MONDO:0001056 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0005595 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007924 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0007962 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008005 |
MAP3K7 |
O43318 |
2.7.11.25
|
R-HSA-9020702
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-202424
R-HSA-4086398
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168638
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-5688426
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-166166
R-HSA-75893
R-HSA-450294
R-HSA-195721
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-4332356
(
R-HSA-4086398
)
R-HSA-4332388
(
R-HSA-4086398
)
R-HSA-4332388
Reaction Name: Activation of MAP3K7 in response to WNT
See in Reactome
R-HSA-4411402
(
R-HSA-4086398
)
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450337
(
R-HSA-450321
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-450302
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5696534
(
R-HSA-5689880
)
R-HSA-5696534
Reaction Name: USP18 deubiquitinates TAK1:TAB1
See in Reactome
R-HSA-688985
(
R-HSA-168638
)
R-HSA-688985
Reaction Name: K63 polyubiquitinated RIP2 associates with the TAK1 complex
See in Reactome
R-HSA-706479
(
R-HSA-168638
)
R-HSA-727819
(
R-HSA-168638;
R-HSA-9020702
)
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-937042
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936991
(
R-HSA-937042
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-975097
(
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975103
(
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
|
MONDO:0008021 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008093 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008170 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008170 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008318 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0008420 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008903 |
MONDO:0008903
Disease Name: lung cancer
OMIM id: OMIM:614210
All associated enzymes in DAR:
ERBB2
MAP3K8
PIK3CA
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0010172 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011240 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0011537 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011738 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011789 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0011962 |
MONDO:0011962
Disease Name: endometrial cancer
OMIM id: OMIM:608089
All associated enzymes in DAR:
PTEN
. The disease is also associated to other non-enzyme proteins (not in DAR).
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0013038 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0013092 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0013125 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0013334 |
CHUK |
O15111 |
2.7.11.10
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-9020702
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-937039
R-HSA-202424
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-168638
R-HSA-1236974
R-HSA-5357905
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-5607764
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-1280218
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-1257604
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-166166
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-75893
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168638
(
R-HSA-1169091
)
R-HSA-1168638
Reaction Name: Activated IKK phosphorylates I-kappaB
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168140
(
R-HSA-1810476;
R-HSA-445989;
R-HSA-9020702;
R-HSA-933542
)
R-HSA-168140
Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-202541
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202541
Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-451561
(
R-HSA-9020702
)
R-HSA-451561
Reaction Name: NEMO binds polyubiquitinated IRAK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905
)
R-HSA-5607720
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607720
Reaction Name: p100:RELB binds active NIK:p-IKKA dimer
See in Reactome
R-HSA-5607722
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607722
Reaction Name: Active NIK phosphorylates IKKA dimer
See in Reactome
R-HSA-5607723
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607723
Reaction Name: SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB
See in Reactome
R-HSA-5607725
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607725
Reaction Name: SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
See in Reactome
R-HSA-5607726
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5676590
)
R-HSA-5607726
Reaction Name: Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5609665
(
R-HSA-445989;
R-HSA-9020702
)
R-HSA-5609665
Reaction Name: CHUK, IKBKB and IKBKG form IKK complex
See in Reactome
R-HSA-5626962
(
R-HSA-5357905
)
R-HSA-5684267
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684267
Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
See in Reactome
R-HSA-5684275
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684275
Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
See in Reactome
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933530
(
R-HSA-933542
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-937032
(
R-HSA-937039
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-975119
(
R-HSA-975144
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
|
MONDO:0014047 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0014197 |
MALT1 |
Q9UDY8 |
3.4.22.-
|
R-HSA-5607764
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-202424
R-HSA-5660668
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168256
R-HSA-168249
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-202403
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-1280218
|
Immune System
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-1168644
(
R-HSA-1169091
)
R-HSA-1168644
Reaction Name: CARMA1 recruits MALT1 and BCL10 forming CBM Complex
See in Reactome
R-HSA-202453
(
R-HSA-202424
)
R-HSA-202472
(
R-HSA-202424
)
R-HSA-202472
Reaction Name: Translocation of TRAF6 to CBM complex
See in Reactome
R-HSA-202478
(
R-HSA-202424
)
R-HSA-202478
Reaction Name: Interaction and oligomerization of MALT1 to Bcl10
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-2730836
(
R-HSA-2871837
)
R-HSA-2730836
Reaction Name: Interaction of BCL10:MALT1 with CARMA1 to form CBM complex
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730864
(
R-HSA-2871837
)
R-HSA-2730864
Reaction Name: Recruitment of TRAF6 to CBM complex by binding to MALT1
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730899
(
R-HSA-2871837
)
R-HSA-2730899
Reaction Name: Oligomerization of BCL10 and MALT1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-2730903
(
R-HSA-2871837
)
R-HSA-2730904
(
R-HSA-2871837
)
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607736
(
R-HSA-5607764
)
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607744
(
R-HSA-5607764
)
R-HSA-5607747
(
R-HSA-5607764
)
R-HSA-5607751
(
R-HSA-5607764
)
R-HSA-5607756
(
R-HSA-5607764
)
R-HSA-5607756
Reaction Name: TRAF6 oligomer autoubiquitinates
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5660662
(
R-HSA-5607764;
R-HSA-5660668
)
R-HSA-5660663
(
R-HSA-5607764;
R-HSA-5660668
)
R-HSA-5660663
Reaction Name: Caspase-8 cleaves IL1B precursor
See in Reactome
R-HSA-5660665
(
R-HSA-5607764;
R-HSA-5660668
)
|
MONDO:0014267 |
IKBKB |
O14920 |
2.7.11.10
2.7.11.1
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-9020702
R-HSA-937039
R-HSA-202424
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-168638
R-HSA-1236974
R-HSA-5357905
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-209543
R-HSA-209543
Reactome Name: p75NTR recruits signalling complexes
See in Reactome
R-HSA-209560
R-HSA-209560
Reactome Name: NF-kB is activated and signals survival
See in Reactome
R-HSA-5607764
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-193639
R-HSA-166166
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-75893
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168638
(
R-HSA-1169091
)
R-HSA-1168638
Reaction Name: Activated IKK phosphorylates I-kappaB
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168140
(
R-HSA-1810476;
R-HSA-445989;
R-HSA-9020702;
R-HSA-933542
)
R-HSA-168140
Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-193641
(
R-HSA-209543
)
R-HSA-193703
(
R-HSA-209560
)
R-HSA-193705
(
R-HSA-209560
)
R-HSA-193705
Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-202541
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202541
Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
See in Reactome
R-HSA-209087
(
R-HSA-9020702
)
R-HSA-209087
Reaction Name: IKBA is phosphorylated by Phospho IKKB kinase
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-451561
(
R-HSA-9020702
)
R-HSA-451561
Reaction Name: NEMO binds polyubiquitinated IRAK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905
