DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-193048)

Number of enzymes:	5
Number of disease:	8
Number of reactomes:	5
Number of reactions:	14

Search results (Reactome ID: R-HSA-193048)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005387	CYP17A1	P05093	1.14.14.32 1.14.14.19	R-HSA-193048 R-HSA-193048 Reactome Name: Androgen biosynthesis See in Reactome R-HSA-194002 R-HSA-194002 Reactome Name: Glucocorticoid biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196071 R-HSA-196071 Reactome Name: Metabolism of steroid hormones See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-193068 ( R-HSA-193048; R-HSA-194002 ) R-HSA-193068 Reaction Name: CYP17A1 17-hydroxylates PREG See in Reactome R-HSA-193070 ( R-HSA-193048 ) R-HSA-193070 Reaction Name: CYP17A1 cleaves 17aHPREG to DHA See in Reactome R-HSA-193072 ( R-HSA-193048 ) R-HSA-193072 Reaction Name: CYP17A1 17-hydroxylates P4 to 17aHPROG See in Reactome R-HSA-193099 ( R-HSA-193048 ) R-HSA-193099 Reaction Name: CYP17A1 cleaves 17aHPROG to ANDST See in Reactome
MONDO:0005518	HSD17B3	P37058	1.1.1.64 1.1.1.62	R-HSA-193048 R-HSA-193048 Reactome Name: Androgen biosynthesis See in Reactome R-HSA-75876 R-HSA-75876 Reactome Name: Synthesis of very long-chain fatty acyl-CoAs See in Reactome	R-HSA-75105 R-HSA-75105 Reactome Name: Fatty acyl-CoA biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-196071 R-HSA-196071 Reactome Name: Metabolism of steroid hormones See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-193064 ( R-HSA-193048 ) R-HSA-193064 Reaction Name: HSD17B3-like proteins reducde ANDST to TEST See in Reactome R-HSA-548818 ( R-HSA-75876 ) R-HSA-548818 Reaction Name: HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA See in Reactome
MONDO:0008727	HSD3B2	P26439	5.3.3.1 1.1.1.145	R-HSA-193048 R-HSA-193048 Reactome Name: Androgen biosynthesis See in Reactome R-HSA-194002 R-HSA-194002 Reactome Name: Glucocorticoid biosynthesis See in Reactome R-HSA-193993 R-HSA-193993 Reactome Name: Mineralocorticoid biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196071 R-HSA-196071 Reactome Name: Metabolism of steroid hormones See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-193052 ( R-HSA-193993 ) R-HSA-193052 Reaction Name: Pregn-5-ene-3,20-dione isomerizes to progesterone See in Reactome R-HSA-193073 ( R-HSA-193048 ) R-HSA-193073 Reaction Name: HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST See in Reactome R-HSA-193961 ( R-HSA-194002 ) R-HSA-193961 Reaction Name: Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone See in Reactome R-HSA-196350 ( R-HSA-193993 ) R-HSA-196350 Reaction Name: Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione See in Reactome R-HSA-196372 ( R-HSA-194002 ) R-HSA-196372 Reaction Name: 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol See in Reactome
MONDO:0009916	HSD17B3	P37058	1.1.1.64 1.1.1.62	R-HSA-193048 R-HSA-193048 Reactome Name: Androgen biosynthesis See in Reactome R-HSA-75876 R-HSA-75876 Reactome Name: Synthesis of very long-chain fatty acyl-CoAs See in Reactome	R-HSA-75105 R-HSA-75105 Reactome Name: Fatty acyl-CoA biosynthesis See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-196071 R-HSA-196071 Reactome Name: Metabolism of steroid hormones See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-193064 ( R-HSA-193048 ) R-HSA-193064 Reaction Name: HSD17B3-like proteins reducde ANDST to TEST See in Reactome R-HSA-548818 ( R-HSA-75876 ) R-HSA-548818 Reaction Name: HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA See in Reactome
MONDO:0009923	SRD5A2	P31213	1.3.1.22	R-HSA-193048 R-HSA-193048 Reactome Name: Androgen biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196071 R-HSA-196071 Reactome Name: Metabolism of steroid hormones See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-9705713 ( R-HSA-193048 ) R-HSA-9705713 Reaction Name: SRD5A2 dehydrogenates TEST to DHTEST See in Reactome
MONDO:0012885	SRD5A3	Q9H8P0	1.3.1.22 1.3.1.94	R-HSA-193048 R-HSA-193048 Reactome Name: Androgen biosynthesis See in Reactome R-HSA-446199 R-HSA-446199 Reactome Name: Synthesis of Dolichyl-phosphate See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-196071 R-HSA-196071 Reactome Name: Metabolism of steroid hormones See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism of proteins Metabolism	R-HSA-4419979 ( R-HSA-446199 ) R-HSA-4419979 Reaction Name: SRD5A3 reduces pPNOL to DCHOL See in Reactome R-HSA-9705714 ( R-HSA-193048 ) R-HSA-9705714 Reaction Name: SRD5A3 dehydrogenates TEST to DHTEST See in Reactome
MONDO:0012991	SRD5A3	Q9H8P0	1.3.1.22 1.3.1.94	R-HSA-193048 R-HSA-193048 Reactome Name: Androgen biosynthesis See in Reactome R-HSA-446199 R-HSA-446199 Reactome Name: Synthesis of Dolichyl-phosphate See in Reactome	R-HSA-446219 R-HSA-446219 Reactome Name: Synthesis of substrates in N-glycan biosythesis See in Reactome R-HSA-446193 R-HSA-446193 Reactome Name: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-446203 R-HSA-446203 Reactome Name: Asparagine N-linked glycosylation See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-196071 R-HSA-196071 Reactome Name: Metabolism of steroid hormones See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism of proteins Metabolism	R-HSA-4419979 ( R-HSA-446199 ) R-HSA-4419979 Reaction Name: SRD5A3 reduces pPNOL to DCHOL See in Reactome R-HSA-9705714 ( R-HSA-193048 ) R-HSA-9705714 Reaction Name: SRD5A3 dehydrogenates TEST to DHTEST See in Reactome
MONDO:0019597	CYP17A1	P05093	1.14.14.32 1.14.14.19	R-HSA-193048 R-HSA-193048 Reactome Name: Androgen biosynthesis See in Reactome R-HSA-194002 R-HSA-194002 Reactome Name: Glucocorticoid biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196071 R-HSA-196071 Reactome Name: Metabolism of steroid hormones See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-193068 ( R-HSA-193048; R-HSA-194002 ) R-HSA-193068 Reaction Name: CYP17A1 17-hydroxylates PREG See in Reactome R-HSA-193070 ( R-HSA-193048 ) R-HSA-193070 Reaction Name: CYP17A1 cleaves 17aHPREG to DHA See in Reactome R-HSA-193072 ( R-HSA-193048 ) R-HSA-193072 Reaction Name: CYP17A1 17-hydroxylates P4 to 17aHPROG See in Reactome R-HSA-193099 ( R-HSA-193048 ) R-HSA-193099 Reaction Name: CYP17A1 cleaves 17aHPROG to ANDST See in Reactome