DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-195399)

Number of enzymes:	2
Number of disease:	5
Number of reactomes:	6
Number of reactions:	49

Search results (Reactome ID: R-HSA-195399)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005387	KDR	P35968	2.7.10.1	R-HSA-216083 R-HSA-216083 Reactome Name: Integrin cell surface interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-195399 R-HSA-195399 Reactome Name: VEGF binds to VEGFR leading to receptor dimerization See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-194306 R-HSA-194306 Reactome Name: Neurophilin interactions with VEGF and VEGFR See in Reactome	R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-194313 R-HSA-194313 Reactome Name: VEGF ligand-receptor interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Extracellular matrix organization Signal Transduction	R-HSA-194310 ( R-HSA-195399 ) R-HSA-194310 Reaction Name: VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization See in Reactome R-HSA-195408 ( R-HSA-194306 ) R-HSA-195408 Reaction Name: NRP-1 forms a ternary complex with VEGF165 and VEGFR1 See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-4088281 ( R-HSA-216083 ) R-HSA-4088281 Reaction Name: Endorepellin binds KDR (VEGFR2) See in Reactome R-HSA-4420083 ( R-HSA-4420097 ) R-HSA-4420083 Reaction Name: PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 See in Reactome R-HSA-4420099 ( R-HSA-4420097 ) R-HSA-4420099 Reaction Name: p-6Y-VEGFR2 binds SHB See in Reactome R-HSA-4420107 ( R-HSA-4420097 ) R-HSA-4420107 Reaction Name: p-6Y-VEGFR2 binds SHC-transforming protein 2 See in Reactome R-HSA-4420117 ( R-HSA-4420097 ) R-HSA-4420117 Reaction Name: VEGFR2 autophosphorylates See in Reactome R-HSA-4420121 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-4420121 Reaction Name: SFKs phosphorylate PLCG1 See in Reactome R-HSA-4420128 ( R-HSA-4420097 ) R-HSA-4420128 Reaction Name: SRC-1 phosphorylates SHB See in Reactome R-HSA-4420140 ( R-HSA-4420097 ) R-HSA-4420140 Reaction Name: SRC1-1 binds SH2D2A and is recruited to VEGFR2 See in Reactome R-HSA-4420143 ( R-HSA-4420097 ) R-HSA-4420143 Reaction Name: p-6Y-VEGFR2 binds SH2D2A See in Reactome R-HSA-4420153 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-4420153 Reaction Name: p-6Y-VEGFR2 binds PLCG1 See in Reactome R-HSA-4420202 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-4420202 Reaction Name: PLCG1 disassociates from VEGFR2 and translocate to PM See in Reactome R-HSA-4420206 ( R-HSA-4420097 ) R-HSA-4420206 Reaction Name: Phosphorylation of SRC-1 See in Reactome R-HSA-5218640 ( R-HSA-4420097 ) R-HSA-5218640 Reaction Name: SRC-1 phosphorylates p-Y397-PTK2 See in Reactome R-HSA-5218642 ( R-HSA-4420097 ) R-HSA-5218642 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-5218643 ( R-HSA-4420097 ) R-HSA-5218643 Reaction Name: HSP90AA1 binds p-6Y-VEGFR2 See in Reactome R-HSA-5218645 ( R-HSA-4420097 ) R-HSA-5218645 Reaction Name: SRC-1 binds p-Y397-PTK2 See in Reactome R-HSA-5218804 ( R-HSA-4420097 ) R-HSA-5218804 Reaction Name: p38 MAPK activation by VEGFR See in Reactome R-HSA-5218806 ( R-HSA-4420097 ) R-HSA-5218806 Reaction Name: FYN autophosphorylates See in Reactome R-HSA-5218809 ( R-HSA-4420097 ) R-HSA-5218809 Reaction Name: PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 See in Reactome R-HSA-5218811 ( R-HSA-4420097 ) R-HSA-5218811 Reaction Name: DOCK180:ELMO binds CRK See in Reactome R-HSA-5218812 ( R-HSA-4420097 ) R-HSA-5218812 Reaction Name: FYN phosphorylates PAK2 See in Reactome R-HSA-5218814 ( R-HSA-4420097 ) R-HSA-5218814 Reaction Name: PAK2 autophorylates See in Reactome R-HSA-5218815 ( R-HSA-4420097 ) R-HSA-5218815 Reaction Name: p-6Y-VEGFR2 binds NCK See in Reactome R-HSA-5218818 ( R-HSA-4420097 ) R-HSA-5218818 Reaction Name: Integrin alphaVbeta3 binds p-6Y-VEGFR2 See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218820 ( R-HSA-4420097 ) R-HSA-5218820 Reaction Name: Src kinases phosphorylate VAV See in Reactome R-HSA-5218822 ( R-HSA-4420097 ) R-HSA-5218822 Reaction Name: CRK binds BCAR1 and or PXN See in Reactome R-HSA-5218824 ( R-HSA-4420097 ) R-HSA-5218824 Reaction Name: p-6Y-VEGFR2 binds FYN See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5218828 ( R-HSA-4420097 ) R-HSA-5218828 Reaction Name: PTK2/SRC-1 phosphorylates BCAR1 See in Reactome R-HSA-5218830 ( R-HSA-4420097 ) R-HSA-5218830 Reaction Name: SRC-1 phosphorylates PTK2-beta See in Reactome R-HSA-5218832 ( R-HSA-4420097 ) R-HSA-5218832 Reaction Name: CDC42:GTP binds PAK2 See in Reactome R-HSA-5218836 ( R-HSA-4420097 ) R-HSA-5218836 Reaction Name: PTK2beta binds alphaVbeta3 See in Reactome R-HSA-5218838 ( R-HSA-4420097 ) R-HSA-5218838 Reaction Name: PXN binds p-6Y,S732-PTK2 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218847 ( R-HSA-4420097 ) R-HSA-5218847 Reaction Name: PAK2 binds NCK See in Reactome R-HSA-5218851 ( R-HSA-4420097 ) R-HSA-5218851 Reaction Name: p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5218854 ( R-HSA-4420097 ) R-HSA-5218854 Reaction Name: p-Y420-FYN is phosphorylated on S21 See in Reactome R-HSA-5218855 ( R-HSA-4420097 ) R-HSA-5218855 Reaction Name: BCAR1 binds p-7Y-PTK2 See in Reactome R-HSA-5357429 ( R-HSA-4420097 ) R-HSA-5357429 Reaction Name: AXL autophosphorylates on Y772 and Y814 See in Reactome R-HSA-5357432 ( R-HSA-4420097 ) R-HSA-5357432 Reaction Name: AXL binds SRC-1 See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-9691215 ( R-HSA-4420097 ) R-HSA-9691215 Reaction Name: VEGFA-165 dimer binds VEGFR2 dimer See in Reactome
MONDO:0007919	FLT4	P35916	2.7.10.1	R-HSA-195399 R-HSA-195399 Reactome Name: VEGF binds to VEGFR leading to receptor dimerization See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome	R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-194313 R-HSA-194313 Reactome Name: VEGF ligand-receptor interactions See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-194308 ( R-HSA-195399 ) R-HSA-194308 Reaction Name: VEGF-C,D bind to VEGFR3 leading to receptor dimerization See in Reactome R-HSA-9604471 ( R-HSA-9013695 ) R-HSA-9604471 Reaction Name: FLT4 gene expression is stimulated by NOTCH4 See in Reactome
MONDO:0008542	FLT4	P35916	2.7.10.1	R-HSA-195399 R-HSA-195399 Reactome Name: VEGF binds to VEGFR leading to receptor dimerization See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome	R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-194313 R-HSA-194313 Reactome Name: VEGF ligand-receptor interactions See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-194308 ( R-HSA-195399 ) R-HSA-194308 Reaction Name: VEGF-C,D bind to VEGFR3 leading to receptor dimerization See in Reactome R-HSA-9604471 ( R-HSA-9013695 ) R-HSA-9604471 Reaction Name: FLT4 gene expression is stimulated by NOTCH4 See in Reactome
MONDO:0011191	FLT4	P35916	2.7.10.1	R-HSA-195399 R-HSA-195399 Reactome Name: VEGF binds to VEGFR leading to receptor dimerization See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome	R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-194313 R-HSA-194313 Reactome Name: VEGF ligand-receptor interactions See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-194308 ( R-HSA-195399 ) R-HSA-194308 Reaction Name: VEGF-C,D bind to VEGFR3 leading to receptor dimerization See in Reactome R-HSA-9604471 ( R-HSA-9013695 ) R-HSA-9604471 Reaction Name: FLT4 gene expression is stimulated by NOTCH4 See in Reactome
MONDO:0011191	KDR	P35968	2.7.10.1	R-HSA-216083 R-HSA-216083 Reactome Name: Integrin cell surface interactions See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-195399 R-HSA-195399 Reactome Name: VEGF binds to VEGFR leading to receptor dimerization See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-194306 R-HSA-194306 Reactome Name: Neurophilin interactions with VEGF and VEGFR See in Reactome	R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-194313 R-HSA-194313 Reactome Name: VEGF ligand-receptor interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Extracellular matrix organization Signal Transduction	R-HSA-194310 ( R-HSA-195399 ) R-HSA-194310 Reaction Name: VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization See in Reactome R-HSA-195408 ( R-HSA-194306 ) R-HSA-195408 Reaction Name: NRP-1 forms a ternary complex with VEGF165 and VEGFR1 See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-4088281 ( R-HSA-216083 ) R-HSA-4088281 Reaction Name: Endorepellin binds KDR (VEGFR2) See in Reactome R-HSA-4420083 ( R-HSA-4420097 ) R-HSA-4420083 Reaction Name: PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 See in Reactome R-HSA-4420099 ( R-HSA-4420097 ) R-HSA-4420099 Reaction Name: p-6Y-VEGFR2 binds SHB See in Reactome R-HSA-4420107 ( R-HSA-4420097 ) R-HSA-4420107 Reaction Name: p-6Y-VEGFR2 binds SHC-transforming protein 2 See in Reactome R-HSA-4420117 ( R-HSA-4420097 ) R-HSA-4420117 Reaction Name: VEGFR2 autophosphorylates See in Reactome R-HSA-4420121 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-4420121 Reaction Name: SFKs phosphorylate PLCG1 See in Reactome R-HSA-4420128 ( R-HSA-4420097 ) R-HSA-4420128 Reaction Name: SRC-1 phosphorylates SHB See in Reactome R-HSA-4420140 ( R-HSA-4420097 ) R-HSA-4420140 Reaction Name: SRC1-1 binds SH2D2A and is recruited to VEGFR2 See in Reactome R-HSA-4420143 ( R-HSA-4420097 ) R-HSA-4420143 Reaction Name: p-6Y-VEGFR2 binds SH2D2A See in Reactome R-HSA-4420153 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-4420153 Reaction Name: p-6Y-VEGFR2 binds PLCG1 See in Reactome R-HSA-4420202 ( R-HSA-4420097; R-HSA-5218921 ) R-HSA-4420202 Reaction Name: PLCG1 disassociates from VEGFR2 and translocate to PM See in Reactome R-HSA-4420206 ( R-HSA-4420097 ) R-HSA-4420206 Reaction Name: Phosphorylation of SRC-1 See in Reactome R-HSA-5218640 ( R-HSA-4420097 ) R-HSA-5218640 Reaction Name: SRC-1 phosphorylates p-Y397-PTK2 See in Reactome R-HSA-5218642 ( R-HSA-4420097 ) R-HSA-5218642 Reaction Name: PTK2 autophosphorylates See in Reactome R-HSA-5218643 ( R-HSA-4420097 ) R-HSA-5218643 Reaction Name: HSP90AA1 binds p-6Y-VEGFR2 See in Reactome R-HSA-5218645 ( R-HSA-4420097 ) R-HSA-5218645 Reaction