)
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5609665
(
R-HSA-445989;
R-HSA-9020702
)
R-HSA-5609665
Reaction Name: CHUK, IKBKB and IKBKG form IKK complex
See in Reactome
R-HSA-5626962
(
R-HSA-5357905
)
R-HSA-5684267
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684267
Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
See in Reactome
R-HSA-5684275
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684275
Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
See in Reactome
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933530
(
R-HSA-933542
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-937032
(
R-HSA-937039
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-975119
(
R-HSA-975144
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
|
MONDO:0014334 |
LCK |
P06239 |
2.7.10.2
|
R-HSA-202433
R-HSA-202433
Reactome Name: Generation of second messenger molecules
See in Reactome
R-HSA-389948
R-HSA-1433559
R-HSA-202424
R-HSA-9020558
R-HSA-1257604
R-HSA-202427
R-HSA-202427
Reactome Name: Phosphorylation of CD3 and TCR zeta chains
See in Reactome
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-1433557
R-HSA-389513
R-HSA-9706374
R-HSA-9706374
Reactome Name: FLT3 signaling through SRC family kinases
See in Reactome
R-HSA-202430
R-HSA-202430
Reactome Name: Translocation of ZAP-70 to Immunological synapse
See in Reactome
R-HSA-2424491
R-HSA-389356
R-HSA-210990
R-HSA-389359
R-HSA-9013407
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-109582
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-9012999
R-HSA-449147
R-HSA-168256
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-451927
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9607240
R-HSA-168249
R-HSA-162582
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-2172127
R-HSA-1280218
R-HSA-202403
|
Hemostasis
Immune System
Signal Transduction
|
R-HSA-1433418
(
R-HSA-1433557
)
R-HSA-1433428
(
R-HSA-1433557
)
R-HSA-1433428
Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2
See in Reactome
R-HSA-1433451
(
R-HSA-1433557
)
R-HSA-1433454
(
R-HSA-1433557
)
R-HSA-1433454
Reaction Name: Phosphorylation of GAB2 by SFKs
See in Reactome
R-HSA-1433456
(
R-HSA-1433557
)
R-HSA-1433488
(
R-HSA-1433557
)
R-HSA-1433488
Reaction Name: Phosphorylation of SHP2 by SFKs
See in Reactome
R-HSA-1433506
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1433542
(
R-HSA-1433557
)
R-HSA-1433542
Reaction Name: Phosphorylation and activation of VAV1
See in Reactome
R-HSA-1470009
(
R-HSA-1433557
)
R-HSA-1470010
(
R-HSA-1433557
)
R-HSA-1470012
(
R-HSA-1433557
)
R-HSA-1470012
Reaction Name: Disassociation and translocation of STATs to the nucleus
See in Reactome
R-HSA-1472121
(
R-HSA-1433557
)
R-HSA-1472121
Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-202165
(
R-HSA-202427
)
R-HSA-202165
Reaction Name: Phosphorylation of ITAM motifs in CD3 complexes
See in Reactome
R-HSA-202168
(
R-HSA-202430
)
R-HSA-202168
Reaction Name: Phosphorylation of ZAP-70 by Lck
See in Reactome
R-HSA-202174
(
R-HSA-202430
)
R-HSA-202214
(
R-HSA-202427
)
R-HSA-202214
Reaction Name: Dephosphorylation of Lck-pY505 by CD45
See in Reactome
R-HSA-202216
(
R-HSA-202433
)
R-HSA-202233
(
R-HSA-202427
)
R-HSA-202245
(
R-HSA-202433
)
R-HSA-202245
Reaction Name: Phosphorylation of TBSMs in LAT
See in Reactome
R-HSA-202248
(
R-HSA-202433
)
R-HSA-202291
(
R-HSA-202427
)
R-HSA-202307
(
R-HSA-202424
)
R-HSA-202307
Reaction Name: Change of PKC theta conformation
See in Reactome
R-HSA-202344
(
R-HSA-202430
)
R-HSA-202344
Reaction Name: Recruitment of ZAP-70 to phosphorylated ITAMs
See in Reactome
R-HSA-205205
(
R-HSA-1433557
)
R-HSA-205205
Reaction Name: Interaction of Src family kinases with p-KIT
See in Reactome
R-HSA-205234
(
R-HSA-1433557
)
R-HSA-205234
Reaction Name: Indirect recruitment of GAB2 to p-KIT
See in Reactome
R-HSA-205238
(
R-HSA-1433557
)
R-HSA-205244
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-205319
(
R-HSA-1433557;
R-HSA-1433559
)
R-HSA-210289
(
R-HSA-2424491
)
R-HSA-210291
(
R-HSA-210990
)
R-HSA-210291
Reaction Name: Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2395412
(
R-HSA-2424491
)
R-HSA-2395439
(
R-HSA-2424491
)
R-HSA-2395801
(
R-HSA-2424491
)
R-HSA-2395801
Reaction Name: Phosphorylation of LAT by p-SYK
See in Reactome
R-HSA-2396594
(
R-HSA-2424491
)
R-HSA-2396594
Reaction Name: Phosphorylation of SLP-76 by p-SYK
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2424484
(
R-HSA-2424491
)
R-HSA-2424484
Reaction Name: Phosphorylation of BTK by p-SYK
See in Reactome
R-HSA-2424486
(
R-HSA-2424491
)
R-HSA-2424486
Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK
See in Reactome
R-HSA-2424487
(
R-HSA-2424491
)
R-HSA-2424487
Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK
See in Reactome
R-HSA-388814
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-388829
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-388831
(
R-HSA-388841;
R-HSA-389356
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-388833
(
R-HSA-388841;
R-HSA-389513
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-389348
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-389350
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-389352
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-389354
(
R-HSA-388841;
R-HSA-389356;
R-HSA-389359
)
R-HSA-389381
(
R-HSA-388841;
R-HSA-389356
)
R-HSA-389758
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389758
Reaction Name: Dephosphorylation of CD3-zeta by PD-1 bound phosphatases
See in Reactome
R-HSA-389759
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-389759
Reaction Name: Interaction of SHP-1 or SHP-2 with phospho PD-1
See in Reactome
R-HSA-389762
(
R-HSA-388841;
R-HSA-389948
)
R-HSA-434836
(
R-HSA-114604
)
R-HSA-452100
(
R-HSA-9020558
)
R-HSA-452100
Reaction Name: SHC1 bound to IL2 receptor is phosphorylated
See in Reactome
R-HSA-8852200
(
R-HSA-202427
)
R-HSA-8855381
(
R-HSA-202430
)
R-HSA-8857925
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-8857925
Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307
See in Reactome
R-HSA-9018758
(
R-HSA-9013407
)
R-HSA-9018758
Reaction Name: RHOH binds effectors at the plasma membrane
See in Reactome
R-HSA-9706312
(
R-HSA-9607240;
R-HSA-9706374
)
|
MONDO:0014935 |
MAP3K7 |
O43318 |
2.7.11.25
|
R-HSA-9020702
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-202424
R-HSA-4086398
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-168638
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-5688426
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-166166
R-HSA-75893
R-HSA-450294
R-HSA-195721
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-4332356
(
R-HSA-4086398
)
R-HSA-4332388
(
R-HSA-4086398
)
R-HSA-4332388
Reaction Name: Activation of MAP3K7 in response to WNT
See in Reactome
R-HSA-4411402
(
R-HSA-4086398
)
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450337
(
R-HSA-450321
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-450302
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-5357860
(
R-HSA-5357956
)
R-HSA-5357860
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex
See in Reactome
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5696534
(
R-HSA-5689880
)
R-HSA-5696534
Reaction Name: USP18 deubiquitinates TAK1:TAB1
See in Reactome
R-HSA-688985
(
R-HSA-168638
)
R-HSA-688985
Reaction Name: K63 polyubiquitinated RIP2 associates with the TAK1 complex
See in Reactome
R-HSA-706479
(
R-HSA-168638
)
R-HSA-727819
(
R-HSA-168638;
R-HSA-9020702
)
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-937042
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936991
(
R-HSA-937042
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-975097
(
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975103
(
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
|
MONDO:0015293 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0015884 |
TRAF6 |
Q9Y4K3 |
2.3.2.27
|
R-HSA-937042
R-HSA-937042
Reactome Name: IRAK2 mediated activation of TAK1 complex
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-937072
R-HSA-937072
Reactome Name: TRAF6-mediated induction of TAK1 complex within TLR4 complex
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-9020702
R-HSA-1257604
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975163
R-HSA-975163
Reactome Name: IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-209543
R-HSA-209543
Reactome Name: p75NTR recruits signalling complexes
See in Reactome
R-HSA-209560
R-HSA-209560
Reactome Name: NF-kB is activated and signals survival
See in Reactome
R-HSA-450321
R-HSA-450321
Reactome Name: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-450302
R-HSA-450302
Reactome Name: activated TAK1 mediates p38 MAPK activation
See in Reactome
R-HSA-933541
R-HSA-202424
R-HSA-9645460
R-HSA-9645460
Reactome Name: Alpha-protein kinase 1 signaling pathway
See in Reactome
R-HSA-168638
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-205043
R-HSA-205043
Reactome Name: NRIF signals cell death from the nucleus
See in Reactome
R-HSA-937039
R-HSA-193692
R-HSA-193692
Reactome Name: Regulated proteolysis of p75NTR
See in Reactome
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975110
R-HSA-975110
Reactome Name: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-5607764
R-HSA-9014325
R-HSA-9014325
Reactome Name: TICAM1,TRAF6-dependent induction of TAK1 complex
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-448424
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168898
R-HSA-73887
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-168256
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-392499
R-HSA-193639
R-HSA-166166
R-HSA-450294
R-HSA-5688426
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Metabolism of proteins
Signal Transduction
|
R-HSA-166362
(
R-HSA-166058
)
R-HSA-166362
Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-166363
(
R-HSA-166058
)
R-HSA-166869
(
R-HSA-166058;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168184
(
R-HSA-166058;
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168915
(
R-HSA-937041
)
R-HSA-168915
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-177690
(
R-HSA-9014325
)
R-HSA-177690
Reaction Name: Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-177692
(
R-HSA-9014325
)
R-HSA-177692
Reaction Name: Activation of recruited TAK1 within the activated TLR3 complex
See in Reactome
R-HSA-177694
(
R-HSA-9014325
)
R-HSA-177694
Reaction Name: Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
See in Reactome
R-HSA-193641
(
R-HSA-209543
)
R-HSA-193665
(
R-HSA-209543
)
R-HSA-193669
(
R-HSA-205043
)
R-HSA-193684
(
R-HSA-209543
)
R-HSA-193694
(
R-HSA-209543
)
R-HSA-193694
Reaction Name: p62 is recruited and forms a complex with TRAF6
See in Reactome
R-HSA-193695
(
R-HSA-209543
)
R-HSA-193700
(
R-HSA-193692
)
R-HSA-193703
(
R-HSA-209560
)
R-HSA-193705
(
R-HSA-209560
)
R-HSA-193705
Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate
See in Reactome
R-HSA-202453
(
R-HSA-202424
)
R-HSA-202472
(
R-HSA-202424
)
R-HSA-202472
Reaction Name: Translocation of TRAF6 to CBM complex
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202510
(
R-HSA-202424
)
R-HSA-202510
Reaction Name: Activation of TAK1-TAB2 complex
See in Reactome
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-204949
(
R-HSA-205043
)
R-HSA-204949
Reaction Name: NRIF and TRAF6 may activate JNK
See in Reactome
R-HSA-205112
(
R-HSA-205043
)
R-HSA-205112
Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
See in Reactome
R-HSA-205118
(
R-HSA-205043
)
R-HSA-209566
(
R-HSA-209543
)
R-HSA-2262775
(
R-HSA-166058
)
R-HSA-2262775
Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
See in Reactome
R-HSA-2262777
(
R-HSA-166058
)
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2730861
(
R-HSA-2871837
)
R-HSA-2730861
Reaction Name: Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
See in Reactome
R-HSA-2730864
(
R-HSA-2871837
)
R-HSA-2730864
Reaction Name: Recruitment of TRAF6 to CBM complex by binding to MALT1
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-2730900
(
R-HSA-2871837
)
R-HSA-2730900
Reaction Name: Activation of TAK1 complex bound to pUb-TRAF6
See in Reactome
R-HSA-2730903
(
R-HSA-2871837
)
R-HSA-2730904
(
R-HSA-2871837
)
R-HSA-446862
(
R-HSA-9020702
)
R-HSA-446862
Reaction Name: Hyperphosphorylated IRAK1 associates with TRAF6
See in Reactome
R-HSA-446870
(
R-HSA-9020702
)
R-HSA-446870
Reaction Name: Polyubiquitinated TRAF6 binds the TAK1 complex
See in Reactome
R-HSA-446877
(
R-HSA-9020702
)
R-HSA-446877
Reaction Name: TRAF6 is K63 poly-ubiquitinated
See in Reactome
R-HSA-446894
(
R-HSA-9020702
)
R-HSA-446894
Reaction Name: TRAF6 binding leads to IRAK1:TRAF6 release
See in Reactome
R-HSA-450173
(
R-HSA-9020702
)
R-HSA-450173
Reaction Name: IRAK1 induces oligomerisation of TRAF6
See in Reactome
R-HSA-450187
(
R-HSA-9020702
)
R-HSA-450187
Reaction Name: TAK1 is activated within the TAK1 complex
See in Reactome
R-HSA-450259
(
R-HSA-9014325
)
R-HSA-450259
Reaction Name: Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex
See in Reactome
R-HSA-450337
(
R-HSA-166058;
R-HSA-450321;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450337
Reaction Name: Activated TAK1 phosphorylates MKK4/MKK7
See in Reactome
R-HSA-450346
(
R-HSA-166058;
R-HSA-450302;
R-HSA-975138;
R-HSA-975155;
R-HSA-975871
)
R-HSA-450346
Reaction Name: activated human TAK1 phosphorylates MKK3/MKK6
See in Reactome
R-HSA-450358
(
R-HSA-937072;
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-450358
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
See in Reactome
R-HSA-507719
(
R-HSA-9020702
)
R-HSA-5607732
(
R-HSA-5607764
)
R-HSA-5607732
Reaction Name: K63polyUb-TAK1 autophosphorylates
See in Reactome
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5607747
(
R-HSA-5607764
)
R-HSA-5607751
(
R-HSA-5607764
)
R-HSA-5607756
(
R-HSA-5607764
)
R-HSA-5607756
Reaction Name: TRAF6 oligomer autoubiquitinates
See in Reactome
R-HSA-5607757
(
R-HSA-5607764
)
R-HSA-5607757
Reaction Name: K63polyUb-TRAF6 ubiquitinates TAK1
See in Reactome
R-HSA-5607759
(
R-HSA-5607764
)
R-HSA-5607759
Reaction Name: TRIKA2 binds K63polyUb-TRAF6 oligomer
See in Reactome
R-HSA-5690843
(
R-HSA-5689896
)
R-HSA-5690843
Reaction Name: OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
See in Reactome
R-HSA-5690870
(
R-HSA-5689896
)
R-HSA-5690870
Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6
See in Reactome
R-HSA-5696627
(
R-HSA-5689880
)
R-HSA-5696627
Reaction Name: CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG
See in Reactome
R-HSA-688137
(
R-HSA-168638
)
R-HSA-741386
(
R-HSA-168638
)
R-HSA-741386
Reaction Name: RIP2 induces K63-linked ubiquitination of NEMO
See in Reactome
R-HSA-847070
(
R-HSA-9014325
)
R-HSA-847070
Reaction Name: Phosphorylated TAK1 dissociates from the TLR3 receptor complex
See in Reactome
R-HSA-8869456
(
R-HSA-5689880
)
R-HSA-8869456
Reaction Name: USP4 deubiquitinate TRAF2,TRAF6
See in Reactome
R-HSA-8869506
(
R-HSA-5689896
)
R-HSA-8869506
Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6
See in Reactome
R-HSA-8948015
(
R-HSA-9020702
)
R-HSA-8948015
Reaction Name: hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb
See in Reactome
R-HSA-8948018
(
R-HSA-9020702
)
R-HSA-8948018
Reaction Name: UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1
See in Reactome
R-HSA-9014342
(
R-HSA-168927
)
R-HSA-9014342
Reaction Name: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
See in Reactome
R-HSA-918230
(
R-HSA-933541
)
R-HSA-918230
Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1
See in Reactome
R-HSA-933525
(
R-HSA-933541
)
R-HSA-933525
Reaction Name: Phosphorylation and release of IRF7
See in Reactome
R-HSA-933527
(
R-HSA-933541
)
R-HSA-933527
Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6
See in Reactome
R-HSA-933528
(
R-HSA-933542
)
R-HSA-933528
Reaction Name: Interaction of MEKK1 with TRAF6
See in Reactome
R-HSA-933530
(
R-HSA-933542
)
R-HSA-933537
(
R-HSA-933541
)
R-HSA-933538
(
R-HSA-933541
)
R-HSA-936942
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936942
Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2
See in Reactome
R-HSA-936947
(
R-HSA-937072
)
R-HSA-936947
Reaction Name: Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
See in Reactome
R-HSA-936951
(
R-HSA-937072
)
R-HSA-936951
Reaction Name: Activation of TAK1 complex bound to activated TLR4 complex
See in Reactome
R-HSA-936952
(
R-HSA-937072
)
R-HSA-936952
Reaction Name: Auto ubiquitination of TRAF6 bound to the activated TLR4 complex
See in Reactome
R-HSA-936960
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936960
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex
See in Reactome
R-HSA-936963
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936963
Reaction Name: IRAK2 induces TRAF6 oligomerization
See in Reactome
R-HSA-936985
(
R-HSA-937072
)
R-HSA-936985
Reaction Name: Activated TLR4:TICAM1 recruits TRAF6
See in Reactome
R-HSA-936986
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936986
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains
See in Reactome
R-HSA-936991
(
R-HSA-166058;
R-HSA-937042;
R-HSA-975871
)
R-HSA-936991
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
See in Reactome
R-HSA-937032
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-937034
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937044
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937050
(
R-HSA-166058;
R-HSA-937039;
R-HSA-975871
)
R-HSA-937075
(
R-HSA-937072
)
R-HSA-937075
Reaction Name: Phosphorylated TAK1 leaves activated TLR receptor complex
See in Reactome
R-HSA-9628444
(
R-HSA-9014325
)
R-HSA-9628444
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
See in Reactome
R-HSA-9645394
(
R-HSA-9645460
)
R-HSA-9645394
Reaction Name: Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
See in Reactome
R-HSA-9645406
(
R-HSA-9645460
)
R-HSA-9645406
Reaction Name: ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
See in Reactome
R-HSA-9645414
(
R-HSA-9645460
)
R-HSA-9645414
Reaction Name: Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
See in Reactome
R-HSA-9645442
(
R-HSA-9645460
)
R-HSA-9645442
Reaction Name: Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
See in Reactome
R-HSA-9645501
(
R-HSA-9645460
)
R-HSA-9645501
Reaction Name: TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex
See in Reactome
R-HSA-9645520
(
R-HSA-9645460
)
R-HSA-9645520
Reaction Name: ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6
See in Reactome
R-HSA-9705145
(
R-HSA-933541
)
R-HSA-9705323
(
R-HSA-933541
)
R-HSA-975097
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975097
Reaction Name: Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-975100
(
R-HSA-975138;
R-HSA-975155
)
R-HSA-975100
Reaction Name: Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
See in Reactome
R-HSA-975103
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975103
Reaction Name: Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975106
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975106
Reaction Name: Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975111
(
R-HSA-975155
)
R-HSA-975111
Reaction Name: TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
See in Reactome
R-HSA-975118
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975118
Reaction Name: TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
See in Reactome
R-HSA-975119
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
R-HSA-975122
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975122
Reaction Name: Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>
See in Reactome
R-HSA-975139
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975139
Reaction Name: IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975142
(
R-HSA-975138;
R-HSA-975144;
R-HSA-975155
)
R-HSA-975142
Reaction Name: Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975147
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975147
Reaction Name: Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane
See in Reactome
R-HSA-975185
(
R-HSA-975138;
R-HSA-975155;
R-HSA-975163
)
R-HSA-975185
Reaction Name: IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
See in Reactome
R-HSA-975188
(
R-HSA-975110;
R-HSA-975155
)
R-HSA-975188
Reaction Name: TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
See in Reactome
R-HSA-975857
(
R-HSA-975871
)
R-HSA-975857
Reaction Name: TRAF6 binds to hp- IRAK1 or p-IRAK2
See in Reactome
R-HSA-975879
(
R-HSA-975871
)
R-HSA-975879
Reaction Name: Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
See in Reactome
|
MONDO:0016216 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016419 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016642 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016995 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0016996 |
PIK3CB |
P42338 |
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-186763
R-HSA-112399
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-5673001
R-HSA-912631
R-HSA-1257604
R-HSA-8853659
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-373753
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-449147
R-HSA-168256
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-9675108
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-1483257
R-HSA-556833
R-HSA-202403
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-168249
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2172127
R-HSA-186797
R-HSA-1430728
R-HSA-422475
R-HSA-109582
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-437118
(
R-HSA-114604
)
R-HSA-437118
Reaction Name: GPVI stimulates PI3K beta, gamma
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
|
MONDO:0017177 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017564 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
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Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017566 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017571 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0017812 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0018338 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0018872 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0019002 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0020492 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0021067 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0021427 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0023122 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0030924 |
PSMB10 |
P40306 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5673001
R-HSA-202403
R-HSA-69239
R-HSA-446652
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-169911
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9675108
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8953854
R-HSA-168249
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-5610787
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-351202
R-HSA-69275
R-HSA-195721
R-HSA-69242
R-HSA-1257604
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-109581
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-69615
R-HSA-69306
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-422475
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-162582
R-HSA-68882
|
Cellular responses to stimuli
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Transport of small molecules
Metabolism of RNA
Metabolism of proteins
DNA Replication
Signal Transduction
|
R-HSA-1168640
(
R-HSA-1169091
)
R-HSA-1234159
(
R-HSA-1234176
)
R-HSA-1234159
Reaction Name: Proteasome proteolyzes ub-HIF-alpha
See in Reactome
R-HSA-1236935
(
R-HSA-1236974
)
R-HSA-1236935
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
R-HSA-1236970
(
R-HSA-1236978
)
R-HSA-1236970
Reaction Name: Proteasomal clevage of exogenous antigen
See in Reactome
R-HSA-1504193
(
R-HSA-4641258
)
R-HSA-1504193
Reaction Name: Ubiquitinated DVL is degraded by the proteasome
See in Reactome
R-HSA-174058
(
R-HSA-174084
)
R-HSA-174058
Reaction Name: Degradation of multiubiquitinated Cdh1
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174202
(
R-HSA-174154;
R-HSA-2467813
)
R-HSA-174202
Reaction Name: Degradation of multiubiquitinated Securin
See in Reactome
R-HSA-174203
(
R-HSA-174113
)
R-HSA-174203
Reaction Name: SCF-mediated degradation of Emi1
See in Reactome
R-HSA-174255
(
R-HSA-174184
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-187574
(
R-HSA-187577
)
R-HSA-187574
Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome
See in Reactome
R-HSA-188191
(
R-HSA-174178
)
R-HSA-188191
Reaction Name: APC/C:Cdh1-mediated degradation of Skp2
See in Reactome
R-HSA-209061
(
R-HSA-9020702
)
R-HSA-209061
Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
See in Reactome
R-HSA-211715
(
R-HSA-211733
)
R-HSA-211715
Reaction Name: Proteasome mediated degradation of PAK-2p34
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-264458
(
R-HSA-349425
)
R-HSA-264458
Reaction Name: Proteasome mediated degradation of COP1
See in Reactome
R-HSA-353125
(
R-HSA-350562
)
R-HSA-353125
Reaction Name: 26S proteosome degrades ODC holoenzyme complex
See in Reactome
R-HSA-3640874
(
R-HSA-4641257
)
R-HSA-3640874
Reaction Name: Ub-RibC-AXIN is degraded by the proteasome
See in Reactome
R-HSA-450466
(
R-HSA-450408
)
R-HSA-4608855
(
R-HSA-4608870
)
R-HSA-4608855
Reaction Name: PRICKLE1 is degraded by the proteasome
See in Reactome
R-HSA-4641256
(
R-HSA-4641257
)
R-HSA-4641256
Reaction Name: Ubiquitinated AXIN is degraded by the proteasome
See in Reactome
R-HSA-4641260
(
R-HSA-4641258
)
R-HSA-4641260
Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome
See in Reactome
R-HSA-5362448
(
R-HSA-5358346
)
R-HSA-5362448
Reaction Name: Hh C-terminal fragments are degraded by the proteasome
See in Reactome
R-HSA-5607724
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-5607724
Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
See in Reactome
R-HSA-5607731
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607731
Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
See in Reactome
R-HSA-5610754
(
R-HSA-5610785
)
R-HSA-5610754
Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
See in Reactome
R-HSA-5610757
(
R-HSA-5610783
)
R-HSA-5610757
Reaction Name: GLI2 is degraded by the proteasome
See in Reactome
R-HSA-5610758
(
R-HSA-5610780
)
R-HSA-5610758
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
See in Reactome
R-HSA-5610760
(
R-HSA-5610780
)
R-HSA-5610760
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH
See in Reactome
R-HSA-5635854
(
R-HSA-5632684
)
R-HSA-5635854
Reaction Name: GLI2,3 are degraded by the proteasome
See in Reactome
R-HSA-5635868
(
R-HSA-5632684
)
R-HSA-5635868
Reaction Name: ub-GLI is degraded by the proteasome
See in Reactome
R-HSA-5658430
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658430
Reaction Name: NF1 is degraded by the proteasome
See in Reactome
R-HSA-5665854
(
R-HSA-5689603
)
R-HSA-5665854
Reaction Name: ADRM1:26S proteaseome binds UCHL5
See in Reactome
R-HSA-5665871
(
R-HSA-5689603
)
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5687112
(
R-HSA-5687128
)
R-HSA-5687112
Reaction Name: MAPK6 is degraded by the 26S proteasome
See in Reactome
R-HSA-5689539
(
R-HSA-5689880
)
R-HSA-5689539
Reaction Name: ADRM1:26S proteaseome binds USP14
See in Reactome
R-HSA-68825
()
R-HSA-68825
Reaction Name: Ubiquitinated geminin is degraded by the proteasome
See in Reactome
R-HSA-68948
(
R-HSA-68949
)
R-HSA-68948
Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome
See in Reactome
R-HSA-69016
(
R-HSA-69017
)
R-HSA-69016
Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome
See in Reactome
R-HSA-69600
(
R-HSA-69601
)
R-HSA-69600
Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A
See in Reactome
R-HSA-75825
(
R-HSA-75815
)
R-HSA-75825
Reaction Name: Proteasome mediated degradation of Cyclin D1
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8852354
(
R-HSA-69481;
R-HSA-8852276
)
R-HSA-8852354
Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53
See in Reactome
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
R-HSA-8854071
(
R-HSA-8854050
)
R-HSA-8854071
Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8932355
(
R-HSA-8951664
)
R-HSA-8932355
Reaction Name: 26S proteasome degrades Ub-NFE2L2
See in Reactome
R-HSA-8939801
(
R-HSA-8939902
)
R-HSA-8939801
Reaction Name: 26S proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-8952408
(
R-HSA-8941858
)
R-HSA-8952408
Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome
See in Reactome
R-HSA-8956140
(
R-HSA-8951664
)
R-HSA-8956140
Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome
See in Reactome
R-HSA-8956184
(
R-HSA-8951664
)
R-HSA-8956184
Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
See in Reactome
R-HSA-8957265
(
R-HSA-8939236
)
R-HSA-8957265
Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH
See in Reactome
R-HSA-9008110
(
R-HSA-8939902
)
R-HSA-9008110
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9008475
(
R-HSA-8939902
)
R-HSA-9008475
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9009362
(
R-HSA-8939902
)
R-HSA-9009362
Reaction Name: Proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-9011313
(
R-HSA-9010553
)
R-HSA-9011313
Reaction Name: Proteasome degrades ubiquitinated ROBO3.1
See in Reactome
R-HSA-9604642
(
R-HSA-9604323
)
R-HSA-9604642
Reaction Name: Proteasome degrades ubiquitinated NICD4
See in Reactome
R-HSA-9755303
(
R-HSA-8951664
)
R-HSA-9755303
Reaction Name: 26S proteasome degrades HIFalpha
See in Reactome
R-HSA-9755306
(
R-HSA-8951664
)
R-HSA-9755306
Reaction Name: ub UBXN7 is degraded by the 26S proteasome
See in Reactome
R-HSA-9762096
()
R-HSA-9762096
Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded
See in Reactome
R-HSA-983150
(
R-HSA-983168
)
R-HSA-983150
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
|
MONDO:0032599 |
IKBKB |
O14920 |
2.7.11.10
2.7.11.1
|
R-HSA-5684264
R-HSA-5684264
Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation
See in Reactome
R-HSA-9020702
R-HSA-937039
R-HSA-202424
R-HSA-933543
R-HSA-933543
Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
See in Reactome
R-HSA-933542
R-HSA-933542
Reactome Name: TRAF6 mediated NF-kB activation
See in Reactome
R-HSA-937041
R-HSA-937041
Reactome Name: IKK complex recruitment mediated by RIP1
See in Reactome
R-HSA-168638
R-HSA-1236974
R-HSA-5357905
R-HSA-975144
R-HSA-975144
Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
See in Reactome
R-HSA-445989
R-HSA-445989
Reactome Name: TAK1-dependent IKK and NF-kappa-B activation
See in Reactome
R-HSA-5357956
R-HSA-5357956
Reactome Name: TNFR1-induced NFkappaB signaling pathway
See in Reactome
R-HSA-1810476
R-HSA-1810476
Reactome Name: RIP-mediated NFkB activation via ZBP1
See in Reactome
R-HSA-209543
R-HSA-209543
Reactome Name: p75NTR recruits signalling complexes
See in Reactome
R-HSA-209560
R-HSA-209560
Reactome Name: NF-kB is activated and signals survival
See in Reactome
R-HSA-5607764
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-168927
R-HSA-168927
Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment
See in Reactome
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-937061
R-HSA-937061
Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling
See in Reactome
R-HSA-449147
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-181438
R-HSA-181438
Reactome Name: Toll Like Receptor 2 (TLR2) Cascade
See in Reactome
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-975871
R-HSA-975871
Reactome Name: MyD88 cascade initiated on plasma membrane
See in Reactome
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-168928
R-HSA-168928
Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-1280218
R-HSA-168142
R-HSA-168142
Reactome Name: Toll Like Receptor 10 (TLR10) Cascade
See in Reactome
R-HSA-168164
R-HSA-168164
Reactome Name: Toll Like Receptor 3 (TLR3) Cascade
See in Reactome
R-HSA-168643
R-HSA-168643
Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
See in Reactome
R-HSA-168898
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-73887
R-HSA-1606322
R-HSA-1606322
Reactome Name: ZBP1(DAI) mediated induction of type I IFNs
See in Reactome
R-HSA-202403
R-HSA-446652
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-168188
R-HSA-168188
Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-166016
R-HSA-166016
Reactome Name: Toll Like Receptor 4 (TLR4) Cascade
See in Reactome
R-HSA-168181
R-HSA-168181
Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade
See in Reactome
R-HSA-168249
R-HSA-168179
R-HSA-168179
Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade
See in Reactome
R-HSA-193639
R-HSA-166166
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-1834949
R-HSA-1834949
Reactome Name: Cytosolic sensors of pathogen-associated DNA
See in Reactome
R-HSA-75893
R-HSA-450294
R-HSA-975138
R-HSA-975138
Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
See in Reactome
R-HSA-448424
R-HSA-168176
R-HSA-168176
Reactome Name: Toll Like Receptor 5 (TLR5) Cascade
See in Reactome
R-HSA-975155
R-HSA-975155
Reactome Name: MyD88 dependent cascade initiated on endosome
See in Reactome
R-HSA-166058
R-HSA-166058
Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane
See in Reactome
R-HSA-162582
R-HSA-168138
R-HSA-168138
Reactome Name: Toll Like Receptor 9 (TLR9) Cascade
See in Reactome
|
Immune System
Signal Transduction
|
R-HSA-1168637
(
R-HSA-1169091
)
R-HSA-1168637
Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK
See in Reactome
R-HSA-1168638
(
R-HSA-1169091
)
R-HSA-1168638
Reaction Name: Activated IKK phosphorylates I-kappaB
See in Reactome
R-HSA-1168641
(
R-HSA-1169091
)
R-HSA-1168641
Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta
See in Reactome
R-HSA-168140
(
R-HSA-1810476;
R-HSA-445989;
R-HSA-9020702;
R-HSA-933542
)
R-HSA-168140
Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor
See in Reactome
R-HSA-168184
(
R-HSA-168638;
R-HSA-445989;
R-HSA-9020702
)
R-HSA-168184
Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex
See in Reactome
R-HSA-168910
(
R-HSA-1810476
)
R-HSA-168910
Reaction Name: RIP1 facilitates IKK complex phosphorylation
See in Reactome
R-HSA-193641
(
R-HSA-209543
)
R-HSA-193703
(
R-HSA-209560
)
R-HSA-193705
(
R-HSA-209560
)
R-HSA-193705
Reaction Name: IKKbeta phosphorylates IkB causing NF-kB to dissociate
See in Reactome
R-HSA-202500
(
R-HSA-202424
)
R-HSA-202534
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202534
Reaction Name: Ubiquitination of NEMO by TRAF6
See in Reactome
R-HSA-202541
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-202541
Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
See in Reactome
R-HSA-209087
(
R-HSA-9020702
)
R-HSA-209087
Reaction Name: IKBA is phosphorylated by Phospho IKKB kinase
See in Reactome
R-HSA-2730876
(
R-HSA-2871837
)
R-HSA-2730876
Reaction Name: Phosphorylation of IKK-beta by TAK1
See in Reactome
R-HSA-451561
(
R-HSA-9020702
)
R-HSA-451561
Reaction Name: NEMO binds polyubiquitinated IRAK1
See in Reactome
R-HSA-5357776
(
R-HSA-5357956
)
R-HSA-5357776
Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG
See in Reactome
R-HSA-5357831
(
R-HSA-5357905
)
R-HSA-5607742
(
R-HSA-5607764
)
R-HSA-5607742
Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
See in Reactome
R-HSA-5609665
(
R-HSA-445989;
R-HSA-9020702
)
R-HSA-5609665
Reaction Name: CHUK, IKBKB and IKBKG form IKK complex
See in Reactome
R-HSA-5626962
(
R-HSA-5357905
)
R-HSA-5684267
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684267
Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex
See in Reactome
R-HSA-5684275
(
R-HSA-5684264;
R-HSA-9020702
)
R-HSA-5684275
Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400
See in Reactome
R-HSA-8863895
(
R-HSA-1236974
)
R-HSA-9014343
(
R-HSA-168927
)
R-HSA-9014343
Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
See in Reactome
R-HSA-933530
(
R-HSA-933542
)
R-HSA-933539
(
R-HSA-933543
)
R-HSA-937029
(
R-HSA-937041
)
R-HSA-937029
Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1
See in Reactome
R-HSA-937032
(
R-HSA-937039
)
R-HSA-937032
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1
See in Reactome
R-HSA-975119
(
R-HSA-975144
)
R-HSA-975119
Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9.
