DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-202433)

Number of enzymes:	6
Number of disease:	10
Number of reactomes:	51
Number of reactions:	151

Search results (Reactome ID: R-HSA-202433)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0004948	PLCG2	P16885	3.1.4.11	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome R-HSA-202407 ( R-HSA-202433 ) R-HSA-202407 Reaction Name: PLC-gamma1 hydrolyses PIP2 See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2396606 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2396606 Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730841 ( R-HSA-2871796 ) R-HSA-2730841 Reaction Name: Phosphorylation and activation of VAV See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730851 ( R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-2730892 ( R-HSA-2871796 ) R-HSA-2730892 Reaction Name: Recruitment of VAV to p-SLP-76 See in Reactome R-HSA-429497 ( R-HSA-114604 ) R-HSA-429497 Reaction Name: SLP-76 stimulates PLC gamma 2 See in Reactome R-HSA-5607735 ( R-HSA-5607764 ) R-HSA-5607735 Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2 See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5607755 ( R-HSA-5607764 ) R-HSA-5607755 Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-9027373 ( R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-9027425 ( R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9032478 ( R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9606894 ( R-HSA-983695 ) R-HSA-9606894 Reaction Name: p-DAPP1 (p-BAM32) binds PLCG2 See in Reactome
MONDO:0010023	ZAP70	P43403	2.7.10.2	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-202430 R-HSA-202430 Reactome Name: Translocation of ZAP-70 to Immunological synapse See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-202168 ( R-HSA-202430 ) R-HSA-202168 Reaction Name: Phosphorylation of ZAP-70 by Lck See in Reactome R-HSA-202174 ( R-HSA-202430 ) R-HSA-202174 Reaction Name: Activation of ZAP-70 See in Reactome R-HSA-202216 ( R-HSA-202433 ) R-HSA-202216 Reaction Name: Phosphorylation of SLP-76 See in Reactome R-HSA-202245 ( R-HSA-202433 ) R-HSA-202245 Reaction Name: Phosphorylation of TBSMs in LAT See in Reactome R-HSA-202248 ( R-HSA-202433 ) R-HSA-202248 Reaction Name: Phosphorylation of PLC-gamma1 See in Reactome R-HSA-202344 ( R-HSA-202430 ) R-HSA-202344 Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs See in Reactome R-HSA-8855381 ( R-HSA-202430 ) R-HSA-8855381 Reaction Name: PTPN22 dephosphorylates ZAP70 See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome
MONDO:0010361	PAK3	O75914	2.7.11.1	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Developmental Biology Signal Transduction	R-HSA-389788 ( R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-428531 ( R-HSA-428540 ) R-HSA-428531 Reaction Name: Recruitment of PAK to NCK See in Reactome R-HSA-430183 ( R-HSA-202433 ) R-HSA-430183 Reaction Name: NCK binds PAK See in Reactome R-HSA-442832 ( R-HSA-5627123 ) R-HSA-442832 Reaction Name: PAK phosphorylates cortactin See in Reactome R-HSA-5357445 ( R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357477 ( R-HSA-5218920 ) R-HSA-5357477 Reaction Name: PAK1-3 phosphorylates VE-cadherin See in Reactome R-HSA-5357483 ( R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5687086 ( R-HSA-5687128 ) R-HSA-5687086 Reaction Name: PAK1,2,3 phosphorylates MAPK6,4 See in Reactome R-HSA-8981926 ( R-HSA-5627123 ) R-HSA-8981926 Reaction Name: RAC1 and CDC42 activate PAK3 See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9017507 ( R-HSA-9013409 ) R-HSA-9017507 Reaction Name: RHOJ binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome
