DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-2179392)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001187	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0001187	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0002911	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005012	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005097	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005233	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005233	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005335	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0005335	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0005575	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0005580	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0007154	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0007256	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0007265	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0007648	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0008021	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0008093	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0008097	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0008097	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0008097	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0008315	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0008566	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0008566	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0009026	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0009578	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0009693	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0010150	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0010854	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0011908	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0011908	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0012371	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0013186	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0013765	MMP3	P08254	3.4.24.17	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Extracellular matrix organization Signal Transduction	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1564184 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564184 Reaction Name: Collagen type IX degradation by MMP3,13 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592362 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592362 Reaction Name: Activation of proMMP7 by MMP3 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604731 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604731 Reaction Name: Autocatalytic activation of MMP3 See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2179402 ( R-HSA-2179392 ) R-HSA-2179402 Reaction Name: Active MMP3 can cleave pro-HBEGF to form active HBEGF See in Reactome R-HSA-2179413 ( R-HSA-2179392 ) R-HSA-2179413 Reaction Name: Activated PKC-alpha activate MMP3 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2484882 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2484882 Reaction Name: Collagen type X degradation by MMP3, 13 See in Reactome R-HSA-2514772 ( R-HSA-1474228 ) R-HSA-2514772 Reaction Name: Fibrillin-1 degradation by MMP3, CTSK, CTSL2 See in Reactome R-HSA-2533970 ( R-HSA-1474228 ) R-HSA-2533970 Reaction Name: NID1 degradation by MMP3, 7 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-4086205 ( R-HSA-1474228 ) R-HSA-4086205 Reaction Name: OPN (osteopontin) degradation by MMP3, MMP7 See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0013767	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0013767	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0014112	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0014481	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0015278	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0015447	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0016419	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0016692	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0016982	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0017317	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0018177	EGFR	P00533	2.7.10.1	R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-1251932 R-HSA-1251932 Reactome Name: PLCG1 events in ERBB2 signaling See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-8856825 R-HSA-8856825 Reactome Name: Cargo recognition for clathrin-mediated endocytosis See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-8847993 R-HSA-8847993 Reactome Name: ERBB2 Activates PTK6 Signaling See in Reactome R-HSA-212718 R-HSA-212718 Reactome Name: EGFR interacts with phospholipase C-gamma See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-6785631 R-HSA-6785631 Reactome Name: ERBB2 Regulates Cell Motility See in Reactome	R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Signal Transduction	R-HSA-1250195 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250195 Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250486 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250486 Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250488 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250488 Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1251922 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251922 Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2 See in Reactome R-HSA-1251944 ( R-HSA-1227986; R-HSA-1251932 ) R-HSA-1251944 Reaction Name: PLCG1 binds to p-ERBB2:p-EGFR See in Reactome R-HSA-1306957 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306963 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306963 Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR See in Reactome R-HSA-1306965 ( R-HSA-1227986; R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-177922 ( R-HSA-177929 ) R-HSA-177922 Reaction Name: EGFR dimerization See in Reactome R-HSA-177923 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177923 Reaction Name: Sustained activation of SRC kinase by SHP2 See in Reactome R-HSA-177924 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177924 Reaction Name: Dephosphorylation of Gab1 by SHP2 See in Reactome R-HSA-177925 