DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-196780)

Number of enzymes:	8
Number of disease:	9
Number of reactomes:	8
Number of reactions:	18

Search results (Reactome ID: R-HSA-196780)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008861	MCCC1	Q96RQ3	6.4.1.4	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome R-HSA-70895 R-HSA-70895 Reactome Name: Branched-chain amino acid catabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome	Metabolism	R-HSA-2993799 ( R-HSA-196780 ) R-HSA-2993799 Reaction Name: HLCS biotinylates 6xMCCC1:6xMCCC2 See in Reactome R-HSA-3065959 ( R-HSA-196780 ) R-HSA-3065959 Reaction Name: An unknown protease degrades hCBXs See in Reactome R-HSA-3323111 ( R-HSA-196780 ) R-HSA-3323111 Reaction Name: Cytoslic carboxylases translocate to mitochondrial matrix See in Reactome R-HSA-508308 ( R-HSA-70895 ) R-HSA-508308 Reaction Name: beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] See in Reactome R-HSA-70773 ( R-HSA-70895 ) R-HSA-70773 Reaction Name: beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] See in Reactome
MONDO:0008862	MCCC2	Q9HCC0	6.4.1.4	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome R-HSA-70895 R-HSA-70895 Reactome Name: Branched-chain amino acid catabolism See in Reactome	R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome	Metabolism	R-HSA-2993799 ( R-HSA-196780 ) R-HSA-2993799 Reaction Name: HLCS biotinylates 6xMCCC1:6xMCCC2 See in Reactome R-HSA-3065959 ( R-HSA-196780 ) R-HSA-3065959 Reaction Name: An unknown protease degrades hCBXs See in Reactome R-HSA-3323111 ( R-HSA-196780 ) R-HSA-3323111 Reaction Name: Cytoslic carboxylases translocate to mitochondrial matrix See in Reactome R-HSA-508308 ( R-HSA-70895 ) R-HSA-508308 Reaction Name: beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] See in Reactome R-HSA-70773 ( R-HSA-70895 ) R-HSA-70773 Reaction Name: beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] See in Reactome
MONDO:0009665	BTD	P43251	3.5.1.12	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-3076905 ( R-HSA-196780 ) R-HSA-3076905 Reaction Name: Extracellular BTD hydrolyses BCTN See in Reactome R-HSA-4167509 ( R-HSA-196780 ) R-HSA-4167509 Reaction Name: Mitochondrial BTD hydrolyses BCTN See in Reactome
MONDO:0009666	HLCS	P50747	6.3.4.- 6.3.4.15 6.3.4.9 6.3.4.10 6.3.4.11	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-2993447 ( R-HSA-196780 ) R-HSA-2993447 Reaction Name: HLCS biotinylates 6x(PCCA:PCCB) See in Reactome R-HSA-2993799 ( R-HSA-196780 ) R-HSA-2993799 Reaction Name: HLCS biotinylates 6xMCCC1:6xMCCC2 See in Reactome R-HSA-2993802 ( R-HSA-196780 ) R-HSA-2993802 Reaction Name: HLCS biotinylates PC:Mn2+ See in Reactome R-HSA-2993814 ( R-HSA-196780 ) R-HSA-2993814 Reaction Name: HLCS biotinylates ACACA:Mn2+ See in Reactome R-HSA-4167511 ( R-HSA-196780 ) R-HSA-4167511 Reaction Name: HLCS biotinylates ACACB See in Reactome
MONDO:0011628	PCCA	P05165	6.4.1.3	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome R-HSA-71032 R-HSA-71032 Reactome Name: Propionyl-CoA catabolism See in Reactome	R-HSA-77289 R-HSA-77289 Reactome Name: Mitochondrial Fatty Acid Beta-Oxidation See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome	Metabolism	R-HSA-2993447 ( R-HSA-196780 ) R-HSA-2993447 Reaction Name: HLCS biotinylates 6x(PCCA:PCCB) See in Reactome R-HSA-3065959 ( R-HSA-196780 ) R-HSA-3065959 Reaction Name: An unknown protease degrades hCBXs See in Reactome R-HSA-3323111 ( R-HSA-196780 ) R-HSA-3323111 Reaction Name: Cytoslic carboxylases translocate to mitochondrial matrix See in Reactome R-HSA-71031 ( R-HSA-71032 ) R-HSA-71031 Reaction Name: propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate See in Reactome
MONDO:0011628	PCCB	P05166	6.4.1.3	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome R-HSA-71032 R-HSA-71032 Reactome Name: Propionyl-CoA catabolism See in Reactome	R-HSA-77289 R-HSA-77289 Reactome Name: Mitochondrial Fatty Acid Beta-Oxidation See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome	Metabolism	R-HSA-2993447 ( R-HSA-196780 ) R-HSA-2993447 Reaction Name: HLCS biotinylates 6x(PCCA:PCCB) See in Reactome R-HSA-3065959 ( R-HSA-196780 ) R-HSA-3065959 Reaction Name: An unknown protease degrades hCBXs See in Reactome R-HSA-3323111 ( R-HSA-196780 ) R-HSA-3323111 Reaction Name: Cytoslic carboxylases translocate to mitochondrial matrix See in Reactome R-HSA-71031 ( R-HSA-71032 ) R-HSA-71031 Reaction Name: propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate See in Reactome
MONDO:0013493	ACACA	Q13085	6.4.1.2	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome R-HSA-163765 R-HSA-163765 Reactome Name: ChREBP activates metabolic gene expression See in Reactome R-HSA-200425 R-HSA-200425 Reactome Name: Carnitine metabolism See in Reactome R-HSA-2426168 R-HSA-2426168 Reactome Name: Activation of gene expression by SREBF (SREBP) See in Reactome R-HSA-75105 R-HSA-75105 Reactome Name: Fatty acyl-CoA biosynthesis See in Reactome	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-163743 ( R-HSA-163765 ) R-HSA-163743 Reaction Name: Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX See in Reactome R-HSA-1655845 ( R-HSA-2426168 ) R-HSA-1655845 Reaction Name: Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) See in Reactome R-HSA-200555 ( R-HSA-75105 ) R-HSA-200555 Reaction Name: acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate See in Reactome R-HSA-2993814 ( R-HSA-196780 ) R-HSA-2993814 Reaction Name: HLCS biotinylates ACACA:Mn2+ See in Reactome R-HSA-3065958 ( R-HSA-196780 ) R-HSA-3065958 Reaction Name: An unknown protease degrades ACACA See in Reactome R-HSA-75851 ( R-HSA-200425 ) R-HSA-75851 Reaction Name: Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA See in Reactome
MONDO:0018141	PC	P11498	6.4.1.1	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2993802 ( R-HSA-196780 ) R-HSA-2993802 Reaction Name: HLCS biotinylates PC:Mn2+ See in Reactome R-HSA-3065959 ( R-HSA-196780 ) R-HSA-3065959 Reaction Name: An unknown protease degrades hCBXs See in Reactome R-HSA-3323111 ( R-HSA-196780 ) R-HSA-3323111 Reaction Name: Cytoslic carboxylases translocate to mitochondrial matrix See in Reactome R-HSA-70501 ( R-HSA-70263 ) R-HSA-70501 Reaction Name: Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate See in Reactome
MONDO:0018142	PC	P11498	6.4.1.1	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2993802 ( R-HSA-196780 ) R-HSA-2993802 Reaction Name: HLCS biotinylates PC:Mn2+ See in Reactome R-HSA-3065959 ( R-HSA-196780 ) R-HSA-3065959 Reaction Name: An unknown protease degrades hCBXs See in Reactome R-HSA-3323111 ( R-HSA-196780 ) R-HSA-3323111 Reaction Name: Cytoslic carboxylases translocate to mitochondrial matrix See in Reactome R-HSA-70501 ( R-HSA-70263 ) R-HSA-70501 Reaction Name: Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate See in Reactome
MONDO:0018143	PC	P11498	6.4.1.1	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Metabolism	R-HSA-2993802 ( R-HSA-196780 ) R-HSA-2993802 Reaction Name: HLCS biotinylates PC:Mn2+ See in Reactome R-HSA-3065959 ( R-HSA-196780 ) R-HSA-3065959 Reaction Name: An unknown protease degrades hCBXs See in Reactome R-HSA-3323111 ( R-HSA-196780 ) R-HSA-3323111 Reaction Name: Cytoslic carboxylases translocate to mitochondrial matrix See in Reactome R-HSA-70501 ( R-HSA-70263 ) R-HSA-70501 Reaction Name: Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate See in Reactome