MONDO:0000437 |
PLA2G6 |
O60733 |
3.1.1.4
3.1.1.5
3.1.2.2
|
R-HSA-1482798
R-HSA-1482839
R-HSA-6811436
R-HSA-6811436
Reactome Name: COPI-independent Golgi-to-ER retrograde traffic
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1482788
|
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-8856688
R-HSA-8856688
Reactome Name: Golgi-to-ER retrograde transport
See in Reactome
R-HSA-168256
R-HSA-1483257
R-HSA-6811442
R-HSA-6811442
Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic
See in Reactome
R-HSA-199991
R-HSA-1483206
R-HSA-1483206
Reactome Name: Glycerophospholipid biosynthesis
See in Reactome
R-HSA-1430728
R-HSA-556833
R-HSA-5653656
|
Immune System
Metabolism
Vesicle-mediated transport
|
R-HSA-1482778
(
R-HSA-1482798
)
R-HSA-1482778
Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM)
See in Reactome
R-HSA-1482856
(
R-HSA-1482788
)
R-HSA-1482856
Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
See in Reactome
R-HSA-1482884
(
R-HSA-1482839
)
R-HSA-1482884
Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
See in Reactome
R-HSA-2029475
(
R-HSA-2029485
)
R-HSA-2029475
Reaction Name: Production of AA by iPLA2 upon FCGR activation
See in Reactome
R-HSA-8848484
(
R-HSA-6811436
)
R-HSA-8848484
Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane
See in Reactome
|
MONDO:0001056 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0001149 |
MONDO:0001149
Disease Name: microcephaly
OMIM id: OMIM:612703
All associated enzymes in DAR:
DHCR7
UFSP2
PLA2G6
SLC2A1
RAG1
ALG13
DHX34
ATRX
PLA2G6 |
O60733 |
3.1.1.4
3.1.1.5
3.1.2.2
|
R-HSA-1482798
R-HSA-1482839
R-HSA-6811436
R-HSA-6811436
Reactome Name: COPI-independent Golgi-to-ER retrograde traffic
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1482788
|
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-8856688
R-HSA-8856688
Reactome Name: Golgi-to-ER retrograde transport
See in Reactome
R-HSA-168256
R-HSA-1483257
R-HSA-6811442
R-HSA-6811442
Reactome Name: Intra-Golgi and retrograde Golgi-to-ER traffic
See in Reactome
R-HSA-199991
R-HSA-1483206
R-HSA-1483206
Reactome Name: Glycerophospholipid biosynthesis
See in Reactome
R-HSA-1430728
R-HSA-556833
R-HSA-5653656
|
Immune System
Metabolism
Vesicle-mediated transport
|
R-HSA-1482778
(
R-HSA-1482798
)
R-HSA-1482778
Reaction Name: CL is hydrolyzed to MLCL by PLA2G6 (IM)
See in Reactome
R-HSA-1482856
(
R-HSA-1482788
)
R-HSA-1482856
Reaction Name: PC is hydrolyzed to 1-acyl LPC by PLA2[5]
See in Reactome
R-HSA-1482884
(
R-HSA-1482839
)
R-HSA-1482884
Reaction Name: PE is hydrolyzed to 1-acyl LPE by PLA2[2]
See in Reactome
R-HSA-2029475
(
R-HSA-2029485
)
R-HSA-2029475
Reaction Name: Production of AA by iPLA2 upon FCGR activation
See in Reactome
R-HSA-8848484
(
R-HSA-6811436
)
R-HSA-8848484
Reaction Name: PLA2s hydrolyze phospholipids at the Golgi membrane
See in Reactome
|
MONDO:0004948 |
PLCG2 |
P16885 |
3.1.4.11
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5621480
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-5607764
R-HSA-2424491
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-9027277
R-HSA-9027277
Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG)
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1483249
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168249
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202403
R-HSA-168898
R-HSA-2172127
R-HSA-1430728
R-HSA-109582
R-HSA-1280218
R-HSA-162582
|
Immune System
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-114689
(
R-HSA-114604
)
R-HSA-114689
Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis
See in Reactome
R-HSA-1855221
(
R-HSA-1855204
)
R-HSA-1855221
Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
See in Reactome
R-HSA-202407
(
R-HSA-202433
)
R-HSA-2029268
(
R-HSA-2029485
)
R-HSA-2029268
Reaction Name: Phosphorylation and activation of PLCG
See in Reactome
R-HSA-2029270
(
R-HSA-2029485
)
R-HSA-2029270
Reaction Name: Recruitment of PLCgamma to membrane
See in Reactome
R-HSA-2029272
(
R-HSA-2029485
)
R-HSA-2201293
(
R-HSA-166016
)
R-HSA-2201293
Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2396606
(
R-HSA-2424491;
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2396606
Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2424481
(
R-HSA-2424491
)
R-HSA-2424481
