DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2142712)

Number of enzymes:	5
Number of disease:	7
Number of reactomes:	13
Number of reactions:	17

Search results (Reactome ID: R-HSA-2142712)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005575	ALOX12	P18054	1.13.11.- 1.13.11.33 3.3.2.- 1.13.11.31	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome R-HSA-9025106 R-HSA-9025106 Reactome Name: Biosynthesis of DPAn-6 SPMs See in Reactome R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-9026290 R-HSA-9026290 Reactome Name: Biosynthesis of DPAn-3-derived maresins See in Reactome R-HSA-2142696 R-HSA-2142696 Reactome Name: Synthesis of Hepoxilins (HX) and Trioxilins (TrX) See in Reactome	R-HSA-9025094 R-HSA-9025094 Reactome Name: Biosynthesis of DPAn-3 SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018683 R-HSA-9018683 Reactome Name: Biosynthesis of DPA-derived SPMs See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome	Metabolism	R-HSA-2161775 ( R-HSA-2142700 ) R-HSA-2161775 Reaction Name: ALOX12 oxidises LTA4 to LXA4/B4 See in Reactome R-HSA-2161794 ( R-HSA-2142696 ) R-HSA-2161794 Reaction Name: Arachidonic acid is converted to HXA3/B3 by ALOX12 See in Reactome R-HSA-2161948 ( R-HSA-2142712 ) R-HSA-2161948 Reaction Name: Arachidonic acid is converted to 12-oxoETE by ALOX12 See in Reactome R-HSA-2161964 ( R-HSA-2142712 ) R-HSA-2161964 Reaction Name: Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 See in Reactome R-HSA-9020274 ( R-HSA-9018677 ) R-HSA-9020274 Reaction Name: ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA See in Reactome R-HSA-9024983 ( R-HSA-9018677 ) R-HSA-9024983 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA See in Reactome R-HSA-9025957 ( R-HSA-9025106 ) R-HSA-9025957 Reaction Name: ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 See in Reactome R-HSA-9026006 ( R-HSA-9026290 ) R-HSA-9026006 Reaction Name: ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 See in Reactome R-HSA-9026007 ( R-HSA-9026290 ) R-HSA-9026007 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 See in Reactome
MONDO:0007576	ALOX12	P18054	1.13.11.- 1.13.11.33 3.3.2.- 1.13.11.31	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome R-HSA-9025106 R-HSA-9025106 Reactome Name: Biosynthesis of DPAn-6 SPMs See in Reactome R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-9026290 R-HSA-9026290 Reactome Name: Biosynthesis of DPAn-3-derived maresins See in Reactome R-HSA-2142696 R-HSA-2142696 Reactome Name: Synthesis of Hepoxilins (HX) and Trioxilins (TrX) See in Reactome	R-HSA-9025094 R-HSA-9025094 Reactome Name: Biosynthesis of DPAn-3 SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018683 R-HSA-9018683 Reactome Name: Biosynthesis of DPA-derived SPMs See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome	Metabolism	R-HSA-2161775 ( R-HSA-2142700 ) R-HSA-2161775 Reaction Name: ALOX12 oxidises LTA4 to LXA4/B4 See in Reactome R-HSA-2161794 ( R-HSA-2142696 ) R-HSA-2161794 Reaction Name: Arachidonic acid is converted to HXA3/B3 by ALOX12 See in Reactome R-HSA-2161948 ( R-HSA-2142712 ) R-HSA-2161948 Reaction Name: Arachidonic acid is converted to 12-oxoETE by ALOX12 See in Reactome R-HSA-2161964 ( R-HSA-2142712 ) R-HSA-2161964 Reaction Name: Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 See in Reactome R-HSA-9020274 ( R-HSA-9018677 ) R-HSA-9020274 Reaction Name: ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA See in Reactome R-HSA-9024983 ( R-HSA-9018677 ) R-HSA-9024983 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA See in Reactome R-HSA-9025957 ( R-HSA-9025106 ) R-HSA-9025957 Reaction Name: ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 See in Reactome R-HSA-9026006 ( R-HSA-9026290 ) R-HSA-9026006 Reaction Name: ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 See in Reactome R-HSA-9026007 ( R-HSA-9026290 ) R-HSA-9026007 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 See in Reactome
MONDO:0009439	ALOX12B	O75342	1.13.11.-	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome	Metabolism	R-HSA-2161950 ( R-HSA-2142712 ) R-HSA-2161950 Reaction Name: Arachidonic acid is oxidised to 12R-HpETE by ALOX12B See in Reactome
MONDO:0009593	GPX4	P36969	1.11.1.12	R-HSA-9023661 R-HSA-9023661 Reactome Name: Biosynthesis of E-series 18(R)-resolvins See in Reactome R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-9020265 R-HSA-9020265 Reactome Name: Biosynthesis of aspirin-triggered D-series resolvins See in Reactome R-HSA-9018676 R-HSA-9018676 Reactome Name: Biosynthesis of D-series resolvins See in Reactome R-HSA-9018896 R-HSA-9018896 Reactome Name: Biosynthesis of E-series 18(S)-resolvins See in Reactome R-HSA-2142770 R-HSA-2142770 Reactome Name: Synthesis of 15-eicosatetraenoic acid derivatives See in Reactome	R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome R-HSA-9018679 R-HSA-9018679 Reactome Name: Biosynthesis of EPA-derived SPMs See in Reactome	Metabolism	R-HSA-2161791 ( R-HSA-2142770 ) R-HSA-2161791 Reaction Name: 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 See in Reactome R-HSA-2161946 ( R-HSA-2142688 ) R-HSA-2161946 Reaction Name: 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 See in Reactome R-HSA-2161959 ( R-HSA-2142712 ) R-HSA-2161959 Reaction Name: 12R-HpETE is reduced to 12R-HETE by GPX1/2/4 See in Reactome R-HSA-2161999 ( R-HSA-2142712 ) R-HSA-2161999 Reaction Name: 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 See in Reactome
MONDO:0011680	ALOXE3	Q9BYJ1	5.4.4.7 4.2.1.152	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome	Metabolism	R-HSA-8942208 ( R-HSA-2142712 ) R-HSA-8942208 Reaction Name: ALOXE3 isomerises 12R-HpETE to HXA3 See in Reactome
MONDO:0013601	GPX1	P07203	1.11.1.9	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-2142770 R-HSA-2142770 Reactome Name: Synthesis of 15-eicosatetraenoic acid derivatives See in Reactome R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Metabolism	R-HSA-2161791 ( R-HSA-2142770 ) R-HSA-2161791 Reaction Name: 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 See in Reactome R-HSA-2161946 ( R-HSA-2142688 ) R-HSA-2161946 Reaction Name: 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 See in Reactome R-HSA-2161959 ( R-HSA-2142712 ) R-HSA-2161959 Reaction Name: 12R-HpETE is reduced to 12R-HETE by GPX1/2/4 See in Reactome R-HSA-2161999 ( R-HSA-2142712 ) R-HSA-2161999 Reaction Name: 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 See in Reactome R-HSA-3323013 ( R-HSA-3299685 ) R-HSA-3323013 Reaction Name: GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O See in Reactome R-HSA-71676 ( R-HSA-3299685 ) R-HSA-71676 Reaction Name: GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O See in Reactome
MONDO:0017778	ALOX12B	O75342	1.13.11.-	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome	Metabolism	R-HSA-2161950 ( R-HSA-2142712 ) R-HSA-2161950 Reaction Name: Arachidonic acid is oxidised to 12R-HpETE by ALOX12B See in Reactome