MONDO:0001071 |
MONDO:0001071
Disease Name: intellectual disability
Orphanet id: Orphanet:319658
All associated enzymes in DAR:
CYP2U1
DHX16
CBS
POLG
UFSP2
P4HTM
PDIA3
DHX30
TET3
ALG3
NAGLU
CHD3
SMPD1
DHX34
GCH1
CARNMT1
CYP27A1
ABCD1
CHD2
DDX54
INO80
PTPN4
DHX37
CYP2U1 |
Q7Z449 |
1.14.14.80
|
R-HSA-2142816
R-HSA-2142816
Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
See in Reactome
R-HSA-211958
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-211960
(
R-HSA-211958
)
R-HSA-2161814
(
R-HSA-2142816
)
R-HSA-2161814
Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
See in Reactome
R-HSA-2161940
(
R-HSA-2142816
)
R-HSA-2161940
Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
See in Reactome
|
MONDO:0007390 |
CYP4F2 |
P78329 |
1.14.14.94
1.14.14.78
1.14.14.1
1.14.14.79
|
R-HSA-211979
R-HSA-2142691
R-HSA-2142691
Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX)
See in Reactome
R-HSA-211935
R-HSA-211958
R-HSA-2142816
R-HSA-2142816
Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
See in Reactome
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-211873
(
R-HSA-211979;
R-HSA-2142691
)
R-HSA-211873
Reaction Name: CYP4F2, 4F3 20-hydroxylate LTB4
See in Reactome
R-HSA-211904
(
R-HSA-211935
)
R-HSA-211919
(
R-HSA-211979
)
R-HSA-211924
(
R-HSA-211935
)
R-HSA-211962
(
R-HSA-211958
)
R-HSA-211962
Reaction Name: CYP4F11 16-hydroxylates 3OH-PALM
See in Reactome
R-HSA-215526
(
R-HSA-211979
)
R-HSA-2161745
(
R-HSA-2142691
)
R-HSA-2161745
Reaction Name: 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3
See in Reactome
R-HSA-2161792
(
R-HSA-2142691
)
R-HSA-2161792
Reaction Name: 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3
See in Reactome
R-HSA-2161940
(
R-HSA-2142816
)
R-HSA-2161940
Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
See in Reactome
R-HSA-76466
(
R-HSA-211935
)
|
MONDO:0011485 |
CYP4F22 |
Q6NT55 |
1.14.14.177
|
R-HSA-211979
R-HSA-2142691
R-HSA-2142691
Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX)
See in Reactome
R-HSA-211935
R-HSA-211958
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-211873
(
R-HSA-211979;
R-HSA-2142691
)
R-HSA-211873
Reaction Name: CYP4F2, 4F3 20-hydroxylate LTB4
See in Reactome
R-HSA-211924
(
R-HSA-211935
)
R-HSA-211962
(
R-HSA-211958
)
R-HSA-211962
Reaction Name: CYP4F11 16-hydroxylates 3OH-PALM
See in Reactome
R-HSA-215526
(
R-HSA-211979
)
R-HSA-2161745
(
R-HSA-2142691
)
R-HSA-2161745
Reaction Name: 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3
See in Reactome
R-HSA-2161792
(
R-HSA-2142691
)
R-HSA-2161792
Reaction Name: 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3
See in Reactome
R-HSA-5602295
(
R-HSA-211979
)
R-HSA-76466
(
R-HSA-211935
)
|
MONDO:0014015 |
CYP2U1 |
Q7Z449 |
1.14.14.80
|
R-HSA-2142816
R-HSA-2142816
Reactome Name: Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
See in Reactome
R-HSA-211958
|
R-HSA-211897
R-HSA-211897
Reactome Name: Cytochrome P450 - arranged by substrate type
See in Reactome
R-HSA-211859
R-HSA-211945
R-HSA-211945
Reactome Name: Phase I - Functionalization of compounds
See in Reactome
R-HSA-1430728
R-HSA-8978868
R-HSA-2142753
R-HSA-556833
|
Metabolism
|
R-HSA-211960
(
R-HSA-211958
)
R-HSA-2161814
(
R-HSA-2142816
)
R-HSA-2161814
Reaction Name: Arachidonic acid is hydroxylated to 19-HETE by CYP(2)
See in Reactome
R-HSA-2161940
(
R-HSA-2142816
)
R-HSA-2161940
Reaction Name: Arachidonic acid is hydroxylated to 20-HETE by CYP(3)
See in Reactome
|