MONDO:0012161	ZAP70	P43403	2.7.10.2	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-202430 R-HSA-202430 Reactome Name: Translocation of ZAP-70 to Immunological synapse See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-202168 ( R-HSA-202430 ) R-HSA-202168 Reaction Name: Phosphorylation of ZAP-70 by Lck See in Reactome R-HSA-202174 ( R-HSA-202430 ) R-HSA-202174 Reaction Name: Activation of ZAP-70 See in Reactome R-HSA-202216 ( R-HSA-202433 ) R-HSA-202216 Reaction Name: Phosphorylation of SLP-76 See in Reactome R-HSA-202245 ( R-HSA-202433 ) R-HSA-202245 Reaction Name: Phosphorylation of TBSMs in LAT See in Reactome R-HSA-202248 ( R-HSA-202433 ) R-HSA-202248 Reaction Name: Phosphorylation of PLC-gamma1 See in Reactome R-HSA-202344 ( R-HSA-202430 ) R-HSA-202344 Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs See in Reactome R-HSA-8855381 ( R-HSA-202430 ) R-HSA-8855381 Reaction Name: PTPN22 dephosphorylates ZAP70 See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome
MONDO:0013081	ITK	Q08881	2.7.10.2	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome	R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome	Immune System	R-HSA-202248 ( R-HSA-202433 ) R-HSA-202248 Reaction Name: Phosphorylation of PLC-gamma1 See in Reactome R-HSA-202375 ( R-HSA-202433 ) R-HSA-202375 Reaction Name: Recruitment of ITK to SLP-76 See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome
MONDO:0013766	PLCG2	P16885	3.1.4.11	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome R-HSA-202407 ( R-HSA-202433 ) R-HSA-202407 Reaction Name: PLC-gamma1 hydrolyses PIP2 See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2396606 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2396606 Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730841 ( R-HSA-2871796 ) R-HSA-2730841 Reaction Name: Phosphorylation and activation of VAV See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730851 ( R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-2730892 ( R-HSA-2871796 ) R-HSA-2730892 Reaction Name: Recruitment of VAV to p-SLP-76 See in Reactome R-HSA-429497 ( R-HSA-114604 ) R-HSA-429497 Reaction Name: SLP-76 stimulates PLC gamma 2 See in Reactome R-HSA-5607735 ( R-HSA-5607764 ) R-HSA-5607735 Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2 See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5607755 ( R-HSA-5607764 ) R-HSA-5607755 Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-9027373 ( R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-9027425 ( R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9032478 ( R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9606894 ( R-HSA-983695 ) R-HSA-9606894 Reaction Name: p-DAPP1 (p-BAM32) binds PLCG2 See in Reactome
MONDO:0013944	PLCG2	P16885	3.1.4.11	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5621480 R-HSA-5621480 Reactome Name: Dectin-2 family See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-9027277 R-HSA-9027277 Reactome Name: Erythropoietin activates Phospholipase C gamma (PLCG) See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-114689 ( R-HSA-114604 ) R-HSA-114689 Reaction Name: PLC gamma 2-mediated PIP2 hydrolysis See in Reactome R-HSA-1855221 ( R-HSA-1855204 ) R-HSA-1855221 Reaction Name: PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane See in Reactome R-HSA-202407 ( R-HSA-202433 ) R-HSA-202407 Reaction Name: PLC-gamma1 hydrolyses PIP2 See in Reactome R-HSA-2029268 ( R-HSA-2029485 ) R-HSA-2029268 Reaction Name: Phosphorylation and activation of PLCG See in Reactome R-HSA-2029270 ( R-HSA-2029485 ) R-HSA-2029270 Reaction Name: Recruitment of PLCgamma to membrane See in Reactome R-HSA-2029272 ( R-HSA-2029485 ) R-HSA-2029272 Reaction Name: Release of PLCG from FCGR See in Reactome R-HSA-2201293 ( R-HSA-166016 ) R-HSA-2201293 Reaction Name: Endocytosis of TLR4:LY96:LPS:CD14 See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2396606 ( R-HSA-2424491; R-HSA-2871796 ) R-HSA-2396606 Reaction Name: Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730840 ( R-HSA-2871796 ) R-HSA-2730840 Reaction Name: Activation of RAC1 by VAV See in Reactome R-HSA-2730841 ( R-HSA-2871796 ) R-HSA-2730841 Reaction Name: Phosphorylation and activation of VAV See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730851 ( R-HSA-2871796 ) R-HSA-2730851 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-2730892 ( R-HSA-2871796 ) R-HSA-2730892 Reaction Name: Recruitment of VAV to p-SLP-76 See in Reactome R-HSA-429497 ( R-HSA-114604 ) R-HSA-429497 Reaction Name: SLP-76 stimulates PLC gamma 2 See in Reactome R-HSA-5607735 ( R-HSA-5607764 ) R-HSA-5607735 Reaction Name: p-Y753,Y759-PLCG2 hydrolyses PIP2 See in Reactome R-HSA-5607745 ( R-HSA-5607764 ) R-HSA-5607745 Reaction Name: 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG See in Reactome R-HSA-5607755 ( R-HSA-5607764 ) R-HSA-5607755 Reaction Name: p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621347 ( R-HSA-5621480 ) R-HSA-5621347 Reaction Name: PLCG2 translocates from cytosol to plasma membrane See in Reactome R-HSA-5621356 ( R-HSA-5621480 ) R-HSA-5621356 Reaction Name: PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G See in Reactome R-HSA-5621363 ( R-HSA-5621480 ) R-HSA-5621363 Reaction Name: SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 See in Reactome R-HSA-9027373 ( R-HSA-9027277 ) R-HSA-9027373 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma See in Reactome R-HSA-9027425 ( R-HSA-9027277 ) R-HSA-9027425 Reaction Name: LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 See in Reactome R-HSA-9032478 ( R-HSA-9027277 ) R-HSA-9032478 Reaction Name: EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome R-HSA-9606894 ( R-HSA-983695 ) R-HSA-9606894 Reaction Name: p-DAPP1 (p-BAM32) binds PLCG2 See in Reactome
MONDO:0014334	LCK	P06239	2.7.10.2	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-389948 R-HSA-389948 Reactome Name: PD-1 signaling See in Reactome R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-9020558 R-HSA-9020558 Reactome Name: Interleukin-2 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-202427 R-HSA-202427 Reactome Name: Phosphorylation of CD3 and TCR zeta chains See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9706374 R-HSA-9706374 Reactome Name: FLT3 signaling through SRC family kinases See in Reactome R-HSA-202430 R-HSA-202430 Reactome Name: Translocation of ZAP-70 to Immunological synapse See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-210990 R-HSA-210990 Reactome Name: PECAM1 interactions See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome	Hemostasis Immune System Signal Transduction	R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-202165 ( R-HSA-202427 ) R-HSA-202165 Reaction Name: Phosphorylation of ITAM motifs in CD3 complexes See in Reactome R-HSA-202168 ( R-HSA-202430 ) R-HSA-202168 Reaction Name: Phosphorylation of ZAP-70 by Lck See in Reactome R-HSA-202174 ( R-HSA-202430 ) R-HSA-202174 Reaction Name: Activation of ZAP-70 See in Reactome R-HSA-202214 ( R-HSA-202427 ) R-HSA-202214 Reaction Name: Dephosphorylation of Lck-pY505 by CD45 See in Reactome R-HSA-202216 ( R-HSA-202433 ) R-HSA-202216 Reaction Name: Phosphorylation of SLP-76 See in Reactome R-HSA-202233 ( R-HSA-202427 ) R-HSA-202233 Reaction Name: Inactivation of Lck by Csk See in Reactome R-HSA-202245 ( R-HSA-202433 ) R-HSA-202245 Reaction Name: Phosphorylation of TBSMs in LAT See in Reactome R-HSA-202248 ( R-HSA-202433 ) R-HSA-202248 Reaction Name: Phosphorylation of PLC-gamma1 See in Reactome R-HSA-202291 ( R-HSA-202427 ) R-HSA-202291 Reaction Name: Activation of Lck See in Reactome R-HSA-202307 ( R-HSA-202424 ) R-HSA-202307 Reaction Name: Change of PKC theta conformation See in Reactome R-HSA-202344 ( R-HSA-202430 ) R-HSA-202344 Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-210289 ( R-HSA-2424491 ) R-HSA-210289 Reaction Name: Recruitment of SYK to p-DAP12 See in Reactome R-HSA-210291 ( R-HSA-210990 ) R-HSA-210291 Reaction Name: Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2395412 ( R-HSA-2424491 ) R-HSA-2395412 Reaction Name: Phosphorylation of SYK See in Reactome R-HSA-2395439 ( R-HSA-2424491 ) R-HSA-2395439 Reaction Name: Phosphorylation of DAP12 See in Reactome R-HSA-2395801 ( R-HSA-2424491 ) R-HSA-2395801 Reaction Name: Phosphorylation of LAT by p-SYK See in Reactome R-HSA-2396594 ( R-HSA-2424491 ) R-HSA-2396594 Reaction Name: Phosphorylation of SLP-76 by p-SYK See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-388814 ( R-HSA-389356; R-HSA-389359 ) R-HSA-388814 Reaction Name: Grb2 binds CD28 See in Reactome R-HSA-388829 ( R-HSA-389513 ) R-HSA-388829 Reaction Name: SHP2 phosphatase binds CTLA-4 See in Reactome R-HSA-388831 ( R-HSA-389356 ) R-HSA-388831 Reaction Name: Phosphorylation of CD28 See in Reactome R-HSA-388832 ( R-HSA-389356; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-388833 ( R-HSA-389513 ) R-HSA-388833 Reaction Name: Phosphorylation of CTLA-4 See in Reactome R-HSA-389158 ( R-HSA-389356; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-389348 ( R-HSA-389356; R-HSA-389359 ) R-HSA-389348 Reaction Name: Activation of Rac1 by pVav1 See in Reactome R-HSA-389350 ( R-HSA-389356; R-HSA-389359 ) R-HSA-389350 Reaction Name: Activation of Cdc42 by pVav1 See in Reactome R-HSA-389352 ( R-HSA-389356; R-HSA-389359 ) R-HSA-389352 Reaction Name: Translocation of Vav1 to CD28 See in Reactome R-HSA-389354 ( R-HSA-389356; R-HSA-389359 ) R-HSA-389354 Reaction Name: Activation of Vav1 See in Reactome R-HSA-389381 ( R-HSA-389356 ) R-HSA-389381 Reaction Name: Gads binds CD28 See in Reactome R-HSA-389758 ( R-HSA-389948 ) R-HSA-389758 Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases See in Reactome R-HSA-389759 ( R-HSA-389948 ) R-HSA-389759 Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1 See in Reactome R-HSA-389762 ( R-HSA-389948 ) R-HSA-389762 Reaction Name: Phosphorylation of PD-1 See in Reactome R-HSA-434836 ( R-HSA-114604 ) R-HSA-434836 Reaction Name: Syk/Lck phosphorylate LAT See in Reactome R-HSA-452100 ( R-HSA-9020558 ) R-HSA-452100 Reaction Name: SHC1 bound to IL2 receptor is phosphorylated See in Reactome R-HSA-8852200 ( R-HSA-202427 ) R-HSA-8852200 Reaction Name: Inactivation of LCK by PTPN22 See in Reactome R-HSA-8855381 ( R-HSA-202430 ) R-HSA-8855381 Reaction Name: PTPN22 dephosphorylates ZAP70 See in Reactome R-HSA-8857925 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-8857925 Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9706312 ( R-HSA-9706374 ) R-HSA-9706312 Reaction Name: Active FLT3 binds to LCK See in Reactome
