DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2142688)

Number of enzymes:	6
Number of disease:	5
Number of reactomes:	12
Number of reactions:	15

Search results (Reactome ID: R-HSA-2142688)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0004976	PON1	P27169	3.1.1.81 3.1.1.2 3.1.8.1	R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome	Metabolism	R-HSA-8932633 ( R-HSA-2142688 ) R-HSA-8932633 Reaction Name: PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE See in Reactome
MONDO:0004976	PON2	Q15165	3.1.1.81 3.1.1.2	R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome	Metabolism	R-HSA-8932633 ( R-HSA-2142688 ) R-HSA-8932633 Reaction Name: PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE See in Reactome
MONDO:0004976	PON3	Q15166	3.1.1.81 3.1.1.2 3.1.8.1	R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome	Metabolism	R-HSA-8932633 ( R-HSA-2142688 ) R-HSA-8932633 Reaction Name: PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE See in Reactome
MONDO:0009593	GPX4	P36969	1.11.1.12	R-HSA-9023661 R-HSA-9023661 Reactome Name: Biosynthesis of E-series 18(R)-resolvins See in Reactome R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-9020265 R-HSA-9020265 Reactome Name: Biosynthesis of aspirin-triggered D-series resolvins See in Reactome R-HSA-9018676 R-HSA-9018676 Reactome Name: Biosynthesis of D-series resolvins See in Reactome R-HSA-9018896 R-HSA-9018896 Reactome Name: Biosynthesis of E-series 18(S)-resolvins See in Reactome R-HSA-2142770 R-HSA-2142770 Reactome Name: Synthesis of 15-eicosatetraenoic acid derivatives See in Reactome	R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome R-HSA-9018679 R-HSA-9018679 Reactome Name: Biosynthesis of EPA-derived SPMs See in Reactome	Metabolism	R-HSA-2161791 ( R-HSA-2142770 ) R-HSA-2161791 Reaction Name: 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 See in Reactome R-HSA-2161946 ( R-HSA-2142688 ) R-HSA-2161946 Reaction Name: 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 See in Reactome R-HSA-2161959 ( R-HSA-2142712 ) R-HSA-2161959 Reaction Name: 12R-HpETE is reduced to 12R-HETE by GPX1/2/4 See in Reactome R-HSA-2161999 ( R-HSA-2142712 ) R-HSA-2161999 Reaction Name: 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 See in Reactome
MONDO:0012969	PON1	P27169	3.1.1.81 3.1.1.2 3.1.8.1	R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome	Metabolism	R-HSA-8932633 ( R-HSA-2142688 ) R-HSA-8932633 Reaction Name: PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE See in Reactome
MONDO:0013539	LTC4S	Q16873	2.5.1.- 4.4.1.20	R-HSA-9026766 R-HSA-9026766 Reactome Name: Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) See in Reactome R-HSA-2142691 R-HSA-2142691 Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX) See in Reactome R-HSA-9026762 R-HSA-9026762 Reactome Name: Biosynthesis of maresin conjugates in tissue regeneration (MCTR) See in Reactome R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome R-HSA-2142700 R-HSA-2142700 Reactome Name: Synthesis of Lipoxins (LX) See in Reactome	R-HSA-9018677 R-HSA-9018677 Reactome Name: Biosynthesis of DHA-derived SPMs See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9018678 R-HSA-9018678 Reactome Name: Biosynthesis of specialized proresolving mediators (SPMs) See in Reactome R-HSA-9026395 R-HSA-9026395 Reactome Name: Biosynthesis of DHA-derived sulfido conjugates See in Reactome	Metabolism	R-HSA-2161768 ( R-HSA-2142691 ) R-HSA-2161768 Reaction Name: EXA4 is converted to EXC4 by LTC4S See in Reactome R-HSA-2161907 ( R-HSA-2142700 ) R-HSA-2161907 Reaction Name: ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 See in Reactome R-HSA-2161917 ( R-HSA-2142700 ) R-HSA-2161917 Reaction Name: ALOX5 oxidises 15S-HpETE to LXA4/B4 See in Reactome R-HSA-265296 ( R-HSA-2142688; R-HSA-2142691 ) R-HSA-265296 Reaction Name: Arachidonic acid is oxidised to 5S-HpETE by ALOX5 See in Reactome R-HSA-266050 ( R-HSA-2142691 ) R-HSA-266050 Reaction Name: LTA4 is converted to LTC4 by LTC4S See in Reactome R-HSA-266051 ( R-HSA-2142691; R-HSA-2142700 ) R-HSA-266051 Reaction Name: 5S-HpETE is dehydrated to LTA4 by ALOX5 See in Reactome R-HSA-9026780 ( R-HSA-9026762 ) R-HSA-9026780 Reaction Name: LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 See in Reactome R-HSA-9026911 ( R-HSA-9026766 ) R-HSA-9026911 Reaction Name: LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 See in Reactome
MONDO:0013601	GPX1	P07203	1.11.1.9	R-HSA-2142712 R-HSA-2142712 Reactome Name: Synthesis of 12-eicosatetraenoic acid derivatives See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-2142770 R-HSA-2142770 Reactome Name: Synthesis of 15-eicosatetraenoic acid derivatives See in Reactome R-HSA-2142688 R-HSA-2142688 Reactome Name: Synthesis of 5-eicosatetraenoic acids See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Metabolism	R-HSA-2161791 ( R-HSA-2142770 ) R-HSA-2161791 Reaction Name: 15S-HpETE is reduced to 15S-HETE by GPX1/2/4 See in Reactome R-HSA-2161946 ( R-HSA-2142688 ) R-HSA-2161946 Reaction Name: 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 See in Reactome R-HSA-2161959 ( R-HSA-2142712 ) R-HSA-2161959 Reaction Name: 12R-HpETE is reduced to 12R-HETE by GPX1/2/4 See in Reactome R-HSA-2161999 ( R-HSA-2142712 ) R-HSA-2161999 Reaction Name: 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 See in Reactome R-HSA-3323013 ( R-HSA-3299685 ) R-HSA-3323013 Reaction Name: GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O See in Reactome R-HSA-71676 ( R-HSA-3299685 ) R-HSA-71676 Reaction Name: GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O See in Reactome