DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2408508)

Number of enzymes:	6
Number of disease:	8
Number of reactomes:	7
Number of reactions:	17

Search results (Reactome ID: R-HSA-2408508)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001071	CBS	P35520	4.2.1.22	R-HSA-1614603 R-HSA-1614603 Reactome Name: Cysteine formation from homocysteine See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome	R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-1614524 ( R-HSA-1614603; R-HSA-1614635 ) R-HSA-1614524 Reaction Name: PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine See in Reactome R-HSA-2408559 ( R-HSA-2408508 ) R-HSA-2408559 Reaction Name: SeHCys and Ser are dehydrated into SeCysta by CBS See in Reactome
MONDO:0005290	AHCY	P23526	3.3.1.1	R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174401 ( R-HSA-156581; R-HSA-1614635 ) R-HSA-174401 Reaction Name: AHCY:NAD+ tetramer hydrolyses AdoHcy See in Reactome R-HSA-2408532 ( R-HSA-2408508 ) R-HSA-2408532 Reaction Name: AdeSeHCys is hydrolysed to SeHCys by AHCY See in Reactome
MONDO:0009058	CTH	P32929	4.4.1.1 4.4.1.2	R-HSA-1614603 R-HSA-1614603 Reactome Name: Cysteine formation from homocysteine See in Reactome R-HSA-1614558 R-HSA-1614558 Reactome Name: Degradation of cysteine and homocysteine See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome	R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-1614567 ( R-HSA-1614558 ) R-HSA-1614567 Reaction Name: Excess homocysteine yields homolanthionine and H2S See in Reactome R-HSA-1614583 ( R-HSA-1614603 ) R-HSA-1614583 Reaction Name: PXLP-K212-CTH cleaves L-Cystathionine See in Reactome R-HSA-1614591 ( R-HSA-1614558 ) R-HSA-1614591 Reaction Name: Excess cysteine yields lanthionine and H2S See in Reactome R-HSA-1614614 ( R-HSA-1614558 ) R-HSA-1614614 Reaction Name: Cysteine is degraded to serine and H2S See in Reactome R-HSA-1614631 ( R-HSA-1614558 ) R-HSA-1614631 Reaction Name: Homocysteine is degraded to oxobutanoate and H2S See in Reactome R-HSA-2408537 ( R-HSA-2408508 ) R-HSA-2408537 Reaction Name: Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH See in Reactome R-HSA-2408539 ( R-HSA-2408508 ) R-HSA-2408539 Reaction Name: MeSec is hydrolysed to MeSeH by PXLP-K212-CTH See in Reactome R-HSA-2408543 ( R-HSA-2408508 ) R-HSA-2408543 Reaction Name: SeCysta is hydrolysed to Sec by PXLP-K212-CTH See in Reactome
MONDO:0009352	CBS	P35520	4.2.1.22	R-HSA-1614603 R-HSA-1614603 Reactome Name: Cysteine formation from homocysteine See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome	R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-1614524 ( R-HSA-1614603; R-HSA-1614635 ) R-HSA-1614524 Reaction Name: PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine See in Reactome R-HSA-2408559 ( R-HSA-2408508 ) R-HSA-2408559 Reaction Name: SeHCys and Ser are dehydrated into SeCysta by CBS See in Reactome
MONDO:0009607	MAT1A	Q00266	2.5.1.6	R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174391 ( R-HSA-156581; R-HSA-1614635 ) R-HSA-174391 Reaction Name: MAT1A multimers transfer Ado from ATP to L-Met See in Reactome R-HSA-2408551 ( R-HSA-2408508 ) R-HSA-2408551 Reaction Name: SeMet is converted to AdoSeMet by MAT See in Reactome
MONDO:0011698	GNMT	Q14749	2.1.1.20	R-HSA-389661 R-HSA-389661 Reactome Name: Glyoxylate metabolism and glycine degradation See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	Metabolism	R-HSA-2408544 ( R-HSA-2408508 ) R-HSA-2408544 Reaction Name: AdoSeMet is converted to AdeSeHCys by MetTrans(1) See in Reactome R-HSA-6798317 ( R-HSA-389661 ) R-HSA-6798317 Reaction Name: GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC See in Reactome
MONDO:0013404	AHCY	P23526	3.3.1.1	R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174401 ( R-HSA-156581; R-HSA-1614635 ) R-HSA-174401 Reaction Name: AHCY:NAD+ tetramer hydrolyses AdoHcy See in Reactome R-HSA-2408532 ( R-HSA-2408508 ) R-HSA-2408532 Reaction Name: AdeSeHCys is hydrolysed to SeHCys by AHCY See in Reactome
MONDO:0014759	HNMT	P50135	2.1.1.8	R-HSA-70921 R-HSA-70921 Reactome Name: Histidine catabolism See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome	Metabolism	R-HSA-175993 ( R-HSA-70921 ) R-HSA-175993 Reaction Name: HNMT transfers CH3 group from AdoMet to Hist See in Reactome R-HSA-2408544 ( R-HSA-2408508 ) R-HSA-2408544 Reaction Name: AdoSeMet is converted to AdeSeHCys by MetTrans(1) See in Reactome