MONDO:0014861	ZAP70	P43403	2.7.10.2	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-202430 R-HSA-202430 Reactome Name: Translocation of ZAP-70 to Immunological synapse See in Reactome	R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-202168 ( R-HSA-202430 ) R-HSA-202168 Reaction Name: Phosphorylation of ZAP-70 by Lck See in Reactome R-HSA-202174 ( R-HSA-202430 ) R-HSA-202174 Reaction Name: Activation of ZAP-70 See in Reactome R-HSA-202216 ( R-HSA-202433 ) R-HSA-202216 Reaction Name: Phosphorylation of SLP-76 See in Reactome R-HSA-202245 ( R-HSA-202433 ) R-HSA-202245 Reaction Name: Phosphorylation of TBSMs in LAT See in Reactome R-HSA-202248 ( R-HSA-202433 ) R-HSA-202248 Reaction Name: Phosphorylation of PLC-gamma1 See in Reactome R-HSA-202344 ( R-HSA-202430 ) R-HSA-202344 Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs See in Reactome R-HSA-8855381 ( R-HSA-202430 ) R-HSA-8855381 Reaction Name: PTPN22 dephosphorylates ZAP70 See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome
MONDO:0032568	PAK1	Q13153	2.7.11.1	R-HSA-202433 R-HSA-202433 Reactome Name: Generation of second messenger molecules See in Reactome R-HSA-376172 R-HSA-376172 Reactome Name: DSCAM interactions See in Reactome R-HSA-428540 R-HSA-428540 Reactome Name: Activation of RAC1 See in Reactome R-HSA-399954 R-HSA-399954 Reactome Name: Sema3A PAK dependent Axon repulsion See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome R-HSA-9013424 R-HSA-9013424 Reactome Name: RHOV GTPase cycle See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-389359 R-HSA-389359 Reactome Name: CD28 dependent Vav1 pathway See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5687128 R-HSA-5687128 Reactome Name: MAPK6/MAPK4 signaling See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-9013148 R-HSA-9013148 Reactome Name: CDC42 GTPase cycle See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-3928664 R-HSA-3928664 Reactome Name: Ephrin signaling See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-5621575 R-HSA-5621575 Reactome Name: CD209 (DC-SIGN) signaling See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-9013420 R-HSA-9013420 Reactome Name: RHOU GTPase cycle See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome R-HSA-9013406 R-HSA-9013406 Reactome Name: RHOQ GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-8964616 R-HSA-8964616 Reactome Name: G beta:gamma signalling through CDC42 See in Reactome	R-HSA-376176 R-HSA-376176 Reactome Name: Signaling by ROBO receptors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-373752 R-HSA-373752 Reactome Name: Netrin-1 signaling See in Reactome	Muscle contraction Immune System Developmental Biology Signal Transduction	R-HSA-2029454 ( R-HSA-2029482 ) R-HSA-2029454 Reaction Name: Autophosphorylation of PAK1 See in Reactome R-HSA-2029456 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029456 Reaction Name: RAC1 and CDC42 activate PAK1 See in Reactome R-HSA-2029460 ( R-HSA-2029482; R-HSA-5627123 ) R-HSA-2029460 Reaction Name: PAK1 phosphorylates LIMK1 See in Reactome R-HSA-2730856 ( R-HSA-2871796 ) R-HSA-2730856 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-2730887 ( R-HSA-2871796 ) R-HSA-2730887 Reaction Name: Autophosphorylation and activation of MEKK1 See in Reactome R-HSA-2730889 ( R-HSA-2871796 ) R-HSA-2730889 Reaction Name: Recruitment of PAK to the membrane by binding active RAC1 See in Reactome R-HSA-376123 ( R-HSA-376172 ) R-HSA-376123 Reaction Name: DSCAM associates with Rac1-GTP:pPAK1 See in Reactome R-HSA-389788 ( R-HSA-389356; R-HSA-389359; R-HSA-5687128 ) R-HSA-389788 Reaction Name: Activation of PAKs by RAC1 and CDC42 See in Reactome R-HSA-3928619 ( R-HSA-3928662 ) R-HSA-3928619 Reaction Name: PAK1 binds RAC1:GTP See in Reactome R-HSA-3928620 ( R-HSA-3928662 ) R-HSA-3928620 Reaction Name: PAK1 autophosphorylates See in Reactome R-HSA-3928625 ( R-HSA-3928664 ) R-HSA-3928625 Reaction Name: PAKs autophosphorylate See in Reactome R-HSA-3928640 ( R-HSA-3928664 ) R-HSA-3928640 Reaction Name: PAKs phosphorylate MLC See in Reactome R-HSA-3928641 ( R-HSA-3928664 ) R-HSA-3928641 Reaction Name: PAK binds RAC and bPIX See in Reactome R-HSA-399930 ( R-HSA-399954 ) R-HSA-399930 Reaction Name: Activation of PAK by Rac1 See in Reactome R-HSA-399939 ( R-HSA-399954 ) R-HSA-399939 Reaction Name: Autophosphorylation of PAK See in Reactome R-HSA-399952 ( R-HSA-399954 ) R-HSA-399952 Reaction Name: Phosphorylation of LIMK-1 by PAK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-428531 ( R-HSA-428540 ) R-HSA-428531 Reaction Name: Recruitment of PAK to NCK See in Reactome R-HSA-430183 ( R-HSA-202433 ) R-HSA-430183 Reaction Name: NCK binds PAK See in Reactome R-HSA-442832 ( R-HSA-5627123 ) R-HSA-442832 Reaction Name: PAK phosphorylates cortactin See in Reactome R-HSA-445072 ( R-HSA-445144 ) R-HSA-445072 Reaction Name: Interaction of PAK1 with Rac1-GTP See in Reactome R-HSA-445797 ( R-HSA-445355; R-HSA-5627123 ) R-HSA-445797 Reaction Name: MYLK (MLCK) Active Calmodulin Binding See in Reactome R-HSA-451347 ( R-HSA-376172 ) R-HSA-451347 Reaction Name: Activation of JNK by DSCAM See in Reactome R-HSA-451366 ( R-HSA-376172 ) R-HSA-451366 Reaction Name: Activation of p38MAPK by DSCAM See in Reactome R-HSA-5357445 ( R-HSA-5218920 ) R-HSA-5357445 Reaction Name: PAK1-3 dimer disassociates See in Reactome R-HSA-5357472 ( R-HSA-5218920 ) R-HSA-5357472 Reaction Name: PAK1-3 autophosphorylates See in Reactome R-HSA-5357477 ( R-HSA-5218920 ) R-HSA-5357477 Reaction Name: PAK1-3 phosphorylates VE-cadherin See in Reactome R-HSA-5357483 ( R-HSA-5218920 ) R-HSA-5357483 Reaction Name: RAC1 binds PAK1-3 See in Reactome R-HSA-5624492 ( R-HSA-5621575 ) R-HSA-5624492 Reaction Name: PAK phosphorylates p21 RAF1 on S338 See in Reactome R-HSA-5627775 ( R-HSA-5627123; R-HSA-5687128 ) R-HSA-5627775 Reaction Name: Autophosphorylation of PAK1,2,3 See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668984 ( R-HSA-5627123 ) R-HSA-5668984 Reaction Name: PAK1 or PAK2 phosphorylates MYLK See in Reactome R-HSA-5669158 ( R-HSA-5627123 ) R-HSA-5669158 Reaction Name: NF2 binds PAK1 See in Reactome R-HSA-5669240 ( R-HSA-5627123 ) R-HSA-5669240 Reaction Name: FLNA binds PAK1 See in Reactome R-HSA-5669250 ( R-HSA-5627123 ) R-HSA-5669250 Reaction Name: PAK1 phosphorylates FLNA See in Reactome R-HSA-5687086 ( R-HSA-5687128 ) R-HSA-5687086 Reaction Name: PAK1,2,3 phosphorylates MAPK6,4 See in Reactome R-HSA-8964599 ( R-HSA-8964616 ) R-HSA-8964599 Reaction Name: Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex See in Reactome R-HSA-8964604 ( R-HSA-8964616 ) R-HSA-8964604 Reaction Name: CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated See in Reactome R-HSA-8964605 ( R-HSA-8964616 ) R-HSA-8964605 Reaction Name: PAK1:ARHGEF6 complex binds G-protein beta-gamma complex See in Reactome R-HSA-8964614 ( R-HSA-8964616 ) R-HSA-8964614 Reaction Name: PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated See in Reactome R-HSA-8964619 ( R-HSA-8964616 ) R-HSA-8964619 Reaction Name: PAK1 binds ARHGEF6 See in Reactome R-HSA-8964634 ( R-HSA-8964616 ) R-HSA-8964634 Reaction Name: CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9013157 ( R-HSA-9013148 ) R-HSA-9013157 Reaction Name: CDC42 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9017507 ( R-HSA-9013409 ) R-HSA-9017507 Reaction Name: RHOJ binds effectors at the plasma membrane See in Reactome R-HSA-9018746 ( R-HSA-9013406 ) R-HSA-9018746 Reaction Name: RHOQ binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018766 ( R-HSA-9013420 ) R-HSA-9018766 Reaction Name: RHOU binds effectors at the plasma membrane See in Reactome R-HSA-9018794 ( R-HSA-9013424 ) R-HSA-9018794 Reaction Name: RHOV binds effectors at the plasma membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome