DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-2022377)

Number of enzymes:	4
Number of disease:	11
Number of reactomes:	5
Number of reactions:	18

Search results (Reactome ID: R-HSA-2022377)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009970	REN	P00797	3.4.23.15	R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-2022403 ( R-HSA-2022377 ) R-HSA-2022403 Reaction Name: Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2022412 ( R-HSA-2022377 ) R-HSA-2022412 Reaction Name: Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2065357 ( R-HSA-2022377 ) R-HSA-2065357 Reaction Name: Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome
MONDO:0009970	ACE	P12821	3.2.1.- 3.4.15.1	R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-2022398 ( R-HSA-2022377 ) R-HSA-2022398 Reaction Name: ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) See in Reactome R-HSA-2022405 ( R-HSA-2022377 ) R-HSA-2022405 Reaction Name: ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) See in Reactome R-HSA-2065355 ( R-HSA-2022377 ) R-HSA-2065355 Reaction Name: Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) See in Reactome R-HSA-9614933 ( R-HSA-2022377 ) R-HSA-9614933 Reaction Name: ACEIs bind ACE See in Reactome
MONDO:0012414	CTSD	P07339	3.4.23.5	R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-2022403 ( R-HSA-2022377 ) R-HSA-2022403 Reaction Name: Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2022412 ( R-HSA-2022377 ) R-HSA-2022412 Reaction Name: Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-2471621 ( R-HSA-1442490 ) R-HSA-2471621 Reaction Name: Endostatin degradation by cathepsins See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-9023846 ( R-HSA-9018519 ) R-HSA-9023846 Reaction Name: Estrogen-responsive CTSD expression See in Reactome
MONDO:0012963	ACE	P12821	3.2.1.- 3.4.15.1	R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-2022398 ( R-HSA-2022377 ) R-HSA-2022398 Reaction Name: ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) See in Reactome R-HSA-2022405 ( R-HSA-2022377 ) R-HSA-2022405 Reaction Name: ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) See in Reactome R-HSA-2065355 ( R-HSA-2022377 ) R-HSA-2065355 Reaction Name: Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) See in Reactome R-HSA-9614933 ( R-HSA-2022377 ) R-HSA-9614933 Reaction Name: ACEIs bind ACE See in Reactome
MONDO:0013128	REN	P00797	3.4.23.15	R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-2022403 ( R-HSA-2022377 ) R-HSA-2022403 Reaction Name: Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2022412 ( R-HSA-2022377 ) R-HSA-2022412 Reaction Name: Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2065357 ( R-HSA-2022377 ) R-HSA-2065357 Reaction Name: Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome
MONDO:0013792	ACE	P12821	3.2.1.- 3.4.15.1	R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-2022398 ( R-HSA-2022377 ) R-HSA-2022398 Reaction Name: ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) See in Reactome R-HSA-2022405 ( R-HSA-2022377 ) R-HSA-2022405 Reaction Name: ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) See in Reactome R-HSA-2065355 ( R-HSA-2022377 ) R-HSA-2065355 Reaction Name: Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) See in Reactome R-HSA-9614933 ( R-HSA-2022377 ) R-HSA-9614933 Reaction Name: ACEIs bind ACE See in Reactome
MONDO:0014866	MME	P08473	3.4.24.11	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Immune System Metabolism of proteins	R-HSA-2022368 ( R-HSA-2022377 ) R-HSA-2022368 Reaction Name: MME:Zn2+ hydrolyses AGT(34-42) See in Reactome R-HSA-2022396 ( R-HSA-2022377 ) R-HSA-2022396 Reaction Name: MME:Zn2+ hydrolyses AGT(34-43) See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome
MONDO:0014867	MME	P08473	3.4.24.11	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Immune System Metabolism of proteins	R-HSA-2022368 ( R-HSA-2022377 ) R-HSA-2022368 Reaction Name: MME:Zn2+ hydrolyses AGT(34-42) See in Reactome R-HSA-2022396 ( R-HSA-2022377 ) R-HSA-2022396 Reaction Name: MME:Zn2+ hydrolyses AGT(34-43) See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome
MONDO:0019068	MME	P08473	3.4.24.11	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Immune System Metabolism of proteins	R-HSA-2022368 ( R-HSA-2022377 ) R-HSA-2022368 Reaction Name: MME:Zn2+ hydrolyses AGT(34-42) See in Reactome R-HSA-2022396 ( R-HSA-2022377 ) R-HSA-2022396 Reaction Name: MME:Zn2+ hydrolyses AGT(34-43) See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome
MONDO:0019638	REN	P00797	3.4.23.15	R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-2022403 ( R-HSA-2022377 ) R-HSA-2022403 Reaction Name: Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2022412 ( R-HSA-2022377 ) R-HSA-2022412 Reaction Name: Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome R-HSA-2065357 ( R-HSA-2022377 ) R-HSA-2065357 Reaction Name: Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) See in Reactome
MONDO:0019638	ACE	P12821	3.2.1.- 3.4.15.1	R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Metabolism of proteins	R-HSA-2022398 ( R-HSA-2022377 ) R-HSA-2022398 Reaction Name: ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) See in Reactome R-HSA-2022405 ( R-HSA-2022377 ) R-HSA-2022405 Reaction Name: ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) See in Reactome R-HSA-2065355 ( R-HSA-2022377 ) R-HSA-2065355 Reaction Name: Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) See in Reactome R-HSA-9614933 ( R-HSA-2022377 ) R-HSA-9614933 Reaction Name: ACEIs bind ACE See in Reactome
MONDO:0044640	MME	P08473	3.4.24.11	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Immune System Metabolism of proteins	R-HSA-2022368 ( R-HSA-2022377 ) R-HSA-2022368 Reaction Name: MME:Zn2+ hydrolyses AGT(34-42) See in Reactome R-HSA-2022396 ( R-HSA-2022377 ) R-HSA-2022396 Reaction Name: MME:Zn2+ hydrolyses AGT(34-43) See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome
MONDO:0044657	MME	P08473	3.4.24.11	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022377 R-HSA-2022377 Reactome Name: Metabolism of Angiotensinogen to Angiotensins See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2980736 R-HSA-2980736 Reactome Name: Peptide hormone metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Immune System Metabolism of proteins	R-HSA-2022368 ( R-HSA-2022377 ) R-HSA-2022368 Reaction Name: MME:Zn2+ hydrolyses AGT(34-42) See in Reactome R-HSA-2022396 ( R-HSA-2022377 ) R-HSA-2022396 Reaction Name: MME:Zn2+ hydrolyses AGT(34-43) See in Reactome R-HSA-6798743 ( R-HSA-6798695 ) R-HSA-6798743 Reaction Name: Exocytosis of secretory granule membrane proteins See in Reactome