DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-196757)

Number of enzymes:	6
Number of disease:	9
Number of reactomes:	4
Number of reactions:	13

Search results (Reactome ID: R-HSA-196757)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005090	MTHFR	P42898	1.5.1.20	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-200676 ( R-HSA-196757 ) R-HSA-200676 Reaction Name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG See in Reactome
MONDO:0005575	MTHFD1	P11586	3.5.4.9 1.5.1.5 6.3.4.3	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-200644 ( R-HSA-196757 ) R-HSA-200644 Reaction Name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ See in Reactome R-HSA-200661 ( R-HSA-196757 ) R-HSA-200661 Reaction Name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG See in Reactome R-HSA-200711 ( R-HSA-196757 ) R-HSA-200711 Reaction Name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG See in Reactome R-HSA-200718 ( R-HSA-196757 ) R-HSA-200718 Reaction Name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG See in Reactome R-HSA-200740 ( R-HSA-196757 ) R-HSA-200740 Reaction Name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate See in Reactome
MONDO:0009353	MTHFR	P42898	1.5.1.20	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-200676 ( R-HSA-196757 ) R-HSA-200676 Reaction Name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG See in Reactome
MONDO:0011120	MTHFD1	P11586	3.5.4.9 1.5.1.5 6.3.4.3	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-200644 ( R-HSA-196757 ) R-HSA-200644 Reaction Name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ See in Reactome R-HSA-200661 ( R-HSA-196757 ) R-HSA-200661 Reaction Name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG See in Reactome R-HSA-200711 ( R-HSA-196757 ) R-HSA-200711 Reaction Name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG See in Reactome R-HSA-200718 ( R-HSA-196757 ) R-HSA-200718 Reaction Name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG See in Reactome R-HSA-200740 ( R-HSA-196757 ) R-HSA-200740 Reaction Name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate See in Reactome
MONDO:0011120	MTHFR	P42898	1.5.1.20	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-200676 ( R-HSA-196757 ) R-HSA-200676 Reaction Name: MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG See in Reactome
MONDO:0011141	SLC19A1	P41440	-	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-200652 ( R-HSA-196757 ) R-HSA-200652 Reaction Name: SLC19A1 transports 5-methyl-THF from extracellular region to cytosol See in Reactome
MONDO:0013456	DHFR	P00374	1.5.1.3	R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome R-HSA-69205 R-HSA-69205 Reactome Name: G1/S-Specific Transcription See in Reactome R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome	Metabolism Cell Cycle	R-HSA-1497794 ( R-HSA-1474151 ) R-HSA-1497794 Reaction Name: Salvage - BH2 is reduced to BH4 by DHFR See in Reactome R-HSA-8961874 ( R-HSA-69205 ) R-HSA-8961874 Reaction Name: DHFR gene expression is stimulated by E2F1 See in Reactome R-HSA-9709098 ( R-HSA-196757 ) R-HSA-9709098 Reaction Name: DHFR dimer reduces FOLA to DHF See in Reactome
MONDO:0030866	SHMT2	P34897	2.1.2.1	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome R-HSA-9013408 R-HSA-9013408 Reactome Name: RHOG GTPase cycle See in Reactome	R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-5694137 ( R-HSA-196757 ) R-HSA-5694137 Reaction Name: PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser See in Reactome R-HSA-9014449 ( R-HSA-9013408 ) R-HSA-9014449 Reaction Name: RHOG binds effectors at the plasma membrane See in Reactome
MONDO:0032705	MTHFS	P49914	6.3.3.2	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-6801342 ( R-HSA-196757 ) R-HSA-6801342 Reaction Name: MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG See in Reactome
MONDO:0060611	MTHFD1	P11586	3.5.4.9 1.5.1.5 6.3.4.3	R-HSA-196757 R-HSA-196757 Reactome Name: Metabolism of folate and pterines See in Reactome	R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-200644 ( R-HSA-196757 ) R-HSA-200644 Reaction Name: 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ See in Reactome R-HSA-200661 ( R-HSA-196757 ) R-HSA-200661 Reaction Name: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG See in Reactome R-HSA-200711 ( R-HSA-196757 ) R-HSA-200711 Reaction Name: MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG See in Reactome R-HSA-200718 ( R-HSA-196757 ) R-HSA-200718 Reaction Name: MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG See in Reactome R-HSA-200740 ( R-HSA-196757 ) R-HSA-200740 Reaction Name: 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate See in Reactome