DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-193368)

Number of enzymes:	14
Number of disease:	22
Number of reactomes:	17
Number of reactions:	65

Search results (Reactome ID: R-HSA-193368)

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DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001071	CYP27A1	Q02318	1.14.15.15	R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-191999 ( R-HSA-193368 ) R-HSA-191999 Reaction Name: CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol See in Reactome R-HSA-192042 ( R-HSA-193368 ) R-HSA-192042 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al See in Reactome R-HSA-192054 ( R-HSA-193368 ) R-HSA-192054 Reaction Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) See in Reactome R-HSA-192123 ( R-HSA-193807; R-HSA-211976 ) R-HSA-192123 Reaction Name: CYP27A1 27-hydroxylates CHOL See in Reactome R-HSA-193393 ( R-HSA-193368 ) R-HSA-193393 Reaction Name: 5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol See in Reactome R-HSA-193460 ( R-HSA-193368 ) R-HSA-193460 Reaction Name: 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) See in Reactome R-HSA-193497 ( R-HSA-193368 ) R-HSA-193497 Reaction Name: 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al See in Reactome R-HSA-193713 ( R-HSA-193775 ) R-HSA-193713 Reaction Name: 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) See in Reactome R-HSA-193719 ( R-HSA-193775 ) R-HSA-193719 Reaction Name: 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al See in Reactome R-HSA-193737 ( R-HSA-193775 ) R-HSA-193737 Reaction Name: 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) See in Reactome R-HSA-193780 ( R-HSA-193775 ) R-HSA-193780 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al See in Reactome R-HSA-193787 ( R-HSA-193775 ) R-HSA-193787 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol See in Reactome R-HSA-193792 ( R-HSA-193775 ) R-HSA-193792 Reaction Name: CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol See in Reactome
MONDO:0007781	PTGIS	Q16647	4.2.1.152 5.3.99.4	R-HSA-197264 R-HSA-197264 Reactome Name: Nicotinamide salvaging See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-211994 R-HSA-211994 Reactome Name: Sterols are 12-hydroxylated by CYP8B1 See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome R-HSA-2162123 R-HSA-2162123 Reactome Name: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) See in Reactome R-HSA-211979 R-HSA-211979 Reactome Name: Eicosanoids See in Reactome	R-HSA-196807 R-HSA-196807 Reactome Name: Nicotinate metabolism See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-192157 ( R-HSA-192105; R-HSA-193368; R-HSA-211976; R-HSA-211994 ) R-HSA-192157 Reaction Name: CYP8B1 12-hydroxylates 4CHOL7aOLONE See in Reactome R-HSA-193709 ( R-HSA-192105; R-HSA-193775; R-HSA-211976; R-HSA-211994 ) R-HSA-193709 Reaction Name: CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL See in Reactome R-HSA-193845 ( R-HSA-192105; R-HSA-193807; R-HSA-211976; R-HSA-211994 ) R-HSA-193845 Reaction Name: CYP8B1 12-hydroxylates 4CHOL7a,27DONE See in Reactome R-HSA-76496 ( R-HSA-197264; R-HSA-211979; R-HSA-2162123 ) R-HSA-76496 Reaction Name: PTGIS, CYP8A1 isomerise PGH2 to PGI2 See in Reactome
MONDO:0008948	CYP27A1	Q02318	1.14.15.15	R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-191999 ( R-HSA-193368 ) R-HSA-191999 Reaction Name: CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol See in Reactome R-HSA-192042 ( R-HSA-193368 ) R-HSA-192042 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al See in Reactome R-HSA-192054 ( R-HSA-193368 ) R-HSA-192054 Reaction Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) See in Reactome R-HSA-192123 ( R-HSA-193807; R-HSA-211976 ) R-HSA-192123 Reaction Name: CYP27A1 27-hydroxylates CHOL See in Reactome R-HSA-193393 ( R-HSA-193368 ) R-HSA-193393 Reaction Name: 5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol See in Reactome R-HSA-193460 ( R-HSA-193368 ) R-HSA-193460 Reaction Name: 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) See in Reactome R-HSA-193497 ( R-HSA-193368 ) R-HSA-193497 Reaction Name: 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al See in Reactome R-HSA-193713 ( R-HSA-193775 ) R-HSA-193713 Reaction Name: 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) See in Reactome R-HSA-193719 ( R-HSA-193775 ) R-HSA-193719 Reaction Name: 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al See in Reactome R-HSA-193737 ( R-HSA-193775 ) R-HSA-193737 Reaction Name: 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) See in Reactome R-HSA-193780 ( R-HSA-193775 ) R-HSA-193780 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al See in Reactome R-HSA-193787 ( R-HSA-193775 ) R-HSA-193787 Reaction Name: 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol See in Reactome R-HSA-193792 ( R-HSA-193775 ) R-HSA-193792 Reaction Name: CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol See in Reactome
MONDO:0008967	AMACR	Q9UHK6	5.1.99.4	R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome R-HSA-389887 R-HSA-389887 Reactome Name: Beta-oxidation of pristanoyl-CoA See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Protein localization Metabolism	R-HSA-192056 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192056 Reaction Name: Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA See in Reactome R-HSA-193452 ( R-HSA-192105; R-HSA-193368 ) R-HSA-193452 Reaction Name: Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA See in Reactome R-HSA-193736 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193736 Reaction Name: Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA See in Reactome R-HSA-193763 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193763 Reaction Name: Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA See in Reactome R-HSA-389897 ( R-HSA-389887 ) R-HSA-389897 Reaction Name: Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome
MONDO:0009300	HSD17B4	P51659	1.1.1.n12 4.2.1.119 4.2.1.107	R-HSA-389887 R-HSA-389887 Reactome Name: Beta-oxidation of pristanoyl-CoA See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-9033500 R-HSA-9033500 Reactome Name: TYSND1 cleaves peroxisomal proteins See in Reactome R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Protein localization Metabolism	R-HSA-192331 ( R-HSA-193368 ) R-HSA-192331 Reaction Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA See in Reactome R-HSA-193455 ( R-HSA-193368 ) R-HSA-193455 Reaction Name: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA See in Reactome R-HSA-193508 ( R-HSA-193368 ) R-HSA-193508 Reaction Name: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA See in Reactome R-HSA-193535 ( R-HSA-193368 ) R-HSA-193535 Reaction Name: 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA See in Reactome R-HSA-2066778 ( R-HSA-2046106 ) R-HSA-2066778 Reaction Name: Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA See in Reactome R-HSA-2066780 ( R-HSA-2046106 ) R-HSA-2066780 Reaction Name: Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA See in Reactome R-HSA-389986 ( R-HSA-389887 ) R-HSA-389986 Reaction Name: trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA See in Reactome R-HSA-389995 ( R-HSA-389887 ) R-HSA-389995 Reaction Name: 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ See in Reactome R-HSA-390251 ( R-HSA-390247 ) R-HSA-390251 Reaction Name: HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA See in Reactome R-HSA-390252 ( R-HSA-390247 ) R-HSA-390252 Reaction Name: HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome R-HSA-9033530 ( R-HSA-9033241; R-HSA-9033500 ) R-HSA-9033530 Reaction Name: TYSND1 cleaves HSD17B4 See in Reactome
MONDO:0009339	AKR1D1	P51857	1.3.1.3	R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-193775 R-HSA-193775 Reactome Name: Synthesis of bile acids and bile salts via 24-hydroxycholesterol See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-192033 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192033 Reaction Name: 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one See in Reactome R-HSA-192067 ( R-HSA-192105; R-HSA-193368 ) R-HSA-192067 Reaction Name: 4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one See in Reactome R-HSA-193746 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193746 Reaction Name: 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one See in Reactome R-HSA-193755 ( R-HSA-192105; R-HSA-193775 ) R-HSA-193755 Reaction Name: 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one See in Reactome R-HSA-193821 ( R-HSA-192105; R-HSA-193807 ) R-HSA-193821 Reaction Name: 4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one See in Reactome R-HSA-193824 ( R-HSA-192105; R-HSA-193807 ) R-HSA-193824 Reaction Name: 4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one See in Reactome