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177925 Reaction Name: SHC1 binds to the phosphorylated EGF receptor:ligand complex See in Reactome R-HSA-177926 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177926 Reaction Name: Dephosphorylation of PAG by SHP2 See in Reactome R-HSA-177927 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177930 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177930 Reaction Name: GAB1 phosphorylation by EGFR kinase See in Reactome R-HSA-177933 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177933 Reaction Name: SHC1 phosphorylation by phosphorylated EGFR See in Reactome R-HSA-177934 ( R-HSA-177929 ) R-HSA-177934 Reaction Name: EGFR autophosphorylation See in Reactome R-HSA-177935 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177935 Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR See in Reactome R-HSA-177936 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177936 Reaction Name: GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR See in Reactome R-HSA-177937 ( R-HSA-177929 ) R-HSA-177937 Reaction Name: Phosphorylation of EGFR by SRC kinase See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177939 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-177941 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177941 Reaction Name: GRB2:GAB1 binds to phosphorylated EGFR See in Reactome R-HSA-177942 ( R-HSA-177929 ) R-HSA-177942 Reaction Name: EGFR binds EGF ligand See in Reactome R-HSA-177943 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177943 Reaction Name: GRB2:SOS1 complex binds to EGF:EGFR complex See in Reactome R-HSA-177944 ( R-HSA-177929; R-HSA-180292 ) R-HSA-177944 Reaction Name: Activation of SHP2 through the binding to phospho-Gab1 See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-182969 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182969 Reaction Name: Phosphorylation of CBL (EGFR:CBL) See in Reactome R-HSA-182986 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182986 Reaction Name: CBL-mediated ubiquitination of CIN85 See in Reactome R-HSA-182990 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182990 Reaction Name: Sprouty sequesters CBL away from active EGFR See in Reactome R-HSA-182993 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182993 Reaction Name: Ubiquitination of stimulated EGFR (CBL) See in Reactome R-HSA-182994 ( R-HSA-177929; R-HSA-182971 ) R-HSA-182994 Reaction Name: Assembly of EGFR complex in clathrin-coated vesicles See in Reactome R-HSA-183002 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183002 Reaction Name: Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 See in Reactome R-HSA-183036 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183036 Reaction Name: Ubiquitination of stimulated EGFR (CBL:GRB2) See in Reactome R-HSA-183051 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183051 Reaction Name: CBL ubiquitinates Sprouty See in Reactome R-HSA-183055 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183055 Reaction Name: Binding of CBL to EGFR See in Reactome R-HSA-183058 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183058 Reaction Name: Phosphorylation of CBL (EGFR:GRB2:CBL) See in Reactome R-HSA-183067 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183067 Reaction Name: Localization of CBL:GRB2 to the membrane See in Reactome R-HSA-183072 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183072 Reaction Name: EGFR non-clathrin mediated endocytosis See in Reactome R-HSA-183084 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183084 Reaction Name: CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix See in Reactome R-HSA-183089 ( R-HSA-177929; R-HSA-182971 ) R-HSA-183089 Reaction Name: CBL binds and ubiquitinates phosphorylated Sprouty See in Reactome R-HSA-1963563 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-1963563 Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2 See in Reactome R-HSA-1963578 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1963581 ( R-HSA-1227986 ) R-HSA-1963581 Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers See in Reactome R-HSA-1963582 ( R-HSA-1227986 ) R-HSA-1963582 Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers See in Reactome R-HSA-1963586 ( R-HSA-1227986 ) R-HSA-1963586 Reaction Name: SRC family kinases phosphorylate ERBB2 See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR See in Reactome R-HSA-1963589 ( R-HSA-1227986 ) R-HSA-1963589 Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 See in Reactome R-HSA-1977959 ( R-HSA-1236394 ) R-HSA-1977959 Reaction Name: ERBB4 forms heterodimers with EGFR See in Reactome R-HSA-212706 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212706 Reaction Name: Phospholipase C-gamma1 binds to the activated EGF receptor See in Reactome R-HSA-212710 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212710 Reaction Name: EGFR activates PLC-gamma1 by phosphorylation See in Reactome R-HSA-212713 ( R-HSA-177929; R-HSA-212718 ) R-HSA-212713 Reaction Name: Active PLC-gamma1 dissociates from EGFR See in Reactome R-HSA-2179387 ( R-HSA-2179392 ) R-HSA-2179387 Reaction Name: Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2179415 ( R-HSA-2179392 ) R-HSA-2179415 Reaction Name: GRB2:SOS1 binds to HBEGF:p-Y-EGFR See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-445069 ( R-HSA-445144 ) R-HSA-445069 Reaction Name: L1-EGFR trans-heterodimerization See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-6785636 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785636 Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1 See in Reactome R-HSA-6785648 ( R-HSA-1227986; R-HSA-6785631 ) R-HSA-6785648 Reaction Name: MEMO1 binds RHOA:GTP:DIAPH1 See in Reactome R-HSA-8847995 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8847995 Reaction Name: Activated ERBB2 binds PTK6 (BRK) See in Reactome R-HSA-8848005 ( R-HSA-1227986; R-HSA-8847993 ) R-HSA-8848005 Reaction Name: ERBB2 promotes PTK6 autophosphorylation See in Reactome R-HSA-8857549 ( R-HSA-8857538 ) R-HSA-8857549 Reaction Name: HBEGF-bound EGFR forms a heterodimer with GPNMB See in Reactome R-HSA-8857555 ( R-HSA-8857538 ) R-HSA-8857555 Reaction Name: EGFR phosphorylates GPNMB See in Reactome