DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2173795)

Number of enzymes:	2
Number of disease:	4
Number of reactomes:	10
Number of reactions:	24

Search results (Reactome ID: R-HSA-2173795)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010487	USP9X	Q93008	3.4.19.12	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Protein localization Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-5660752 ( R-HSA-977225 ) R-HSA-5660752 Reaction Name: USP9X deubiquitinates Ub-SNCA See in Reactome R-HSA-5661157 ( R-HSA-977225 ) R-HSA-5661157 Reaction Name: USP9X binds Ub-SNCA See in Reactome R-HSA-5661161 ( R-HSA-977225 ) R-HSA-5661161 Reaction Name: USP9X:SNCA dissociates See in Reactome R-HSA-870437 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870437 Reaction Name: USP9X (FAM) deubiquitinates SMAD4 See in Reactome R-HSA-870479 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870479 Reaction Name: USP9X (FAM) binds to ubiquitinated SMAD4 See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9033478 ( R-HSA-9033241 ) R-HSA-9033478 Reaction Name: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin See in Reactome R-HSA-9033491 ( R-HSA-9033241 ) R-HSA-9033491 Reaction Name: USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin See in Reactome R-HSA-9033509 ( R-HSA-9033241 ) R-HSA-9033509 Reaction Name: USP9X binds Ub:PEX5L See in Reactome R-HSA-9033526 ( R-HSA-9033241 ) R-HSA-9033526 Reaction Name: USP9X binds Ub:PEX5S See in Reactome
MONDO:0010502	USP9X	Q93008	3.4.19.12	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Protein localization Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-5660752 ( R-HSA-977225 ) R-HSA-5660752 Reaction Name: USP9X deubiquitinates Ub-SNCA See in Reactome R-HSA-5661157 ( R-HSA-977225 ) R-HSA-5661157 Reaction Name: USP9X binds Ub-SNCA See in Reactome R-HSA-5661161 ( R-HSA-977225 ) R-HSA-5661161 Reaction Name: USP9X:SNCA dissociates See in Reactome R-HSA-870437 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870437 Reaction Name: USP9X (FAM) deubiquitinates SMAD4 See in Reactome R-HSA-870479 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870479 Reaction Name: USP9X (FAM) binds to ubiquitinated SMAD4 See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9033478 ( R-HSA-9033241 ) R-HSA-9033478 Reaction Name: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin See in Reactome R-HSA-9033491 ( R-HSA-9033241 ) R-HSA-9033491 Reaction Name: USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin See in Reactome R-HSA-9033509 ( R-HSA-9033241 ) R-HSA-9033509 Reaction Name: USP9X binds Ub:PEX5L See in Reactome R-HSA-9033526 ( R-HSA-9033241 ) R-HSA-9033526 Reaction Name: USP9X binds Ub:PEX5S See in Reactome
MONDO:0014966	NEDD4L	Q96PU5	2.3.2.26	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-2672351 R-HSA-2672351 Reactome Name: Stimuli-sensing channels See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Transport of small molecules Signal Transduction	R-HSA-178218 ( R-HSA-2173788 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2169050 ( R-HSA-2173788 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2176416 ( R-HSA-2173788 ) R-HSA-2176416 Reaction Name: NEDD4L ubiquitin ligase binds SMAD7 See in Reactome R-HSA-2176417 ( R-HSA-2173788 ) R-HSA-2176417 Reaction Name: SMAD7:NEDD4L complex translocates to the cytosol See in Reactome R-HSA-2176491 ( R-HSA-2173795 ) R-HSA-2176491 Reaction Name: NEDD4L binds phosphorylated linker region of SMAD2/3 See in Reactome R-HSA-2176502 ( R-HSA-2173795 ) R-HSA-2176502 Reaction Name: NEDD4L ubiquitinates SMAD2/3 See in Reactome R-HSA-2682349 ( R-HSA-2672351 ) R-HSA-2682349 Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0018821	USP9X	Q93008	3.4.19.12	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Protein localization Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-5660752 ( R-HSA-977225 ) R-HSA-5660752 Reaction Name: USP9X deubiquitinates Ub-SNCA See in Reactome R-HSA-5661157 ( R-HSA-977225 ) R-HSA-5661157 Reaction Name: USP9X binds Ub-SNCA See in Reactome R-HSA-5661161 ( R-HSA-977225 ) R-HSA-5661161 Reaction Name: USP9X:SNCA dissociates See in Reactome R-HSA-870437 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870437 Reaction Name: USP9X (FAM) deubiquitinates SMAD4 See in Reactome R-HSA-870479 ( R-HSA-2173795; R-HSA-5689880 ) R-HSA-870479 Reaction Name: USP9X (FAM) binds to ubiquitinated SMAD4 See in Reactome R-HSA-8853503 ( R-HSA-8866652 ) R-HSA-8853503 Reaction Name: UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin See in Reactome R-HSA-8853514 ( R-HSA-8866652 ) R-HSA-8853514 Reaction Name: UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9033478 ( R-HSA-9033241 ) R-HSA-9033478 Reaction Name: USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin See in Reactome R-HSA-9033491 ( R-HSA-9033241 ) R-HSA-9033491 Reaction Name: USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin See in Reactome R-HSA-9033509 ( R-HSA-9033241 ) R-HSA-9033509 Reaction Name: USP9X binds Ub:PEX5L See in Reactome R-HSA-9033526 ( R-HSA-9033241 ) R-HSA-9033526 Reaction Name: USP9X binds Ub:PEX5S See in Reactome