DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-193807)

Number of enzymes:	8
Number of disease:	9
Number of reactomes:	11
Number of reactions:	37

Search results (Reactome ID: R-HSA-193807)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001071	CYP27A1	Q02318	1.14.15.15	R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-191999 ( R-HSA-192105; R-HSA-193368 ) R-HSA-191999 Reaction Name: CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol See in Reactome R-HSA-192042 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192042 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al See in Reactome R-HSA-192054 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192054 Reaction Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) See in Reactome R-HSA-192123 ( R-HSA-192105; R-HSA-193807; R-HSA-211976 ) R-HSA-192123 Reaction Name: CYP27A1 27-hydroxylates CHOL See in Reactome R-HSA-193393 ( R-HSA-192105; R-HSA-193368 ) R-HSA-193393 Reaction Name: 5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol See in Reactome R-HSA-193460 ( R-HSA-192105; R-HSA-193368 ) R-HSA-193460 Reaction Name: 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) See in Reactome R-HSA-193497 ( R-HSA-192105; R-HSA-193368 ) R-HSA-193497 Reaction Name: 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al See in Reactome R-HSA-193713 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193713 Reaction Name: 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) See in Reactome R-HSA-193719 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193719 Reaction Name: 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al See in Reactome R-HSA-193737 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193737 Reaction Name: 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) See in Reactome R-HSA-193780 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193780 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al See in Reactome R-HSA-193787 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193787 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol See in Reactome R-HSA-193792 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193792 Reaction Name: CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol See in Reactome
MONDO:0007781	PTGIS	Q16647	4.2.1.152 5.3.99.4	R-HSA-197264 R-HSA-197264 Reactome Name: Nicotinamide salvaging See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-211994 R-HSA-211994 Reactome Name: Sterols are 12-hydroxylated by CYP8B1 See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome R-HSA-2162123 R-HSA-2162123 Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) See in Reactome R-HSA-211979 R-HSA-211979 Reactome Name: Eicosanoids See in Reactome	R-HSA-196807 R-HSA-196807 Reactome Name: Nicotinate metabolism See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-192157 ( R-HSA-193368; R-HSA-211994 ) R-HSA-192157 Reaction Name: CYP8B1 12-hydroxylates 4CHOL7aOLONE See in Reactome R-HSA-193709 ( R-HSA-193775; R-HSA-211994 ) R-HSA-193709 Reaction Name: CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL See in Reactome R-HSA-193845 ( R-HSA-193807; R-HSA-211994 ) R-HSA-193845 Reaction Name: CYP8B1 12-hydroxylates 4CHOL7a,27DONE See in Reactome R-HSA-76496 ( R-HSA-197264; R-HSA-211979; R-HSA-2162123 ) R-HSA-76496 Reaction Name: PTGIS, CYP8A1 isomerise PGH2 to PGI2 See in Reactome
MONDO:0008948	CYP27A1	Q02318	1.14.15.15	R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-191999 ( R-HSA-192105; R-HSA-193368 ) R-HSA-191999 Reaction Name: CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol See in Reactome R-HSA-192042 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192042 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al See in Reactome R-HSA-192054 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192054 Reaction Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) See in Reactome R-HSA-192123 ( R-HSA-192105; R-HSA-193807; R-HSA-211976 ) R-HSA-192123 Reaction Name: CYP27A1 27-hydroxylates CHOL See in Reactome R-HSA-193393 ( R-HSA-192105; R-HSA-193368 ) R-HSA-193393 Reaction Name: 5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol See in Reactome R-HSA-193460 ( R-HSA-192105; R-HSA-193368 ) R-HSA-193460 Reaction Name: 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) See in Reactome R-HSA-193497 ( R-HSA-192105; R-HSA-193368 ) R-HSA-193497 Reaction Name: 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al See in Reactome R-HSA-193713 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193713 Reaction Name: 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) See in Reactome R-HSA-193719 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193719 Reaction Name: 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al See in Reactome R-HSA-193737 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193737 Reaction Name: 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) See in Reactome R-HSA-193780 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193780 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al See in Reactome R-HSA-193787 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193787 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol See in Reactome R-HSA-193792 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193792 Reaction Name: CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol See in Reactome
MONDO:0009339	AKR1D1	P51857	1.3.1.3	R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-192033 ( R-HSA-193368 ) R-HSA-192033 Reaction Name: 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one See in Reactome R-HSA-192067 ( R-HSA-193368 ) R-HSA-192067 Reaction Name: 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one See in Reactome R-HSA-193746 ( R-HSA-193775 ) R-HSA-193746 Reaction Name: 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one See in Reactome R-HSA-193755 ( R-HSA-193775 ) R-HSA-193755 Reaction Name: 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one See in Reactome R-HSA-193821 ( R-HSA-193807 ) R-HSA-193821 Reaction Name: 4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one See in Reactome R-HSA-193824 ( R-HSA-193807 ) R-HSA-193824 Reaction Name: 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one See in Reactome
MONDO:0010047	CYP7B1	O75881	1.14.14.26 1.14.14.29	R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-191972 ( R-HSA-192105; R-HSA-193807 ) R-HSA-191972 Reaction Name: 27-hydroxycholesterol is 7alpha-hydroxylated See in Reactome R-HSA-192051 ( R-HSA-192105; R-HSA-193368; R-HSA-211976 ) R-HSA-192051 Reaction Name: CYP7A1 7-hydroxylates CHOL See in Reactome R-HSA-192065 ( R-HSA-192105; R-HSA-211976 ) R-HSA-192065 Reaction Name: CYP7B1 7-hydroxylates 25OH-CHOL See in Reactome
MONDO:0011906	HSD3B7	Q9H2F3	1.1.1.- 1.1.1.181	R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-192097 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192097 Reaction Name: 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one See in Reactome R-HSA-193789 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193789 Reaction Name: Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one See in Reactome R-HSA-193816 ( R-HSA-192105; R-HSA-193807 ) R-HSA-193816 Reaction Name: Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one See in Reactome
MONDO:0013439	CYP7B1	O75881	1.14.14.26 1.14.14.29	R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-191972 ( R-HSA-192105; R-HSA-193807 ) R-HSA-191972 Reaction Name: 27-hydroxycholesterol is 7alpha-hydroxylated See in Reactome R-HSA-192051 ( R-HSA-192105; R-HSA-193368; R-HSA-211976 ) R-HSA-192051 Reaction Name: CYP7A1 7-hydroxylates CHOL See in Reactome R-HSA-192065 ( R-HSA-192105; R-HSA-211976 ) R-HSA-192065 Reaction Name: CYP7B1 7-hydroxylates 25OH-CHOL See in Reactome
MONDO:0013664	AKR1C4	P17516	1.1.1.62 1.1.1.- 1.1.1.357 1.1.1.209 1.1.1.53 1.1.1.51 1.1.1.225 1.1.1.210	R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-975634 R-HSA-975634 Reactome Name: Retinoid metabolism and transport See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-2187338 R-HSA-2187338 Reactome Name: Visual phototransduction See in Reactome R-HSA-6806667 R-HSA-6806667 Reactome Name: Metabolism of fat-soluble vitamins See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-9709957 R-HSA-9709957 Reactome Name: Sensory Perception See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Sensory Perception Metabolism	R-HSA-192036 ( R-HSA-193368 ) R-HSA-192036 Reaction Name: 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol See in Reactome R-HSA-192160 ( R-HSA-193368 ) R-HSA-192160 Reaction Name: 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol See in Reactome R-HSA-193758 ( R-HSA-193775 ) R-HSA-193758 Reaction Name: 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol See in Reactome R-HSA-193781 ( R-HSA-193775 ) R-HSA-193781 Reaction Name: 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol See in Reactome R-HSA-193800 ( R-HSA-193807 ) R-HSA-193800 Reaction Name: 5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol See in Reactome R-HSA-193841 ( R-HSA-193807 ) R-HSA-193841 Reaction Name: 5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol See in Reactome R-HSA-2855252 ( R-HSA-975634 ) R-HSA-2855252 Reaction Name: AKRs reduce RBP2:atRAL to RBP2:atROL See in Reactome
MONDO:0013664	AKR1C2	P52895	1.3.1.20 1.1.1.62 1.1.1.357 1.1.1.112 1.-.-.- 1.1.1.209 1.1.1.53	R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-192036 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192036 Reaction Name: 5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol See in Reactome R-HSA-192160 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192160 Reaction Name: 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol See in Reactome R-HSA-193758 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193758 Reaction Name: 5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol See in Reactome R-HSA-193781 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193781 Reaction Name: 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol See in Reactome R-HSA-193800 ( R-HSA-192105; R-HSA-193807 ) R-HSA-193800 Reaction Name: 5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol See in Reactome R-HSA-193841 ( R-HSA-192105; R-HSA-193807 ) R-HSA-193841 Reaction Name: 5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol See in Reactome
MONDO:0016203	CYP7A1	P22680	1.14.14.26 1.14.14.23	R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-191972 ( R-HSA-192105; R-HSA-193807 ) R-HSA-191972 Reaction Name: 27-hydroxycholesterol is 7alpha-hydroxylated See in Reactome R-HSA-192051 ( R-HSA-192105; R-HSA-193368; R-HSA-211976 ) R-HSA-192051 Reaction Name: CYP7A1 7-hydroxylates CHOL See in Reactome R-HSA-192065 ( R-HSA-192105; R-HSA-211976 ) R-HSA-192065 Reaction Name: CYP7B1 7-hydroxylates 25OH-CHOL See in Reactome R-HSA-1989746 ( R-HSA-1989781 ) R-HSA-1989746 Reaction Name: Expression of CYP7A1 See in Reactome