DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-189483)

Number of enzymes:	5
Number of disease:	8
Number of reactomes:	12
Number of reactions:	23

Search results (Reactome ID: R-HSA-189483)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007745	UGT1A1	P22309	2.4.1.17	R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome R-HSA-156588 R-HSA-156588 Reactome Name: Glucuronidation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174931 ( R-HSA-156588 ) R-HSA-174931 Reaction Name: UGTs transfer GlcA from UDP-GlcA to O-centre substrates See in Reactome R-HSA-9632038 ( R-HSA-156588; R-HSA-189483 ) R-HSA-9632038 Reaction Name: UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG See in Reactome R-HSA-9632039 ( R-HSA-156588; R-HSA-189483 ) R-HSA-9632039 Reaction Name: UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG See in Reactome
MONDO:0009380	ABCC2	Q92887	7.6.2.2 7.6.2.3 7.6.2.-	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism Transport of small molecules	R-HSA-1454916 ( R-HSA-382556 ) R-HSA-1454916 Reaction Name: The ABCC family mediates organic anion transport See in Reactome R-HSA-5679041 ( R-HSA-189483 ) R-HSA-5679041 Reaction Name: ABCC2 transports BMG,BDG from cytosol to extracellular region See in Reactome
MONDO:0009383	UGT1A1	P22309	2.4.1.17	R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome R-HSA-156588 R-HSA-156588 Reactome Name: Glucuronidation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174931 ( R-HSA-156588 ) R-HSA-174931 Reaction Name: UGTs transfer GlcA from UDP-GlcA to O-centre substrates See in Reactome R-HSA-9632038 ( R-HSA-156588; R-HSA-189483 ) R-HSA-9632038 Reaction Name: UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG See in Reactome R-HSA-9632039 ( R-HSA-156588; R-HSA-189483 ) R-HSA-9632039 Reaction Name: UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG See in Reactome
MONDO:0011725	UGT1A1	P22309	2.4.1.17	R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome R-HSA-156588 R-HSA-156588 Reactome Name: Glucuronidation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174931 ( R-HSA-156588 ) R-HSA-174931 Reaction Name: UGTs transfer GlcA from UDP-GlcA to O-centre substrates See in Reactome R-HSA-9632038 ( R-HSA-156588; R-HSA-189483 ) R-HSA-9632038 Reaction Name: UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG See in Reactome R-HSA-9632039 ( R-HSA-156588; R-HSA-189483 ) R-HSA-9632039 Reaction Name: UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG See in Reactome
MONDO:0013536	HMOX1	P09601	1.14.14.18	R-HSA-9707616 R-HSA-9707616 Reactome Name: Heme signaling See in Reactome R-HSA-9707587 R-HSA-9707587 Reactome Name: Regulation of HMOX1 expression and activity See in Reactome R-HSA-844456 R-HSA-844456 Reactome Name: The NLRP3 inflammasome See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9707564 R-HSA-9707564 Reactome Name: Cytoprotection by HMOX1 See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9609523 R-HSA-9609523 Reactome Name: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane See in Reactome R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-622312 R-HSA-622312 Reactome Name: Inflammasomes See in Reactome	Cellular responses to stimuli Protein localization Immune System Transport of small molecules Metabolism	R-HSA-1250272 ( R-HSA-844456; R-HSA-9707564 ) R-HSA-1250272 Reaction Name: TXNIP binds NLRP3 See in Reactome R-HSA-189398 ( R-HSA-189483; R-HSA-917937; R-HSA-9707564 ) R-HSA-189398 Reaction Name: HMOX1 dimer, HMOX2 cleave heme See in Reactome R-HSA-6797268 ( R-HSA-6785807 ) R-HSA-6797268 Reaction Name: Expression of HMOX1 See in Reactome R-HSA-9609860 ( R-HSA-9609523 ) R-HSA-9609860 Reaction Name: Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP See in Reactome R-HSA-9609899 ( R-HSA-9609523 ) R-HSA-9609899 Reaction Name: Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane See in Reactome R-HSA-9609917 ( R-HSA-9609523 ) R-HSA-9609917 Reaction Name: Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane See in Reactome R-HSA-9609921 ( R-HSA-9609523 ) R-HSA-9609921 Reaction Name: SGTA binds Tail-anchored protein See in Reactome R-HSA-9610442 ( R-HSA-9609523 ) R-HSA-9610442 Reaction Name: Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP See in Reactome R-HSA-9707645 ( R-HSA-9707564; R-HSA-9707587; R-HSA-9707616 ) R-HSA-9707645 Reaction Name: HMOX1 gene produces HMOX1 dimer See in Reactome R-HSA-9708457 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708457 Reaction Name: HM13 cleaves HMOX1 dimer See in Reactome R-HSA-9708536 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708536 Reaction Name: HMOX1 translocates from the cytosol to the nucleoplasm See in Reactome R-HSA-9708558 ( R-HSA-9707564; R-HSA-9707587 ) R-HSA-9708558 Reaction Name: HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane See in Reactome R-HSA-9709918 ( R-HSA-9707564 ) R-HSA-9709918 Reaction Name: PTK6 phosphorylates STAT3 See in Reactome R-HSA-9759176 () R-HSA-9759176 Reaction Name: NFE2L2-dependent HMOX1 gene expression See in Reactome
MONDO:0013595	BLVRA	P53004	1.3.1.24	R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome R-HSA-9707564 R-HSA-9707564 Reactome Name: Cytoprotection by HMOX1 See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Metabolism Cellular responses to stimuli	R-HSA-189384 ( R-HSA-189483; R-HSA-9707564 ) R-HSA-189384 Reaction Name: BLVRA:Zn2+, BLVRB reduce BV to BIL See in Reactome
MONDO:0021020	UGT1A1	P22309	2.4.1.17	R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome R-HSA-156588 R-HSA-156588 Reactome Name: Glucuronidation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174931 ( R-HSA-156588 ) R-HSA-174931 Reaction Name: UGTs transfer GlcA from UDP-GlcA to O-centre substrates See in Reactome R-HSA-9632038 ( R-HSA-156588; R-HSA-189483 ) R-HSA-9632038 Reaction Name: UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG See in Reactome R-HSA-9632039 ( R-HSA-156588; R-HSA-189483 ) R-HSA-9632039 Reaction Name: UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG See in Reactome
MONDO:0030058	ABCC1	P33527	7.6.2.2 7.6.2.3	R-HSA-2142691 R-HSA-2142691 Reactome Name: Synthesis of Leukotrienes (LT) and Eoxins (EX) See in Reactome R-HSA-9707564 R-HSA-9707564 Reactome Name: Cytoprotection by HMOX1 See in Reactome R-HSA-196741 R-HSA-196741 Reactome Name: Cobalamin (Cbl, vitamin B12) transport and metabolism See in Reactome R-HSA-189483 R-HSA-189483 Reactome Name: Heme degradation See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-2142753 R-HSA-2142753 Reactome Name: Arachidonic acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Transport of small molecules Metabolism	R-HSA-1454916 ( R-HSA-382556 ) R-HSA-1454916 Reaction Name: The ABCC family mediates organic anion transport See in Reactome R-HSA-266070 ( R-HSA-2142691 ) R-HSA-266070 Reaction Name: LTC4 is exported from the cytosol by ABCC1 See in Reactome R-HSA-3095901 ( R-HSA-196741 ) R-HSA-3095901 Reaction Name: ABCC1 transports cytosolic RCbl to extracellular region See in Reactome R-HSA-9661405 ( R-HSA-189483; R-HSA-9707564 ) R-HSA-9661405 Reaction Name: ABCC1 transports BIL from cytosol to extracellular region (blood) See in Reactome