DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2122948)

Number of enzymes:	6
Number of disease:	13
Number of reactomes:	26
Number of reactions:	56

Search results (Reactome ID: R-HSA-2122948)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007088	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0008243	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0010857	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011743	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011743	PSEN2	P49810	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011913	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013245	ITCH	Q96J02	2.3.2.26	R-HSA-5610780 R-HSA-5610780 Reactome Name: Degradation of GLI1 by the proteasome See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5632684 R-HSA-5632684 Reactome Name: Hedgehog 'on' state See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-1253288 R-HSA-1253288 Reactome Name: Downregulation of ERBB4 signaling See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-5610787 R-HSA-5610787 Reactome Name: Hedgehog 'off' state See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Signal Transduction	R-HSA-1253282 ( R-HSA-1253288 ) R-HSA-1253282 Reaction Name: ERBB4 ubiquitination by WWP1/ITCH See in Reactome R-HSA-1253300 ( R-HSA-1253288 ) R-HSA-1253300 Reaction Name: ERBB4 binds WWP1/ITCH ubiquitin ligases See in Reactome R-HSA-1912357 ( R-HSA-2122948 ) R-HSA-1912357 Reaction Name: ITCH ubiquitinates DTX See in Reactome R-HSA-1912386 ( R-HSA-2122948 ) R-HSA-1912386 Reaction Name: Ubiquitination of NOTCH1 by ITCH in the absence of ligand See in Reactome R-HSA-1980125 ( R-HSA-2122948 ) R-HSA-1980125 Reaction Name: ITCH binds DTX See in Reactome R-HSA-1980128 ( R-HSA-2122948 ) R-HSA-1980128 Reaction Name: NOTCH1 associates with negative regulators NUMB and ITCH See in Reactome R-HSA-5610735 ( R-HSA-5610780; R-HSA-5632684 ) R-HSA-5610735 Reaction Name: NUMB binds ITCH See in Reactome R-HSA-5610737 ( R-HSA-5610780 ) R-HSA-5610737 Reaction Name: NUMB:ITCH bind and ubiquitnate GLI1 See in Reactome R-HSA-5610760 ( R-HSA-5610780 ) R-HSA-5610760 Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH See in Reactome R-HSA-5635861 ( R-HSA-5632684 ) R-HSA-5635861 Reaction Name: NUMB:ITCH binds GLI1 See in Reactome R-HSA-5635864 ( R-HSA-5632684 ) R-HSA-5635864 Reaction Name: NUMB:ITCH ubiquitinates GLI1 See in Reactome R-HSA-5635868 ( R-HSA-5632684 ) R-HSA-5635868 Reaction Name: ub-GLI is degraded by the proteasome See in Reactome R-HSA-688137 ( R-HSA-168638 ) R-HSA-688137 Reaction Name: RIP2 is K63 polyubiquitinated See in Reactome R-HSA-8956652 ( R-HSA-8939236 ) R-HSA-8956652 Reaction Name: ITCH gene expression is stimulated by RUNX1 and YAP1 See in Reactome R-HSA-8956684 ( R-HSA-8939236 ) R-HSA-8956684 Reaction Name: ITCH polyubiquitinates TP73 See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome R-HSA-990526 ( R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome
MONDO:0013371	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013373	PSEN2	P49810	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013398	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013693	ADAM17	P78536	3.4.24.86	R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-5362798 R-HSA-5362798 Reactome Name: Release of Hh-Np from the secreting cell See in Reactome	R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Extracellular matrix organization Signal Transduction	R-HSA-1168777 ( R-HSA-982772 ) R-HSA-1168777 Reaction Name: Metalloprotease cleavage of GHR See in Reactome R-HSA-1251992 ( R-HSA-1251985 ) R-HSA-1251992 Reaction Name: Cleavage of P-ERBB4jmA isoforms by ADAM17 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-193679 ( R-HSA-193692 ) R-HSA-193679 Reaction Name: alpha-secretase cleaves the p75NTR extracellular domain See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3371385 ( R-HSA-75893 ) R-HSA-3371385 Reaction Name: TNF-alpha is cleaved by ADAM17 (TACE) See in Reactome R-HSA-5362793 ( R-HSA-5362798 ) R-HSA-5362793 Reaction Name: Hh-Np is cleaved by ADAM17 to promote ligand shedding See in Reactome
MONDO:0014042	MIB1	Q86YT6	2.3.2.27	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome	Signal Transduction	R-HSA-1980074 ( R-HSA-2122948 ) R-HSA-1980074 Reaction Name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 See in Reactome R-HSA-2172172 ( R-HSA-2979096 ) R-HSA-2172172 Reaction Name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 See in Reactome R-HSA-9013069 ( R-HSA-9013507 ) R-HSA-9013069 Reaction Name: Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 See in Reactome
MONDO:0014234	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome
MONDO:0014265	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome