DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-189451)

Number of enzymes:	9
Number of disease:	14
Number of reactomes:	2
Number of reactions:	13

Search results (Reactome ID: R-HSA-189451)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007369	CPOX	P36551	1.3.3.3	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189421 ( R-HSA-189451 ) R-HSA-189421 Reaction Name: CPO transforms COPRO3 to PPGEN9 See in Reactome
MONDO:0008294	HMBS	P08397	2.5.1.61	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189406 ( R-HSA-189451 ) R-HSA-189406 Reaction Name: 4 PBGs bind to form HMB See in Reactome
MONDO:0008295	UROD	P06132	4.1.1.37	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189425 ( R-HSA-189451 ) R-HSA-189425 Reaction Name: UROD decarboxylates URO3 to COPRO3 See in Reactome R-HSA-190182 ( R-HSA-189451 ) R-HSA-190182 Reaction Name: UROD decarboxylates URO1 to COPRO1 See in Reactome
MONDO:0008296	UROD	P06132	4.1.1.37	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189425 ( R-HSA-189451 ) R-HSA-189425 Reaction Name: UROD decarboxylates URO3 to COPRO3 See in Reactome R-HSA-190182 ( R-HSA-189451 ) R-HSA-190182 Reaction Name: UROD decarboxylates URO1 to COPRO1 See in Reactome
MONDO:0008297	PPOX	P50336	1.3.3.4	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189423 ( R-HSA-189451 ) R-HSA-189423 Reaction Name: PPO oxidises PPGEN9 to PRIN9 See in Reactome
MONDO:0008319	FECH	P22830	4.99.1.1	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189465 ( R-HSA-189451 ) R-HSA-189465 Reaction Name: FECH binds Fe2+ to PRIN9 to form heme See in Reactome
MONDO:0009068	COX10	Q12887	2.5.1.141	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-2995330 ( R-HSA-189451 ) R-HSA-2995330 Reaction Name: COX10 transforms heme to heme O See in Reactome
MONDO:0009902	UROS	P10746	4.2.1.75	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189488 ( R-HSA-189451 ) R-HSA-189488 Reaction Name: UROS transforms HMB to URO3 See in Reactome
MONDO:0010420	ALAS2	P22557	2.3.1.37	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189442 ( R-HSA-189451 ) R-HSA-189442 Reaction Name: ALAS condenses SUCC-CoA and Gly to form dALA See in Reactome
MONDO:0013000	ALAD	P13716	4.2.1.24	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism Immune System	R-HSA-189439 ( R-HSA-189451 ) R-HSA-189439 Reaction Name: ALAD condenses 2 dALAs to form PBG See in Reactome R-HSA-190141 ( R-HSA-189451 ) R-HSA-190141 Reaction Name: ALAD binds to Pb2+ See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0019799	UROD	P06132	4.1.1.37	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189425 ( R-HSA-189451 ) R-HSA-189425 Reaction Name: UROD decarboxylates URO3 to COPRO3 See in Reactome R-HSA-190182 ( R-HSA-189451 ) R-HSA-190182 Reaction Name: UROD decarboxylates URO1 to COPRO1 See in Reactome
MONDO:0020721	ALAS2	P22557	2.3.1.37	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189442 ( R-HSA-189451 ) R-HSA-189442 Reaction Name: ALAS condenses SUCC-CoA and Gly to form dALA See in Reactome
MONDO:0030048	CPOX	P36551	1.3.3.3	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-189421 ( R-HSA-189451 ) R-HSA-189421 Reaction Name: CPO transforms COPRO3 to PPGEN9 See in Reactome
MONDO:0033635	COX10	Q12887	2.5.1.141	R-HSA-189451 R-HSA-189451 Reactome Name: Heme biosynthesis See in Reactome	R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-189445 R-HSA-189445 Reactome Name: Metabolism of porphyrins See in Reactome	Metabolism	R-HSA-2995330 ( R-HSA-189451 ) R-HSA-2995330 Reaction Name: COX10 transforms heme to heme O See in Reactome