R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-8863804 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864105 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864105 Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers See in Reactome R-HSA-8864125 ( R-HSA-1227986; R-HSA-8863795 ) R-HSA-8864125 Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 See in Reactome R-HSA-8866279 ( R-HSA-8856825; R-HSA-8856828 ) R-HSA-8866279 Reaction Name: Epsin family proteins bind ubiquitinated cargo See in Reactome R-HSA-8867041 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867041 Reaction Name: EGFR phosphorylates EPS15 See in Reactome R-HSA-8867044 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867044 Reaction Name: EGFR binds EPS15, EPN1, EPS15L1 See in Reactome R-HSA-8867047 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8867047 Reaction Name: PTPN3 dephosphorylates EPS15 See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8867756 ( R-HSA-8856828 ) R-HSA-8867756 Reaction Name: CLASP proteins and cargo are recruited to the nascent clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome R-HSA-8868230 ( R-HSA-8856828 ) R-HSA-8868230 Reaction Name: SNX9 recruits components of the actin polymerizing machinery See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8874797 ( R-HSA-8866910 ) R-HSA-8874797 Reaction Name: EGFR gene expression is stimulated by TFAP2C See in Reactome R-HSA-8951490 ( R-HSA-177929; R-HSA-182971 ) R-HSA-8951490 Reaction Name: CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 See in Reactome R-HSA-9018572 ( R-HSA-9013507 ) R-HSA-9018572 Reaction Name: EGFR phosphorylates NOTCH3 See in Reactome R-HSA-9018573 ( R-HSA-9013507 ) R-HSA-9018573 Reaction Name: NOTCH3 binds activated EGFR See in Reactome R-HSA-9625465 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9625465 Reaction Name: E2-mediated FOS gene expression See in Reactome R-HSA-9625482 ( R-HSA-9009391 ) R-HSA-9625482 Reaction Name: PTK2 binds activated EGFR See in Reactome R-HSA-9625487 ( R-HSA-9009391 ) R-HSA-9625487 Reaction Name: PTK2 autophosphorylates downstream of EGFR See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome R-HSA-9674531 ( R-HSA-177929 ) R-HSA-9674531 Reaction Name: AAMP binds EGFR See in Reactome
MONDO:0018874	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0019086	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0019311	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome
MONDO:0019438	KRAS	P01116	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Gene expression (Transcription) Neuronal System Hemostasis Signal Transduction	R-HSA-8951977 ( R-HSA-8951936 ) R-HSA-8951977 Reaction Name: Acetylated RUNX3 binds to BRD2 See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome
MONDO:0044792	NRAS	P01111	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0044792	HRAS	P01112	3.6.5.2	R-HSA-171007 R-HSA-171007 Reactome Name: p38MAPK events See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-1963640 R-HSA-1963640 Reactome Name: GRB2 events in ERBB2 signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-9027284 R-HSA-9027284 Reactome Name: Erythropoietin activates RAS See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-442982 R-HSA-442982 Reactome Name: Ras activation upon Ca2+ influx through NMDA receptor See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-9648002 R-HSA-9648002 Reactome Name: RAS processing See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-5654688 R-HSA-5654688 Reactome Name: SHC-mediated cascade:FGFR1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-5654700 R-HSA-5654700 Reactome Name: FRS-mediated FGFR2 signaling See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654706 R-HSA-5654706 Reactome Name: FRS-mediated FGFR3 signaling See in Reactome R-HSA-5654704 R-HSA-5654704 Reactome Name: SHC-mediated cascade:FGFR3 See in Reactome R-HSA-1169092 R-HSA-1169092 Reactome Name: Activation of RAS in B cells See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-9034864 R-HSA-9034864 Reactome Name: Activated NTRK3 signals through RAS See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-180336 R-HSA-180336 Reactome Name: SHC1 events in EGFR signaling See in Reactome R-HSA-5654693 R-HSA-5654693 Reactome Name: FRS-mediated FGFR1 signaling See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-5658442 R-HSA-5658442 Reactome Name: Regulation of RAS by GAPs See in Reactome R-HSA-179812 R-HSA-179812 Reactome Name: GRB2 events in EGFR signaling See in Reactome R-HSA-1250347 R-HSA-1250347 Reactome Name: SHC1 events in ERBB4 signaling See in Reactome R-HSA-8851805 R-HSA-8851805 Reactome Name: MET activates RAS signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-112412 R-HSA-112412 Reactome Name: SOS-mediated signalling See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-5654699 R-HSA-5654699 Reactome Name: SHC-mediated cascade:FGFR2 See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Neuronal System Hemostasis Signal Transduction	R-HSA-109807 ( R-HSA-74751 ) R-HSA-109807 Reaction Name: GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-109817 ( R-HSA-112412; R-HSA-74751 ) R-HSA-109817 Reaction Name: GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS See in Reactome R-HSA-1168636 ( R-HSA-1169092 ) R-HSA-1168636 Reaction Name: p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349 See in Reactome R-HSA-1250383 ( R-HSA-1236394; R-HSA-1250347 ) R-HSA-1250383 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 See in Reactome R-HSA-1250463 ( R-HSA-1227986; R-HSA-1250196 ) R-HSA-1250463 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers See in Reactome R-HSA-1250498 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1250498 Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. See in Reactome R-HSA-1306972 ( R-HSA-1227986; R-HSA-1963640 ) R-HSA-1306972 Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-170986 ( R-HSA-167044; R-HSA-171007 ) R-HSA-170986 Reaction Name: Ral-GDS binds to Ras-GTP See in Reactome R-HSA-171026 ( R-HSA-167044; R-HSA-171007 ) R-HSA-171026 Reaction Name: Guanine nucleotide exchange on RAL See in Reactome R-HSA-177938 ( R-HSA-177929; R-HSA-179812 ) R-HSA-177938 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) See