Reaction Name: Recruitment of VAV and BTK to p-SLP-76
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424485
(
R-HSA-2424491
)
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2730833
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730840
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730841
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730841
Reaction Name: Phosphorylation and activation of VAV
See in Reactome
R-HSA-2730847
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730851
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730851
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2730856
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730858
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730858
Reaction Name: Autophosphorylation of BTK/ITK
See in Reactome
R-HSA-2730885
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730885
Reaction Name: Recruitment of TEC kinases to p-SLP-76
See in Reactome
R-HSA-2730888
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730889
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-2730892
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730892
Reaction Name: Recruitment of VAV to p-SLP-76
See in Reactome
R-HSA-429497
(
R-HSA-114604
)
R-HSA-5607735
(
R-HSA-5607764
)
R-HSA-5607735
Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2
See in Reactome
R-HSA-5607745
(
R-HSA-5607764
)
R-HSA-5607745
Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
See in Reactome
R-HSA-5607755
(
R-HSA-5607764
)
R-HSA-5607755
Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane
See in Reactome
R-HSA-5621347
(
R-HSA-5621480
)
R-HSA-5621347
Reaction Name: PLCG2 translocates from cytosol to plasma membrane
See in Reactome
R-HSA-5621356
(
R-HSA-5621480
)
R-HSA-5621356
Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
See in Reactome
R-HSA-5621363
(
R-HSA-5621480
)
R-HSA-5621363
Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
See in Reactome
R-HSA-9027373
(
R-HSA-9027277
)
R-HSA-9027373
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma
See in Reactome
R-HSA-9027425
(
R-HSA-9027277
)
R-HSA-9027425
Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
See in Reactome
R-HSA-9032478
(
R-HSA-9027277
)
R-HSA-9032478
Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
See in Reactome
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
R-HSA-9606894
(
R-HSA-983695
)
|
MONDO:0005292 |
MONDO:0005292
Disease Name: colitis
OMIM id: OMIM:191390
All associated enzymes in DAR:
SYK
SYK |
P43405 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-912631
R-HSA-2029481
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5621480
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9674555
R-HSA-354192
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-5607764
R-HSA-2424491
R-HSA-9020558
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-109582
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-162582
|
Immune System
Hemostasis
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-114689
(
R-HSA-114604
)
R-HSA-114689
Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis
See in Reactome
R-HSA-139842
(
R-HSA-114604
)
R-HSA-2029268
(
R-HSA-2029485
)
R-HSA-2029268
Reaction Name: Phosphorylation and activation of PLCG
See in Reactome
R-HSA-2029270
(
R-HSA-2029485
)
R-HSA-2029270
Reaction Name: Recruitment of PLCgamma to membrane
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029272
(
R-HSA-2029485
)
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-2029449
(
R-HSA-2029481
)
R-HSA-2029449
Reaction Name: Phosphorylation of SYK by Src kinases
See in Reactome
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029452
(
R-HSA-2029481
)
R-HSA-2029452
Reaction Name: Recruitment of SYK to phosphorylated ITAMs
See in Reactome
R-HSA-2029453
(
R-HSA-2029482
)
R-HSA-2029458
(
R-HSA-2029482
)
R-HSA-2029458
Reaction Name: Recruitment of VAV1 to p-6Y-SYK
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-2197697
(
R-HSA-2029482
)
R-HSA-2197697
Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2454239
(
R-HSA-2454202
)
R-HSA-2454240
(
R-HSA-2454202
)
R-HSA-2454240
Reaction Name: Recruitment of SYK to p-FCERI gamma subunit
See in Reactome
R-HSA-2730833
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730843
(
R-HSA-2454202
)
R-HSA-2730843