Name: SRC-1 binds p-Y397-PTK2 See in Reactome R-HSA-5218804 ( R-HSA-4420097 ) R-HSA-5218804 Reaction Name: p38 MAPK activation by VEGFR See in Reactome R-HSA-5218806 ( R-HSA-4420097 ) R-HSA-5218806 Reaction Name: FYN autophosphorylates See in Reactome R-HSA-5218809 ( R-HSA-4420097 ) R-HSA-5218809 Reaction Name: PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 See in Reactome R-HSA-5218811 ( R-HSA-4420097 ) R-HSA-5218811 Reaction Name: DOCK180:ELMO binds CRK See in Reactome R-HSA-5218812 ( R-HSA-4420097 ) R-HSA-5218812 Reaction Name: FYN phosphorylates PAK2 See in Reactome R-HSA-5218814 ( R-HSA-4420097 ) R-HSA-5218814 Reaction Name: PAK2 autophorylates See in Reactome R-HSA-5218815 ( R-HSA-4420097 ) R-HSA-5218815 Reaction Name: p-6Y-VEGFR2 binds NCK See in Reactome R-HSA-5218818 ( R-HSA-4420097 ) R-HSA-5218818 Reaction Name: Integrin alphaVbeta3 binds p-6Y-VEGFR2 See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218820 ( R-HSA-4420097 ) R-HSA-5218820 Reaction Name: Src kinases phosphorylate VAV See in Reactome R-HSA-5218822 ( R-HSA-4420097 ) R-HSA-5218822 Reaction Name: CRK binds BCAR1 and or PXN See in Reactome R-HSA-5218824 ( R-HSA-4420097 ) R-HSA-5218824 Reaction Name: p-6Y-VEGFR2 binds FYN See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5218828 ( R-HSA-4420097 ) R-HSA-5218828 Reaction Name: PTK2/SRC-1 phosphorylates BCAR1 See in Reactome R-HSA-5218830 ( R-HSA-4420097 ) R-HSA-5218830 Reaction Name: SRC-1 phosphorylates PTK2-beta See in Reactome R-HSA-5218832 ( R-HSA-4420097 ) R-HSA-5218832 Reaction Name: CDC42:GTP binds PAK2 See in Reactome R-HSA-5218836 ( R-HSA-4420097 ) R-HSA-5218836 Reaction Name: PTK2beta binds alphaVbeta3 See in Reactome R-HSA-5218838 ( R-HSA-4420097 ) R-HSA-5218838 Reaction Name: PXN binds p-6Y,S732-PTK2 See in Reactome R-HSA-5218839 ( R-HSA-4420097 ) R-HSA-5218839 Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1 See in Reactome R-HSA-5218847 ( R-HSA-4420097 ) R-HSA-5218847 Reaction Name: PAK2 binds NCK See in Reactome R-HSA-5218851 ( R-HSA-4420097 ) R-HSA-5218851 Reaction Name: p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5218854 ( R-HSA-4420097 ) R-HSA-5218854 Reaction Name: p-Y420-FYN is phosphorylated on S21 See in Reactome R-HSA-5218855 ( R-HSA-4420097 ) R-HSA-5218855 Reaction Name: BCAR1 binds p-7Y-PTK2 See in Reactome R-HSA-5357429 ( R-HSA-4420097 ) R-HSA-5357429 Reaction Name: AXL autophosphorylates on Y772 and Y814 See in Reactome R-HSA-5357432 ( R-HSA-4420097 ) R-HSA-5357432 Reaction Name: AXL binds SRC-1 See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-9691215 ( R-HSA-4420097 ) R-HSA-9691215 Reaction Name: VEGFA-165 dimer binds VEGFR2 dimer See in Reactome
MONDO:0032913	FLT4	P35916	2.7.10.1	R-HSA-195399 R-HSA-195399 Reactome Name: VEGF binds to VEGFR leading to receptor dimerization See in Reactome R-HSA-9013695 R-HSA-9013695 Reactome Name: NOTCH4 Intracellular Domain Regulates Transcription See in Reactome	R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-194313 R-HSA-194313 Reactome Name: VEGF ligand-receptor interactions See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-194308 ( R-HSA-195399 ) R-HSA-194308 Reaction Name: VEGF-C,D bind to VEGFR3 leading to receptor dimerization See in Reactome R-HSA-9604471 ( R-HSA-9013695 ) R-HSA-9604471 Reaction Name: FLT4 gene expression is stimulated by NOTCH4 See in Reactome