See in Reactome
|
MONDO:0044638 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044704 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044705 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0044740 |
PTEN |
P60484 |
3.1.3.16
3.1.3.67
3.1.3.48
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-202424
R-HSA-1855204
R-HSA-1855204
Reactome Name: Synthesis of IP3 and IP4 in the cytosol
See in Reactome
R-HSA-5689896
R-HSA-5689896
Reactome Name: Ovarian tumor domain proteases
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-8986944
R-HSA-8986944
Reactome Name: Transcriptional Regulation by MECP2
See in Reactome
R-HSA-8948747
R-HSA-8948747
Reactome Name: Regulation of PTEN localization
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8943723
R-HSA-8943723
Reactome Name: Regulation of PTEN mRNA translation
See in Reactome
|
R-HSA-1483249
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-1257604
R-HSA-212436
R-HSA-74160
R-HSA-168256
R-HSA-1483257
R-HSA-392499
R-HSA-1483255
R-HSA-202403
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1430728
R-HSA-5688426
R-HSA-6807070
R-HSA-556833
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-1280218
R-HSA-162582
R-HSA-73857
|
Gene expression (Transcription)
Immune System
Metabolism of proteins
Metabolism
Signal Transduction
|
R-HSA-1676149
(
R-HSA-1660499
)
R-HSA-1676149
Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane
See in Reactome
R-HSA-1855205
(
R-HSA-1855204
)
R-HSA-1855205
Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
See in Reactome
R-HSA-199456
(
R-HSA-1257604;
R-HSA-1660499;
R-HSA-199418;
R-HSA-202424
)
R-HSA-2321904
(
R-HSA-5628897
)
R-HSA-2321904
Reaction Name: PTEN mRNA translation negatively regulated by microRNAs
See in Reactome
R-HSA-5689950
(
R-HSA-5689880
)
R-HSA-5689950
Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN
See in Reactome
R-HSA-6807105
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807105
Reaction Name: Monoubiquitinated PTEN translocates to the nucleus
See in Reactome
R-HSA-6807106
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807106
Reaction Name: PTEN undergoes monoubiquitination
See in Reactome
R-HSA-6807118
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807118
Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN
See in Reactome
R-HSA-6807126
(
R-HSA-1257604;
R-HSA-8948747
)
R-HSA-6807126
Reaction Name: Deubiquitinated PTEN translocates to the cytosol
See in Reactome
R-HSA-6807134
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807134
Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
See in Reactome
R-HSA-6807206
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-6807206
Reaction Name: USP13 and OTUD3 deubiquitinate PTEN
See in Reactome
R-HSA-8847968
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8847977
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850945
Reaction Name: Casein kinase II phosphorylates PTEN
See in Reactome
R-HSA-8850961
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850961
Reaction Name: PREX2 binds PTEN and inhibits it
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8850997
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8851011
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8873946
(
R-HSA-5689896
)
R-HSA-8944497
(
R-HSA-1257604;
R-HSA-8943723
)
R-HSA-8944497
Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs
See in Reactome
R-HSA-8948775
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948800
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8948832
Reaction Name: RNF146 polyubiquitinates PARylated PTEN
See in Reactome
R-HSA-9615571
(
R-HSA-8986944
)
R-HSA-9615571
Reaction Name: PTEN mRNA translation is inhibited by miR-137
See in Reactome
|
MONDO:0054698 |
PSMB8 |
P28062 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-909733
R-HSA-909733
Reactome Name: Interferon alpha/beta signaling
See in Reactome
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-913531
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5673001
R-HSA-202403
R-HSA-69239
R-HSA-446652
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-169911
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9675108
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8953854
R-HSA-168249
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-5610787
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-351202
R-HSA-69275
R-HSA-195721
R-HSA-69242
R-HSA-1257604
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-109581
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-69615
R-HSA-69306
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-422475
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-162582
R-HSA-68882
|
Cellular responses to stimuli
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Transport of small molecules
Metabolism of RNA
Metabolism of proteins
DNA Replication
Signal Transduction
|
R-HSA-1015702
(
R-HSA-909733
)
R-HSA-1015702
Reaction Name: Expression of IFN-induced genes
See in Reactome
R-HSA-1168640
(
R-HSA-1169091
)
R-HSA-1234159
(
R-HSA-1234176
)
R-HSA-1234159
Reaction Name: Proteasome proteolyzes ub-HIF-alpha
See in Reactome
R-HSA-1236935
(
R-HSA-1236974
)
R-HSA-1236935
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
R-HSA-1236970
(
R-HSA-1236978
)
R-HSA-1236970
Reaction Name: Proteasomal clevage of exogenous antigen
See in Reactome
R-HSA-1504193
(
R-HSA-4641258
)
R-HSA-1504193
Reaction Name: Ubiquitinated DVL is degraded by the proteasome
See in Reactome
R-HSA-174058
(
R-HSA-174084
)
R-HSA-174058
Reaction Name: Degradation of multiubiquitinated Cdh1
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174202
(
R-HSA-174154;
R-HSA-2467813
)
R-HSA-174202
Reaction Name: Degradation of multiubiquitinated Securin
See in Reactome
R-HSA-174203
(
R-HSA-174113
)
R-HSA-174203
Reaction Name: SCF-mediated degradation of Emi1
See in Reactome
R-HSA-174255
(
R-HSA-174184
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-187574
(
R-HSA-187577
)
R-HSA-187574
Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome
See in Reactome
R-HSA-188191
(
R-HSA-174178
)
R-HSA-188191
Reaction Name: APC/C:Cdh1-mediated degradation of Skp2
See in Reactome
R-HSA-209061
(
R-HSA-9020702
)
R-HSA-209061
Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
See in Reactome
R-HSA-211715
(
R-HSA-211733
)
R-HSA-211715
Reaction Name: Proteasome mediated degradation of PAK-2p34
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-264458
(
R-HSA-349425
)
R-HSA-264458
Reaction Name: Proteasome mediated degradation of COP1
See in Reactome
R-HSA-353125
(
R-HSA-350562
)
R-HSA-353125
Reaction Name: 26S proteosome degrades ODC holoenzyme complex
See in Reactome
R-HSA-3640874
(
R-HSA-4641257
)
R-HSA-3640874
Reaction Name: Ub-RibC-AXIN is degraded by the proteasome
See in Reactome
R-HSA-450466
(
R-HSA-450408
)
R-HSA-4608855
(
R-HSA-4608870
)
R-HSA-4608855
Reaction Name: PRICKLE1 is degraded by the proteasome
See in Reactome
R-HSA-4641256
(
R-HSA-4641257
)
R-HSA-4641256
Reaction Name: Ubiquitinated AXIN is degraded by the proteasome
See in Reactome
R-HSA-4641260
(
R-HSA-4641258
)
R-HSA-4641260
Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome
See in Reactome
R-HSA-5362448
(
R-HSA-5358346
)
R-HSA-5362448
Reaction Name: Hh C-terminal fragments are degraded by the proteasome
See in Reactome
R-HSA-5607724
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-5607724
Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
See in Reactome
R-HSA-5607731
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607731
Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
See in Reactome
R-HSA-5610754
(
R-HSA-5610785
)
R-HSA-5610754
Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
See in Reactome
R-HSA-5610757
(
R-HSA-5610783
)
R-HSA-5610757
Reaction Name: GLI2 is degraded by the proteasome
See in Reactome
R-HSA-5610758
(
R-HSA-5610780
)
R-HSA-5610758
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
See in Reactome
R-HSA-5610760
(
R-HSA-5610780
)
R-HSA-5610760
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH
See in Reactome
R-HSA-5635854
(
R-HSA-5632684
)
R-HSA-5635854
Reaction Name: GLI2,3 are degraded by the proteasome
See in Reactome
R-HSA-5635868
(
R-HSA-5632684
)
R-HSA-5635868
Reaction Name: ub-GLI is degraded by the proteasome
See in Reactome
R-HSA-5658430
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658430
Reaction Name: NF1 is degraded by the proteasome
See in Reactome
R-HSA-5665854
(
R-HSA-5689603
)
R-HSA-5665854
Reaction Name: ADRM1:26S proteaseome binds UCHL5
See in Reactome
R-HSA-5665871
(
R-HSA-5689603
)
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5687112
