DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2142700)

Number of enzymes:	3
Number of disease:	7
Number of reactomes:	13
Number of reactions:	21

Search results (Reactome ID: R-HSA-2142700)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005575	ALOX12	P18054	1.13.11.- 1.13.11.33 3.3.2.- 1.13.11.31	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome R-HSA-9025106 R-HSA-9025106 Reactome Name: Biosynthesis of DPAn-6 SPMs See in Reactome R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-9026290 R-HSA-9026290 Reactome Name: Biosynthesis of DPAn-3-derived maresins See in Reactome R-HSA-2142696 R-HSA-2142696 Reactome Name: Synthesis of Hepoxilins (HX) and Trioxilins (TrX) See in Reactome	R-HSA-9025094 R-HSA-9025094 Reactome Name: Biosynthesis of DPAn-3 SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018683 R-HSA-9018683 Reactome Name: Biosynthesis of DPA-derived SPMs See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome	Metabolism	R-HSA-2161775 ( R-HSA-2142700 ) R-HSA-2161775 Reaction Name: ALOX12 oxidises LTA4 to LXA4/B4 See in Reactome R-HSA-2161794 ( R-HSA-2142696 ) R-HSA-2161794 Reaction Name: Arachidonic acid is converted to HXA3/B3 by ALOX12 See in Reactome R-HSA-2161948 ( R-HSA-2142712 ) R-HSA-2161948 Reaction Name: Arachidonic acid is converted to 12-oxoETE by ALOX12 See in Reactome R-HSA-2161964 ( R-HSA-2142712 ) R-HSA-2161964 Reaction Name: Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 See in Reactome R-HSA-9020274 ( R-HSA-9018677 ) R-HSA-9020274 Reaction Name: ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA See in Reactome R-HSA-9024983 ( R-HSA-9018677 ) R-HSA-9024983 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA See in Reactome R-HSA-9025957 ( R-HSA-9025106 ) R-HSA-9025957 Reaction Name: ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 See in Reactome R-HSA-9026006 ( R-HSA-9026290 ) R-HSA-9026006 Reaction Name: ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 See in Reactome R-HSA-9026007 ( R-HSA-9026290 ) R-HSA-9026007 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 See in Reactome
MONDO:0007343	HPGD	P15428	1.1.1.- 1.1.1.232 1.1.1.141	R-HSA-9018676 R-HSA-9018676 Reactome Name: Biosynthesis of D-series resolvins See in Reactome R-HSA-9018896 R-HSA-9018896 Reactome Name: Biosynthesis of E-series 18(S)-resolvins See in Reactome R-HSA-2162123 R-HSA-2162123 Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome	R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome R-HSA-9018679 R-HSA-9018679 Reactome Name: Biosynthesis of EPA-derived SPMs See in Reactome	Metabolism	R-HSA-2161662 ( R-HSA-2162123 ) R-HSA-2161662 Reaction Name: PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD See in Reactome R-HSA-2161779 ( R-HSA-2142700 ) R-HSA-2161779 Reaction Name: LXA4 is oxidised to 15k-LXA4 by HPGD See in Reactome R-HSA-9023968 ( R-HSA-9018896 ) R-HSA-9023968 Reaction Name: HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 See in Reactome R-HSA-9024766 ( R-HSA-9018676; R-HSA-9018677 ) R-HSA-9024766 Reaction Name: HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 See in Reactome
MONDO:0007576	ALOX12	P18054	1.13.11.- 1.13.11.33 3.3.2.- 1.13.11.31	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome R-HSA-9025106 R-HSA-9025106 Reactome Name: Biosynthesis of DPAn-6 SPMs See in Reactome R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-9026290 R-HSA-9026290 Reactome Name: Biosynthesis of DPAn-3-derived maresins See in Reactome R-HSA-2142696 R-HSA-2142696 Reactome Name: Synthesis of Hepoxilins (HX) and Trioxilins (TrX) See in Reactome	R-HSA-9025094 R-HSA-9025094 Reactome Name: Biosynthesis of DPAn-3 SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018683 R-HSA-9018683 Reactome Name: Biosynthesis of DPA-derived SPMs See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome	Metabolism	R-HSA-2161775 ( R-HSA-2142700 ) R-HSA-2161775 Reaction Name: ALOX12 oxidises LTA4 to LXA4/B4 See in Reactome R-HSA-2161794 ( R-HSA-2142696 ) R-HSA-2161794 Reaction Name: Arachidonic acid is converted to HXA3/B3 by ALOX12 See in Reactome R-HSA-2161948 ( R-HSA-2142712 ) R-HSA-2161948 Reaction Name: Arachidonic acid is converted to 12-oxoETE by ALOX12 See in Reactome R-HSA-2161964 ( R-HSA-2142712 ) R-HSA-2161964 Reaction Name: Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 See in Reactome R-HSA-9020274 ( R-HSA-9018677 ) R-HSA-9020274 Reaction Name: ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA See in Reactome R-HSA-9024983 ( R-HSA-9018677 ) R-HSA-9024983 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA See in Reactome R-HSA-9025957 ( R-HSA-9025106 ) R-HSA-9025957 Reaction Name: ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 See in Reactome R-HSA-9026006 ( R-HSA-9026290 ) R-HSA-9026006 Reaction Name: ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 See in Reactome R-HSA-9026007 ( R-HSA-9026290 ) R-HSA-9026007 Reaction Name: ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 See in Reactome
