DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2142789)

Number of enzymes:	6
Number of disease:	8
Number of reactomes:	2
Number of reactions:	9

Search results (Reactome ID: R-HSA-2142789)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007803	COQ2	Q96H96	2.5.1.39	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-2142789 R-HSA-2142789 Reactome Name: Ubiquinol biosynthesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism Protein localization	R-HSA-1299476 ( R-HSA-1268020 ) R-HSA-1299476 Reaction Name: MPP cleaves targeting peptide (presequence) of inner membrane precursors See in Reactome R-HSA-1299482 ( R-HSA-1268020 ) R-HSA-1299482 Reaction Name: TIMM23 SORT inserts proteins into inner membrane See in Reactome R-HSA-1299487 ( R-HSA-1268020 ) R-HSA-1299487 Reaction Name: Precursor proteins enter TIMM23 SORT See in Reactome R-HSA-2162192 ( R-HSA-2142789 ) R-HSA-2162192 Reaction Name: PHB and all-E-10PrP2 are combined into DHB by COQ2 See in Reactome R-HSA-8986181 ( R-HSA-1268020 ) R-HSA-8986181 Reaction Name: PITRM1 proteolyzes mitochondrial targeting peptides (presequences) See in Reactome
MONDO:0011829	COQ2	Q96H96	2.5.1.39	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-2142789 R-HSA-2142789 Reactome Name: Ubiquinol biosynthesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism Protein localization	R-HSA-1299476 ( R-HSA-1268020 ) R-HSA-1299476 Reaction Name: MPP cleaves targeting peptide (presequence) of inner membrane precursors See in Reactome R-HSA-1299482 ( R-HSA-1268020 ) R-HSA-1299482 Reaction Name: TIMM23 SORT inserts proteins into inner membrane See in Reactome R-HSA-1299487 ( R-HSA-1268020 ) R-HSA-1299487 Reaction Name: Precursor proteins enter TIMM23 SORT See in Reactome R-HSA-2162192 ( R-HSA-2142789 ) R-HSA-2162192 Reaction Name: PHB and all-E-10PrP2 are combined into DHB by COQ2 See in Reactome R-HSA-8986181 ( R-HSA-1268020 ) R-HSA-8986181 Reaction Name: PITRM1 proteolyzes mitochondrial targeting peptides (presequences) See in Reactome
MONDO:0013836	COQ6	Q9Y2Z9	1.14.13.-	R-HSA-2142789 R-HSA-2142789 Reactome Name: Ubiquinol biosynthesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism	R-HSA-2162187 ( R-HSA-2142789 ) R-HSA-2162187 Reaction Name: DHB is hydroxylated to DHDB by COQ6 See in Reactome
MONDO:0013837	PDSS1	Q5T2R2	2.5.1.91	R-HSA-2142789 R-HSA-2142789 Reactome Name: Ubiquinol biosynthesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism	R-HSA-2162253 ( R-HSA-2142789 ) R-HSA-2162253 Reaction Name: FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer See in Reactome
MONDO:0013838	PDSS2	Q86YH6	2.5.1.91	R-HSA-2142789 R-HSA-2142789 Reactome Name: Ubiquinol biosynthesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism	R-HSA-2162253 ( R-HSA-2142789 ) R-HSA-2162253 Reaction Name: FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer See in Reactome
MONDO:0014754	COQ7	Q99807	1.14.99.60	R-HSA-2142789 R-HSA-2142789 Reactome Name: Ubiquinol biosynthesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism	R-HSA-2162194 ( R-HSA-2142789 ) R-HSA-2162194 Reaction Name: COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2 See in Reactome
MONDO:0020715	COQ2	Q96H96	2.5.1.39	R-HSA-1268020 R-HSA-1268020 Reactome Name: Mitochondrial protein import See in Reactome R-HSA-2142789 R-HSA-2142789 Reactome Name: Ubiquinol biosynthesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism Protein localization	R-HSA-1299476 ( R-HSA-1268020 ) R-HSA-1299476 Reaction Name: MPP cleaves targeting peptide (presequence) of inner membrane precursors See in Reactome R-HSA-1299482 ( R-HSA-1268020 ) R-HSA-1299482 Reaction Name: TIMM23 SORT inserts proteins into inner membrane See in Reactome R-HSA-1299487 ( R-HSA-1268020 ) R-HSA-1299487 Reaction Name: Precursor proteins enter TIMM23 SORT See in Reactome R-HSA-2162192 ( R-HSA-2142789 ) R-HSA-2162192 Reaction Name: PHB and all-E-10PrP2 are combined into DHB by COQ2 See in Reactome R-HSA-8986181 ( R-HSA-1268020 ) R-HSA-8986181 Reaction Name: PITRM1 proteolyzes mitochondrial targeting peptides (presequences) See in Reactome
MONDO:0033615	COQ5	Q5HYK3	2.1.1.201	R-HSA-2142789 R-HSA-2142789 Reactome Name: Ubiquinol biosynthesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome	Metabolism	R-HSA-2162188 ( R-HSA-2142789 ) R-HSA-2162188 Reaction Name: MDMQ10H2 is methylated to DMQ10H2 by COQ5 See in Reactome