(
R-HSA-5687128
)
R-HSA-5687112
Reaction Name: MAPK6 is degraded by the 26S proteasome
See in Reactome
R-HSA-5689539
(
R-HSA-5689880
)
R-HSA-5689539
Reaction Name: ADRM1:26S proteaseome binds USP14
See in Reactome
R-HSA-68825
()
R-HSA-68825
Reaction Name: Ubiquitinated geminin is degraded by the proteasome
See in Reactome
R-HSA-68948
(
R-HSA-68949
)
R-HSA-68948
Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome
See in Reactome
R-HSA-69016
(
R-HSA-69017
)
R-HSA-69016
Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome
See in Reactome
R-HSA-69600
(
R-HSA-69601
)
R-HSA-69600
Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A
See in Reactome
R-HSA-75825
(
R-HSA-75815
)
R-HSA-75825
Reaction Name: Proteasome mediated degradation of Cyclin D1
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8852354
(
R-HSA-69481;
R-HSA-8852276
)
R-HSA-8852354
Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53
See in Reactome
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
R-HSA-8854071
(
R-HSA-8854050
)
R-HSA-8854071
Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8932355
(
R-HSA-8951664
)
R-HSA-8932355
Reaction Name: 26S proteasome degrades Ub-NFE2L2
See in Reactome
R-HSA-8939801
(
R-HSA-8939902
)
R-HSA-8939801
Reaction Name: 26S proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-8952408
(
R-HSA-8941858
)
R-HSA-8952408
Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome
See in Reactome
R-HSA-8956140
(
R-HSA-8951664
)
R-HSA-8956140
Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome
See in Reactome
R-HSA-8956184
(
R-HSA-8951664
)
R-HSA-8956184
Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
See in Reactome
R-HSA-8957265
(
R-HSA-8939236
)
R-HSA-8957265
Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH
See in Reactome
R-HSA-9008110
(
R-HSA-8939902
)
R-HSA-9008110
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9008475
(
R-HSA-8939902
)
R-HSA-9008475
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9009362
(
R-HSA-8939902
)
R-HSA-9009362
Reaction Name: Proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-9011313
(
R-HSA-9010553
)
R-HSA-9011313
Reaction Name: Proteasome degrades ubiquitinated ROBO3.1
See in Reactome
R-HSA-9604642
(
R-HSA-9604323
)
R-HSA-9604642
Reaction Name: Proteasome degrades ubiquitinated NICD4
See in Reactome
R-HSA-9755303
(
R-HSA-8951664
)
R-HSA-9755303
Reaction Name: 26S proteasome degrades HIFalpha
See in Reactome
R-HSA-9755306
(
R-HSA-8951664
)
R-HSA-9755306
Reaction Name: ub UBXN7 is degraded by the 26S proteasome
See in Reactome
R-HSA-9762096
()
R-HSA-9762096
Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded
See in Reactome
R-HSA-983150
(
R-HSA-983168
)
R-HSA-983150
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
|
MONDO:0054699 |
PSMB9 |
P28065 |
3.4.25.1
|
R-HSA-8951664
R-HSA-4608870
R-HSA-4608870
Reactome Name: Asymmetric localization of PCP proteins
See in Reactome
R-HSA-2467813
R-HSA-2467813
Reactome Name: Separation of Sister Chromatids
See in Reactome
R-HSA-382556
R-HSA-382556
Reactome Name: ABC-family proteins mediated transport
See in Reactome
R-HSA-8852276
R-HSA-8852276
Reactome Name: The role of GTSE1 in G2/M progression after G2 checkpoint
See in Reactome
R-HSA-8941858
R-HSA-8941858
Reactome Name: Regulation of RUNX3 expression and activity
See in Reactome
R-HSA-174184
R-HSA-174184
Reactome Name: Cdc20:Phospho-APC/C mediated degradation of Cyclin A
See in Reactome
R-HSA-69017
R-HSA-69017
Reactome Name: CDK-mediated phosphorylation and removal of Cdc6
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-187577
R-HSA-187577
Reactome Name: SCF(Skp2)-mediated degradation of p27/p21
See in Reactome
R-HSA-1236978
R-HSA-1236978
Reactome Name: Cross-presentation of soluble exogenous antigens (endosomes)
See in Reactome
R-HSA-5610780
R-HSA-5610780
Reactome Name: Degradation of GLI1 by the proteasome
See in Reactome
R-HSA-5610785
R-HSA-5610785
Reactome Name: GLI3 is processed to GLI3R by the proteasome
See in Reactome
R-HSA-8854050
R-HSA-8854050
Reactome Name: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
See in Reactome
R-HSA-69601
R-HSA-69601
Reactome Name: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
See in Reactome
R-HSA-1236974
R-HSA-5610783
R-HSA-5610783
Reactome Name: Degradation of GLI2 by the proteasome
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-5668541
R-HSA-5668541
Reactome Name: TNFR2 non-canonical NF-kB pathway
See in Reactome
R-HSA-1169091
R-HSA-1169091
Reactome Name: Activation of NF-kappaB in B cells
See in Reactome
R-HSA-4641258
R-HSA-9010553
R-HSA-9010553
Reactome Name: Regulation of expression of SLITs and ROBOs
See in Reactome
R-HSA-202424
R-HSA-450408
R-HSA-450408
Reactome Name: AUF1 (hnRNP D0) binds and destabilizes mRNA
See in Reactome
R-HSA-5687128
R-HSA-5676590
R-HSA-5676590
Reactome Name: NIK-->noncanonical NF-kB signaling
See in Reactome
R-HSA-1234176
R-HSA-1234176
Reactome Name: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
See in Reactome
R-HSA-211733
R-HSA-211733
Reactome Name: Regulation of activated PAK-2p34 by proteasome mediated degradation
See in Reactome
R-HSA-4641257
R-HSA-5607761
R-HSA-5607761
Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling
See in Reactome
R-HSA-5358346
R-HSA-5607764
R-HSA-8939236
R-HSA-8939236
Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of HSCs
See in Reactome
R-HSA-174178
R-HSA-174178
Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
See in Reactome
R-HSA-8939902
R-HSA-8939902
Reactome Name: Regulation of RUNX2 expression and activity
See in Reactome
R-HSA-349425
R-HSA-349425
Reactome Name: Autodegradation of the E3 ubiquitin ligase COP1
See in Reactome
R-HSA-68949
R-HSA-69481
R-HSA-5658442
R-HSA-174154
R-HSA-174154
Reactome Name: APC/C:Cdc20 mediated degradation of Securin
See in Reactome
R-HSA-195253
R-HSA-195253
Reactome Name: Degradation of beta-catenin by the destruction complex
See in Reactome
R-HSA-174084
R-HSA-174084
Reactome Name: Autodegradation of Cdh1 by Cdh1:APC/C
See in Reactome
R-HSA-174113
R-HSA-174113
Reactome Name: SCF-beta-TrCP mediated degradation of Emi1
See in Reactome
R-HSA-983168
R-HSA-983168
Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation
See in Reactome
R-HSA-350562
R-HSA-350562
Reactome Name: Regulation of ornithine decarboxylase (ODC)
See in Reactome
R-HSA-5632684
R-HSA-5689603
R-HSA-75815
R-HSA-75815
Reactome Name: Ubiquitin-dependent degradation of Cyclin D
See in Reactome
R-HSA-9020702
R-HSA-2871837
R-HSA-2871837
Reactome Name: FCERI mediated NF-kB activation
See in Reactome
|
R-HSA-5621481
R-HSA-5621481
Reactome Name: C-type lectin receptors (CLRs)
See in Reactome
R-HSA-1168372
R-HSA-1168372
Reactome Name: Downstream signaling events of B Cell Receptor (BCR)
See in Reactome
R-HSA-376176
R-HSA-449147
R-HSA-8953897
R-HSA-5688426
R-HSA-168256
R-HSA-983705
R-HSA-983705
Reactome Name: Signaling by the B Cell Receptor (BCR)
See in Reactome
R-HSA-9013694
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-5358351
R-HSA-1640170
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-5684996
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-174143
R-HSA-174143
Reactome Name: APC/C-mediated degradation of cell cycle proteins
See in Reactome
R-HSA-69052
R-HSA-69052
Reactome Name: Switching of origins to a post-replicative state
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-2555396
R-HSA-2555396
Reactome Name: Mitotic Metaphase and Anaphase
See in Reactome
R-HSA-4086400
R-HSA-212436
R-HSA-74160
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-2262752
R-HSA-69620
R-HSA-1234174
R-HSA-69278
R-HSA-69541
R-HSA-382551
R-HSA-179419
R-HSA-179419
Reactome Name: APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
See in Reactome
R-HSA-69580
R-HSA-69580
Reactome Name: p53-Dependent G1/S DNA damage checkpoint
See in Reactome
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-5673001
R-HSA-202403
R-HSA-69239
R-HSA-446652
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-176408
R-HSA-176408
Reactome Name: Regulation of APC/C activators between G1/S and early anaphase
See in Reactome
R-HSA-176409
R-HSA-176409
Reactome Name: APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-169911
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-9675108
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-8953854
R-HSA-168249
R-HSA-453274
R-HSA-392499
R-HSA-453276
R-HSA-453276
Reactome Name: Regulation of mitotic cell cycle
See in Reactome
R-HSA-68886
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-69563
R-HSA-69563
Reactome Name: p53-Dependent G1 DNA Damage Response