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2730851
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730851
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2730860
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730860
Reaction Name: Phosphorylation of GAB2 by SYK/FYN
See in Reactome
R-HSA-2730884
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730884
Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn
See in Reactome
R-HSA-2730886
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730886
Reaction Name: Phosphorylation of SHC by SYK kinase
See in Reactome
R-HSA-2730888
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-429449
(
R-HSA-114604
)
R-HSA-429449
Reaction Name: Syk activation leads to SLP-76 activation
See in Reactome
R-HSA-434836
(
R-HSA-114604
)
R-HSA-437118
(
R-HSA-114604
)
R-HSA-437118
Reaction Name: GPVI stimulates PI3K beta, gamma
See in Reactome
R-HSA-437932
(
R-HSA-114604
)
R-HSA-437936
(
R-HSA-114604
)
R-HSA-437936
Reaction Name: p-Y348-SYK phosphorylates VAV family
See in Reactome
R-HSA-453183
(
R-HSA-114604
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-5607738
(
R-HSA-5607764
)
R-HSA-5607738
Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan
See in Reactome
R-HSA-5607745
(
R-HSA-5607764
)
R-HSA-5607745
Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
See in Reactome
R-HSA-5621347
(
R-HSA-5621480
)
R-HSA-5621347
Reaction Name: PLCG2 translocates from cytosol to plasma membrane
See in Reactome
R-HSA-5621356
(
R-HSA-5621480
)
R-HSA-5621356
Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
See in Reactome
R-HSA-5621363
(
R-HSA-5621480
)
R-HSA-5621363
Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
See in Reactome
R-HSA-5621366
(
R-HSA-5621480
)
R-HSA-5621370
(
R-HSA-5621480
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-9706336
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-983700
(
R-HSA-983695
)
R-HSA-983703
(
R-HSA-983695
)
R-HSA-983703
Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65)
See in Reactome
R-HSA-983707
(
R-HSA-983695
)
R-HSA-983707
Reaction Name: SYK autophosphorylates at the activated BCR
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0005578 |
SYK |
P43405 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-912631
R-HSA-2029481
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5621480
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9674555
R-HSA-354192
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-5607764
R-HSA-2424491
R-HSA-9020558
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-109582
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-162582
|
Immune System
Hemostasis
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-114689
(
R-HSA-114604
)
R-HSA-114689
Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis
See in Reactome
R-HSA-139842
(
R-HSA-114604
)
R-HSA-2029268
(
R-HSA-2029485
)
R-HSA-2029268
Reaction Name: Phosphorylation and activation of PLCG
See in Reactome
R-HSA-2029270
(
R-HSA-2029485
)
R-HSA-2029270
Reaction Name: Recruitment of PLCgamma to membrane
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029272
(
R-HSA-2029485
)
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-2029449
(
R-HSA-2029481
)
R-HSA-2029449
Reaction Name: Phosphorylation of SYK by Src kinases
See in Reactome
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029452
(
R-HSA-2029481
)
R-HSA-2029452
Reaction Name: Recruitment of SYK to phosphorylated ITAMs
See in Reactome
R-HSA-2029453
(
R-HSA-2029482
)
R-HSA-2029458
(
R-HSA-2029482
)
R-HSA-2029458
Reaction Name: Recruitment of VAV1 to p-6Y-SYK
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-2197697
(
R-HSA-2029482
)
R-HSA-2197697
Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2454239
(
R-HSA-2454202
)
R-HSA-2454240
(
R-HSA-2454202
)
R-HSA-2454240
Reaction Name: Recruitment of SYK to p-FCERI gamma subunit
See in Reactome
R-HSA-2730833
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730843
(
R-HSA-2454202
)
R-HSA-2730843
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2730851
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730851
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2730860
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730860
Reaction Name: Phosphorylation of GAB2 by SYK/FYN