MONDO:0009855	HSD17B4	P51659	1.1.1.n12 4.2.1.119 4.2.1.107	R-HSA-389887 R-HSA-389887 Reactome Name: Beta-oxidation of pristanoyl-CoA See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-9033500 R-HSA-9033500 Reactome Name: TYSND1 cleaves peroxisomal proteins See in Reactome R-HSA-9033241 R-HSA-9033241 Reactome Name: Peroxisomal protein import See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Protein localization Metabolism	R-HSA-192331 ( R-HSA-193368 ) R-HSA-192331 Reaction Name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA See in Reactome R-HSA-193455 ( R-HSA-193368 ) R-HSA-193455 Reaction Name: (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA See in Reactome R-HSA-193508 ( R-HSA-193368 ) R-HSA-193508 Reaction Name: (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA See in Reactome R-HSA-193535 ( R-HSA-193368 ) R-HSA-193535 Reaction Name: 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA See in Reactome R-HSA-2066778 ( R-HSA-2046106 ) R-HSA-2066778 Reaction Name: Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA See in Reactome R-HSA-2066780 ( R-HSA-2046106 ) R-HSA-2066780 Reaction Name: Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA See in Reactome R-HSA-389986 ( R-HSA-389887 ) R-HSA-389986 Reaction Name: trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA See in Reactome R-HSA-389995 ( R-HSA-389887 ) R-HSA-389995 Reaction Name: 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ See in Reactome R-HSA-390251 ( R-HSA-390247 ) R-HSA-390251 Reaction Name: HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA See in Reactome R-HSA-390252 ( R-HSA-390247 ) R-HSA-390252 Reaction Name: HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S See in Reactome R-HSA-9033233 ( R-HSA-9033241 ) R-HSA-9033233 Reaction Name: PEX5S,L binds cargo proteins containing PTS1 See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S See in Reactome R-HSA-9033235 ( R-HSA-9033241 ) R-HSA-9033235 Reaction Name: Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S See in Reactome R-HSA-9033236 ( R-HSA-9033241 ) R-HSA-9033236 Reaction Name: PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) See in Reactome R-HSA-9033530 ( R-HSA-9033241; R-HSA-9033500 ) R-HSA-9033530 Reaction Name: TYSND1 cleaves HSD17B4 See in Reactome
MONDO:0010047	CYP7B1	O75881	1.14.14.26 1.14.14.29	R-HSA-211976 R-HSA-211976 Reactome Name: Endogenous sterols See in Reactome R-HSA-193807 R-HSA-193807 Reactome Name: Synthesis of bile acids and bile salts via 27-hydroxycholesterol See in Reactome R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome	R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-211897 R-HSA-211897 Reactome Name: Cytochrome P450 - arranged by substrate type See in Reactome R-HSA-211945 R-HSA-211945 Reactome Name: Phase I - Functionalization of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-191972 ( R-HSA-192105; R-HSA-193807 ) R-HSA-191972 Reaction Name: 27-hydroxycholesterol is 7alpha-hydroxylated See in Reactome R-HSA-192051 ( R-HSA-192105; R-HSA-193368; R-HSA-211976 ) R-HSA-192051 Reaction Name: CYP7A1 7-hydroxylates CHOL See in Reactome R-HSA-192065 ( R-HSA-192105; R-HSA-211976 ) R-HSA-192065 Reaction Name: CYP7B1 7-hydroxylates 25OH-CHOL See in Reactome
MONDO:0011156	ABCB11	O95342	7.6.2.-	R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-159418 R-HSA-159418 Reactome Name: Recycling of bile acids and salts See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-193362 ( R-HSA-159418; R-HSA-192105; R-HSA-193368 ) R-HSA-193362 Reaction Name: ABCB11 transports bile salts from cytosol to extracellular region See in Reactome
MONDO:0011214	ABCB11	O95342	7.6.2.-	R-HSA-193368 R-HSA-193368 Reactome Name: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol See in Reactome R-HSA-159418 R-HSA-159418 Reactome Name: Recycling of bile acids and salts See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-194068 R-HSA-194068 Reactome Name: Bile acid and bile salt metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-192105 R-HSA-192105 Reactome Name: Synthesis of bile acids and bile salts See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-193362 ( R-HSA-159418; R-HSA-192105; R-HSA-193368 ) R-HSA-193362 Reaction Name: ABCB11 transports bile salts from cytosol to extracellular region See in Reactome

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