in Reactome R-HSA-177945 ( R-HSA-177929; R-HSA-180336 ) R-HSA-177945 Reaction Name: SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) See in Reactome R-HSA-186834 ( R-HSA-186763 ) R-HSA-186834 Reaction Name: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) See in Reactome R-HSA-210977 ( R-HSA-210993 ) R-HSA-210977 Reaction Name: Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) See in Reactome R-HSA-2179407 ( R-HSA-2179392 ) R-HSA-2179407 Reaction Name: SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) See in Reactome R-HSA-2424477 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2424477 Reaction Name: SOS mediated nucleotide exchange of RAS (SHC) See in Reactome R-HSA-392054 ( R-HSA-375165 ) R-HSA-392054 Reaction Name: NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras See in Reactome R-HSA-4093331 ( R-HSA-3928662 ) R-HSA-4093331 Reaction Name: Ras:GTP binds p120-RasGAP See in Reactome R-HSA-4093339 ( R-HSA-3928662 ) R-HSA-4093339 Reaction Name: p120-RasGAP activates GTP hydrolysis on RAS, inactivating it See in Reactome R-HSA-442732 ( R-HSA-442982 ) R-HSA-442732 Reaction Name: NMDA-activated RASGRF1 activates RAS See in Reactome R-HSA-5218845 ( R-HSA-5218921 ) R-HSA-5218845 Reaction Name: p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate See in Reactome R-HSA-5621573 ( R-HSA-5621575 ) R-HSA-5621573 Reaction Name: CD209 activate GTPase RAS See in Reactome R-HSA-5624486 ( R-HSA-5621575 ) R-HSA-5624486 Reaction Name: SFKs phosphorylates RAF1 on Y340,Y341 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5624494 ( R-HSA-5621575 ) R-HSA-5624494 Reaction Name: RAF1 binds p21 RAS:GTP See in Reactome R-HSA-5654392 ( R-HSA-5654693 ) R-HSA-5654392 Reaction Name: Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654402 ( R-HSA-5654699 ) R-HSA-5654402 Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654413 ( R-HSA-5654706 ) R-HSA-5654413 Reaction Name: Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654600 ( R-HSA-5654688 ) R-HSA-5654600 Reaction Name: Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654618 ( R-HSA-5654700 ) R-HSA-5654618 Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654647 ( R-HSA-5654704 ) R-HSA-5654647 Reaction Name: Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5658231 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658231 Reaction Name: RAS GAPs stimulate RAS GTPase activity See in Reactome R-HSA-5658435 ( R-HSA-5658442; R-HSA-5673001 ) R-HSA-5658435 Reaction Name: RAS GAPs bind RAS:GTP See in Reactome R-HSA-5672950 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-5672966 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674018 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674018 Reaction Name: BRAP binds RAS:GTP See in Reactome R-HSA-5674022 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5674022 Reaction Name: BRAP autoubiquitinates See in Reactome R-HSA-5675417 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-5686071 ( R-HSA-167044 ) R-HSA-5686071 Reaction Name: GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS See in Reactome R-HSA-5686318 ( R-HSA-2428933 ) R-HSA-5686318 Reaction Name: GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS See in Reactome R-HSA-8851827 ( R-HSA-8851805 ) R-HSA-8851827 Reaction Name: RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 See in Reactome R-HSA-8851877 ( R-HSA-8851805 ) R-HSA-8851877 Reaction Name: RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET See in Reactome R-HSA-8851899 ( R-HSA-8851805 ) R-HSA-8851899 Reaction Name: RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941618 ( R-HSA-5654700 ) R-HSA-8941618 Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941623 ( R-HSA-5654693 ) R-HSA-8941623 Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8941628 ( R-HSA-5654706 ) R-HSA-8941628 Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome R-HSA-8981353 ( R-HSA-8849471 ) R-HSA-8981353 Reaction Name: RASA1 stimulates RAS GTPase activity See in Reactome R-HSA-8981355 ( R-HSA-8849471 ) R-HSA-8981355 Reaction Name: RASA1 binds RAS:GTP See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9029158 ( R-HSA-9027284 ) R-HSA-9029158 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9036970 ( R-HSA-9034864 ) R-HSA-9036970 Reaction Name: NTRK3 activates RAS through SHC1 See in Reactome R-HSA-9607304 ( R-HSA-9607240 ) R-HSA-9607304 Reaction Name: SOS1-mediated nucleotide exchange of RAS downstream of FLT3 See in Reactome R-HSA-9632906 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632906 Reaction Name: PRKCZ recruits RAS in response to estrogen stimulation See in Reactome R-HSA-9632910 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9632918 ( R-HSA-9009391; R-HSA-9634635 ) R-HSA-9632918 Reaction Name: PRKCZ stimulates RAS nucleotide exchange in response to estrogen See in Reactome R-HSA-9647977 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647977 Reaction Name: ICMT methylates S-Farn RAS proteins See in Reactome R-HSA-9647978 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647978 Reaction Name: pro-RAS proteins are farnesylated See in Reactome R-HSA-9647980 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647980 Reaction Name: mature RAS proteins translocate to plasma membrane See in Reactome R-HSA-9647982 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647982 Reaction Name: S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated See in Reactome R-HSA-9647994 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647994 Reaction Name: RAS proteins are depalmitoylated See in Reactome R-HSA-9647999 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9647999 Reaction Name: RCE1 cleaves S-Farn proRAS proteins See in Reactome R-HSA-9649733 ( R-HSA-5673001; R-HSA-9648002 ) R-HSA-9649733 Reaction Name: mature p21 RAS binds GDP See in Reactome R-HSA-9649735 ( R-HSA-5673001 ) R-HSA-9649735 Reaction Name: Intrinsic nucleotide exchange on RAS See in Reactome R-HSA-9649736 ( R-HSA-5673001 ) R-HSA-9649736 Reaction Name: RAS intrinsic GTPase activity hydrolyzes GTP to GDP See in Reactome R-HSA-9653108 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9660557 ( R-HSA-5673001 ) R-HSA-9660557 Reaction Name: RAS:GTP binds RAL GDS proteins See in Reactome