See in Reactome
R-HSA-176814
R-HSA-176814
Reactome Name: Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
See in Reactome
R-HSA-5610787
R-HSA-8878171
R-HSA-8878171
Reactome Name: Transcriptional regulation by RUNX1
See in Reactome
R-HSA-157118
R-HSA-351202
R-HSA-69275
R-HSA-195721
R-HSA-69242
R-HSA-1257604
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-109581
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-69615
R-HSA-69306
R-HSA-69610
R-HSA-69610
Reactome Name: p53-Independent DNA Damage Response
See in Reactome
R-HSA-69613
R-HSA-69613
Reactome Name: p53-Independent G1/S DNA damage checkpoint
See in Reactome
R-HSA-71291
R-HSA-71291
Reactome Name: Metabolism of amino acids and derivatives
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-422475
R-HSA-8878159
R-HSA-8878159
Reactome Name: Transcriptional regulation by RUNX3
See in Reactome
R-HSA-162582
R-HSA-68882
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Cellular responses to stimuli
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Transport of small molecules
Metabolism of RNA
Metabolism of proteins
DNA Replication
Signal Transduction
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R-HSA-1168640
(
R-HSA-1169091
)
R-HSA-1234159
(
R-HSA-1234176
)
R-HSA-1234159
Reaction Name: Proteasome proteolyzes ub-HIF-alpha
See in Reactome
R-HSA-1236935
(
R-HSA-1236974
)
R-HSA-1236935
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
R-HSA-1236970
(
R-HSA-1236978
)
R-HSA-1236970
Reaction Name: Proteasomal clevage of exogenous antigen
See in Reactome
R-HSA-1504193
(
R-HSA-4641258
)
R-HSA-1504193
Reaction Name: Ubiquitinated DVL is degraded by the proteasome
See in Reactome
R-HSA-174058
(
R-HSA-174084
)
R-HSA-174058
Reaction Name: Degradation of multiubiquitinated Cdh1
See in Reactome
R-HSA-174105
(
R-HSA-174178
)
R-HSA-174105
Reaction Name: Degradation of multiubiquitinated cell cycle proteins
See in Reactome
R-HSA-174202
(
R-HSA-174154;
R-HSA-2467813
)
R-HSA-174202
Reaction Name: Degradation of multiubiquitinated Securin
See in Reactome
R-HSA-174203
(
R-HSA-174113
)
R-HSA-174203
Reaction Name: SCF-mediated degradation of Emi1
See in Reactome
R-HSA-174255
(
R-HSA-174184
)
R-HSA-174255
Reaction Name: Degradation multiubiquitinated Cyclin A
See in Reactome
R-HSA-187574
(
R-HSA-187577
)
R-HSA-187574
Reaction Name: Degradation of ubiquitinated p27/p21 by the 26S proteasome
See in Reactome
R-HSA-188191
(
R-HSA-174178
)
R-HSA-188191
Reaction Name: APC/C:Cdh1-mediated degradation of Skp2
See in Reactome
R-HSA-209061
(
R-HSA-9020702
)
R-HSA-209061
Reaction Name: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
See in Reactome
R-HSA-211715
(
R-HSA-211733
)
R-HSA-211715
Reaction Name: Proteasome mediated degradation of PAK-2p34
See in Reactome
R-HSA-2130282
(
R-HSA-195253
)
R-HSA-2130282
Reaction Name: Degradation of ubiquitinated beta catenin by the proteasome
See in Reactome
R-HSA-264458
(
R-HSA-349425
)
R-HSA-264458
Reaction Name: Proteasome mediated degradation of COP1
See in Reactome
R-HSA-353125
(
R-HSA-350562
)
R-HSA-353125
Reaction Name: 26S proteosome degrades ODC holoenzyme complex
See in Reactome
R-HSA-3640874
(
R-HSA-4641257
)
R-HSA-3640874
Reaction Name: Ub-RibC-AXIN is degraded by the proteasome
See in Reactome
R-HSA-450466
(
R-HSA-450408
)
R-HSA-4608855
(
R-HSA-4608870
)
R-HSA-4608855
Reaction Name: PRICKLE1 is degraded by the proteasome
See in Reactome
R-HSA-4641256
(
R-HSA-4641257
)
R-HSA-4641256
Reaction Name: Ubiquitinated AXIN is degraded by the proteasome
See in Reactome
R-HSA-4641260
(
R-HSA-4641258
)
R-HSA-4641260
Reaction Name: Ubiquitinated DVL1 is degraded by the proteasome
See in Reactome
R-HSA-5362448
(
R-HSA-5358346
)
R-HSA-5362448
Reaction Name: Hh C-terminal fragments are degraded by the proteasome
See in Reactome
R-HSA-5607724
(
R-HSA-202424;
R-HSA-2871837;
R-HSA-5607764
)
R-HSA-5607724
Reaction Name: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
See in Reactome
R-HSA-5607731
(
R-HSA-5607761;
R-HSA-5607764;
R-HSA-5668541;
R-HSA-5676590
)
R-HSA-5607731
Reaction Name: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
See in Reactome
R-HSA-5610754
(
R-HSA-5610785
)
R-HSA-5610754
Reaction Name: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
See in Reactome
R-HSA-5610757
(
R-HSA-5610783
)
R-HSA-5610757
Reaction Name: GLI2 is degraded by the proteasome
See in Reactome
R-HSA-5610758
(
R-HSA-5610780
)
R-HSA-5610758
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
See in Reactome
R-HSA-5610760
(
R-HSA-5610780
)
R-HSA-5610760
Reaction Name: GLI1 is degraded by the proteasome after ubiquitination by ITCH
See in Reactome
R-HSA-5635854
(
R-HSA-5632684
)
R-HSA-5635854
Reaction Name: GLI2,3 are degraded by the proteasome
See in Reactome
R-HSA-5635868
(
R-HSA-5632684
)
R-HSA-5635868
Reaction Name: ub-GLI is degraded by the proteasome
See in Reactome
R-HSA-5658430
(
R-HSA-5658442;
R-HSA-5673001
)
R-HSA-5658430
Reaction Name: NF1 is degraded by the proteasome
See in Reactome
R-HSA-5665854
(
R-HSA-5689603
)
R-HSA-5665854
Reaction Name: ADRM1:26S proteaseome binds UCHL5
See in Reactome
R-HSA-5665871
(
R-HSA-5689603
)
R-HSA-5668481
(
R-HSA-5668541
)
R-HSA-5668481
Reaction Name: Protesomal degradation of K48polyUb-TRAF3
See in Reactome
R-HSA-5668520
(
R-HSA-5668541
)
R-HSA-5668520
Reaction Name: 26Sproteasome degrades K48polyUb-NIK
See in Reactome
R-HSA-5687112
(
R-HSA-5687128
)
R-HSA-5687112
Reaction Name: MAPK6 is degraded by the 26S proteasome
See in Reactome
R-HSA-5689539
(
R-HSA-5689880
)
R-HSA-5689539
Reaction Name: ADRM1:26S proteaseome binds USP14
See in Reactome
R-HSA-68825
()
R-HSA-68825
Reaction Name: Ubiquitinated geminin is degraded by the proteasome
See in Reactome
R-HSA-68948
(
R-HSA-68949
)
R-HSA-68948
Reaction Name: Ubiquitinated Orc1 is degraded by the proteasome
See in Reactome
R-HSA-69016
(
R-HSA-69017
)
R-HSA-69016
Reaction Name: Ubiquitinated Cdc6 is degraded by the proteasome
See in Reactome
R-HSA-69600
(
R-HSA-69601
)
R-HSA-69600
Reaction Name: Proteolytic degradation of ubiquitinated-Cdc25A
See in Reactome
R-HSA-75825
(
R-HSA-75815
)
R-HSA-75825
Reaction Name: Proteasome mediated degradation of Cyclin D1
See in Reactome
R-HSA-8850992
(
R-HSA-1257604;
R-HSA-8948751
)
R-HSA-8850992
Reaction Name: Proteasome degrades polyubiquitinated PTEN
See in Reactome
R-HSA-8852354
(
R-HSA-69481;
R-HSA-8852276
)
R-HSA-8852354
Reaction Name: GTSE1 facilitates proteasome-mediated degradation of TP53
See in Reactome
R-HSA-8854044
(
R-HSA-8854050
)
R-HSA-8854044
Reaction Name: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
See in Reactome
R-HSA-8854071
(
R-HSA-8854050
)
R-HSA-8854071
Reaction Name: Proteasome-mediated degradation of PolyUb-FBXL7
See in Reactome
R-HSA-8866553
(
R-HSA-382556
)
R-HSA-8866553
Reaction Name: misfolded CFTR is degraded by the 26S proteasome
See in Reactome
R-HSA-8932355
(
R-HSA-8951664
)
R-HSA-8932355
Reaction Name: 26S proteasome degrades Ub-NFE2L2
See in Reactome
R-HSA-8939801
(
R-HSA-8939902
)
R-HSA-8939801
Reaction Name: 26S proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-8952408
(
R-HSA-8941858
)
R-HSA-8952408
Reaction Name: Polyubiquitinated RUNX3 is degraded by the proteasome
See in Reactome
R-HSA-8956140
(
R-HSA-8951664
)
R-HSA-8956140
Reaction Name: NEDD8 and UBD bind NUB1 and the 26S proteasome
See in Reactome
R-HSA-8956184
(
R-HSA-8951664
)
R-HSA-8956184
Reaction Name: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
See in Reactome
R-HSA-8957265
(
R-HSA-8939236
)
R-HSA-8957265
Reaction Name: 26S proteasome degrades TP73 polyubiquitinated by ITCH
See in Reactome
R-HSA-9008110
(
R-HSA-8939902
)
R-HSA-9008110
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9008475
(
R-HSA-8939902
)
R-HSA-9008475
Reaction Name: Proteasome degrades polyubiquitinated RUNX2
See in Reactome
R-HSA-9009362
(
R-HSA-8939902
)
R-HSA-9009362
Reaction Name: Proteasome degrades PolyUb-RUNX2
See in Reactome
R-HSA-9011313
(
R-HSA-9010553
)
R-HSA-9011313
Reaction Name: Proteasome degrades ubiquitinated ROBO3.1
See in Reactome
R-HSA-9604642
(
R-HSA-9604323
)
R-HSA-9604642
Reaction Name: Proteasome degrades ubiquitinated NICD4
See in Reactome
R-HSA-9755303
(
R-HSA-8951664
)
R-HSA-9755303
Reaction Name: 26S proteasome degrades HIFalpha
See in Reactome
R-HSA-9755306
(
R-HSA-8951664
)
R-HSA-9755306
Reaction Name: ub UBXN7 is degraded by the 26S proteasome
See in Reactome
R-HSA-9762096
()
R-HSA-9762096
Reaction Name: Ub,pS335,S338,T NFE2L2 is degraded
See in Reactome
R-HSA-983150
(
R-HSA-983168
)
R-HSA-983150
Reaction Name: Proteasomal cleavage of substrate
See in Reactome
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