DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2132295)

Number of enzymes:	9
Number of disease:	14
Number of reactomes:	38
Number of reactions:	78

Search results (Reactome ID: R-HSA-2132295)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007854	CTSB	P07858	3.4.22.1	R-HSA-1679131 R-HSA-1679131 Reactome Name: Trafficking and processing of endosomal TLR See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System Extracellular matrix organization	R-HSA-1678920 ( R-HSA-1679131 ) R-HSA-1678920 Reaction Name: TLR processing at low pH See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-2168923 ( R-HSA-1442490 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2471621 ( R-HSA-1442490 ) R-HSA-2471621 Reaction Name: Endostatin degradation by cathepsins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0008048	DNM2	P50570	3.6.5.5	R-HSA-432720 R-HSA-432720 Reactome Name: Lysosome Vesicle Biogenesis See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-190873 R-HSA-190873 Reactome Name: Gap junction degradation See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-196025 R-HSA-196025 Reactome Name: Formation of annular gap junctions See in Reactome R-HSA-203641 R-HSA-203641 Reactome Name: NOSTRIN mediated eNOS trafficking See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome	R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-190828 R-HSA-190828 Reactome Name: Gap junction trafficking See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Signal Transduction Metabolism Immune System Developmental Biology Vesicle-mediated transport	R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-190519 ( R-HSA-190873 ) R-HSA-190519 Reaction Name: Internalization of gap junction plaques See in Reactome R-HSA-190829 ( R-HSA-190873 ) R-HSA-190829 Reaction Name: Lysosomal degradation of gap junction plaques See in Reactome R-HSA-196017 ( R-HSA-190873; R-HSA-196025 ) R-HSA-196017 Reaction Name: Dynamin is recruited to the gap junction plaque See in Reactome R-HSA-203565 ( R-HSA-203641 ) R-HSA-203565 Reaction Name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP See in Reactome R-HSA-203625 ( R-HSA-203641 ) R-HSA-203625 Reaction Name: NOSTRIN mediated translocation of eNOS from plasma membrane See in Reactome R-HSA-203662 ( R-HSA-203641 ) R-HSA-203662 Reaction Name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 See in Reactome R-HSA-2130619 ( R-HSA-2132295 ) R-HSA-2130619 Reaction Name: TGN-lysosomal vesicle coat assembly See in Reactome R-HSA-2130641 ( R-HSA-2132295 ) R-HSA-2130641 Reaction Name: Translocation of TGN-lysosome vesicle to lysosome See in Reactome R-HSA-2130725 ( R-HSA-2132295 ) R-HSA-2130725 Reaction Name: Internalization of MHC II:Ii clathrin coated vesicle See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-432706 ( R-HSA-432720 ) R-HSA-432706 Reaction Name: trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly See in Reactome R-HSA-432707 ( R-HSA-432720 ) R-HSA-432707 Reaction Name: trans-Golgi Network Lysosomal Vesicle Scission See in Reactome R-HSA-555065 ( R-HSA-437239 ) R-HSA-555065 Reaction Name: Formation of clathrin coated vesicle See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8951498 ( R-HSA-2132295 ) R-HSA-8951498 Reaction Name: Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex See in Reactome R-HSA-9619838 ( R-HSA-9031628 ) R-HSA-9619838 Reaction Name: ARC binds DNM2 and SH3GL3 See in Reactome
MONDO:0008226	CTSC	P53634	3.4.14.1	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5694530 R-HSA-5694530 Reactome Name: Cargo concentration in the ER See in Reactome R-HSA-204005 R-HSA-204005 Reactome Name: COPII-mediated vesicle transport See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-199977 R-HSA-199977 Reactome Name: ER to Golgi Anterograde Transport See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-948021 R-HSA-948021 Reactome Name: Transport to the Golgi and subsequent modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism of proteins Vesicle-mediated transport	R-HSA-203973 ( R-HSA-204005 ) R-HSA-203973 Reaction Name: Vesicle budding See in Reactome R-HSA-204008 ( R-HSA-204005 ) R-HSA-204008 Reaction Name: SEC31:SEC13 and v-SNARE recruitment See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-5694409 ( R-HSA-204005 ) R-HSA-5694409 Reaction Name: Nucleotide exchange on RAB1 See in Reactome R-HSA-5694417 ( R-HSA-204005 ) R-HSA-5694417 Reaction Name: SEC16 complex binds SAR1B:GTP:SEC23:SEC24 See in Reactome R-HSA-5694418 ( R-HSA-204005 ) R-HSA-5694418 Reaction Name: RAB1:GTP binds USO1 and GORASP1:GOLGA2 See in Reactome R-HSA-5694428 ( R-HSA-5694530 ) R-HSA-5694428 Reaction Name: LMAN family proteins bind glycosylated cargo See in Reactome R-HSA-5694439 ( R-HSA-204005 ) R-HSA-5694439 Reaction Name: COPII coat binds TRAPPCII and RAB1:GDP See in Reactome R-HSA-5694441 ( R-HSA-204005 ) R-HSA-5694441 Reaction Name: CSNK1D phosphorylates SEC23 See in Reactome R-HSA-5694446 ( R-HSA-204005 ) R-HSA-5694446 Reaction Name: BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle See in Reactome R-HSA-5694522 ( R-HSA-204005; R-HSA-5694530 ) R-HSA-5694522 Reaction Name: Inner coat assembly and cargo binding See in Reactome R-HSA-5694527 ( R-HSA-204005 ) R-HSA-5694527 Reaction Name: Loss of SAR1B GTPase See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome
MONDO:0009490	CTSC	P53634	3.4.14.1	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5694530 R-HSA-5694530 Reactome Name: Cargo concentration in the ER See in Reactome R-HSA-204005 R-HSA-204005 Reactome Name: COPII-mediated vesicle transport See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-199977 R-HSA-199977 Reactome Name: ER to Golgi Anterograde Transport See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-948021 R-HSA-948021 Reactome Name: Transport to the Golgi and subsequent modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism of proteins Vesicle-mediated transport	R-HSA-203973 ( R-HSA-204005 ) R-HSA-203973 Reaction Name: Vesicle budding See in Reactome R-HSA-204008 ( R-HSA-204005 ) R-HSA-204008 Reaction Name: SEC31:SEC13 and v-SNARE recruitment See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-5694409 ( R-HSA-204005 ) R-HSA-5694409 Reaction Name: Nucleotide exchange on RAB1 See in Reactome R-HSA-5694417 ( R-HSA-204005 ) R-HSA-5694417 Reaction Name: SEC16 complex binds SAR1B:GTP:SEC23:SEC24 See in Reactome R-HSA-5694418 ( R-HSA-204005 ) R-HSA-5694418 Reaction Name: RAB1:GTP binds USO1 and GORASP1:GOLGA2 See in Reactome R-HSA-5694428 ( R-HSA-5694530 ) R-HSA-5694428 Reaction Name: LMAN family proteins bind glycosylated cargo See in Reactome R-HSA-5694439 ( R-HSA-204005 ) R-HSA-5694439 Reaction Name: COPII coat binds TRAPPCII and RAB1:GDP See in Reactome R-HSA-5694441 ( R-HSA-204005 ) R-HSA-5694441 Reaction Name: CSNK1D phosphorylates SEC23 See in Reactome R-HSA-5694446 ( R-HSA-204005 ) R-HSA-5694446 Reaction Name: BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle See in Reactome R-HSA-5694522 ( R-HSA-204005; R-HSA-5694530 ) R-HSA-5694522 Reaction Name: Inner coat assembly and cargo binding See in Reactome R-HSA-5694527 ( R-HSA-204005 ) R-HSA-5694527 Reaction Name: Loss of SAR1B GTPase See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome
MONDO:0009491	CTSC	P53634	3.4.14.1	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5694530 R-HSA-5694530 Reactome Name: Cargo concentration in the ER See in Reactome R-HSA-204005 R-HSA-204005 Reactome Name: COPII-mediated vesicle transport See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-199977 R-HSA-199977 Reactome Name: ER to Golgi Anterograde Transport See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-948021 R-HSA-948021 Reactome Name: Transport to the Golgi and subsequent modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism of proteins Vesicle-mediated transport	R-HSA-203973 ( R-HSA-204005 ) R-HSA-203973 Reaction Name: Vesicle budding See in Reactome R-HSA-204008 ( R-HSA-204005 ) R-HSA-204008 Reaction Name: SEC31:SEC13 and v-SNARE recruitment See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-5694409 ( R-HSA-204005 ) R-HSA-5694409 Reaction Name: Nucleotide exchange on RAB1 See in Reactome R-HSA-5694417 ( R-HSA-204005 ) R-HSA-5694417 Reaction Name: SEC16 complex binds SAR1B:GTP:SEC23:SEC24 See in Reactome R-HSA-5694418 ( R-HSA-204005 ) R-HSA-5694418 Reaction Name: RAB1:GTP binds USO1 and GORASP1:GOLGA2 See in Reactome R-HSA-5694428 ( R-HSA-5694530 ) R-HSA-5694428 Reaction Name: LMAN family proteins bind glycosylated cargo See in Reactome R-HSA-5694439 ( R-HSA-204005 ) R-HSA-5694439 Reaction Name: COPII coat binds TRAPPCII and RAB1:GDP See in Reactome R-HSA-5694441 ( R-HSA-204005 ) R-HSA-5694441 Reaction Name: CSNK1D phosphorylates SEC23 See in Reactome R-HSA-5694446 ( R-HSA-204005 ) R-HSA-5694446 Reaction Name: BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle See in Reactome R-HSA-5694522 ( R-HSA-204005; R-HSA-5694530 ) R-HSA-5694522 Reaction Name: Inner coat assembly and cargo binding See in Reactome R-HSA-5694527 ( R-HSA-204005 ) R-HSA-5694527 Reaction Name: Loss of SAR1B GTPase See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome
MONDO:0009737	CTSA	P10619	3.4.16.5	R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0009940	CTSK	P43235	3.4.22.38	R-HSA-8939242 R-HSA-8939242 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of keratinocytes See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-1679131 R-HSA-1679131 Reactome Name: Trafficking and processing of endosomal TLR See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Extracellular matrix organization	R-HSA-1592362 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592362 Reaction Name: Activation of proMMP7 by MMP3 See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-1678920 ( R-HSA-1679131 ) R-HSA-1678920 Reaction Name: TLR processing at low pH See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2471621 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2471621 Reaction Name: Endostatin degradation by cathepsins See in Reactome R-HSA-2514772 ( R-HSA-1474228 ) R-HSA-2514772 Reaction Name: Fibrillin-1 degradation by MMP3, CTSK, CTSL2 See in Reactome R-HSA-8938121 ( R-HSA-8939242 ) R-HSA-8938121 Reaction Name: SERPINB13 binds CTSK See in Reactome
MONDO:0010683	DNM2	P50570	3.6.5.5	R-HSA-432720 R-HSA-432720 Reactome Name: Lysosome Vesicle Biogenesis See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-190873 R-HSA-190873 Reactome Name: Gap junction degradation See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-196025 R-HSA-196025 Reactome Name: Formation of annular gap junctions See in Reactome R-HSA-203641 R-HSA-203641 Reactome Name: NOSTRIN mediated eNOS trafficking See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome	R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-190828 R-HSA-190828 Reactome Name: Gap junction trafficking See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Signal Transduction Metabolism Immune System Developmental Biology Vesicle-mediated transport	R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-190519 ( R-HSA-190873 ) R-HSA-190519 Reaction Name: Internalization of gap junction plaques See in Reactome