DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2022854)

Number of enzymes:	4
Number of disease:	5
Number of reactomes:	10
Number of reactions:	22

Search results (Reactome ID: R-HSA-2022854)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009020	CHST6	Q9GZX3	2.8.2.21	R-HSA-2022854 R-HSA-2022854 Reactome Name: Keratan sulfate biosynthesis See in Reactome	R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome	Metabolism	R-HSA-2046222 ( R-HSA-2022854 ) R-HSA-2046222 Reaction Name: CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG See in Reactome
MONDO:0011772	B4GALT1	P15291	2.4.1.90 2.4.1.- 2.4.1.275 2.4.1.38 2.4.1.22	R-HSA-2022854 R-HSA-2022854 Reactome Name: Keratan sulfate biosynthesis See in Reactome R-HSA-5653890 R-HSA-5653890 Reactome Name: Lactose synthesis See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-1912420 R-HSA-1912420 Reactome Name: Pre-NOTCH Processing in Golgi See in Reactome R-HSA-2534343 R-HSA-2534343 Reactome Name: Interaction With Cumulus Cells And The Zona Pellucida See in Reactome R-HSA-975577 R-HSA-975577 Reactome Name: N-Glycan antennae elongation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1187000 R-HSA-1187000 Reactome Name: Fertilization See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-948021 R-HSA-948021 Reactome Name: Transport to the Golgi and subsequent modification See in Reactome R-HSA-1474165 R-HSA-1474165 Reactome Name: Reproduction See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-975576 R-HSA-975576 Reactome Name: N-glycan antennae elongation in the medial/trans-Golgi See in Reactome	Immune System Metabolism of proteins Metabolism Reproduction Signal Transduction	R-HSA-1297338 ( R-HSA-2534343 ) R-HSA-1297338 Reaction Name: Association of ADAM and B4GALT1 With ZP3 See in Reactome R-HSA-1912352 ( R-HSA-1912420 ) R-HSA-1912352 Reaction Name: Galactosylation of Pre-NOTCH See in Reactome R-HSA-2025723 ( R-HSA-2022854 ) R-HSA-2025723 Reaction Name: B4GALTs transfer Gal to the N-glycan precursor See in Reactome R-HSA-2046265 ( R-HSA-2022854 ) R-HSA-2046265 Reaction Name: B4GALTs transfer Gal to the keratan chain See in Reactome R-HSA-2046298 ( R-HSA-2022854 ) R-HSA-2046298 Reaction Name: B4GALTs transfer Gal to a branch of keratan See in Reactome R-HSA-5653878 ( R-HSA-5653890 ) R-HSA-5653878 Reaction Name: B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac See in Reactome R-HSA-5653886 ( R-HSA-5653890 ) R-HSA-5653886 Reaction Name: B4GALT1 binds LALBA See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome R-HSA-975919 ( R-HSA-975577 ) R-HSA-975919 Reaction Name: Addition of galactose by beta 4-galactosyltransferases See in Reactome
MONDO:0012612	ST3GAL3	Q11203	2.4.99.6	R-HSA-1912420 R-HSA-1912420 Reactome Name: Pre-NOTCH Processing in Golgi See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome R-HSA-2022854 R-HSA-2022854 Reactome Name: Keratan sulfate biosynthesis See in Reactome R-HSA-9037629 R-HSA-9037629 Reactome Name: Lewis blood group biosynthesis See in Reactome R-HSA-977068 R-HSA-977068 Reactome Name: Termination of O-glycan biosynthesis See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-9033658 R-HSA-9033658 Reactome Name: Blood group systems biosynthesis See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-913709 R-HSA-913709 Reactome Name: O-linked glycosylation of mucins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Metabolism of proteins Metabolism Signal Transduction	R-HSA-1912378 ( R-HSA-1912420 ) R-HSA-1912378 Reaction Name: Sialylation of Pre-NOTCH See in Reactome R-HSA-2046285 ( R-HSA-2022854 ) R-HSA-2046285 Reaction Name: The keratan chain can be capped by N-acetylneuraminic acid See in Reactome R-HSA-4084984 ( R-HSA-4085001 ) R-HSA-4084984 Reaction Name: ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) See in Reactome R-HSA-9603987 ( R-HSA-9037629 ) R-HSA-9603987 Reaction Name: ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG See in Reactome R-HSA-9605600 ( R-HSA-9037629 ) R-HSA-9605600 Reaction Name: ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG See in Reactome R-HSA-981497 ( R-HSA-977068 ) R-HSA-981497 Reaction Name: ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position See in Reactome
MONDO:0014003	ST3GAL3	Q11203	2.4.99.6	R-HSA-1912420 R-HSA-1912420 Reactome Name: Pre-NOTCH Processing in Golgi See in Reactome R-HSA-4085001 R-HSA-4085001 Reactome Name: Sialic acid metabolism See in Reactome R-HSA-2022854 R-HSA-2022854 Reactome Name: Keratan sulfate biosynthesis See in Reactome R-HSA-9037629 R-HSA-9037629 Reactome Name: Lewis blood group biosynthesis See in Reactome R-HSA-977068 R-HSA-977068 Reactome Name: Termination of O-glycan biosynthesis See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-9033658 R-HSA-9033658 Reactome Name: Blood group systems biosynthesis See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-913709 R-HSA-913709 Reactome Name: O-linked glycosylation of mucins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome	Metabolism of proteins Metabolism Signal Transduction	R-HSA-1912378 ( R-HSA-1912420 ) R-HSA-1912378 Reaction Name: Sialylation of Pre-NOTCH See in Reactome R-HSA-2046285 ( R-HSA-2022854 ) R-HSA-2046285 Reaction Name: The keratan chain can be capped by N-acetylneuraminic acid See in Reactome R-HSA-4084984 ( R-HSA-4085001 ) R-HSA-4084984 Reaction Name: ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) See in Reactome R-HSA-9603987 ( R-HSA-9037629 ) R-HSA-9603987 Reaction Name: ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG See in Reactome R-HSA-9605600 ( R-HSA-9037629 ) R-HSA-9605600 Reaction Name: ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG See in Reactome R-HSA-981497 ( R-HSA-977068 ) R-HSA-981497 Reaction Name: ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position See in Reactome
MONDO:0014120	B4GAT1	O43505	2.4.1.-	R-HSA-2022854 R-HSA-2022854 Reactome Name: Keratan sulfate biosynthesis See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1638074 R-HSA-1638074 Reactome Name: Keratan sulfate/keratin metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome	Metabolism of proteins Metabolism	R-HSA-2025724 ( R-HSA-2022854 ) R-HSA-2025724 Reaction Name: B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG See in Reactome R-HSA-5617138 ( R-HSA-5173105 ) R-HSA-5617138 Reaction Name: B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA See in Reactome R-HSA-5617143 ( R-HSA-5173105 ) R-HSA-5617143 Reaction Name: B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA See in Reactome R-HSA-9638090 ( R-HSA-5173105 ) R-HSA-9638090 Reaction Name: B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA See in Reactome R-HSA-9638097 ( R-HSA-5173105 ) R-HSA-9638097 Reaction Name: B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA See in Reactome