DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-210745)

Number of enzymes:	3
Number of disease:	9
Number of reactomes:	8
Number of reactions:	16

Search results (Reactome ID: R-HSA-210745)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005148	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0005406	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0007067	PKLR	P30613	2.7.1.40	R-HSA-163765 R-HSA-163765 Reactome Name: ChREBP activates metabolic gene expression See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome	Metabolism Developmental Biology	R-HSA-163669 ( R-HSA-163765 ) R-HSA-163669 Reaction Name: Transcriptional activation of pyruvate kinase gene by ChREBP:MLX See in Reactome R-HSA-211461 ( R-HSA-210745 ) R-HSA-211461 Reaction Name: HNF1A-dependent synthesis of the L isoform of PKLR protein See in Reactome R-HSA-71670 ( R-HSA-70171 ) R-HSA-71670 Reaction Name: phosphoenolpyruvate + ADP => pyruvate + ATP See in Reactome
MONDO:0007453	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0009216	SLC2A2	P11168	-	R-HSA-189200 R-HSA-189200 Reactome Name: Cellular hexose transport See in Reactome R-HSA-8981373 R-HSA-8981373 Reactome Name: Intestinal hexose absorption See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-8963743 R-HSA-8963743 Reactome Name: Digestion and absorption See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8963676 R-HSA-8963676 Reactome Name: Intestinal absorption See in Reactome R-HSA-425407 R-HSA-425407 Reactome Name: SLC-mediated transmembrane transport See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Transport of small molecules Digestion and absorption Metabolism Developmental Biology	R-HSA-189242 ( R-HSA-8981373 ) R-HSA-189242 Reaction Name: SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region See in Reactome R-HSA-211476 ( R-HSA-210745 ) R-HSA-211476 Reaction Name: HNF1A-dependent synthesis of GLUT2 protein See in Reactome R-HSA-450095 ( R-HSA-189200 ) R-HSA-450095 Reaction Name: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region See in Reactome R-HSA-499981 ( R-HSA-422356 ) R-HSA-499981 Reaction Name: Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 See in Reactome R-HSA-8981574 ( R-HSA-189200 ) R-HSA-8981574 Reaction Name: GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol See in Reactome
MONDO:0009950	PKLR	P30613	2.7.1.40	R-HSA-163765 R-HSA-163765 Reactome Name: ChREBP activates metabolic gene expression See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome	Metabolism Developmental Biology	R-HSA-163669 ( R-HSA-163765 ) R-HSA-163669 Reaction Name: Transcriptional activation of pyruvate kinase gene by ChREBP:MLX See in Reactome R-HSA-211461 ( R-HSA-210745 ) R-HSA-211461 Reaction Name: HNF1A-dependent synthesis of the L isoform of PKLR protein See in Reactome R-HSA-71670 ( R-HSA-70171 ) R-HSA-71670 Reaction Name: phosphoenolpyruvate + ADP => pyruvate + ATP See in Reactome
MONDO:0011236	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0015967	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0100165	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome