DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2022857)

Number of enzymes:	5
Number of disease:	13
Number of reactomes:	8
Number of reactions:	23

Search results (Reactome ID: R-HSA-2022857)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009260	GLB1	P16278	3.2.1.23	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024096 R-HSA-2024096 Reactome Name: HS-GAG degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605624 ( R-HSA-1660662 ) R-HSA-1605624 Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2 See in Reactome R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-1606312 ( R-HSA-1660662 ) R-HSA-1606312 Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides See in Reactome R-HSA-1630306 ( R-HSA-2022857 ) R-HSA-1630306 Reaction Name: GLB1 hydrolyses a glycosaminoglycan See in Reactome R-HSA-2090079 ( R-HSA-2024096 ) R-HSA-2090079 Reaction Name: GLB1 hydrolyses linker chain(2) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0009261	GLB1	P16278	3.2.1.23	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024096 R-HSA-2024096 Reactome Name: HS-GAG degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605624 ( R-HSA-1660662 ) R-HSA-1605624 Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2 See in Reactome R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-1606312 ( R-HSA-1660662 ) R-HSA-1606312 Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides See in Reactome R-HSA-1630306 ( R-HSA-2022857 ) R-HSA-1630306 Reaction Name: GLB1 hydrolyses a glycosaminoglycan See in Reactome R-HSA-2090079 ( R-HSA-2024096 ) R-HSA-2090079 Reaction Name: GLB1 hydrolyses linker chain(2) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0009262	GLB1	P16278	3.2.1.23	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024096 R-HSA-2024096 Reactome Name: HS-GAG degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605624 ( R-HSA-1660662 ) R-HSA-1605624 Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2 See in Reactome R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-1606312 ( R-HSA-1660662 ) R-HSA-1606312 Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides See in Reactome R-HSA-1630306 ( R-HSA-2022857 ) R-HSA-1630306 Reaction Name: GLB1 hydrolyses a glycosaminoglycan See in Reactome R-HSA-2090079 ( R-HSA-2024096 ) R-HSA-2090079 Reaction Name: GLB1 hydrolyses linker chain(2) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0009658	GNS	P15586	3.1.6.14	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-432720 R-HSA-432720 Reactome Name: Lysosome Vesicle Biogenesis See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Metabolism Vesicle-mediated transport	R-HSA-1638032 ( R-HSA-2022857 ) R-HSA-1638032 Reaction Name: N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate See in Reactome R-HSA-432688 ( R-HSA-432720 ) R-HSA-432688 Reaction Name: trans-Golgi Network Derived Lysosomal Vesicle Uncoating See in Reactome R-HSA-432706 ( R-HSA-432720 ) R-HSA-432706 Reaction Name: trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly See in Reactome R-HSA-432707 ( R-HSA-432720 ) R-HSA-432707 Reaction Name: trans-Golgi Network Lysosomal Vesicle Scission See in Reactome R-HSA-432712 ( R-HSA-432720 ) R-HSA-432712 Reaction Name: Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0009659	GALNS	P34059	3.1.6.4	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome	Immune System Metabolism	R-HSA-1630304 ( R-HSA-2022857 ) R-HSA-1630304 Reaction Name: GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome
MONDO:0009660	GLB1	P16278	3.2.1.23	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024096 R-HSA-2024096 Reactome Name: HS-GAG degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1638091 R-HSA-1638091 Reactome Name: Heparan sulfate/heparin (HS-GAG) metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1605624 ( R-HSA-1660662 ) R-HSA-1605624 Reaction Name: Beta-galactosidase hydrolyses GM1 to GM2 See in Reactome R-HSA-1605724 ( R-HSA-1660662 ) R-HSA-1605724 Reaction Name: Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen) See in Reactome R-HSA-1606312 ( R-HSA-1660662 ) R-HSA-1606312 Reaction Name: Beta-galactosidase can also hydrolyse globosides to form cerebrosides See in Reactome R-HSA-1630306 ( R-HSA-2022857 ) R-HSA-1630306 Reaction Name: GLB1 hydrolyses a glycosaminoglycan See in Reactome R-HSA-2090079 ( R-HSA-2024096 ) R-HSA-2090079 Reaction Name: GLB1 hydrolyses linker chain(2) See in Reactome R-HSA-4084999 ( R-HSA-4085001 ) R-HSA-4084999 Reaction Name: NEU1 hydrolyses Neu5Ac from glycoconjugates See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9638120 ( R-HSA-4085001 ) R-HSA-9638120 Reaction Name: NEU4 hydrolyses Neu5Ac from glycoconjugates See in Reactome
MONDO:0017721	HEXB	P07686	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Immune System Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-9638075 ( R-HSA-2024101 ) R-HSA-9638075 Reaction Name: HEXB cleaves the terminal GalNAc from DS See in Reactome R-HSA-9638076 ( R-HSA-2160916 ) R-HSA-9638076 Reaction Name: HEXB cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-9638078 ( R-HSA-2022857 ) R-HSA-9638078 Reaction Name: HEXB cleaves the terminal GalNAc from keratan sulfate See in Reactome
MONDO:0017722	HEXB	P07686	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Immune System Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-9638075 ( R-HSA-2024101 ) R-HSA-9638075 Reaction Name: HEXB cleaves the terminal GalNAc from DS See in Reactome R-HSA-9638076 ( R-HSA-2160916 ) R-HSA-9638076 Reaction Name: HEXB cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-9638078 ( R-HSA-2022857 ) R-HSA-9638078 Reaction Name: HEXB cleaves the terminal GalNAc from keratan sulfate See in Reactome
MONDO:0017723	HEXB	P07686	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Immune System Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-9638075 ( R-HSA-2024101 ) R-HSA-9638075 Reaction Name: HEXB cleaves the terminal GalNAc from DS See in Reactome R-HSA-9638076 ( R-HSA-2160916 ) R-HSA-9638076 Reaction Name: HEXB cleaves the terminal GalNAc from small HA fragments See in Reactome R-HSA-9638078 ( R-HSA-2022857 ) R-HSA-9638078 Reaction Name: HEXB cleaves the terminal GalNAc from keratan sulfate See in Reactome
MONDO:0017724	HEXA	P06865	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome
MONDO:0017725	HEXA	P06865	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome
MONDO:0017726	HEXA	P06865	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome
MONDO:0017728	HEXA	P06865	3.2.1.52	R-HSA-2022857 R-HSA-2022857 Reactome Name: Keratan sulfate degradation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-2160916 R-HSA-2160916 Reactome Name: Hyaluronan uptake and degradation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-2142845 R-HSA-2142845 Reactome Name: Hyaluronan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Metabolism	R-HSA-1605595 ( R-HSA-1660662 ) R-HSA-1605595 Reaction Name: Hexosaminidase A cleaves GalNAc from GM2 to form GM3 See in Reactome R-HSA-1605632 ( R-HSA-1660662 ) R-HSA-1605632 Reaction Name: Both hexosaminidase A and B can cleave GalNAc from globoside See in Reactome R-HSA-1638053 ( R-HSA-2022857 ) R-HSA-1638053 Reaction Name: HEXA cleaves the terminal GalNAc from keratan sulfate See in Reactome R-HSA-2105001 ( R-HSA-2024101 ) R-HSA-2105001 Reaction Name: HEXA cleaves the terminal GalNAc from DS See in Reactome R-HSA-2162225 ( R-HSA-2160916 ) R-HSA-2162225 Reaction Name: HEXA cleaves the terminal GalNAc from small HA fragments See in Reactome