See in Reactome
R-HSA-2730884
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730884
Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn
See in Reactome
R-HSA-2730886
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730886
Reaction Name: Phosphorylation of SHC by SYK kinase
See in Reactome
R-HSA-2730888
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-429449
(
R-HSA-114604
)
R-HSA-429449
Reaction Name: Syk activation leads to SLP-76 activation
See in Reactome
R-HSA-434836
(
R-HSA-114604
)
R-HSA-437118
(
R-HSA-114604
)
R-HSA-437118
Reaction Name: GPVI stimulates PI3K beta, gamma
See in Reactome
R-HSA-437932
(
R-HSA-114604
)
R-HSA-437936
(
R-HSA-114604
)
R-HSA-437936
Reaction Name: p-Y348-SYK phosphorylates VAV family
See in Reactome
R-HSA-453183
(
R-HSA-114604
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-5607738
(
R-HSA-5607764
)
R-HSA-5607738
Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan
See in Reactome
R-HSA-5607745
(
R-HSA-5607764
)
R-HSA-5607745
Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
See in Reactome
R-HSA-5621347
(
R-HSA-5621480
)
R-HSA-5621347
Reaction Name: PLCG2 translocates from cytosol to plasma membrane
See in Reactome
R-HSA-5621356
(
R-HSA-5621480
)
R-HSA-5621356
Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
See in Reactome
R-HSA-5621363
(
R-HSA-5621480
)
R-HSA-5621363
Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
See in Reactome
R-HSA-5621366
(
R-HSA-5621480
)
R-HSA-5621370
(
R-HSA-5621480
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-9706336
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-983700
(
R-HSA-983695
)
R-HSA-983703
(
R-HSA-983695
)
R-HSA-983703
Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65)
See in Reactome
R-HSA-983707
(
R-HSA-983695
)
R-HSA-983707
Reaction Name: SYK autophosphorylates at the activated BCR
See in Reactome
|
MONDO:0006547 |
MONDO:0006547
Disease Name: exanthem
All associated enzymes in DAR:
SYK
SYK |
P43405 |
2.7.10.2
|
R-HSA-983695
R-HSA-983695
Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-912631
R-HSA-2029481
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5621480
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9705462
R-HSA-9705462
Reactome Name: Inactivation of CSF3 (G-CSF) signaling
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-9674555
R-HSA-354192
R-HSA-2871809
R-HSA-2871809
Reactome Name: FCERI mediated Ca+2 mobilization
See in Reactome
R-HSA-5607764
R-HSA-2424491
R-HSA-9020558
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-109582
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-162582
|
Immune System
Hemostasis
Signal Transduction
|
R-HSA-1112666
(
R-HSA-983695
)
R-HSA-1112666
Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
See in Reactome
R-HSA-114689
(
R-HSA-114604
)
R-HSA-114689
Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis
See in Reactome
R-HSA-139842
(
R-HSA-114604
)
R-HSA-2029268
(
R-HSA-2029485
)
R-HSA-2029268
Reaction Name: Phosphorylation and activation of PLCG
See in Reactome
R-HSA-2029270
(
R-HSA-2029485
)
R-HSA-2029270
Reaction Name: Recruitment of PLCgamma to membrane
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029272
(
R-HSA-2029485
)
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-2029449
(
R-HSA-2029481
)
R-HSA-2029449
Reaction Name: Phosphorylation of SYK by Src kinases
See in Reactome
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029452
(
R-HSA-2029481
)
R-HSA-2029452
Reaction Name: Recruitment of SYK to phosphorylated ITAMs
See in Reactome
R-HSA-2029453
(
R-HSA-2029482
)
R-HSA-2029458
(
R-HSA-2029482
)
R-HSA-2029458
Reaction Name: Recruitment of VAV1 to p-6Y-SYK
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-2197697
(
R-HSA-2029482
)
R-HSA-2197697
Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-2454239
(
R-HSA-2454202
)
R-HSA-2454240
(
R-HSA-2454202
)
R-HSA-2454240
Reaction Name: Recruitment of SYK to p-FCERI gamma subunit
See in Reactome
R-HSA-2730833
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-2730833
Reaction Name: Phosphorylation of TEC kinases by p-SYK
See in Reactome
R-HSA-2730843
(
R-HSA-2454202
)
R-HSA-2730843
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2730851
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730851
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2730860
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730860
Reaction Name: Phosphorylation of GAB2 by SYK/FYN
See in Reactome
R-HSA-2730884
(
R-HSA-2454202;
R-HSA-2730905
)
R-HSA-2730884
Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn
See in Reactome
R-HSA-2730886
(
R-HSA-2454202;
R-HSA-2871796
)
R-HSA-2730886
Reaction Name: Phosphorylation of SHC by SYK kinase
See in Reactome
R-HSA-2730888
(
R-HSA-2454202;
R-HSA-2871809
)
R-HSA-429415
(
R-HSA-354192
)
R-HSA-429415
Reaction Name: SYK binds to integrin alphaIIb beta3
See in Reactome
R-HSA-429441
(
R-HSA-354192
)
R-HSA-429449
(
R-HSA-114604
)
R-HSA-429449
Reaction Name: Syk activation leads to SLP-76 activation
See in Reactome
R-HSA-434836
(
R-HSA-114604
)
R-HSA-437118
(
R-HSA-114604
)
R-HSA-437118
Reaction Name: GPVI stimulates PI3K beta, gamma
See in Reactome
R-HSA-437932
(
R-HSA-114604
)
R-HSA-437936
(
R-HSA-114604
)
R-HSA-437936
Reaction Name: p-Y348-SYK phosphorylates VAV family
See in Reactome
R-HSA-453183
(
R-HSA-114604
)
R-HSA-453200
(
R-HSA-114604
)
R-HSA-508282
(
R-HSA-9020558
)
R-HSA-508292
(
R-HSA-9020558
)
R-HSA-5607738
(
R-HSA-5607764
)
R-HSA-5607738
Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan
See in Reactome
R-HSA-5607745
(
R-HSA-5607764
)
R-HSA-5607745
Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
See in Reactome
R-HSA-5621347
(
R-HSA-5621480
)
R-HSA-5621347
Reaction Name: PLCG2 translocates from cytosol to plasma membrane
See in Reactome
R-HSA-5621356
(
R-HSA-5621480
)
R-HSA-5621356
Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
See in Reactome
R-HSA-5621363
(
R-HSA-5621480
)
R-HSA-5621363
Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
See in Reactome
R-HSA-5621366
(
R-HSA-5621480
)
R-HSA-5621370
(
R-HSA-5621480
)
R-HSA-5684801
(
R-HSA-114604
)
R-HSA-5684801
Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK
See in Reactome
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-9606151
(
R-HSA-983695
)
R-HSA-9606151
Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
See in Reactome
R-HSA-9606159
(
R-HSA-983695
)
R-HSA-9606162
(
R-HSA-983695
)
R-HSA-9606162
Reaction Name: Phosphorylated BTK phosphorylates PLCG2
See in Reactome
R-HSA-9606163
(
R-HSA-983695
)
R-HSA-9606163
Reaction Name: p-SYK and LYN phosphorylate BTK
See in Reactome
R-HSA-9674562
(
R-HSA-9674555
)
R-HSA-9674562
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5
See in Reactome
R-HSA-9674563
(
R-HSA-9674555
)
R-HSA-9674563
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
See in Reactome
R-HSA-9674567
(
R-HSA-9674555
)
R-HSA-9674567
Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
See in Reactome
R-HSA-9674808
(
R-HSA-9674555
)
R-HSA-9674808
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)
See in Reactome
R-HSA-9674816
(
R-HSA-9674555
)
R-HSA-9674816
Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS
See in Reactome
R-HSA-9676071
(
R-HSA-9674555
)
R-HSA-9676071
Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK
See in Reactome
R-HSA-9705467
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705467
Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
See in Reactome
R-HSA-9705726
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705726
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
See in Reactome
R-HSA-9705729
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705729
Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
See in Reactome
R-HSA-9705738
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9705738
Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
See in Reactome
R-HSA-9706336
(
R-HSA-9607240;
R-HSA-9706374
)
R-HSA-9707977
(
R-HSA-9674555;
R-HSA-9705462
)
R-HSA-9707977
Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
See in Reactome
R-HSA-983700
(
R-HSA-983695
)
R-HSA-983703
(
R-HSA-983695
)
R-HSA-983703
Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65)
See in Reactome
R-HSA-983707
(
R-HSA-983695
)
R-HSA-983707
Reaction Name: SYK autophosphorylates at the activated BCR
See in Reactome
|
MONDO:0007962 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
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R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
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