DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2046105)

Number of enzymes:	3
Number of disease:	7
Number of reactomes:	6
Number of reactions:	14

Search results (Reactome ID: R-HSA-2046105)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001071	ABCD1	P33897	3.1.2.- 7.6.2.-	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Protein localization Transport of small molecules Metabolism	R-HSA-2046087 ( R-HSA-2046106 ) R-HSA-2046087 Reaction Name: Translocation of tetracosahexaenoyl-CoA to peroxisomes See in Reactome R-HSA-2046093 ( R-HSA-2046105 ) R-HSA-2046093 Reaction Name: Translocation of tetracosapentaenoyl-CoA to peroxisomes See in Reactome R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-390393 ( R-HSA-390247 ) R-HSA-390393 Reaction Name: Peroxisomal uptake of very long-chain fatty acyl CoA See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0009410	ABCD1	P33897	3.1.2.- 7.6.2.-	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Protein localization Transport of small molecules Metabolism	R-HSA-2046087 ( R-HSA-2046106 ) R-HSA-2046087 Reaction Name: Translocation of tetracosahexaenoyl-CoA to peroxisomes See in Reactome R-HSA-2046093 ( R-HSA-2046105 ) R-HSA-2046093 Reaction Name: Translocation of tetracosapentaenoyl-CoA to peroxisomes See in Reactome R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-390393 ( R-HSA-390247 ) R-HSA-390393 Reaction Name: Peroxisomal uptake of very long-chain fatty acyl CoA See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0010247	ABCD1	P33897	3.1.2.- 7.6.2.-	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Protein localization Transport of small molecules Metabolism	R-HSA-2046087 ( R-HSA-2046106 ) R-HSA-2046087 Reaction Name: Translocation of tetracosahexaenoyl-CoA to peroxisomes See in Reactome R-HSA-2046093 ( R-HSA-2046105 ) R-HSA-2046093 Reaction Name: Translocation of tetracosapentaenoyl-CoA to peroxisomes See in Reactome R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-390393 ( R-HSA-390247 ) R-HSA-390393 Reaction Name: Peroxisomal uptake of very long-chain fatty acyl CoA See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0014417	ELOVL5	Q9NYP7	2.3.1.199	R-HSA-75876 R-HSA-75876 Reactome Name: Synthesis of very long-chain fatty acyl-CoAs See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-75105 R-HSA-75105 Reactome Name: Fatty acyl-CoA biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome	Metabolism	R-HSA-2046083 ( R-HSA-2046105 ) R-HSA-2046083 Reaction Name: Elongation of arachidonyl-CoA to docosatetraenoyl-CoA See in Reactome R-HSA-2046088 ( R-HSA-2046106 ) R-HSA-2046088 Reaction Name: Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA See in Reactome R-HSA-2046094 ( R-HSA-2046105 ) R-HSA-2046094 Reaction Name: Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA See in Reactome R-HSA-2046100 ( R-HSA-2046106 ) R-HSA-2046100 Reaction Name: Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA See in Reactome R-HSA-548800 ( R-HSA-75876 ) R-HSA-548800 Reaction Name: ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA See in Reactome
MONDO:0015339	ABCD1	P33897	3.1.2.- 7.6.2.-	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Protein localization Transport of small molecules Metabolism	R-HSA-2046087 ( R-HSA-2046106 ) R-HSA-2046087 Reaction Name: Translocation of tetracosahexaenoyl-CoA to peroxisomes See in Reactome R-HSA-2046093 ( R-HSA-2046105 ) R-HSA-2046093 Reaction Name: Translocation of tetracosapentaenoyl-CoA to peroxisomes See in Reactome R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-390393 ( R-HSA-390247 ) R-HSA-390393 Reaction Name: Peroxisomal uptake of very long-chain fatty acyl CoA See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0018309	ABCD1	P33897	3.1.2.- 7.6.2.-	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Protein localization Transport of small molecules Metabolism	R-HSA-2046087 ( R-HSA-2046106 ) R-HSA-2046087 Reaction Name: Translocation of tetracosahexaenoyl-CoA to peroxisomes See in Reactome R-HSA-2046093 ( R-HSA-2046105 ) R-HSA-2046093 Reaction Name: Translocation of tetracosapentaenoyl-CoA to peroxisomes See in Reactome R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-390393 ( R-HSA-390247 ) R-HSA-390393 Reaction Name: Peroxisomal uptake of very long-chain fatty acyl CoA See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0032798	ELOVL1	Q9BW60	2.3.1.199	R-HSA-75876 R-HSA-75876 Reactome Name: Synthesis of very long-chain fatty acyl-CoAs See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-75105 R-HSA-75105 Reactome Name: Fatty acyl-CoA biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome	Metabolism	R-HSA-2046088 ( R-HSA-2046106 ) R-HSA-2046088 Reaction Name: Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA See in Reactome R-HSA-2046094 ( R-HSA-2046105 ) R-HSA-2046094 Reaction Name: Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA See in Reactome R-HSA-548800 ( R-HSA-75876 ) R-HSA-548800 Reaction Name: ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA See in Reactome R-HSA-548830 ( R-HSA-75876 ) R-HSA-548830 Reaction Name: ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA See in Reactome