DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-202670)

Number of enzymes:	4
Number of disease:	6
Number of reactomes:	70
Number of reactions:	144

Search results (Reactome ID: R-HSA-202670)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009327	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0014105	DUSP6	Q16828	3.1.3.16 3.1.3.48	R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Signal Transduction	R-HSA-203797 ( R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome
MONDO:0016225	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0032697	PPP2CA	P67775	3.1.3.16	R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-2995383 R-HSA-2995383 Reactome Name: Initiation of Nuclear Envelope (NE) Reformation See in Reactome R-HSA-4641262 R-HSA-4641262 Reactome Name: Disassembly of the destruction complex and recruitment of AXIN to the membrane See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-2500257 R-HSA-2500257 Reactome Name: Resolution of Sister Chromatid Cohesion See in Reactome R-HSA-2465910 R-HSA-2465910 Reactome Name: MASTL Facilitates Mitotic Progression See in Reactome R-HSA-9648025 R-HSA-9648025 Reactome Name: EML4 and NUDC in mitotic spindle formation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-196299 R-HSA-196299 Reactome Name: Beta-catenin phosphorylation cascade See in Reactome R-HSA-69231 R-HSA-69231 Reactome Name: Cyclin D associated events in G1 See in Reactome R-HSA-432142 R-HSA-432142 Reactome Name: Platelet sensitization by LDL See in Reactome R-HSA-113501 R-HSA-113501 Reactome Name: Inhibition of replication initiation of damaged DNA by RB1/E2F1 See in Reactome R-HSA-141444 R-HSA-141444 Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-9634600 R-HSA-9634600 Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolism See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-69273 R-HSA-69273 Reactome Name: Cyclin A/B1/B2 associated events during G2/M transition See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-163767 R-HSA-163767 Reactome Name: PP2A-mediated dephosphorylation of key metabolic factors See in Reactome R-HSA-195253 R-HSA-195253 Reactome Name: Degradation of beta-catenin by the destruction complex See in Reactome R-HSA-975957 R-HSA-975957 Reactome Name: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69236 R-HSA-69236 Reactome Name: G1 Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-141424 R-HSA-141424 Reactome Name: Amplification of signal from the kinetochores See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-113510 R-HSA-113510 Reactome Name: E2F mediated regulation of DNA replication See in Reactome R-HSA-927802 R-HSA-927802 Reactome Name: Nonsense-Mediated Decay (NMD) See in Reactome R-HSA-69618 R-HSA-69618 Reactome Name: Mitotic Spindle Checkpoint See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome	Metabolism Cell Cycle Gene expression (Transcription) Immune System Metabolism of RNA Hemostasis Signal Transduction	R-HSA-113503 ( R-HSA-113501 ) R-HSA-113503 Reaction Name: PP2A mediated localization of RB1 protein in chromatin See in Reactome R-HSA-1295599 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295599 Reaction Name: SPRY2 translocates to the plasma membrane See in Reactome R-HSA-1295609 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295609 Reaction Name: SRC phosphorylates SPRY2 on Y55 and Y227 See in Reactome R-HSA-1295613 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295613 Reaction Name: SPRY2 binds GRB2 See in Reactome R-HSA-1295622 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295622 Reaction Name: SPRY2 binds CBL See in Reactome R-HSA-1295632 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295632 Reaction Name: PPA2A dephosphorylates SPRY2 See in Reactome R-HSA-1363274 ( R-HSA-69231 ) R-HSA-1363274 Reaction Name: Dephosphorylation of p107 (RBL1) by PP2A See in Reactome R-HSA-1363276 ( R-HSA-69231 ) R-HSA-1363276 