R-HSA-190829 ( R-HSA-190873 ) R-HSA-190829 Reaction Name: Lysosomal degradation of gap junction plaques See in Reactome R-HSA-196017 ( R-HSA-190873; R-HSA-196025 ) R-HSA-196017 Reaction Name: Dynamin is recruited to the gap junction plaque See in Reactome R-HSA-203565 ( R-HSA-203641 ) R-HSA-203565 Reaction Name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP See in Reactome R-HSA-203625 ( R-HSA-203641 ) R-HSA-203625 Reaction Name: NOSTRIN mediated translocation of eNOS from plasma membrane See in Reactome R-HSA-203662 ( R-HSA-203641 ) R-HSA-203662 Reaction Name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 See in Reactome R-HSA-2130619 ( R-HSA-2132295 ) R-HSA-2130619 Reaction Name: TGN-lysosomal vesicle coat assembly See in Reactome R-HSA-2130641 ( R-HSA-2132295 ) R-HSA-2130641 Reaction Name: Translocation of TGN-lysosome vesicle to lysosome See in Reactome R-HSA-2130725 ( R-HSA-2132295 ) R-HSA-2130725 Reaction Name: Internalization of MHC II:Ii clathrin coated vesicle See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-432706 ( R-HSA-432720 ) R-HSA-432706 Reaction Name: trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly See in Reactome R-HSA-432707 ( R-HSA-432720 ) R-HSA-432707 Reaction Name: trans-Golgi Network Lysosomal Vesicle Scission See in Reactome R-HSA-555065 ( R-HSA-437239 ) R-HSA-555065 Reaction Name: Formation of clathrin coated vesicle See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8951498 ( R-HSA-2132295 ) R-HSA-8951498 Reaction Name: Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex See in Reactome R-HSA-9619838 ( R-HSA-9031628 ) R-HSA-9619838 Reaction Name: ARC binds DNM2 and SH3GL3 See in Reactome
MONDO:0010949	RAB7A	P51149	3.6.5.2	R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-8873719 R-HSA-8873719 Reactome Name: RAB geranylgeranylation See in Reactome R-HSA-8854214 R-HSA-8854214 Reactome Name: TBC/RABGAPs See in Reactome R-HSA-9035034 R-HSA-9035034 Reactome Name: RHOF GTPase cycle See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9013405 R-HSA-9013405 Reactome Name: RHOD GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism of proteins Signal Transduction Vesicle-mediated transport	R-HSA-2213248 ( R-HSA-2132295 ) R-HSA-2213248 Reaction Name: Transport of antigen loaded MHC II molecules to surface See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-8854255 ( R-HSA-8854214 ) R-HSA-8854255 Reaction Name: TBC1D2A accelerates GTP hydrolysis by RAB7 See in Reactome R-HSA-8854329 ( R-HSA-8854214 ) R-HSA-8854329 Reaction Name: TBC1D15 accelerates GTP hydrolysis by RAB7 See in Reactome R-HSA-8870466 ( R-HSA-8873719 ) R-HSA-8870466 Reaction Name: RGGT:CHM binds RABs See in Reactome R-HSA-8870469 ( R-HSA-8873719 ) R-HSA-8870469 Reaction Name: RGGT geranylgeranylates RAB proteins See in Reactome R-HSA-8877451 ( R-HSA-8876198 ) R-HSA-8877451 Reaction Name: MON1:CCZ1 exchanges GTP for GDP on RAB7 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome R-HSA-9017507 ( R-HSA-9013409 ) R-HSA-9017507 Reaction Name: RHOJ binds effectors at the plasma membrane See in Reactome R-HSA-9018746 ( R-HSA-9013406 ) R-HSA-9018746 Reaction Name: RHOQ binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9693125 ( R-HSA-9035034 ) R-HSA-9693125 Reaction Name: RHOF binds effectors at the plasma membrane See in Reactome R-HSA-9693198 ( R-HSA-9013405 ) R-HSA-9693198 Reaction Name: RHOD binds effectors at the plasma membrane See in Reactome
MONDO:0012414	CTSD	P07339	3.4.23.5	R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-2022403 ( R-HSA-2022377 ) R-HSA-2022403 Reaction Name: Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2022412 ( R-HSA-2022377 ) R-HSA-2022412 Reaction Name: Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-2471621 ( R-HSA-1442490 ) R-HSA-2471621 Reaction Name: Endostatin degradation by cathepsins See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome
MONDO:0014147	CTSF	Q9UBX1	3.4.22.41	R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome
MONDO:0014149	DNM2	P50570	3.6.5.5	R-HSA-432720 R-HSA-432720 Reactome Name: Lysosome Vesicle Biogenesis See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-190873 R-HSA-190873 Reactome Name: Gap junction degradation See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-196025 R-HSA-196025 Reactome Name: Formation of annular gap junctions See in Reactome R-HSA-203641 R-HSA-203641 Reactome Name: NOSTRIN mediated eNOS trafficking See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome	R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-190828 R-HSA-190828 Reactome Name: Gap junction trafficking See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Signal Transduction Metabolism Immune System Developmental Biology Vesicle-mediated transport	R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-190519 ( R-HSA-190873 ) R-HSA-190519 Reaction Name: Internalization of gap junction plaques See in Reactome R-HSA-190829 ( R-HSA-190873 ) R-HSA-190829 Reaction Name: Lysosomal degradation of gap junction plaques See in Reactome R-HSA-196017 ( R-HSA-190873; R-HSA-196025 ) R-HSA-196017 Reaction Name: Dynamin is recruited to the gap junction plaque See in Reactome R-HSA-203565 ( R-HSA-203641 ) R-HSA-203565 Reaction Name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP See in Reactome R-HSA-203625 ( R-HSA-203641 ) R-HSA-203625 Reaction Name: NOSTRIN mediated translocation of eNOS from plasma membrane See in Reactome R-HSA-203662 ( R-HSA-203641 ) R-HSA-203662 Reaction Name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 See in Reactome R-HSA-2130619 ( R-HSA-2132295 ) R-HSA-2130619 Reaction Name: TGN-lysosomal vesicle coat assembly See in Reactome R-HSA-2130641 ( R-HSA-2132295 ) R-HSA-2130641 Reaction Name: Translocation of TGN-lysosome vesicle to lysosome See in Reactome R-HSA-2130725 ( R-HSA-2132295 ) R-HSA-2130725 Reaction Name: Internalization of MHC II:Ii clathrin coated vesicle See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-432706 ( R-HSA-432720 ) R-HSA-432706 Reaction Name: trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly See in Reactome R-HSA-432707 ( R-HSA-432720 ) R-HSA-432707 Reaction Name: trans-Golgi Network Lysosomal Vesicle Scission See in Reactome R-HSA-555065 ( R-HSA-437239 ) R-HSA-555065 Reaction Name: Formation of clathrin coated vesicle See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8951498 ( R-HSA-2132295 ) R-HSA-8951498 Reaction Name: Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex See in Reactome R-HSA-9619838 ( R-HSA-9031628 ) R-HSA-9619838 Reaction Name: ARC binds DNM2 and SH3GL3 See in Reactome
MONDO:0014598	DNM1	Q05193	3.6.5.5	R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-190873 R-HSA-190873 Reactome Name: Gap junction degradation See in Reactome R-HSA-196025 R-HSA-196025 Reactome Name: Formation of annular gap junctions See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome	R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-190828 R-HSA-190828 Reactome Name: Gap junction trafficking See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Signal Transduction Developmental Biology Vesicle-mediated transport	R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-190519 ( R-HSA-190873 ) R-HSA-190519 Reaction Name: Internalization of gap junction plaques See in Reactome R-HSA-190829 ( R-HSA-190873 ) R-HSA-190829 Reaction Name: Lysosomal degradation of gap junction plaques See in Reactome R-HSA-196017 ( R-HSA-190873; R-HSA-196025 ) R-HSA-196017 Reaction Name: Dynamin is recruited to the gap junction plaque See in Reactome R-HSA-2130619 ( R-HSA-2132295 ) R-HSA-2130619 Reaction Name: TGN-lysosomal vesicle coat assembly See in Reactome R-HSA-2130641 ( R-HSA-2132295 ) R-HSA-2130641 Reaction Name: Translocation of TGN-lysosome vesicle to lysosome See in Reactome R-HSA-2130725 ( R-HSA-2132295 ) R-HSA-2130725 Reaction Name: Internalization of MHC II:Ii clathrin coated vesicle See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-3928654 ( R-HSA-3928665 ) R-HSA-3928654 Reaction Name: Clathrin internalises EPH:EFN complexes See in Reactome R-HSA-555065 ( R-HSA-437239 ) R-HSA-555065 Reaction Name: Formation of clathrin coated vesicle See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8951498 ( R-HSA-2132295 ) R-HSA-8951498 Reaction Name: Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex See in Reactome
MONDO:0016431	DNM2	P50570	3.6.5.5	R-HSA-432720 R-HSA-432720 Reactome Name: Lysosome Vesicle Biogenesis See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-190873 R-HSA-190873 Reactome Name: Gap junction degradation See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-196025 R-HSA-196025 Reactome Name: Formation of annular gap junctions See in Reactome R-HSA-203641 R-HSA-203641 Reactome Name: NOSTRIN mediated eNOS trafficking See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome	R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-190828 R-HSA-190828 Reactome Name: Gap junction trafficking See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-157858 R-HSA-157858 Reactome Name: Gap junction trafficking and regulation See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Signal Transduction Metabolism Immune System Developmental Biology Vesicle-mediated transport	R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-190519 ( R-HSA-190873 ) R-HSA-190519 Reaction Name: Internalization of gap junction plaques See in Reactome R-HSA-190829 ( R-HSA-190873 ) R-HSA-190829 Reaction Name: Lysosomal degradation of gap junction plaques See in Reactome R-HSA-196017 ( R-HSA-190873; R-HSA-196025 ) R-HSA-196017 Reaction Name: Dynamin is recruited to the gap junction plaque See in Reactome R-HSA-203565 ( R-HSA-203641 ) R-HSA-203565 Reaction Name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP See in Reactome R-HSA-203625 ( R-HSA-203641 ) R-HSA-203625 Reaction Name: NOSTRIN mediated translocation of eNOS from plasma membrane See in Reactome R-HSA-203662 ( R-HSA-203641 ) R-HSA-203662 Reaction Name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 See in Reactome R-HSA-2130619 ( R-HSA-2132295 ) R-HSA-2130619 Reaction Name: TGN-lysosomal vesicle coat assembly See in Reactome R-HSA-2130641 ( R-HSA-2132295 ) R-HSA-2130641 Reaction Name: Translocation of TGN-lysosome vesicle to lysosome See in Reactome R-HSA-2130725 ( R-HSA-2132295 ) R-HSA-2130725 Reaction Name: Internalization of MHC II:Ii clathrin coated vesicle See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-432706 ( R-HSA-432720 ) R-HSA-432706 Reaction Name: trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly See in Reactome R-HSA-432707 ( R-HSA-432720 ) R-HSA-432707 Reaction Name: trans-Golgi Network Lysosomal Vesicle Scission See in Reactome R-HSA-555065 ( R-HSA-437239 ) R-HSA-555065 Reaction Name: Formation of clathrin coated vesicle See in Reactome R-HSA-8868236 ( R-HSA-8856828 ) R-HSA-8868236 Reaction Name: BAR domain proteins recruit dynamin See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-8951498 ( R-HSA-2132295 ) R-HSA-8951498 Reaction Name: Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex See in Reactome R-HSA-9619838 ( R-HSA-9031628 ) R-HSA-9619838 Reaction Name: ARC binds DNM2 and SH3GL3 See in Reactome