R-HSA-389948
R-HSA-418886
R-HSA-418886
Reactome Name: Netrin mediated repulsion signals
See in Reactome
R-HSA-9674555
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2586552
R-HSA-5654732
R-HSA-5654732
Reactome Name: Negative regulation of FGFR3 signaling
See in Reactome
R-HSA-912694
R-HSA-912694
Reactome Name: Regulation of IFNA/IFNB signaling
See in Reactome
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9008059
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-9607240
R-HSA-389513
R-HSA-5654726
R-HSA-5654726
Reactome Name: Negative regulation of FGFR1 signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-5654700
R-HSA-5654706
R-HSA-432142
R-HSA-391160
R-HSA-391160
Reactome Name: Signal regulatory protein family interactions
See in Reactome
R-HSA-1295596
R-HSA-1295596
Reactome Name: Spry regulation of FGF signaling
See in Reactome
R-HSA-8934593
R-HSA-8934593
Reactome Name: Regulation of RUNX1 Expression and Activity
See in Reactome
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-1433557
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5654693
R-HSA-1059683
R-HSA-9645135
R-HSA-8865999
R-HSA-5654733
R-HSA-5654733
Reactome Name: Negative regulation of FGFR4 signaling
See in Reactome
R-HSA-1170546
R-HSA-112411
R-HSA-109704
R-HSA-877312
R-HSA-5654712
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-210990
R-HSA-9028731
R-HSA-9028731
Reactome Name: Activated NTRK2 signals through FRS2 and FRS3
See in Reactome
R-HSA-110056
R-HSA-8854691
R-HSA-8854691
Reactome Name: Interleukin-20 family signaling
See in Reactome
R-HSA-936964
R-HSA-936964
Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-5654741
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-168898
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-877300
R-HSA-418346
R-HSA-166166
R-HSA-6783589
R-HSA-6783589
Reactome Name: Interleukin-6 family signaling
See in Reactome
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654743
R-HSA-446652
R-HSA-190236
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5684996
R-HSA-168249
R-HSA-913531
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-5654738
R-HSA-5654736
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-186797
R-HSA-422475
R-HSA-112409
R-HSA-112409
Reactome Name: RAF-independent MAPK1/3 activation
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
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R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-109857
(
R-HSA-110056
)
R-HSA-109858
(
R-HSA-112411
)
R-HSA-1112690
(
R-HSA-1059683
)
R-HSA-1112703
(
R-HSA-1059683
)
R-HSA-1112708
(
R-HSA-1059683
)
R-HSA-1369114
(
R-HSA-1170546
)
R-HSA-1369115
(
R-HSA-1170546
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1549564
(
R-HSA-1295596;
R-HSA-5654726;
R-HSA-5654727;
R-HSA-5654732;
R-HSA-5654733
)
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-166271
(
R-HSA-936964
)
R-HSA-166271
Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
See in Reactome
R-HSA-177923
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177923
Reaction Name: Sustained activation of SRC kinase by SHP2
See in Reactome
R-HSA-177924
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177924
Reaction Name: Dephosphorylation of Gab1 by SHP2
See in Reactome
R-HSA-177926
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177926
Reaction Name: Dephosphorylation of PAG by SHP2
See in Reactome
R-HSA-177935
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177935
Reaction Name: SHP2 dephosphorylates Tyr 992 on EGFR
See in Reactome
R-HSA-177944
(
R-HSA-177929;
R-HSA-180292
)
R-HSA-177944
Reaction Name: Activation of SHP2 through the binding to phospho-Gab1
See in Reactome
R-HSA-186778
(
R-HSA-186763
)
R-HSA-186778
Reaction Name: SHP2 binds to the active receptor
See in Reactome
R-HSA-204873
(
R-HSA-210993
)
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-210294
(
R-HSA-210990;
R-HSA-432142
)
R-HSA-210294
Reaction Name: Interaction of PECAM-1 and SHP-2
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2671742
(
R-HSA-2586552
)
R-HSA-2671742
Reaction Name: JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
See in Reactome
R-HSA-2671747
(
R-HSA-2586552
)
R-HSA-2671747
Reaction Name: Phosphorylated LEPR Binds SHP2 (PTPN11)
See in Reactome
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389941
(
R-HSA-388841
)
R-HSA-391150
(
R-HSA-391160
)
R-HSA-391150
Reaction Name: p-4Y-SIRPA:CD47 binds PTPN6,PTPN11
See in Reactome
R-HSA-418863
(
R-HSA-418886
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-5654584
(
R-HSA-5654693
)
R-HSA-5654584
Reaction Name: Activated FGFR1:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654587
(
R-HSA-5654693
)
R-HSA-5654587
Reaction Name: Activated FGFR1:p-FRS phosphorylates PPTN11
See in Reactome
R-HSA-5654594
(
R-HSA-5654689
)
R-HSA-5654594
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654631
(
R-HSA-5654706
)
R-HSA-5654631
Reaction Name: Activated FGFR3 phosphorylates PPTN11
See in Reactome
R-HSA-5654633
(
R-HSA-5654706
)
R-HSA-5654633
Reaction Name: Activated FGFR3:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654641
(
R-HSA-5654710
)
R-HSA-5654641
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654655
(
R-HSA-5654712
)
R-HSA-5654655
Reaction Name: Activated FGFR4 phosphorylates PPTN11
See in Reactome
R-HSA-5654658
(
R-HSA-5654712
)
R-HSA-5654658
Reaction Name: Activated FGFR4:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654667
(
R-HSA-5654720
)
R-HSA-5654667
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654672
(
R-HSA-5654726
)
R-HSA-5654672
Reaction Name: CBL ubiquitinates FRS2 and FGFR1
See in Reactome
R-HSA-5654673
(
R-HSA-5654726
)
R-HSA-5654673
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR1
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654679
(
R-HSA-5654732
)
R-HSA-5654679
Reaction Name: CBL ubiquitinates FRS2 and FGFR3
See in Reactome
R-HSA-5654684
(
R-HSA-5654733
)
R-HSA-5654684
Reaction Name: CBL ubiquitinates FRS2 and FGFR4
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5654730
(
R-HSA-5654732
)
R-HSA-5654730
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR3
See in Reactome
R-HSA-5654734
(
R-HSA-5654733
)
R-HSA-5654734
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4
See in Reactome
R-HSA-5684169
(
R-HSA-114604
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-877308
(
R-HSA-877312
)
R-HSA-877308
Reaction Name: Dephosphorylation of JAKs by PTPs
See in Reactome
R-HSA-8855508
(
R-HSA-8853659
)
R-HSA-8855508
Reaction Name: p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
See in Reactome
R-HSA-8865994
(
R-HSA-8865999
)
R-HSA-8937744
(
R-HSA-8934593
)
R-HSA-8937767
(
R-HSA-8934593
)
R-HSA-8941613
(
R-HSA-5654712
)
R-HSA-8941613
Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941623
(
R-HSA-5654693
)
R-HSA-8941623
Reaction Name: Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8941628
(
R-HSA-5654706
)
R-HSA-8941628
Reaction Name: Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
R-HSA-8987014
(
R-HSA-8854691
)
R-HSA-8987014
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3
See in Reactome
R-HSA-8987070
(
R-HSA-8854691
)
R-HSA-8987070
Reaction Name: IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3
See in Reactome
R-HSA-8987132
(
R-HSA-8854691
)
R-HSA-8987132
Reaction Name: IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11
See in Reactome
R-HSA-8987236
(
R-HSA-8854691
)
R-HSA-8987236
Reaction Name: p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3
See in Reactome
R-HSA-9008894
(
R-HSA-9008059
)
R-HSA-9008894
Reaction Name: PTPNs gene transcription and translation
See in Reactome
R-HSA-9031981
(
R-HSA-9028731
)
R-HSA-9031981
Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11
See in Reactome
R-HSA-9032067
(
R-HSA-9028731
)
R-HSA-9032067
Reaction Name: NTRK2 activates RAS signaling through FRS2
See in Reactome
R-HSA-909726
(
R-HSA-909733
)
R-HSA-909738
(
R-HSA-512988
)
R-HSA-909738
Reaction Name: SHP1 and SHP2 bind the common beta chain
See in Reactome
R-HSA-914022
(
R-HSA-512988
)
R-HSA-914036
(
R-HSA-512988
)
R-HSA-914036
Reaction Name: SHP1 and SHP2 dephosphorylate Y628 of IL3RB
See in Reactome
R-HSA-9604969
(
R-HSA-9607240
)
R-HSA-9606784
(
R-HSA-9607240
)
R-HSA-9606784
Reaction Name: Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
See in Reactome
R-HSA-9645126
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645134
Reaction Name: p-STAT5 dissociates from activator:STAT5 complex
See in Reactome
R-HSA-9645137
(
R-HSA-9607240;
R-HSA-9645135
)
R-HSA-9645137
Reaction Name: Activator phosphorylates STAT5
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-997309
(
R-HSA-909733;
R-HSA-912694
)
R-HSA-997309
Reaction Name: Dephosphorylation of STAT1 by SHP2
See in Reactome
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