DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2142691)

Number of enzymes:	5
Number of disease:	5
Number of reactomes:	15
Number of reactions:	26

Search results (Reactome ID: R-HSA-2142691)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007390	CYP4F2	P78329	1.14.14.94 1.14.14.78 1.14.14.1 1.14.14.79	R-HSA-211979 R-HSA-211979 Reactome Name: Eicosanoids See in Reactome R-HSA-2142691 R-HSA-2142691 Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX) See in Reactome R-HSA-211935 R-HSA-211935 Reactome Name: Fatty acids See in Reactome R-HSA-211958 R-HSA-211958 Reactome Name: Miscellaneous substrates See in Reactome R-HSA-2142816 R-HSA-2142816 Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-211873 ( R-HSA-211979; R-HSA-2142691 ) R-HSA-211873 Reaction Name: CYP4F2, 4F3 20-hydroxylate LTB4 See in Reactome R-HSA-211904 ( R-HSA-211935 ) R-HSA-211904 Reaction Name: CYP4F12 18-hydroxylates ARA See in Reactome R-HSA-211919 ( R-HSA-211979 ) R-HSA-211919 Reaction Name: CYP4F8 19-hydroxylates PGH2 See in Reactome R-HSA-211924 ( R-HSA-211935 ) R-HSA-211924 Reaction Name: CYP4B1 12-hydroxylates ARA See in Reactome R-HSA-211962 ( R-HSA-211958 ) R-HSA-211962 Reaction Name: CYP4F11 16-hydroxylates 3OH-PALM See in Reactome R-HSA-215526 ( R-HSA-211979 ) R-HSA-215526 Reaction Name: CYP4F3 20-hydroxylates LTB4 See in Reactome R-HSA-2161745 ( R-HSA-2142691 ) R-HSA-2161745 Reaction Name: 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 See in Reactome R-HSA-2161792 ( R-HSA-2142691 ) R-HSA-2161792 Reaction Name: 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 See in Reactome R-HSA-2161940 ( R-HSA-2142816 ) R-HSA-2161940 Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3) See in Reactome R-HSA-76466 ( R-HSA-211935 ) R-HSA-76466 Reaction Name: CYP4A11 12-hydroxylates DDCX See in Reactome
MONDO:0009285	GGT1	P19440	3.4.19.14 2.3.2.2 3.4.19.13	R-HSA-174403 R-HSA-174403 Reactome Name: Glutathione synthesis and recycling See in Reactome R-HSA-2142691 R-HSA-2142691 Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX) See in Reactome R-HSA-5423646 R-HSA-5423646 Reactome Name: Aflatoxin activation and detoxification See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-156590 R-HSA-156590 Reactome Name: Glutathione conjugation See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-266046 ( R-HSA-2142691 ) R-HSA-266046 Reaction Name: GGT1, 5 dimers hydrolyse LTC4 to LTD4 See in Reactome R-HSA-5433072 ( R-HSA-5423646 ) R-HSA-5433072 Reaction Name: GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG See in Reactome R-HSA-8943279 ( R-HSA-174403 ) R-HSA-8943279 Reaction Name: GGT dimers hydrolyse GSH See in Reactome
MONDO:0011485	CYP4F22	Q6NT55	1.14.14.177	R-HSA-211979 R-HSA-211979 Reactome Name: Eicosanoids See in Reactome R-HSA-2142691 R-HSA-2142691 Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX) See in Reactome R-HSA-211935 R-HSA-211935 Reactome Name: Fatty acids See in Reactome R-HSA-211958 R-HSA-211958 Reactome Name: Miscellaneous substrates See in Reactome	R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Metabolism	R-HSA-211873 ( R-HSA-211979; R-HSA-2142691 ) R-HSA-211873 Reaction Name: CYP4F2, 4F3 20-hydroxylate LTB4 See in Reactome R-HSA-211924 ( R-HSA-211935 ) R-HSA-211924 Reaction Name: CYP4B1 12-hydroxylates ARA See in Reactome R-HSA-211962 ( R-HSA-211958 ) R-HSA-211962 Reaction Name: CYP4F11 16-hydroxylates 3OH-PALM See in Reactome R-HSA-215526 ( R-HSA-211979 ) R-HSA-215526 Reaction Name: CYP4F3 20-hydroxylates LTB4 See in Reactome R-HSA-2161745 ( R-HSA-2142691 ) R-HSA-2161745 Reaction Name: 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 See in Reactome R-HSA-2161792 ( R-HSA-2142691 ) R-HSA-2161792 Reaction Name: 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 See in Reactome R-HSA-5602295 ( R-HSA-211979 ) R-HSA-5602295 Reaction Name: CYP4F22 20-hydroxylates TrXA3 See in Reactome R-HSA-76466 ( R-HSA-211935 ) R-HSA-76466 Reaction Name: CYP4A11 12-hydroxylates DDCX See in Reactome
MONDO:0013539	LTC4S	Q16873	2.5.1.- 4.4.1.20	R-HSA-9026766 R-HSA-9026766 Reactome Name: Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) See in Reactome R-HSA-2142691 R-HSA-2142691 Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX) See in Reactome R-HSA-9026762 R-HSA-9026762 Reactome Name: Biosynthesis of maresin conjugates in tissue regeneration (MCTR) See in Reactome R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome	R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome R-HSA-9026395 R-HSA-9026395 Reactome Name: Biosynthesis of DHA-derived sulfido conjugates See in Reactome	Metabolism	R-HSA-2161768 ( R-HSA-2142691 ) R-HSA-2161768 Reaction Name: EXA4 is converted to EXC4 by LTC4S See in Reactome R-HSA-2161907 ( R-HSA-2142700 ) R-HSA-2161907 Reaction Name: ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 See in Reactome R-HSA-2161917 ( R-HSA-2142700 ) R-HSA-2161917 Reaction Name: ALOX5 oxidises 15S-HpETE to LXA4/B4 See in Reactome R-HSA-265296 ( R-HSA-2142688; R-HSA-2142691 ) R-HSA-265296 Reaction Name: Arachidonic acid is oxidised to 5S-HpETE by ALOX5 See in Reactome R-HSA-266050 ( R-HSA-2142691 ) R-HSA-266050 Reaction Name: LTA4 is converted to LTC4 by LTC4S See in Reactome R-HSA-266051 ( R-HSA-2142691; R-HSA-2142700 ) R-HSA-266051 Reaction Name: 5S-HpETE is dehydrated to LTA4 by ALOX5 See in Reactome R-HSA-9026780 ( R-HSA-9026762 ) R-HSA-9026780 Reaction Name: LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 See in Reactome R-HSA-9026911 ( R-HSA-9026766 ) R-HSA-9026911 Reaction Name: LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 See in Reactome
MONDO:0030058	ABCC1	P33527	7.6.2.2 7.6.2.3	R-HSA-2142691 R-HSA-2142691 Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX) See in Reactome R-HSA-9707564 R-HSA-9707564 Reactome Name: Cytoprotection by HMOX1 See in Reactome R-HSA-196741 R-HSA-196741 Reactome Name: Cobalamin (Cbl, vitamin B12) transport and metabolism See in Reactome R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Transport of small molecules Metabolism	R-HSA-1454916 ( R-HSA-382556 ) R-HSA-1454916 Reaction Name: The ABCC family mediates organic anion transport See in Reactome R-HSA-266070 ( R-HSA-2142691 ) R-HSA-266070 Reaction Name: LTC4 is exported from the cytosol by ABCC1 See in Reactome R-HSA-3095901 ( R-HSA-196741 ) R-HSA-3095901 Reaction Name: ABCC1 transports cytosolic RCbl to extracellular region See in Reactome R-HSA-9661405 ( R-HSA-189483; R-HSA-9707564 ) R-HSA-9661405 Reaction Name: ABCC1 transports BIL from cytosol to extracellular region (blood) See in Reactome