DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-198323)

Number of enzymes:	5
Number of disease:	18
Number of reactomes:	69
Number of reactions:	118

Search results (Reactome ID: R-HSA-198323)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0000087	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0002407	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005148	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005233	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005335	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0005575	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0008170	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0008318	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0009416	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0011240	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0013334	CHUK	O15111	2.7.11.10	R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-937039 R-HSA-937039 Reactome Name: IRAK1 recruits IKK complex See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-5607761 R-HSA-5607761 Reactome Name: Dectin-1 mediated noncanonical NF-kB signaling See in Reactome R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-937041 R-HSA-937041 Reactome Name: IKK complex recruitment mediated by RIP1 See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-975144 R-HSA-975144 Reactome Name: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation See in Reactome R-HSA-445989 R-HSA-445989 Reactome Name: TAK1-dependent IKK and NF-kappa-B activation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-1810476 R-HSA-1810476 Reactome Name: RIP-mediated NFkB activation via ZBP1 See in Reactome R-HSA-5676590 R-HSA-5676590 Reactome Name: NIK-->noncanonical NF-kB signaling See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-1169091 R-HSA-1169091 Reactome Name: Activation of NF-kappaB in B cells See in Reactome R-HSA-168927 R-HSA-168927 Reactome Name: TICAM1, RIP1-mediated IKK complex recruitment See in Reactome R-HSA-2871837 R-HSA-2871837 Reactome Name: FCERI mediated NF-kB activation See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-5668541 R-HSA-5668541 Reactome Name: TNFR2 non-canonical NF-kB pathway See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System Signal Transduction	R-HSA-1168637 ( R-HSA-1169091 ) R-HSA-1168637 Reaction Name: CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK See in Reactome R-HSA-1168638 ( R-HSA-1169091 ) R-HSA-1168638 Reaction Name: Activated IKK phosphorylates I-kappaB See in Reactome R-HSA-1168641 ( R-HSA-1169091 ) R-HSA-1168641 Reaction Name: TAK1 associated with the CBM complex phosphorylates IKKbeta See in Reactome R-HSA-168140 ( R-HSA-1810476; R-HSA-445989; R-HSA-9020702; R-HSA-933542 ) R-HSA-168140 Reaction Name: Active IKK Complex phosphorylates NF-kappa-B inhibitor See in Reactome R-HSA-168184 ( R-HSA-168638; R-HSA-445989; R-HSA-9020702 ) R-HSA-168184 Reaction Name: Activated TAK1 mediates phosphorylation of the IKK Complex See in Reactome R-HSA-168910 ( R-HSA-1810476 ) R-HSA-168910 Reaction Name: RIP1 facilitates IKK complex phosphorylation See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-202500 ( R-HSA-202424 ) R-HSA-202500 Reaction Name: Activation of IKK complex See in Reactome R-HSA-202534 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202534 Reaction Name: Ubiquitination of NEMO by TRAF6 See in Reactome R-HSA-202541 ( R-HSA-202424; R-HSA-2871837; R-HSA-5607764 ) R-HSA-202541 Reaction Name: p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB See in Reactome R-HSA-2730876 ( R-HSA-2871837 ) R-HSA-2730876 Reaction Name: Phosphorylation of IKK-beta by TAK1 See in Reactome R-HSA-451561 ( R-HSA-9020702 ) R-HSA-451561 Reaction Name: NEMO binds polyubiquitinated IRAK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357831 ( R-HSA-5357905 ) R-HSA-5357831 Reaction Name: CYLD is phosphorylated by IKK See in Reactome R-HSA-5607720 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607720 Reaction Name: p100:RELB binds active NIK:p-IKKA dimer See in Reactome R-HSA-5607722 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607722 Reaction Name: Active NIK phosphorylates IKKA dimer See in Reactome R-HSA-5607723 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607723 Reaction Name: SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB See in Reactome R-HSA-5607725 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607725 Reaction Name: SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP See in Reactome R-HSA-5607726 ( R-HSA-5607761; R-HSA-5607764; R-HSA-5676590 ) R-HSA-5607726 Reaction Name: Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB See in Reactome R-HSA-5607742 ( R-HSA-5607764 ) R-HSA-5607742 Reaction Name: K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta See in Reactome R-HSA-5609665 ( R-HSA-445989; R-HSA-9020702 ) R-HSA-5609665 Reaction Name: CHUK, IKBKB and IKBKG form IKK complex See in Reactome R-HSA-5626962 ( R-HSA-5357905 ) R-HSA-5626962 Reaction Name: GNB2L1 binds IKKA:IKKB:NEMO See in Reactome R-HSA-5684267 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684267 Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex See in Reactome R-HSA-5684275 ( R-HSA-5684264; R-HSA-9020702 ) R-HSA-5684275 Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-9014343 ( R-HSA-168927 ) R-HSA-9014343 Reaction Name: IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex See in Reactome R-HSA-933530 ( R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-937029 ( R-HSA-937041 ) R-HSA-937029 Reaction Name: IKBKG subunit of IKK complex binds polyubiquinated RIP1 See in Reactome R-HSA-937032 ( R-HSA-937039 ) R-HSA-937032 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 See in Reactome R-HSA-975119 ( R-HSA-975144 ) R-HSA-975119 Reaction Name: NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. See in Reactome
MONDO:0014048	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0014407	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0016419	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0016642	AKT1	P31749	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-9604323 R-HSA-9604323 Reactome Name: Negative regulation of NOTCH4 signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-450385 R-HSA-450385 Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8849469 R-HSA-8849469 Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-354192 R-HSA-354192 Reactome Name: Integrin signaling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-450604 R-HSA-450604 Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Metabolism Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Metabolism of RNA Vesicle-mediated transport Hemostasis	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9009391; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-432110 ( R-HSA-354192 ) R-HSA-432110 Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding See in Reactome R-HSA-450490 ( R-HSA-450385 ) R-HSA-450490 Reaction Name: Protein Kinase B/Akt phosphorylates BRF1 See in Reactome R-HSA-450499 ( R-HSA-450604 ) R-HSA-450499 Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP See in Reactome R-HSA-6790041 ( R-HSA-6785807 ) R-HSA-6790041 Reaction Name: Expression of STAT3-upregulated cytosolic proteins See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-6811504 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-6811504 Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma See in Reactome R-HSA-8848751 ( R-HSA-8849469 ) R-HSA-8848751 Reaction Name: PTK6 binds AKT1 See in Reactome R-HSA-8848758 ( R-HSA-8849469 ) R-HSA-8848758 Reaction Name: PTK6 phosphorylates AKT1 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9604328 ( R-HSA-9604323 ) R-HSA-9604328 Reaction Name: AKT1 phosphorylates NOTCH4 See in Reactome R-HSA-9624526 ( R-HSA-9009391; R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0019192	AKT2	P31751	2.7.11.1	R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-165160 R-HSA-165160 Reactome Name: PDE3B signalling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-165181 R-HSA-165181 Reactome Name: Inhibition of TSC complex formation by PKB See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-1445148 R-HSA-1445148 Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-165158 R-HSA-165158 Reactome Name: Activation of AKT2 See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-109703 R-HSA-109703 Reactome Name: PKB-mediated events See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Vesicle-mediated transport Programmed Cell Death Signal Transduction	R-HSA-109700 ( R-HSA-165158 ) R-HSA-109700 Reaction Name: AKT2 binds PIP3 See in Reactome R-HSA-109702 ( R-HSA-165158 ) R-HSA-109702 Reaction Name: PDPK1 phosphorylates AKT2 See in Reactome R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1445144 ( R-HSA-1445148 ) R-HSA-1445144 Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) See in Reactome R-HSA-1449597 ( R-HSA-1445148 ) R-HSA-1449597 Reaction Name: p-AKT2 phosphorylates Myosin 5A See in Reactome R-HSA-1458463 ( R-HSA-1445148 ) R-HSA-1458463 Reaction Name: p-AKT2 phosphorylates RGC2 See in Reactome R-HSA-162363 ( R-HSA-165160 ) R-HSA-162363 Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B See in Reactome R-HSA-165162 ( R-HSA-165181 ) R-HSA-165162 Reaction Name: Phosphorylation of TSC2 by PKB See in Reactome R-HSA-165182 ( R-HSA-165181 ) R-HSA-165182 Reaction Name: Phosphorylation of complexed TSC2 by PKB See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-3769394 ( R-HSA-3769402 ) R-HSA-3769394 Reaction Name: AKT phosphorylates CBY1 See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-5260201 ( R-HSA-1445148 ) R-HSA-5260201 Reaction Name: p-AKT2 phosphorylates C2CD5 See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0020492	AKT3	Q9Y243	2.7.11.1	R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-198693 R-HSA-198693 Reactome Name: AKT phosphorylates targets in the nucleus See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111447 R-HSA-111447 Reactome Name: Activation of BAD and translocation to mitochondria See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-389513 R-HSA-389513 Reactome Name: CTLA4 inhibitory signaling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-211163 R-HSA-211163 Reactome Name: AKT-mediated inactivation of FOXO1A See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-6804759 R-HSA-6804759 Reactome Name: Regulation of TP53 Activity through Association with Co-factors See in Reactome R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-9614399 R-HSA-9614399 Reactome Name: Regulation of localization of FOXO transcription factors See in Reactome R-HSA-392451 R-HSA-392451 Reactome Name: G beta:gamma signalling through PI3Kgamma See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8876198 R-HSA-8876198 Reactome Name: RAB GEFs exchange GTP for GDP on RABs See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome R-HSA-69656 R-HSA-69656 Reactome Name: Cyclin A:Cdk2-associated events at S phase entry See in Reactome R-HSA-69202 R-HSA-69202 Reactome Name: Cyclin E associated events during G1/S transition See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-9007101 R-HSA-9007101 Reactome Name: Rab regulation of trafficking See in Reactome R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-114452 R-HSA-114452 Reactome Name: Activation of BH3-only proteins See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Cell Cycle Developmental Biology Gene expression (Transcription) Signal Transduction Vesicle-mediated transport Programmed Cell Death	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-198270 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198270 Reaction Name: PDPK1 phosphorylates AKT at T308 See in Reactome R-HSA-198298 ( R-HSA-1257604 ) R-HSA-198298 Reaction Name: AKT translocates to the nucleus See in Reactome R-HSA-198347 ( R-HSA-111447; R-HSA-1257604; R-HSA-198323 ) R-HSA-198347 Reaction Name: AKT phosphorylates BAD See in Reactome R-HSA-198371 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198371 Reaction Name: AKT phosphorylates GSK3 See in Reactome R-HSA-198599 ( R-HSA-1257604; R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-198609 ( R-HSA-1257604; R-HSA-198323; R-HSA-5628897 ) R-HSA-198609 Reaction Name: AKT phosphorylates TSC2, inhibiting it See in Reactome R-HSA-198611 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198611 Reaction Name: AKT phosphorylates IKKalpha See in Reactome R-HSA-198613 ( R-HSA-1257604; R-HSA-198323; R-HSA-69202; R-HSA-69656 ) R-HSA-198613 Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1 See in Reactome R-HSA-198621 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-198621 Reaction Name: AKT phosphorylates caspase-9 See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-199298 ( R-HSA-1257604; R-HSA-198693; R-HSA-9634638 ) R-HSA-199298 Reaction Name: AKT phosphorylates CREB1 See in Reactome R-HSA-199299 ( R-HSA-1257604; R-HSA-198693; R-HSA-9614399 ) R-HSA-199299 Reaction Name: AKT phosphorylates FOXO transcription factors See in Reactome R-HSA-199425 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199425 Reaction Name: PHLPP dephosphorylates S473 in AKT See in Reactome R-HSA-199443 ( R-HSA-1257604; R-HSA-199418 ) R-HSA-199443 Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation See in Reactome R-HSA-199839 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199839 Reaction Name: AKT can phosphorylate RSK See in Reactome R-HSA-199863 ( R-HSA-1257604; R-HSA-198693 ) R-HSA-199863 Reaction Name: AKT can phosphorylate NR4A1 (NUR77) See in Reactome R-HSA-200143 ( R-HSA-1257604; R-HSA-198323 ) R-HSA-200143 Reaction Name: AKT phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-211164 ( R-HSA-211163 ) R-HSA-211164 Reaction Name: AKT phosphorylates FOXO1A See in Reactome R-HSA-2317314 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-2317314 Reaction Name: AKT binds PDPK1 See in Reactome R-HSA-2317332 ( R-HSA-1257604; R-HSA-389357 ) R-HSA-2317332 Reaction Name: PIP3 recruits AKT to the membrane See in Reactome R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-390329 ( R-HSA-389513 ) R-HSA-390329 Reaction Name: Dephosphorylation of AKT by PP2A See in Reactome R-HSA-6805620 ( R-HSA-6804758 ) R-HSA-6805620 Reaction Name: KAT6A and PML bind TP53 See in Reactome R-HSA-6805640 ( R-HSA-6804758 ) R-HSA-6805640 Reaction Name: AKT phosphorylates KAT6A See in Reactome R-HSA-6805785 ( R-HSA-6804759 ) R-HSA-6805785 Reaction Name: AKT phosphorylates PHF20 See in Reactome R-HSA-8932309 () R-HSA-8932309 Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm See in Reactome R-HSA-8933446 ( R-HSA-8876198 ) R-HSA-8933446 Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling See in Reactome R-HSA-8939963 ( R-HSA-8941332 ) R-HSA-8939963 Reaction Name: Activated AKT phosphorylates RUNX2 See in Reactome R-HSA-8948757 ( R-HSA-1257604; R-HSA-198323; R-HSA-8948751 ) R-HSA-8948757 Reaction Name: AKT phosphorylates MKRN1 See in Reactome R-HSA-9603279 ( R-HSA-392451 ) R-HSA-9603279 Reaction Name: PIP3 recruits PDK1 and AKT to the membrane See in Reactome R-HSA-9624526 ( R-HSA-9634638 ) R-HSA-9624526 Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR See in Reactome R-HSA-9699579 ( R-HSA-9607240 ) R-HSA-9699579 Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3 See in Reactome
MONDO:0032868	MDM2	Q00987	2.3.2.27	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-6804760 R-HSA-6804760 Reactome Name: Regulation of TP53 Activity through Methylation See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-3232118 R-HSA-3232118 Reactome Name: SUMOylation of transcription factors See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-3232142 R-HSA-3232142 Reactome Name: SUMOylation of ubiquitinylation proteins See in Reactome R-HSA-399719 R-HSA-399719 Reactome Name: Trafficking of AMPA receptors See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-69541 R-HSA-69541 Reactome Name: Stabilization of p53 See in Reactome R-HSA-198323 R-HSA-198323 Reactome Name: AKT phosphorylates targets in the cytosol See in Reactome R-HSA-8941858 R-HSA-8941858 Reactome Name: Regulation of RUNX3 expression and activity See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69563 R-HSA-69563 Reactome Name: p53-Dependent G1 DNA Damage Response See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-69580 R-HSA-69580 Reactome Name: p53-Dependent G1/S DNA damage checkpoint See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-399721 R-HSA-399721 Reactome Name: Glutamate binding, activation of AMPA receptors and synaptic plasticity See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-69615 R-HSA-69615 Reactome Name: G1/S DNA Damage Checkpoints See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Gene expression (Transcription) Neuronal System Cellular responses to stimuli Metabolism of proteins Signal Transduction	R-HSA-198599 ( R-HSA-198323; R-HSA-6804757 ) R-HSA-198599 Reaction Name: AKT phosphorylates MDM2 See in Reactome R-HSA-2997706 ( R-HSA-3232118 ) R-HSA-2997706 Reaction Name: MDM2 SUMOylates TP53 with SUMO2,3 See in Reactome R-HSA-3000434 ( R-HSA-3232142 ) R-HSA-3000434 Reaction Name: PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 See in Reactome R-HSA-3215295 ( R-HSA-6804757 ) R-HSA-3215295 Reaction Name: USP7 deubiquitinates MDM2 See in Reactome R-HSA-3222072 ( R-HSA-6804757 ) R-HSA-3222072 Reaction Name: DAXX binds Ub-MDM2 and USP7 See in Reactome R-HSA-349426 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349426 Reaction Name: Phosphorylation of MDM4 by CHEK2 See in Reactome R-HSA-349455 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-349455 Reaction Name: Phosphorylation of MDM4 by ATM See in Reactome R-HSA-3700992 ( R-HSA-6804757 ) R-HSA-3700992 Reaction Name: TP53 stimulates MDM2 transcription See in Reactome R-HSA-416320 ( R-HSA-399719 ) R-HSA-416320 Reaction Name: Trafficking of GluR1-containing AMPA receptors See in Reactome R-HSA-5228523 ( R-HSA-3232142 ) R-HSA-5228523 Reaction Name: RANBP2 SUMOylates MDM2 with SUMO1 See in Reactome R-HSA-5633460 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-5633460 Reaction Name: MDM2 binds TP53 See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-5689972 ( R-HSA-5689880; R-HSA-6804757 ) R-HSA-5689972 Reaction Name: USP2 deubiquitinates MDM2,MDM4 See in Reactome R-HSA-6792863 ( R-HSA-6804757 ) R-HSA-6792863 Reaction Name: PP2A-PP2R5C dephosphorylates MDM2 See in Reactome R-HSA-6792871 ( R-HSA-6804757 ) R-HSA-6792871 Reaction Name: CCNG1 recruits PP2A-PPP2R5C to MDM2 See in Reactome R-HSA-6793661 ( R-HSA-6804757 ) R-HSA-6793661 Reaction Name: (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 See in Reactome R-HSA-6793666 ( R-HSA-6804757 ) R-HSA-6793666 Reaction Name: MDM2 translocates to the nucleus See in Reactome R-HSA-6795460 ( R-HSA-6804757 ) R-HSA-6795460 Reaction Name: SGK1 phosphorylates MDM2 See in Reactome R-HSA-6795667 ( R-HSA-6804757 ) R-HSA-6795667 Reaction Name: MDM2 translocates to the cytosol See in Reactome R-HSA-6798373 ( R-HSA-6804756 ) R-HSA-6798373 Reaction Name: MDM2 ubiquitinates DYRK2 See in Reactome R-HSA-6804253 ( R-HSA-6804760 ) R-HSA-6804253 Reaction Name: MDM2 ubiquitinates JMY See in Reactome R-HSA-6804724 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804724 Reaction Name: MDM2 ubiquitinates phosphorylated MDM4 See in Reactome R-HSA-6804741 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804741 Reaction Name: MDM2 forms homo- or heterodimers See in Reactome R-HSA-6804879 ( R-HSA-2559580; R-HSA-2559585; R-HSA-6804757; R-HSA-69541 ) R-HSA-6804879 Reaction Name: MDM2 ubiquitinates TP53 See in Reactome R-HSA-6804942 ( R-HSA-6804757 ) R-HSA-6804942 Reaction Name: MDM2 homodimers auto-ubiquitinate See in Reactome R-HSA-6804955 ( R-HSA-6804757; R-HSA-69541 ) R-HSA-6804955 Reaction Name: ATM phosphorylates MDM2 See in Reactome R-HSA-6804996 ( R-HSA-2559580; R-HSA-2559585; R-HSA-6804757 ) R-HSA-6804996 Reaction Name: p14ARF sequesters MDM2 See in Reactome R-HSA-6804998 ( R-HSA-2559580; R-HSA-2559585; R-HSA-6804757 ) R-HSA-6804998 Reaction Name: p14ARF forms a ternary complex with MDM2 and TP53 See in Reactome R-HSA-6805022 ( R-HSA-6804757 ) R-HSA-6805022 Reaction Name: USP2 binds the heterodimer of MDM2 and MDM4 See in Reactome R-HSA-8952371 ( R-HSA-8941858 ) R-HSA-8952371 Reaction Name: MDM2 binds RUNX3 See in Reactome R-HSA-8952382 ( R-HSA-8941858 ) R-HSA-8952382 Reaction Name: MDM2 polyubiquitinates RUNX3 See in Reactome