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0013338	KARS1	Q15046	6.1.1.6 2.7.7.-	R-HSA-379726 R-HSA-379726 Reactome Name: Mitochondrial tRNA aminoacylation See in Reactome R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome R-HSA-380233 ( R-HSA-379726 ) R-HSA-380233 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0013489	KARS1	Q15046	6.1.1.6 2.7.7.-	R-HSA-379726 R-HSA-379726 Reactome Name: Mitochondrial tRNA aminoacylation See in Reactome R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome R-HSA-380233 ( R-HSA-379726 ) R-HSA-380233 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0014115	DARS1	P14868	6.1.1.12	R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0014206	MARS1	P56192	6.1.1.10	R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0014335	QARS1	P47897	6.1.1.18	R-HSA-379726 R-HSA-379726 Reactome Name: Mitochondrial tRNA aminoacylation See in Reactome R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome R-HSA-380241 ( R-HSA-379726 ) R-HSA-380241 Reaction Name: glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome
MONDO:0014506	RARS1	P54136	6.1.1.19	R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0014566	MARS1	P56192	6.1.1.10	R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0014911	IARS1	P41252	6.1.1.5	R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0018422	MARS1	P56192	6.1.1.10	R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0018494	QARS1	P47897	6.1.1.18	R-HSA-379726 R-HSA-379726 Reactome Name: Mitochondrial tRNA aminoacylation See in Reactome R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome R-HSA-380241 ( R-HSA-379726 ) R-HSA-380241 Reaction Name: glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome
MONDO:0024568	LARS1	Q9P2J5	6.1.1.4	R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0030893	KARS1	Q15046	6.1.1.6 2.7.7.-	R-HSA-379726 R-HSA-379726 Reactome Name: Mitochondrial tRNA aminoacylation See in Reactome R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome R-HSA-380233 ( R-HSA-379726 ) R-HSA-380233 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0030967	KARS1	Q15046	6.1.1.6 2.7.7.-	R-HSA-379726 R-HSA-379726 Reactome Name: Mitochondrial tRNA aminoacylation See in Reactome R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome	Metabolism Metabolism of proteins	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome R-HSA-380233 ( R-HSA-379726 ) R-HSA-380233 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome
MONDO:0054782	EPRS1	P07814	6.1.1.17 6.1.1.15	R-HSA-379716 R-HSA-379716 Reactome Name: Cytosolic tRNA aminoacylation See in Reactome R-HSA-6782315 R-HSA-6782315 Reactome Name: tRNA modification in the nucleus and cytosol See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	R-HSA-379724 R-HSA-379724 Reactome Name: tRNA Aminoacylation See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-72766 R-HSA-72766 Reactome Name: Translation See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome	Metabolism of RNA Metabolism of proteins Metabolism	R-HSA-2408546 ( R-HSA-2408522 ) R-HSA-2408546 Reaction Name: tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex See in Reactome R-HSA-379861 ( R-HSA-379716 ) R-HSA-379861 Reaction Name: glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate See in Reactome R-HSA-379865 ( R-HSA-379716 ) R-HSA-379865 Reaction Name: proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate See in Reactome R-HSA-379867 ( R-HSA-379716 ) R-HSA-379867 Reaction Name: aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate See in Reactome R-HSA-379893 ( R-HSA-379716 ) R-HSA-379893 Reaction Name: isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate See in Reactome R-HSA-379974 ( R-HSA-379716 ) R-HSA-379974 Reaction Name: leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate See in Reactome R-HSA-379982 ( R-HSA-379716 ) R-HSA-379982 Reaction Name: glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate See in Reactome R-HSA-379993 ( R-HSA-379716 ) R-HSA-379993 Reaction Name: arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate See in Reactome R-HSA-379994 ( R-HSA-379716 ) R-HSA-379994 Reaction Name: methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate See in Reactome R-HSA-380008 ( R-HSA-379716 ) R-HSA-380008 Reaction Name: lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate See in Reactome R-HSA-6782296 ( R-HSA-6782315 ) R-HSA-6782296 Reaction Name: DUS2:EPRS reduces uridine to dihydrouridine in tRNAs See in Reactome