MONDO:0009799	HPGD	P15428	1.1.1.- 1.1.1.232 1.1.1.141	R-HSA-9018676 R-HSA-9018676 Reactome Name: Biosynthesis of D-series resolvins See in Reactome R-HSA-9018896 R-HSA-9018896 Reactome Name: Biosynthesis of E-series 18(S)-resolvins See in Reactome R-HSA-2162123 R-HSA-2162123 Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome	R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome R-HSA-9018679 R-HSA-9018679 Reactome Name: Biosynthesis of EPA-derived SPMs See in Reactome	Metabolism	R-HSA-2161662 ( R-HSA-2162123 ) R-HSA-2161662 Reaction Name: PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD See in Reactome R-HSA-2161779 ( R-HSA-2142700 ) R-HSA-2161779 Reaction Name: LXA4 is oxidised to 15k-LXA4 by HPGD See in Reactome R-HSA-9023968 ( R-HSA-9018896 ) R-HSA-9023968 Reaction Name: HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 See in Reactome R-HSA-9024766 ( R-HSA-9018676; R-HSA-9018677 ) R-HSA-9024766 Reaction Name: HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 See in Reactome
MONDO:0013539	LTC4S	Q16873	2.5.1.- 4.4.1.20	R-HSA-9026766 R-HSA-9026766 Reactome Name: Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) See in Reactome R-HSA-2142691 R-HSA-2142691 Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX) See in Reactome R-HSA-9026762 R-HSA-9026762 Reactome Name: Biosynthesis of maresin conjugates in tissue regeneration (MCTR) See in Reactome R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome	R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome R-HSA-9026395 R-HSA-9026395 Reactome Name: Biosynthesis of DHA-derived sulfido conjugates See in Reactome	Metabolism	R-HSA-2161768 ( R-HSA-2142691 ) R-HSA-2161768 Reaction Name: EXA4 is converted to EXC4 by LTC4S See in Reactome R-HSA-2161907 ( R-HSA-2142700 ) R-HSA-2161907 Reaction Name: ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 See in Reactome R-HSA-2161917 ( R-HSA-2142700 ) R-HSA-2161917 Reaction Name: ALOX5 oxidises 15S-HpETE to LXA4/B4 See in Reactome R-HSA-265296 ( R-HSA-2142688; R-HSA-2142691 ) R-HSA-265296 Reaction Name: Arachidonic acid is oxidised to 5S-HpETE by ALOX5 See in Reactome R-HSA-266050 ( R-HSA-2142691 ) R-HSA-266050 Reaction Name: LTA4 is converted to LTC4 by LTC4S See in Reactome R-HSA-266051 ( R-HSA-2142691; R-HSA-2142700 ) R-HSA-266051 Reaction Name: 5S-HpETE is dehydrated to LTA4 by ALOX5 See in Reactome R-HSA-9026780 ( R-HSA-9018677; R-HSA-9026762 ) R-HSA-9026780 Reaction Name: LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 See in Reactome R-HSA-9026911 ( R-HSA-9018677; R-HSA-9026766 ) R-HSA-9026911 Reaction Name: LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 See in Reactome
MONDO:0015466	HPGD	P15428	1.1.1.- 1.1.1.232 1.1.1.141	R-HSA-9018676 R-HSA-9018676 Reactome Name: Biosynthesis of D-series resolvins See in Reactome R-HSA-9018896 R-HSA-9018896 Reactome Name: Biosynthesis of E-series 18(S)-resolvins See in Reactome R-HSA-2162123 R-HSA-2162123 Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome	R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome R-HSA-9018679 R-HSA-9018679 Reactome Name: Biosynthesis of EPA-derived SPMs See in Reactome	Metabolism	R-HSA-2161662 ( R-HSA-2162123 ) R-HSA-2161662 Reaction Name: PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD See in Reactome R-HSA-2161779 ( R-HSA-2142700 ) R-HSA-2161779 Reaction Name: LXA4 is oxidised to 15k-LXA4 by HPGD See in Reactome R-HSA-9023968 ( R-HSA-9018896 ) R-HSA-9023968 Reaction Name: HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 See in Reactome R-HSA-9024766 ( R-HSA-9018676; R-HSA-9018677 ) R-HSA-9024766 Reaction Name: HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 See in Reactome
MONDO:0024546	HPGD	P15428	1.1.1.- 1.1.1.232 1.1.1.141	R-HSA-9018676 R-HSA-9018676 Reactome Name: Biosynthesis of D-series resolvins See in Reactome R-HSA-9018896 R-HSA-9018896 Reactome Name: Biosynthesis of E-series 18(S)-resolvins See in Reactome R-HSA-2162123 R-HSA-2162123 Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome	R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome R-HSA-9018679 R-HSA-9018679 Reactome Name: Biosynthesis of EPA-derived SPMs See in Reactome	Metabolism	R-HSA-2161662 ( R-HSA-2162123 ) R-HSA-2161662 Reaction Name: PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD See in Reactome R-HSA-2161779 ( R-HSA-2142700 ) R-HSA-2161779 Reaction Name: LXA4 is oxidised to 15k-LXA4 by HPGD See in Reactome R-HSA-9023968 ( R-HSA-9018896 ) R-HSA-9023968 Reaction Name: HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 See in Reactome R-HSA-9024766 ( R-HSA-9018676; R-HSA-9018677 ) R-HSA-9024766 Reaction Name: HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 See in Reactome