DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2022928)

Number of enzymes:	6
Number of disease:	10
Number of reactomes:	1
Number of reactions:	8

Search results (Reactome ID: R-HSA-2022928)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007585	EXT1	Q16394	2.4.1.224 2.4.1.225	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2022851 ( R-HSA-2022928 ) R-HSA-2022851 Reaction Name: EXT1:EXT2 transfer GlcNAc to the heparan chain See in Reactome R-HSA-2022856 ( R-HSA-2022928 ) R-HSA-2022856 Reaction Name: EXT1:EXT2 transfers GlcNAc to heparan See in Reactome R-HSA-2022919 ( R-HSA-2022928 ) R-HSA-2022919 Reaction Name: EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue See in Reactome R-HSA-2076392 ( R-HSA-2022928 ) R-HSA-2076392 Reaction Name: EXT1:EXT2 transfers GlcA to heparan See in Reactome
MONDO:0007586	EXT2	Q93063	2.4.1.224 2.4.1.225	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2022851 ( R-HSA-2022928 ) R-HSA-2022851 Reaction Name: EXT1:EXT2 transfer GlcNAc to the heparan chain See in Reactome R-HSA-2022856 ( R-HSA-2022928 ) R-HSA-2022856 Reaction Name: EXT1:EXT2 transfers GlcNAc to heparan See in Reactome R-HSA-2022919 ( R-HSA-2022928 ) R-HSA-2022919 Reaction Name: EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue See in Reactome R-HSA-2076392 ( R-HSA-2022928 ) R-HSA-2076392 Reaction Name: EXT1:EXT2 transfers GlcA to heparan See in Reactome
MONDO:0007874	EXT1	Q16394	2.4.1.224 2.4.1.225	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2022851 ( R-HSA-2022928 ) R-HSA-2022851 Reaction Name: EXT1:EXT2 transfer GlcNAc to the heparan chain See in Reactome R-HSA-2022856 ( R-HSA-2022928 ) R-HSA-2022856 Reaction Name: EXT1:EXT2 transfers GlcNAc to heparan See in Reactome R-HSA-2022919 ( R-HSA-2022928 ) R-HSA-2022919 Reaction Name: EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue See in Reactome R-HSA-2076392 ( R-HSA-2022928 ) R-HSA-2076392 Reaction Name: EXT1:EXT2 transfers GlcA to heparan See in Reactome
MONDO:0008977	EXT1	Q16394	2.4.1.224 2.4.1.225	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2022851 ( R-HSA-2022928 ) R-HSA-2022851 Reaction Name: EXT1:EXT2 transfer GlcNAc to the heparan chain See in Reactome R-HSA-2022856 ( R-HSA-2022928 ) R-HSA-2022856 Reaction Name: EXT1:EXT2 transfers GlcNAc to heparan See in Reactome R-HSA-2022919 ( R-HSA-2022928 ) R-HSA-2022919 Reaction Name: EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue See in Reactome R-HSA-2076392 ( R-HSA-2022928 ) R-HSA-2076392 Reaction Name: EXT1:EXT2 transfers GlcA to heparan See in Reactome
MONDO:0011022	EXT2	Q93063	2.4.1.224 2.4.1.225	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2022851 ( R-HSA-2022928 ) R-HSA-2022851 Reaction Name: EXT1:EXT2 transfer GlcNAc to the heparan chain See in Reactome R-HSA-2022856 ( R-HSA-2022928 ) R-HSA-2022856 Reaction Name: EXT1:EXT2 transfers GlcNAc to heparan See in Reactome R-HSA-2022919 ( R-HSA-2022928 ) R-HSA-2022919 Reaction Name: EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue See in Reactome R-HSA-2076392 ( R-HSA-2022928 ) R-HSA-2076392 Reaction Name: EXT1:EXT2 transfers GlcA to heparan See in Reactome
MONDO:0013946	HS6ST1	O60243	2.8.2.-	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2076419 ( R-HSA-2022928 ) R-HSA-2076419 Reaction Name: HS6STs sulfate GlcN at C6 in heparan sulfate/heparin See in Reactome
MONDO:0014499	NDST1	P52848	2.8.2.- 3.-.-.- 2.8.2.8	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2022860 ( R-HSA-2022928 ) R-HSA-2022860 Reaction Name: NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) See in Reactome R-HSA-2022887 ( R-HSA-2022928 ) R-HSA-2022887 Reaction Name: NDST1-4 N-deacetylates GlcNAc residues in heparan See in Reactome
MONDO:0014731	EXT2	Q93063	2.4.1.224 2.4.1.225	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2022851 ( R-HSA-2022928 ) R-HSA-2022851 Reaction Name: EXT1:EXT2 transfer GlcNAc to the heparan chain See in Reactome R-HSA-2022856 ( R-HSA-2022928 ) R-HSA-2022856 Reaction Name: EXT1:EXT2 transfers GlcNAc to heparan See in Reactome R-HSA-2022919 ( R-HSA-2022928 ) R-HSA-2022919 Reaction Name: EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue See in Reactome R-HSA-2076392 ( R-HSA-2022928 ) R-HSA-2076392 Reaction Name: EXT1:EXT2 transfers GlcA to heparan See in Reactome
MONDO:0026724	HS6ST2	Q96MM7	2.8.2.-	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2076419 ( R-HSA-2022928 ) R-HSA-2076419 Reaction Name: HS6STs sulfate GlcN at C6 in heparan sulfate/heparin See in Reactome
MONDO:0030966	HS2ST1	Q7LGA3	2.8.2.-	R-HSA-2022928 R-HSA-2022928 Reactome Name: HS-GAG biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2076508 ( R-HSA-2022928 ) R-HSA-2076508 Reaction Name: HS2ST1 sulfates IdoA at C2 in heparan sulfate See in Reactome