Reaction Name: Dephosphorylation of p130 (RBL2) by PP2A See in Reactome R-HSA-141409 ( R-HSA-141444 ) R-HSA-141409 Reaction Name: Mad1 binds kinetochore See in Reactome R-HSA-141422 ( R-HSA-141444 ) R-HSA-141422 Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1 See in Reactome R-HSA-141431 ( R-HSA-141444 ) R-HSA-141431 Reaction Name: MAD2 associates with the Mad1 kinetochore complex See in Reactome R-HSA-141439 ( R-HSA-141444 ) R-HSA-141439 Reaction Name: Release of activated MAD2 from kinetochores See in Reactome R-HSA-1549564 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1549564 Reaction Name: PPTN11 dephosphorylates SPRY2 See in Reactome R-HSA-163688 ( R-HSA-163685; R-HSA-163767 ) R-HSA-163688 Reaction Name: Dephosphorylation of pChREBP (Thr 666) by PP2A See in Reactome R-HSA-163689 ( R-HSA-163685; R-HSA-163767 ) R-HSA-163689 Reaction Name: Dephosphorylation of pChREBP (Ser 196) by PP2A See in Reactome R-HSA-163750 ( R-HSA-163685; R-HSA-163767; R-HSA-9634600 ) R-HSA-163750 Reaction Name: Dephosphorylation of phosphoPFKFB1 by PP2A complex See in Reactome R-HSA-163769 ( R-HSA-163685 ) R-HSA-163769 Reaction Name: Activation of PP2A by Xylulose-5-phosphate See in Reactome R-HSA-1638803 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638803 Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres See in Reactome R-HSA-1638821 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638821 Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin See in Reactome R-HSA-164056 ( R-HSA-163685; R-HSA-163767 ) R-HSA-164056 Reaction Name: Dephosphorylation of pChREBP (Ser 568) by PP2A See in Reactome R-HSA-195251 ( R-HSA-195253 ) R-HSA-195251 Reaction Name: Assembly of the destruction complex See in Reactome R-HSA-195275 ( R-HSA-195253 ) R-HSA-195275 Reaction Name: Phosphorylation of APC component of the destruction complex See in Reactome R-HSA-195280 ( R-HSA-195253 ) R-HSA-195280 Reaction Name: Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex See in Reactome R-HSA-195283 ( R-HSA-195253; R-HSA-196299 ) R-HSA-195283 Reaction Name: Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 See in Reactome R-HSA-195287 ( R-HSA-195253; R-HSA-196299 ) R-HSA-195287 Reaction Name: Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 See in Reactome R-HSA-195300 ( R-HSA-195253; R-HSA-196299 ) R-HSA-195300 Reaction Name: Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 See in Reactome R-HSA-195304 ( R-HSA-195253 ) R-HSA-195304 Reaction Name: Association of beta-catenin with the destruction complex See in Reactome R-HSA-195318 ( R-HSA-195253; R-HSA-196299 ) R-HSA-195318 Reaction Name: Phosphorylation of beta-catenin at Ser45 by CK1 alpha See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-201685 ( R-HSA-4641262 ) R-HSA-201685 Reaction Name: Beta-catenin is released from the destruction complex See in Reactome R-HSA-201790 ( R-HSA-180024 ) R-HSA-201790 Reaction Name: DARPP-32 is dephosphorylated on Thr75 by PP2A See in Reactome R-HSA-2130279 ( R-HSA-195253 ) R-HSA-2130279 Reaction Name: Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex See in Reactome R-HSA-2130282 ( R-HSA-195253 ) R-HSA-2130282 Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome See in Reactome R-HSA-2130286 ( R-HSA-195253 ) R-HSA-2130286 Reaction Name: Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) See in Reactome R-HSA-2430552 ( R-HSA-2465910 ) R-HSA-2430552 Reaction Name: p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D See in Reactome R-HSA-2467809 ( R-HSA-2467813 ) R-HSA-2467809 Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin See in Reactome R-HSA-2467811 ( R-HSA-2467813 ) R-HSA-2467811 Reaction Name: Separation of sister chromatids See in Reactome R-HSA-2468287 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2468287 Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres See in Reactome R-HSA-2484822 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2484822 