DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2173788)

Number of enzymes:	5
Number of disease:	15
Number of reactomes:	21
Number of reactions:	54

Search results (Reactome ID: R-HSA-2173788)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0000561	STUB1	Q9UNE7	2.3.2.27	R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome	R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Programmed Cell Death Signal Transduction	R-HSA-1918092 ( R-HSA-8863795 ) R-HSA-1918092 Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2 See in Reactome R-HSA-2187368 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2187368 Reaction Name: STUB1 (CHIP) ubiquitinates SMAD3 See in Reactome R-HSA-2187375 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2187375 Reaction Name: SMAD3 binds STUB1 (CHIP) See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-9009308 ( R-HSA-8939902 ) R-HSA-9009308 Reaction Name: STUB1 polyubiquitinates RUNX2 See in Reactome R-HSA-9009309 ( R-HSA-8939902 ) R-HSA-9009309 Reaction Name: RUNX2 binds STUB1 See in Reactome R-HSA-9688831 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688831 Reaction Name: STUB1 ubiquitinates RIPK3 at K55, K363 See in Reactome R-HSA-9688838 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688838 Reaction Name: RIPK3 binds STUB1 See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0005580	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0007522	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0007566	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0007947	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0007947	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0009072	PPP1CB	P62140	3.1.3.16 3.1.3.53	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Circadian Clock Metabolism Signal Transduction Cell Cycle	R-HSA-163568 ( R-HSA-163560 ) R-HSA-163568 Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-3002811 ( R-HSA-2565942 ) R-HSA-3002811 Reaction Name: Myosin phosphatase dephosphorylates PLK1 See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5671772 ( R-HSA-5625740 ) R-HSA-5671772 Reaction Name: p-T38-PPP1R14A binds MLCP See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0012212	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0012212	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0012427	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0013695	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0014339	STUB1	Q9UNE7	2.3.2.27	R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome	R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Programmed Cell Death Signal Transduction	R-HSA-1918092 ( R-HSA-8863795 ) R-HSA-1918092 Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2 See in Reactome R-HSA-2187368 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2187368 Reaction Name: STUB1 (CHIP) ubiquitinates SMAD3 See in Reactome R-HSA-2187375 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2187375 Reaction Name: SMAD3 binds STUB1 (CHIP) See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-9009308 ( R-HSA-8939902 ) R-HSA-9009308 Reaction Name: STUB1 polyubiquitinates RUNX2 See in Reactome R-HSA-9009309 ( R-HSA-8939902 ) R-HSA-9009309 Reaction Name: RUNX2 binds STUB1 See in Reactome R-HSA-9688831 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688831 Reaction Name: STUB1 ubiquitinates RIPK3 at K55, K363 See in Reactome R-HSA-9688838 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688838 Reaction Name: RIPK3 binds STUB1 See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0014966	NEDD4L	Q96PU5	2.3.2.26	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-2672351 R-HSA-2672351 Reactome Name: Stimuli-sensing channels See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Transport of small molecules Signal Transduction	R-HSA-178218 ( R-HSA-2173788 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2169050 ( R-HSA-2173788 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2176416 ( R-HSA-2173788 ) R-HSA-2176416 Reaction Name: NEDD4L ubiquitin ligase binds SMAD7 See in Reactome R-HSA-2176417 ( R-HSA-2173788 ) R-HSA-2176417 Reaction Name: SMAD7:NEDD4L complex translocates to the cytosol See in Reactome R-HSA-2176491 ( R-HSA-2173795 ) R-HSA-2176491 Reaction Name: NEDD4L binds phosphorylated linker region of SMAD2/3 See in Reactome R-HSA-2176502 ( R-HSA-2173795 ) R-HSA-2176502 Reaction Name: NEDD4L ubiquitinates SMAD2/3 See in Reactome R-HSA-2682349 ( R-HSA-2672351 ) R-HSA-2682349 Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0018997	PPP1CB	P62140	3.1.3.16 3.1.3.53	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Circadian Clock Metabolism Signal Transduction Cell Cycle	R-HSA-163568 ( R-HSA-163560 ) R-HSA-163568 Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-3002811 ( R-HSA-2565942 ) R-HSA-3002811 Reaction Name: Myosin phosphatase dephosphorylates PLK1 See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5671772 ( R-HSA-5625740 ) R-HSA-5671772 Reaction Name: p-T38-PPP1R14A binds MLCP See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0019625	TGFBR1	P36897	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134506 ( R-HSA-2173791 ) R-HSA-2134506 Reaction Name: TGFBR1 is recruited to tight junctions by PARD6A See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-6781764 ( R-HSA-5689880 ) R-HSA-6781764 Reaction Name: USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 See in Reactome