Number of enzymes:	5
Number of disease:	41
Number of reactomes:	74
Number of reactions:	213

Search summary (Reactome ID: R-HSA-2179392)

Search results (Reactome ID: R-HSA-2179392)

MONDO:0001187

R-HSA-171007

R-HSA-2871796

R-HSA-9634635

R-HSA-1963640

R-HSA-5674135

R-HSA-9027284

R-HSA-9607240

R-HSA-8849471

R-HSA-186763

R-HSA-442982

R-HSA-5673000

R-HSA-5673001

R-HSA-9648002

R-HSA-9026519

R-HSA-5654688

R-HSA-9028731

R-HSA-5654700

R-HSA-5654712

R-HSA-5654706

R-HSA-5654704

R-HSA-1169092

R-HSA-74751

R-HSA-9034864

R-HSA-1433557

R-HSA-375165

R-HSA-167044

R-HSA-2428933

R-HSA-2424491

R-HSA-180336

R-HSA-5654693

R-HSA-5675221

R-HSA-5658442

R-HSA-179812

R-HSA-1250347

R-HSA-8851805

R-HSA-3928662

R-HSA-5621575

R-HSA-112412

R-HSA-210993

R-HSA-1250196

R-HSA-2179392

R-HSA-5654719

R-HSA-5218921

R-HSA-5654699

R-HSA-186797

R-HSA-8848021

R-HSA-2404192

R-HSA-168256

R-HSA-983705

R-HSA-202733

R-HSA-9006927

R-HSA-2428924

R-HSA-438064

R-HSA-2428928

R-HSA-1236394

R-HSA-112399

R-HSA-74752

R-HSA-442742

R-HSA-1266738

R-HSA-5654687

R-HSA-5683057

R-HSA-166520

R-HSA-194138

R-HSA-5684996

R-HSA-881907

R-HSA-9675108

R-HSA-177929

R-HSA-1168372

R-HSA-112316

R-HSA-5654708

R-HSA-112315

R-HSA-5654743

R-HSA-5654741

R-HSA-5621481

R-HSA-4420097

R-HSA-9006335

R-HSA-190236