Reaction Name: Kinetochore assembly See in Reactome R-HSA-2995388 ( R-HSA-2995383 ) R-HSA-2995388 Reaction Name: PP2A dephosphorylates BANF1 See in Reactome R-HSA-3601585 ( R-HSA-4641262 ) R-HSA-3601585 Reaction Name: PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex See in Reactome R-HSA-375302 ( R-HSA-68877 ) R-HSA-375302 Reaction Name: Kinetochore capture of astral microtubules See in Reactome R-HSA-388809 ( R-HSA-389513 ) R-HSA-388809 Reaction Name: CTLA-4 binds B7-1/B7-2 See in Reactome R-HSA-388833 ( R-HSA-389513 ) R-HSA-388833 Reaction Name: Phosphorylation of CTLA-4 See in Reactome R-HSA-389532 ( R-HSA-389513 ) R-HSA-389532 Reaction Name: PP2A binds CTLA4 dimer See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-4088141 ( R-HSA-69273 ) R-HSA-4088141 Reaction Name: PP2A-PPP2R2A dephosphorylates FOXM1 See in Reactome R-HSA-432143 ( R-HSA-432142 ) R-HSA-432143 Reaction Name: PECAM-1 binds PP2A See in Reactome R-HSA-5229343 ( R-HSA-195253 ) R-HSA-5229343 Reaction Name: AXIN is phosphorylated in the destruction complex See in Reactome R-HSA-5666129 ( R-HSA-5663220 ) R-HSA-5666129 Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores See in Reactome R-HSA-5666160 ( R-HSA-5663220 ) R-HSA-5666160 Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores See in Reactome R-HSA-5666169 ( R-HSA-5663220 ) R-HSA-5666169 Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 See in Reactome R-HSA-5672957 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672957 Reaction Name: PP2A dephosphorylates KSR1 See in Reactome R-HSA-5672961 ( R-HSA-5673000; R-HSA-5673001 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5675431 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-6792863 ( R-HSA-6804757 ) R-HSA-6792863 Reaction Name: PP2A-PP2R5C dephosphorylates MDM2 See in Reactome R-HSA-6792871 ( R-HSA-6804757 ) R-HSA-6792871 Reaction Name: CCNG1 recruits PP2A-PPP2R5C to MDM2 See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-6811504 ( R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8856945 ( R-HSA-69273 ) R-HSA-8856945 Reaction Name: PP2A methylation by LCMT1 See in Reactome R-HSA-8856951 ( R-HSA-69273 ) R-HSA-8856951 Reaction Name: PP2A demethylation by PPME1 See in Reactome R-HSA-8857925 ( R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-927813 ( R-HSA-975957 ) R-HSA-927813 Reaction Name: p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A See in Reactome R-HSA-927830 ( R-HSA-975957 ) R-HSA-927830 Reaction Name: Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex See in Reactome R-HSA-927836 ( R-HSA-975957 ) R-HSA-927836 Reaction Name: SMG6 hydrolyzes mRNA with premature termination codon See in Reactome R-HSA-934559 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-934559 Reaction Name: SPRY2 is phosphorylated by phosphorylated MNK1 See in Reactome R-HSA-9648114 ( R-HSA-68877; R-HSA-9648025 ) R-HSA-9648114 Reaction Name: EML4 recruits NUDC to mitotic spindle See in Reactome R-HSA-9667965 ( R-HSA-2995383 ) R-HSA-9667965 Reaction Name: ANKLE2 binds PP2A See in Reactome
MONDO:0033669	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
OMIM:181800	MAPK7	Q13164	2.7.11.24	R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-198765 R-HSA-198765 Reactome Name: Signalling to ERK5 See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Developmental Biology Cellular responses to stimuli Signal Transduction	R-HSA-198714 ( R-HSA-198765 ) R-HSA-198714 Reaction Name: ERK5 translocates to the nucleus See in Reactome R-HSA-198733 ( R-HSA-198765 ) R-HSA-198733 Reaction Name: ERK5 is activated See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-199929 ( R-HSA-198753 ) R-HSA-199929 Reaction Name: ERK5 activates the transcription factor MEF2 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-8855915 ( R-HSA-8853659 ) R-HSA-8855915 Reaction Name: 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors See in Reactome