MONDO:0019625	TGFBR2	P37173	2.7.11.30	R-HSA-2173791 R-HSA-2173791 Reactome Name: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) See in Reactome R-HSA-5689603 R-HSA-5689603 Reactome Name: UCH proteinases See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-170835 ( R-HSA-2173789 ) R-HSA-170835 Reaction Name: An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 See in Reactome R-HSA-170843 ( R-HSA-2173789 ) R-HSA-170843 Reaction Name: TGFBR2 phosphorylates TGFBR1 See in Reactome R-HSA-170846 ( R-HSA-2173789 ) R-HSA-170846 Reaction Name: TGFBR2 recruits TGFBR1 See in Reactome R-HSA-170850 ( R-HSA-2173789 ) R-HSA-170850 Reaction Name: Phosphorylated SMAD2/3 dissociates from TGFBR See in Reactome R-HSA-170861 ( R-HSA-2173789 ) R-HSA-170861 Reaction Name: Dimeric TGF-beta-1 binds to the receptor See in Reactome R-HSA-170868 ( R-HSA-2173789 ) R-HSA-170868 Reaction Name: Activated type I receptor phosphorylates SMAD2/3 directly See in Reactome R-HSA-173483 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173483 Reaction Name: BAMBI interferes with the interaction of type I receptor with type II receptor See in Reactome R-HSA-173512 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-173512 Reaction Name: I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-178218 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2127562 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2127562 Reaction Name: STRAP binds phosphorylated TGF-beta receptor complex See in Reactome R-HSA-2128994 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2128994 Reaction Name: STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 See in Reactome R-HSA-2134519 ( R-HSA-2173791 ) R-HSA-2134519 Reaction Name: TGFBR2 is recruited to tight junctions after TGF-beta stimulation See in Reactome R-HSA-2134532 ( R-HSA-2173791 ) R-HSA-2134532 Reaction Name: TGFBR2 phosphorylates TGFBR1 and PARD6A See in Reactome R-HSA-2160931 ( R-HSA-2173791 ) R-HSA-2160931 Reaction Name: Disassembly of tight junctions See in Reactome R-HSA-2160932 ( R-HSA-2173791 ) R-HSA-2160932 Reaction Name: SMURF1 binds phosphorylated PARD6A See in Reactome R-HSA-2160935 ( R-HSA-2173791 ) R-HSA-2160935 Reaction Name: SMURF1 ubiquitinates RHOA See in Reactome R-HSA-2169046 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169046 Reaction Name: Degradation of TGF-beta receptor complex See in Reactome R-HSA-2169050 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2179291 ( R-HSA-2173788; R-HSA-2173789; R-HSA-5689603 ) R-HSA-2179291 Reaction Name: UCHL5, USP15 deubiquitinate TGFBR1 See in Reactome R-HSA-2179293 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2179293 Reaction Name: UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 See in Reactome R-HSA-4332235 ( R-HSA-2173789 ) R-HSA-4332235 Reaction Name: CBL binds TGFBR2 See in Reactome R-HSA-4332236 ( R-HSA-2173789 ) R-HSA-4332236 Reaction Name: CBL neddylates TGFBR2 See in Reactome
MONDO:0032526	STUB1	Q9UNE7	2.3.2.27	R-HSA-8939902 R-HSA-8939902 Reactome Name: Regulation of RUNX2 expression and activity See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome	R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Programmed Cell Death Signal Transduction	R-HSA-1918092 ( R-HSA-8863795 ) R-HSA-1918092 Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2 See in Reactome R-HSA-2187368 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2187368 Reaction Name: STUB1 (CHIP) ubiquitinates SMAD3 See in Reactome R-HSA-2187375 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-2187375 Reaction Name: SMAD3 binds STUB1 (CHIP) See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-9009308 ( R-HSA-8939902 ) R-HSA-9009308 Reaction Name: STUB1 polyubiquitinates RUNX2 See in Reactome R-HSA-9009309 ( R-HSA-8939902 ) R-HSA-9009309 Reaction Name: RUNX2 binds STUB1 See in Reactome R-HSA-9688831 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688831 Reaction Name: STUB1 ubiquitinates RIPK3 at K55, K363 See in Reactome R-HSA-9688838 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9688838 Reaction Name: RIPK3 binds STUB1 See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0054588	PPP1CB	P62140	3.1.3.16 3.1.3.53	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Circadian Clock Metabolism Signal Transduction Cell Cycle	R-HSA-163568 ( R-HSA-163560 ) R-HSA-163568 Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate See in Reactome R-HSA-178178 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788; R-HSA-2173789 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-3002811 ( R-HSA-2565942 ) R-HSA-3002811 Reaction Name: Myosin phosphatase dephosphorylates PLK1 See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5671772 ( R-HSA-5625740 ) R-HSA-5671772 Reaction Name: p-T38-PPP1R14A binds MLCP See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome