DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2029482)

Number of enzymes:	7
Number of disease:	21
Number of reactomes:	120
Number of reactions:	355

Search results (Reactome ID: R-HSA-2029482)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002529	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0005012	RAC1	P63000	3.6.5.2	R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-418885 R-HSA-418885 Reactome Name: DCC mediated attractive signaling See in Reactome R-HSA-9619229 R-HSA-9619229 Reactome Name: Activation of RAC1 downstream of NMDARs See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-428543 R-HSA-428543 Reactome Name: Inactivation of CDC42 and RAC1 See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-8849471 R-HSA-8849471 Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-193648 R-HSA-193648 Reactome Name: NRAGE signals death through JNK See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-5626467 R-HSA-5626467 Reactome Name: RHO GTPases activate IQGAPs See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-8875555 R-HSA-8875555 Reactome Name: MET activates RAP1 and RAC1 See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-416550 R-HSA-416550 Reactome Name: Sema4D mediated inhibition of cell attachment and migration See in Reactome R-HSA-4086400 R-HSA-4086400 Reactome Name: PCP/CE pathway See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5625970 R-HSA-5625970 Reactome Name: RHO GTPases activate KTN1 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-8875878 R-HSA-8875878 Reactome Name: MET promotes cell motility See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Immune System Developmental Biology Neuronal System Vesicle-mediated transport Hemostasis Signal Transduction	R-HSA-1011598 ( R-HSA-983231 ) R-HSA-1011598 Reaction Name: DOCKs bind to RhoGEFs See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1433415 ( R-HSA-1433557 ) R-HSA-1433415 Reaction Name: Activation of RAC1 See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029465 ( R-HSA-2029482; R-HSA-4420097; R-HSA-5663213 ) R-HSA-2029465 Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) See in Reactome R-HSA-2029466 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029466 Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-205039 ( R-HSA-193648 ) R-HSA-205039 Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor See in Reactome R-HSA-205136 ( R-HSA-193648 ) R-HSA-205136 Reaction Name: GTP-bound RAC contributes to JNK activation See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-2197690 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197690 Reaction Name: Detachment of WASP/WAVE See in Reactome R-HSA-2316352 ( R-HSA-1445148 ) R-HSA-2316352 Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-3858475 ( R-HSA-4086400 ) R-HSA-3858475 Reaction Name: ppDVL recruits RAC See in Reactome R-HSA-389348 ( R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928612 ( R-HSA-3928662 ) R-HSA-3928612 Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928628 ( R-HSA-3928665 ) R-HSA-3928628 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-3928633 ( R-HSA-3928664 ) R-HSA-3928633 Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-3928642 ( R-HSA-3928665 ) R-HSA-3928642 Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-399928 ( R-HSA-399955 ) R-HSA-399928 Reaction Name: Recruitment of Rnd1 to Plexin A See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399935 ( R-HSA-399955 ) R-HSA-399935 Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity See in Reactome R-HSA-399938 ( R-HSA-399955 ) R-HSA-399938 Reaction Name: Activation of Rac1 by FARP2 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399941 ( R-HSA-399955 ) R-HSA-399941 Reaction Name: Rac1 binds PlexinA See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-400682 ( R-HSA-416550 ) R-HSA-400682 Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D See in Reactome R-HSA-4093336 ( R-HSA-3928662 ) R-HSA-4093336 Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-418856 ( R-HSA-418885 ) R-HSA-418856 Reaction Name: Activation of Rac1 See in Reactome R-HSA-418865 ( R-HSA-418885 ) R-HSA-418865 Reaction Name: Recruitment of ABLIM to the plasma membrane See in Reactome R-HSA-428522 ( R-HSA-428543 ) R-HSA-428522 Reaction Name: Inactivation of RAC1 See in Reactome R-HSA-428535 ( R-HSA-428540 ) R-HSA-428535 Reaction Name: Activation of RAC1 by SOS See in Reactome R-HSA-442273 ( R-HSA-114604 ) R-HSA-442273 Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases See in Reactome R-HSA-442291 ( R-HSA-114604 ) R-HSA-442291 Reaction Name: VAV2 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442314 ( R-HSA-114604 ) R-HSA-442314 Reaction Name: VAV3 is a GEF for Rho/Rac family kinases See in Reactome R-HSA-442592 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-442592 Reaction Name: WASPs or WAVEs activate the ARP2/3 complex See in Reactome R-HSA-445064 ( R-HSA-445144 ) R-HSA-445064 Reaction Name: Activation of Rac1 by VAV2 See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5218850 ( R-HSA-4420097 ) R-HSA-5218850 Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it See in Reactome R-HSA-5357445 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357483 ( R-HSA-4420097; R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5623622 ( R-HSA-5625740 ) R-HSA-5623622 Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 See in Reactome R-HSA-5623632 ( R-HSA-5625740 ) R-HSA-5623632 Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 See in Reactome R-HSA-5623667 ( R-HSA-5625740 ) R-HSA-5623667 Reaction Name: PDPK1 phosphorylates PKN1,2,3 See in Reactome R-HSA-5625901 ( R-HSA-5625900 ) R-HSA-5625901 Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-5625959 ( R-HSA-5625970 ) R-HSA-5625959 Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) See in Reactome R-HSA-5626469 ( R-HSA-5626467 ) R-HSA-5626469 Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs See in Reactome R-HSA-5626507 ( R-HSA-5626467 ) R-HSA-5626507 Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin See in Reactome R-HSA-5626549 ( R-HSA-5626467 ) R-HSA-5626549 Reaction Name: IQGAPs bind CALM1 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5663232 ( R-HSA-5663220 ) R-HSA-5663232 Reaction Name: FMNL1 binds RAC1:GTP See in Reactome R-HSA-5665659 ( R-HSA-5663220 ) R-HSA-5665659 Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin See in Reactome R-HSA-5665802 ( R-HSA-5663220 ) R-HSA-5665802 Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin See in Reactome R-HSA-5665809 ( R-HSA-5663220 ) R-HSA-5665809 Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments See in Reactome R-HSA-5668714 ( R-HSA-5668599 ) R-HSA-5668714 Reaction Name: RAC1:GTP binds NOX1 complex See in Reactome R-HSA-5668718 ( R-HSA-5668599 ) R-HSA-5668718 Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668731 ( R-HSA-5668599 ) R-HSA-5668731 Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen See in Reactome R-HSA-5668735 ( R-HSA-5668599 ) R-HSA-5668735 Reaction Name: RAC1:GTP binds NOX3 complex See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-5671970 ( R-HSA-5625900 ) R-HSA-5671970 Reaction Name: Activated CIT binds KIF14 and PRC1 See in Reactome R-HSA-5671993 ( R-HSA-5625900 ) R-HSA-5671993 Reaction Name: CIT-3 binds DLG4 See in Reactome R-HSA-5672083 ( R-HSA-5625970 ) R-HSA-5672083 Reaction Name: KTN1 binds Kinesin-1 See in Reactome R-HSA-5672304 ( R-HSA-5626467 ) R-HSA-5672304 Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 See in Reactome R-HSA-5672329 ( R-HSA-5626467 ) R-HSA-5672329 Reaction Name: IQGAP1 binds CLIP1 and microtubules See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-6800426 ( R-HSA-6798695 ) R-HSA-6800426 Reaction Name: Exocytosis of ficolin-rich granule membrane proteins See in Reactome R-HSA-8848618 ( R-HSA-8849471 ) R-HSA-8848618 Reaction Name: Activation of RAC1 by the PXN:CRK complex See in Reactome R-HSA-8875591 ( R-HSA-8875555 ) R-HSA-8875591 Reaction Name: DOCK7 activates RAC1 See in Reactome R-HSA-8951586 ( R-HSA-4420097 ) R-HSA-8951586 Reaction Name: p-VAV family:PIP3 binds RAC1:GDP See in Reactome R-HSA-8981443 ( R-HSA-5625900 ) R-HSA-8981443 Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-8981931 ( R-HSA-5627123 ) R-HSA-8981931 Reaction Name: RAC1 and CDC42 activate PAK2 See in Reactome R-HSA-9013143 ( R-HSA-9013149 ) R-HSA-9013143 Reaction Name: RAC1 GEFs activate RAC1 See in Reactome R-HSA-9013144 ( R-HSA-9013149 ) R-HSA-9013144 Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013147 ( R-HSA-9013149 ) R-HSA-9013147 Reaction Name: RAC1 GDIs block activation of RAC1 See in Reactome R-HSA-9032798 ( R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9619803 ( R-HSA-9619229 ) R-HSA-9619803 Reaction Name: p-S516-ARHGEF7 activates RAC1 See in Reactome R-HSA-9691168 ( R-HSA-9013149 ) R-HSA-9691168 Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane See in Reactome R-HSA-9691174 ( R-HSA-9013149 ) R-HSA-9691174 Reaction Name: RAC1 binds effectors at the ER membrane See in Reactome
MONDO:0005292	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0005453	ABL1	P00519	2.7.10.2	R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-8939236 R-HSA-8939236 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-428890 R-HSA-428890 Reactome Name: Role of ABL in ROBO-SLIT signaling See in Reactome R-HSA-983231 R-HSA-983231 Reactome Name: Factors involved in megakaryocyte development and platelet production See in Reactome R-HSA-525793 R-HSA-525793 Reactome Name: Myogenesis See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) DNA Repair Hemostasis Signal Transduction	R-HSA-1013833 ( R-HSA-983231 ) R-HSA-1013833 Reaction Name: Cables link CDK5 and ABL1 See in Reactome R-HSA-2130194 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2130194 Reaction Name: ABL phosphorylates WAVEs See in Reactome R-HSA-376141 ( R-HSA-428890 ) R-HSA-376141 Reaction Name: Interaction of ABL with ROBO1:SLIT2 See in Reactome R-HSA-428883 ( R-HSA-428890 ) R-HSA-428883 Reaction Name: Recruitment of CAP to ABL See in Reactome R-HSA-428885 ( R-HSA-428890 ) R-HSA-428885 Reaction Name: Activation of CLASP See in Reactome R-HSA-428888 ( R-HSA-428890 ) R-HSA-428888 Reaction Name: Phosphorylation of ROBO1 by ABL kinase See in Reactome R-HSA-448951 ( R-HSA-525793 ) R-HSA-448951 Reaction Name: Activation of p38 alpha/beta MAPK See in Reactome R-HSA-448957 ( R-HSA-525793 ) R-HSA-448957 Reaction Name: Interaction of p38 MAPK with JLP See in Reactome R-HSA-448958 ( R-HSA-525793 ) R-HSA-448958 Reaction Name: Nuclear translocation of p38 MAPK See in Reactome R-HSA-449200 ( R-HSA-525793 ) R-HSA-449200 Reaction Name: Interaction of ABL1 with CDO complex See in Reactome R-HSA-5686578 ( R-HSA-5693565 ) R-HSA-5686578 Reaction Name: Activated ATM phosphorylates ABL1 See in Reactome R-HSA-5686587 ( R-HSA-5685938 ) R-HSA-5686587 Reaction Name: ABL1 phosphorylates RAD52 See in Reactome R-HSA-8942607 ( R-HSA-69231 ) R-HSA-8942607 Reaction Name: Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes See in Reactome R-HSA-8956639 ( R-HSA-8939236 ) R-HSA-8956639 Reaction Name: RUNX1 binds YAP1 See in Reactome R-HSA-8956659 ( R-HSA-8939236 ) R-HSA-8956659 Reaction Name: ABL1 phosphorylates YAP1 See in Reactome R-HSA-8985227 ( R-HSA-8940973 ) R-HSA-8985227 Reaction Name: The complex of RUNX2 and WWTR1 (TAZ) binds the BGLAP gene promoter See in Reactome
MONDO:0005578	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0006547	SYK	P43405	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-2029481 R-HSA-2029481 Reactome Name: FCGR activation See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-9705462 R-HSA-9705462 Reactome Name: Inactivation of CSF3 (G-CSF) signaling See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-9674555 R-HSA-9674555 Reactome Name: Signaling by CSF3 (G-CSF) See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-139842 ( R-HSA-114604 ) R-HSA-139842 Reaction Name: Binding of Syk tyrosine kinase See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-2029449 ( R-HSA-2029481 ) R-HSA-2029449 Reaction Name: Phosphorylation of SYK by Src kinases See in Reactome R-HSA-2029451 ( R-HSA-2029482 ) R-HSA-2029451 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2029452 ( R-HSA-2029481 ) R-HSA-2029452 Reaction Name: Recruitment of SYK to phosphorylated ITAMs See in Reactome R-HSA-2029453 ( R-HSA-2029482 ) R-HSA-2029453 Reaction Name: Phosphorylation of VAV See in Reactome R-HSA-2029458 ( R-HSA-2029482 ) R-HSA-2029458 Reaction Name: Recruitment of VAV1 to p-6Y-SYK See in Reactome R-HSA-2029467 ( R-HSA-2029482 ) R-HSA-2029467 Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-2197697 ( R-HSA-2029482 ) R-HSA-2197697 Reaction Name: Recruitment of CRKII:DOCK180:ELMO complex to FCGR See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2454239 ( R-HSA-2454202 ) R-HSA-2454239 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2454240 ( R-HSA-2454202 ) R-HSA-2454240 Reaction Name: Recruitment of SYK to p-FCERI gamma subunit See in Reactome R-HSA-2730833 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730843 ( R-HSA-2454202 ) R-HSA-2730843 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2730851 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730860 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730860 Reaction Name: Phosphorylation of GAB2 by SYK/FYN See in Reactome R-HSA-2730884 ( R-HSA-2454202; R-HSA-2730905 ) R-HSA-2730884 Reaction Name: Phosphorylation of NTAL by p-SYK/Lyn See in Reactome R-HSA-2730886 ( R-HSA-2454202; R-HSA-2871796 ) R-HSA-2730886 Reaction Name: Phosphorylation of SHC by SYK kinase See in Reactome R-HSA-2730888 ( R-HSA-2454202; R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-429415 ( R-HSA-354192 ) R-HSA-429415 Reaction Name: SYK binds to integrin alphaIIb beta3 See in Reactome R-HSA-429441 ( R-HSA-354192 ) R-HSA-429441 Reaction Name: SYK activation by SRC See in Reactome R-HSA-429449 ( R-HSA-114604 ) R-HSA-429449 Reaction Name: Syk activation leads to SLP-76 activation See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437932 ( R-HSA-114604 ) R-HSA-437932 Reaction Name: p-Y348-SYK binds VAV family See in Reactome R-HSA-437936 ( R-HSA-114604 ) R-HSA-437936 Reaction Name: p-Y348-SYK phosphorylates VAV family See in Reactome R-HSA-453183 ( R-HSA-114604 ) R-HSA-453183 Reaction Name: p-Y348-SYK dissociates See in Reactome R-HSA-453200 ( R-HSA-114604 ) R-HSA-453200 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-508282 ( R-HSA-9020558 ) R-HSA-508282 Reaction Name: SYK is a substrate for JAK1 See in Reactome R-HSA-508292 ( R-HSA-9020558 ) R-HSA-508292 Reaction Name: SYK binds IL2RB See in Reactome R-HSA-5607738 ( R-HSA-5607764 ) R-HSA-5607738 Reaction Name: SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-5621366 ( R-HSA-5621480 ) R-HSA-5621366 Reaction Name: SYK binds to p-Y65,Y76-FCER1G See in Reactome R-HSA-5621370 ( R-HSA-5621480 ) R-HSA-5621370 Reaction Name: SYK autophosphorylates See in Reactome R-HSA-5684801 ( R-HSA-114604 ) R-HSA-5684801 Reaction Name: p-Y7-CLEC1B dimer:PDPN binds SYK See in Reactome R-HSA-879917 ( R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-912627 ( R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9674562 ( R-HSA-9674555 ) R-HSA-9674562 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 See in Reactome R-HSA-9674563 ( R-HSA-9674555 ) R-HSA-9674563 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 See in Reactome R-HSA-9674567 ( R-HSA-9674555 ) R-HSA-9674567 Reaction Name: p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 See in Reactome R-HSA-9674808 ( R-HSA-9674555 ) R-HSA-9674808 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) See in Reactome R-HSA-9674816 ( R-HSA-9674555 ) R-HSA-9674816 Reaction Name: p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS See in Reactome R-HSA-9676071 ( R-HSA-9674555 ) R-HSA-9676071 Reaction Name: CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK See in Reactome R-HSA-9705467 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705467 Reaction Name: SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 See in Reactome R-HSA-9705726 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705726 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed See in Reactome R-HSA-9705729 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705729 Reaction Name: SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 See in Reactome R-HSA-9705738 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9705738 Reaction Name: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 See in Reactome R-HSA-9706336 ( R-HSA-9706374 ) R-HSA-9706336 Reaction Name: Active FLT3 binds to SYK See in Reactome R-HSA-9707977 ( R-HSA-9674555; R-HSA-9705462 ) R-HSA-9707977 Reaction Name: CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane See in Reactome R-HSA-983700 ( R-HSA-983695 ) R-HSA-983700 Reaction Name: SYK binds the activated BCR See in Reactome R-HSA-983703 ( R-HSA-983695 ) R-HSA-983703 Reaction Name: p-6Y-SYK phosphorylates BLNK (SLP65) See in Reactome R-HSA-983707 ( R-HSA-983695 ) R-HSA-983707 Reaction Name: SYK autophosphorylates at the activated BCR See in Reactome
MONDO:0009327	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome