DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-187024)

Number of enzymes:	2
Number of disease:	6
Number of reactomes:	20
Number of reactions:	68

Search results (Reactome ID: R-HSA-187024)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007958	NTRK1	P04629	2.7.10.1	R-HSA-198745 R-HSA-198745 Reactome Name: Signalling to STAT3 See in Reactome R-HSA-167021 R-HSA-167021 Reactome Name: PLC-gamma1 signalling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-187042 R-HSA-187042 Reactome Name: TRKA activation by NGF See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-166538 ( R-HSA-187042 ) R-HSA-166538 Reaction Name: The bound receptor dimerizes See in Reactome R-HSA-166542 ( R-HSA-187042 ) R-HSA-166542 Reaction Name: beta-NGF dimer binds to TrkA receptor See in Reactome R-HSA-166544 ( R-HSA-187042 ) R-HSA-166544 Reaction Name: TrkA receptor autophosphorylates See in Reactome R-HSA-167019 ( R-HSA-167044 ) R-HSA-167019 Reaction Name: SHC, complexed with TrkA, is tyrosine-phosphorylated See in Reactome R-HSA-167056 ( R-HSA-167044 ) R-HSA-167056 Reaction Name: SHC binds to the activated TrkA receptor See in Reactome R-HSA-167217 ( R-HSA-167044 ) R-HSA-167217 Reaction Name: Phospho-Shc dissociates from the TrkA receptor See in Reactome R-HSA-167674 ( R-HSA-167021 ) R-HSA-167674 Reaction Name: Binding of PLCG1 to active TrkA receptor See in Reactome R-HSA-167683 ( R-HSA-167021 ) R-HSA-167683 Reaction Name: TrkA phosphorylates PLCG1 See in Reactome R-HSA-167684 ( R-HSA-167021 ) R-HSA-167684 Reaction Name: Active PLCG1 dissociates from TrkA receptor See in Reactome R-HSA-169891 ( R-HSA-170984 ) R-HSA-169891 Reaction Name: ARMS:Crk complex binds to active TrkA receptor See in Reactome R-HSA-169895 ( R-HSA-170984 ) R-HSA-169895 Reaction Name: Crk's SH3 domain engages C3G See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-169904 ( R-HSA-170984 ) R-HSA-169904 Reaction Name: C3G stimulates nucleotide exchange on Rap1 See in Reactome R-HSA-169905 ( R-HSA-170984 ) R-HSA-169905 Reaction Name: ARMS is phosphorylated by active TrkA receptor See in Reactome R-HSA-177479 ( R-HSA-177504 ) R-HSA-177479 Reaction Name: Axonal transport of NGF:Trk complexes See in Reactome R-HSA-177491 ( R-HSA-177504 ) R-HSA-177491 Reaction Name: Formation of clathrin-coated vesicle See in Reactome R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-187697 ( R-HSA-187706 ) R-HSA-187697 Reaction Name: TRKA recruits RIT and RIN See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-187746 ( R-HSA-187706 ) R-HSA-187746 Reaction Name: RIT/RIN are activated See in Reactome R-HSA-190065 ( R-HSA-187042 ) R-HSA-190065 Reaction Name: Activated TrkA receptor internalizes to endosomes See in Reactome R-HSA-198211 ( R-HSA-198203 ) R-HSA-198211 Reaction Name: Active TRKA binds IRS1/2 See in Reactome R-HSA-198295 ( R-HSA-198203 ) R-HSA-198295 Reaction Name: TRKA phosphorylates IRS See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-198732 ( R-HSA-198745 ) R-HSA-198732 Reaction Name: STAT3 activation See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome
MONDO:0009746	NTRK1	P04629	2.7.10.1	R-HSA-198745 R-HSA-198745 Reactome Name: Signalling to STAT3 See in Reactome R-HSA-167021 R-HSA-167021 Reactome Name: PLC-gamma1 signalling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-187042 R-HSA-187042 Reactome Name: TRKA activation by NGF See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-166538 ( R-HSA-187042 ) R-HSA-166538 Reaction Name: The bound receptor dimerizes See in Reactome R-HSA-166542 ( R-HSA-187042 ) R-HSA-166542 Reaction Name: beta-NGF dimer binds to TrkA receptor See in Reactome R-HSA-166544 ( R-HSA-187042 ) R-HSA-166544 Reaction Name: TrkA receptor autophosphorylates See in Reactome R-HSA-167019 ( R-HSA-167044 ) R-HSA-167019 Reaction Name: SHC, complexed with TrkA, is tyrosine-phosphorylated See in Reactome R-HSA-167056 ( R-HSA-167044 ) R-HSA-167056 Reaction Name: SHC binds to the activated TrkA receptor See in Reactome R-HSA-167217 ( R-HSA-167044 ) R-HSA-167217 Reaction Name: Phospho-Shc dissociates from the TrkA receptor See in Reactome R-HSA-167674 ( R-HSA-167021 ) R-HSA-167674 Reaction Name: Binding of PLCG1 to active TrkA receptor See in Reactome R-HSA-167683 ( R-HSA-167021 ) R-HSA-167683 Reaction Name: TrkA phosphorylates PLCG1 See in Reactome R-HSA-167684 ( R-HSA-167021 ) R-HSA-167684 Reaction Name: Active PLCG1 dissociates from TrkA receptor See in Reactome R-HSA-169891 ( R-HSA-170984 ) R-HSA-169891 Reaction Name: ARMS:Crk complex binds to active TrkA receptor See in Reactome R-HSA-169895 ( R-HSA-170984 ) R-HSA-169895 Reaction Name: Crk's SH3 domain engages C3G See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-169904 ( R-HSA-170984 ) R-HSA-169904 Reaction Name: C3G stimulates nucleotide exchange on Rap1 See in Reactome R-HSA-169905 ( R-HSA-170984 ) R-HSA-169905 Reaction Name: ARMS is phosphorylated by active TrkA receptor See in Reactome R-HSA-177479 ( R-HSA-177504 ) R-HSA-177479 Reaction Name: Axonal transport of NGF:Trk complexes See in Reactome R-HSA-177491 ( R-HSA-177504 ) R-HSA-177491 Reaction Name: Formation of clathrin-coated vesicle See in Reactome R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-187697 ( R-HSA-187706 ) R-HSA-187697 Reaction Name: TRKA recruits RIT and RIN See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-187746 ( R-HSA-187706 ) R-HSA-187746 Reaction Name: RIT/RIN are activated See in Reactome R-HSA-190065 ( R-HSA-187042 ) R-HSA-190065 Reaction Name: Activated TrkA receptor internalizes to endosomes See in Reactome R-HSA-198211 ( R-HSA-198203 ) R-HSA-198211 Reaction Name: Active TRKA binds IRS1/2 See in Reactome R-HSA-198295 ( R-HSA-198203 ) R-HSA-198295 Reaction Name: TRKA phosphorylates IRS See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-198732 ( R-HSA-198745 ) R-HSA-198732 Reaction Name: STAT3 activation See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome
MONDO:0013483	NTRK2	Q16620	2.7.10.1	R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-9024909 R-HSA-9024909 Reactome Name: BDNF activates NTRK2 (TRKB) signaling See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-9025046 R-HSA-9025046 Reactome Name: NTF3 activates NTRK2 (TRKB) signaling See in Reactome R-HSA-9026527 R-HSA-9026527 Reactome Name: Activated NTRK2 signals through PLCG1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9026357 R-HSA-9026357 Reactome Name: NTF4 activates NTRK2 (TRKB) signaling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome	R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-9024906 ( R-HSA-9024909 ) R-HSA-9024906 Reaction Name: BDNF binds NTRK2 (TRKB) See in Reactome R-HSA-9024967 ( R-HSA-9024909 ) R-HSA-9024967 Reaction Name: BDNF-bound NTRK2 dimerizes See in Reactome R-HSA-9025033 ( R-HSA-9025046 ) R-HSA-9025033 Reaction Name: NTF3 binds NTRK2 (TRKB) See in Reactome R-HSA-9026358 ( R-HSA-9026357 ) R-HSA-9026358 Reaction Name: NTF4 binds NTRK2 See in Reactome R-HSA-9026366 ( R-HSA-9025046 ) R-HSA-9026366 Reaction Name: NTF3-bound NTRK2 dimerizes See in Reactome R-HSA-9026377 ( R-HSA-9026357 ) R-HSA-9026377 Reaction Name: NTF4-bound NTRK2 dimerizes See in Reactome R-HSA-9026464 ( R-HSA-9024909 ) R-HSA-9026464 Reaction Name: BDNF-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026493 ( R-HSA-9026519 ) R-HSA-9026493 Reaction Name: p-Y516 of p-5Y-NTRK2 recruits SHC1 See in Reactome R-HSA-9026502 ( R-HSA-9025046 ) R-HSA-9026502 Reaction Name: NTF3-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026510 ( R-HSA-9026357 ) R-HSA-9026510 Reaction Name: NTF4-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026531 ( R-HSA-9026527 ) R-HSA-9026531 Reaction Name: p-Y817 of p-5Y-NTRK2 recruits PLCG1 See in Reactome R-HSA-9026579 ( R-HSA-9026527 ) R-HSA-9026579 Reaction Name: NTRK2 phosphorylates PLCG1 See in Reactome R-HSA-9026890 ( R-HSA-9026519 ) R-HSA-9026890 Reaction Name: NTRK2 phosphorylates SHC1 See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9026894 ( R-HSA-9026527 ) R-HSA-9026894 Reaction Name: Activated PCLG1 dissociates from NTRK2 See in Reactome R-HSA-9028328 ( R-HSA-9026519 ) R-HSA-9028328 Reaction Name: SHC1 bound to activated NTRK2 recruits GRB2:SOS1 See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-9028728 ( R-HSA-9028731 ) R-HSA-9028728 Reaction Name: NTRK2 phosphorylates FRS2 See in Reactome R-HSA-9028730 ( R-HSA-9028731 ) R-HSA-9028730 Reaction Name: Activated NTRK2 binds FRS2 See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9032073 ( R-HSA-9028731 ) R-HSA-9032073 Reaction Name: NTRK2-phosphorylated FRS2 binds GRB2 See in Reactome R-HSA-9032402 ( R-HSA-9028731 ) R-HSA-9032402 Reaction Name: Activated NTRK2 binds FRS3 See in Reactome R-HSA-9032426 ( R-HSA-9028731 ) R-HSA-9032426 Reaction Name: NTRK2 phosphorylates FRS3 See in Reactome R-HSA-9032502 ( R-HSA-9032500 ) R-HSA-9032502 Reaction Name: Activated NTRK2 binds FYN See in Reactome R-HSA-9032532 ( R-HSA-9032500 ) R-HSA-9032532 Reaction Name: NTRK2-bound FYN autophosphorylates See in Reactome R-HSA-9032582 ( R-HSA-9032500 ) R-HSA-9032582 Reaction Name: Activated FYN binds GRIN2B See in Reactome R-HSA-9032601 ( R-HSA-9032500 ) R-HSA-9032601 Reaction Name: FYN-mediated phosphorylation of GRIN2B See in Reactome R-HSA-9032761 ( R-HSA-9032500; R-HSA-9032759 ) R-HSA-9032761 Reaction Name: DOCK3 binds FYN associated with NTRK2 See in Reactome R-HSA-9032798 ( R-HSA-9032500; R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9032841 ( R-HSA-9032845 ) R-HSA-9032841 Reaction Name: Activated NTRK2 binds CDK5 See in Reactome R-HSA-9032854 ( R-HSA-9032845 ) R-HSA-9032854 Reaction Name: NTRK2 phosphorylates CDK5 See in Reactome R-HSA-9032863 ( R-HSA-9032845 ) R-HSA-9032863 Reaction Name: CDK5 phosphorylates NTRK2 See in Reactome R-HSA-9033276 ( R-HSA-9032845 ) R-HSA-9033276 Reaction Name: NTRK2 binds TIAM1 See in Reactome R-HSA-9033284 ( R-HSA-9032845 ) R-HSA-9033284 Reaction Name: NTRK2 promotes TIAM1 phosphorylation See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome
MONDO:0018097	NTRK2	Q16620	2.7.10.1	R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-9024909 R-HSA-9024909 Reactome Name: BDNF activates NTRK2 (TRKB) signaling See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-9025046 R-HSA-9025046 Reactome Name: NTF3 activates NTRK2 (TRKB) signaling See in Reactome R-HSA-9026527 R-HSA-9026527 Reactome Name: Activated NTRK2 signals through PLCG1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9026357 R-HSA-9026357 Reactome Name: NTF4 activates NTRK2 (TRKB) signaling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome	R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-9024906 ( R-HSA-9024909 ) R-HSA-9024906 Reaction Name: BDNF binds NTRK2 (TRKB) See in Reactome R-HSA-9024967 ( R-HSA-9024909 ) R-HSA-9024967 Reaction Name: BDNF-bound NTRK2 dimerizes See in Reactome R-HSA-9025033 ( R-HSA-9025046 ) R-HSA-9025033 Reaction Name: NTF3 binds NTRK2 (TRKB) See in Reactome R-HSA-9026358 ( R-HSA-9026357 ) R-HSA-9026358 Reaction Name: NTF4 binds NTRK2 See in Reactome R-HSA-9026366 ( R-HSA-9025046 ) R-HSA-9026366 Reaction Name: NTF3-bound NTRK2 dimerizes See in Reactome R-HSA-9026377 ( R-HSA-9026357 ) R-HSA-9026377 Reaction Name: NTF4-bound NTRK2 dimerizes See in Reactome R-HSA-9026464 ( R-HSA-9024909 ) R-HSA-9026464 Reaction Name: BDNF-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026493 ( R-HSA-9026519 ) R-HSA-9026493 Reaction Name: p-Y516 of p-5Y-NTRK2 recruits SHC1 See in Reactome R-HSA-9026502 ( R-HSA-9025046 ) R-HSA-9026502 Reaction Name: NTF3-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026510 ( R-HSA-9026357 ) R-HSA-9026510 Reaction Name: NTF4-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026531 ( R-HSA-9026527 ) R-HSA-9026531 Reaction Name: p-Y817 of p-5Y-NTRK2 recruits PLCG1 See in Reactome R-HSA-9026579 ( R-HSA-9026527 ) R-HSA-9026579 Reaction Name: NTRK2 phosphorylates PLCG1 See in Reactome R-HSA-9026890 ( R-HSA-9026519 ) R-HSA-9026890 Reaction Name: NTRK2 phosphorylates SHC1 See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9026894 ( R-HSA-9026527 ) R-HSA-9026894 Reaction Name: Activated PCLG1 dissociates from NTRK2 See in Reactome R-HSA-9028328 ( R-HSA-9026519 ) R-HSA-9028328 Reaction Name: SHC1 bound to activated NTRK2 recruits GRB2:SOS1 See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-9028728 ( R-HSA-9028731 ) R-HSA-9028728 Reaction Name: NTRK2 phosphorylates FRS2 See in Reactome R-HSA-9028730 ( R-HSA-9028731 ) R-HSA-9028730 Reaction Name: Activated NTRK2 binds FRS2 See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9032073 ( R-HSA-9028731 ) R-HSA-9032073 Reaction Name: NTRK2-phosphorylated FRS2 binds GRB2 See in Reactome R-HSA-9032402 ( R-HSA-9028731 ) R-HSA-9032402 Reaction Name: Activated NTRK2 binds FRS3 See in Reactome R-HSA-9032426 ( R-HSA-9028731 ) R-HSA-9032426 Reaction Name: NTRK2 phosphorylates FRS3 See in Reactome R-HSA-9032502 ( R-HSA-9032500 ) R-HSA-9032502 Reaction Name: Activated NTRK2 binds FYN See in Reactome R-HSA-9032532 ( R-HSA-9032500 ) R-HSA-9032532 Reaction Name: NTRK2-bound FYN autophosphorylates See in Reactome R-HSA-9032582 ( R-HSA-9032500 ) R-HSA-9032582 Reaction Name: Activated FYN binds GRIN2B See in Reactome R-HSA-9032601 ( R-HSA-9032500 ) R-HSA-9032601 Reaction Name: FYN-mediated phosphorylation of GRIN2B See in Reactome R-HSA-9032761 ( R-HSA-9032500; R-HSA-9032759 ) R-HSA-9032761 Reaction Name: DOCK3 binds FYN associated with NTRK2 See in Reactome R-HSA-9032798 ( R-HSA-9032500; R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9032841 ( R-HSA-9032845 ) R-HSA-9032841 Reaction Name: Activated NTRK2 binds CDK5 See in Reactome R-HSA-9032854 ( R-HSA-9032845 ) R-HSA-9032854 Reaction Name: NTRK2 phosphorylates CDK5 See in Reactome R-HSA-9032863 ( R-HSA-9032845 ) R-HSA-9032863 Reaction Name: CDK5 phosphorylates NTRK2 See in Reactome R-HSA-9033276 ( R-HSA-9032845 ) R-HSA-9033276 Reaction Name: NTRK2 binds TIAM1 See in Reactome R-HSA-9033284 ( R-HSA-9032845 ) R-HSA-9033284 Reaction Name: NTRK2 promotes TIAM1 phosphorylation See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome
MONDO:0018614	NTRK2	Q16620	2.7.10.1	R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-9024909 R-HSA-9024909 Reactome Name: BDNF activates NTRK2 (TRKB) signaling See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-9025046 R-HSA-9025046 Reactome Name: NTF3 activates NTRK2 (TRKB) signaling See in Reactome R-HSA-9026527 R-HSA-9026527 Reactome Name: Activated NTRK2 signals through PLCG1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9026357 R-HSA-9026357 Reactome Name: NTF4 activates NTRK2 (TRKB) signaling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome	R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-9024906 ( R-HSA-9024909 ) R-HSA-9024906 Reaction Name: BDNF binds NTRK2 (TRKB) See in Reactome R-HSA-9024967 ( R-HSA-9024909 ) R-HSA-9024967 Reaction Name: BDNF-bound NTRK2 dimerizes See in Reactome R-HSA-9025033 ( R-HSA-9025046 ) R-HSA-9025033 Reaction Name: NTF3 binds NTRK2 (TRKB) See in Reactome R-HSA-9026358 ( R-HSA-9026357 ) R-HSA-9026358 Reaction Name: NTF4 binds NTRK2 See in Reactome R-HSA-9026366 ( R-HSA-9025046 ) R-HSA-9026366 Reaction Name: NTF3-bound NTRK2 dimerizes See in Reactome R-HSA-9026377 ( R-HSA-9026357 ) R-HSA-9026377 Reaction Name: NTF4-bound NTRK2 dimerizes See in Reactome R-HSA-9026464 ( R-HSA-9024909 ) R-HSA-9026464 Reaction Name: BDNF-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026493 ( R-HSA-9026519 ) R-HSA-9026493 Reaction Name: p-Y516 of p-5Y-NTRK2 recruits SHC1 See in Reactome R-HSA-9026502 ( R-HSA-9025046 ) R-HSA-9026502 Reaction Name: NTF3-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026510 ( R-HSA-9026357 ) R-HSA-9026510 Reaction Name: NTF4-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026531 ( R-HSA-9026527 ) R-HSA-9026531 Reaction Name: p-Y817 of p-5Y-NTRK2 recruits PLCG1 See in Reactome R-HSA-9026579 ( R-HSA-9026527 ) R-HSA-9026579 Reaction Name: NTRK2 phosphorylates PLCG1 See in Reactome R-HSA-9026890 ( R-HSA-9026519 ) R-HSA-9026890 Reaction Name: NTRK2 phosphorylates SHC1 See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9026894 ( R-HSA-9026527 ) R-HSA-9026894 Reaction Name: Activated PCLG1 dissociates from NTRK2 See in Reactome R-HSA-9028328 ( R-HSA-9026519 ) R-HSA-9028328 Reaction Name: SHC1 bound to activated NTRK2 recruits GRB2:SOS1 See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-9028728 ( R-HSA-9028731 ) R-HSA-9028728 Reaction Name: NTRK2 phosphorylates FRS2 See in Reactome R-HSA-9028730 ( R-HSA-9028731 ) R-HSA-9028730 Reaction Name: Activated NTRK2 binds FRS2 See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9032073 ( R-HSA-9028731 ) R-HSA-9032073 Reaction Name: NTRK2-phosphorylated FRS2 binds GRB2 See in Reactome R-HSA-9032402 ( R-HSA-9028731 ) R-HSA-9032402 Reaction Name: Activated NTRK2 binds FRS3 See in Reactome R-HSA-9032426 ( R-HSA-9028731 ) R-HSA-9032426 Reaction Name: NTRK2 phosphorylates FRS3 See in Reactome R-HSA-9032502 ( R-HSA-9032500 ) R-HSA-9032502 Reaction Name: Activated NTRK2 binds FYN See in Reactome R-HSA-9032532 ( R-HSA-9032500 ) R-HSA-9032532 Reaction Name: NTRK2-bound FYN autophosphorylates See in Reactome R-HSA-9032582 ( R-HSA-9032500 ) R-HSA-9032582 Reaction Name: Activated FYN binds GRIN2B See in Reactome R-HSA-9032601 ( R-HSA-9032500 ) R-HSA-9032601 Reaction Name: FYN-mediated phosphorylation of GRIN2B See in Reactome R-HSA-9032761 ( R-HSA-9032500; R-HSA-9032759 ) R-HSA-9032761 Reaction Name: DOCK3 binds FYN associated with NTRK2 See in Reactome R-HSA-9032798 ( R-HSA-9032500; R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9032841 ( R-HSA-9032845 ) R-HSA-9032841 Reaction Name: Activated NTRK2 binds CDK5 See in Reactome R-HSA-9032854 ( R-HSA-9032845 ) R-HSA-9032854 Reaction Name: NTRK2 phosphorylates CDK5 See in Reactome R-HSA-9032863 ( R-HSA-9032845 ) R-HSA-9032863 Reaction Name: CDK5 phosphorylates NTRK2 See in Reactome R-HSA-9033276 ( R-HSA-9032845 ) R-HSA-9033276 Reaction Name: NTRK2 binds TIAM1 See in Reactome R-HSA-9033284 ( R-HSA-9032845 ) R-HSA-9033284 Reaction Name: NTRK2 promotes TIAM1 phosphorylation See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome
MONDO:0033367	NTRK2	Q16620	2.7.10.1	R-HSA-9032759 R-HSA-9032759 Reactome Name: NTRK2 activates RAC1 See in Reactome R-HSA-9032500 R-HSA-9032500 Reactome Name: Activated NTRK2 signals through FYN See in Reactome R-HSA-9024909 R-HSA-9024909 Reactome Name: BDNF activates NTRK2 (TRKB) signaling See in Reactome R-HSA-9026519 R-HSA-9026519 Reactome Name: Activated NTRK2 signals through RAS See in Reactome R-HSA-9025046 R-HSA-9025046 Reactome Name: NTF3 activates NTRK2 (TRKB) signaling See in Reactome R-HSA-9026527 R-HSA-9026527 Reactome Name: Activated NTRK2 signals through PLCG1 See in Reactome R-HSA-9028731 R-HSA-9028731 Reactome Name: Activated NTRK2 signals through FRS2 and FRS3 See in Reactome R-HSA-9032845 R-HSA-9032845 Reactome Name: Activated NTRK2 signals through CDK5 See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9026357 R-HSA-9026357 Reactome Name: NTF4 activates NTRK2 (TRKB) signaling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome	R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-9024906 ( R-HSA-9024909 ) R-HSA-9024906 Reaction Name: BDNF binds NTRK2 (TRKB) See in Reactome R-HSA-9024967 ( R-HSA-9024909 ) R-HSA-9024967 Reaction Name: BDNF-bound NTRK2 dimerizes See in Reactome R-HSA-9025033 ( R-HSA-9025046 ) R-HSA-9025033 Reaction Name: NTF3 binds NTRK2 (TRKB) See in Reactome R-HSA-9026358 ( R-HSA-9026357 ) R-HSA-9026358 Reaction Name: NTF4 binds NTRK2 See in Reactome R-HSA-9026366 ( R-HSA-9025046 ) R-HSA-9026366 Reaction Name: NTF3-bound NTRK2 dimerizes See in Reactome R-HSA-9026377 ( R-HSA-9026357 ) R-HSA-9026377 Reaction Name: NTF4-bound NTRK2 dimerizes See in Reactome R-HSA-9026464 ( R-HSA-9024909 ) R-HSA-9026464 Reaction Name: BDNF-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026493 ( R-HSA-9026519 ) R-HSA-9026493 Reaction Name: p-Y516 of p-5Y-NTRK2 recruits SHC1 See in Reactome R-HSA-9026502 ( R-HSA-9025046 ) R-HSA-9026502 Reaction Name: NTF3-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026510 ( R-HSA-9026357 ) R-HSA-9026510 Reaction Name: NTF4-bound NTRK2 dimers trans-autophosphorylate See in Reactome R-HSA-9026531 ( R-HSA-9026527 ) R-HSA-9026531 Reaction Name: p-Y817 of p-5Y-NTRK2 recruits PLCG1 See in Reactome R-HSA-9026579 ( R-HSA-9026527 ) R-HSA-9026579 Reaction Name: NTRK2 phosphorylates PLCG1 See in Reactome R-HSA-9026890 ( R-HSA-9026519 ) R-HSA-9026890 Reaction Name: NTRK2 phosphorylates SHC1 See in Reactome R-HSA-9026891 ( R-HSA-9026519 ) R-HSA-9026891 Reaction Name: NTRK2 activates RAS signaling through SHC1 See in Reactome R-HSA-9026894 ( R-HSA-9026527 ) R-HSA-9026894 Reaction Name: Activated PCLG1 dissociates from NTRK2 See in Reactome R-HSA-9028328 ( R-HSA-9026519 ) R-HSA-9028328 Reaction Name: SHC1 bound to activated NTRK2 recruits GRB2:SOS1 See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-9028728 ( R-HSA-9028731 ) R-HSA-9028728 Reaction Name: NTRK2 phosphorylates FRS2 See in Reactome R-HSA-9028730 ( R-HSA-9028731 ) R-HSA-9028730 Reaction Name: Activated NTRK2 binds FRS2 See in Reactome R-HSA-9031981 ( R-HSA-9028731 ) R-HSA-9031981 Reaction Name: NTRK2-phosphorylated FRS2 binds PTPN11 See in Reactome R-HSA-9032067 ( R-HSA-9028731 ) R-HSA-9032067 Reaction Name: NTRK2 activates RAS signaling through FRS2 See in Reactome R-HSA-9032073 ( R-HSA-9028731 ) R-HSA-9032073 Reaction Name: NTRK2-phosphorylated FRS2 binds GRB2 See in Reactome R-HSA-9032402 ( R-HSA-9028731 ) R-HSA-9032402 Reaction Name: Activated NTRK2 binds FRS3 See in Reactome R-HSA-9032426 ( R-HSA-9028731 ) R-HSA-9032426 Reaction Name: NTRK2 phosphorylates FRS3 See in Reactome R-HSA-9032502 ( R-HSA-9032500 ) R-HSA-9032502 Reaction Name: Activated NTRK2 binds FYN See in Reactome R-HSA-9032532 ( R-HSA-9032500 ) R-HSA-9032532 Reaction Name: NTRK2-bound FYN autophosphorylates See in Reactome R-HSA-9032582 ( R-HSA-9032500 ) R-HSA-9032582 Reaction Name: Activated FYN binds GRIN2B See in Reactome R-HSA-9032601 ( R-HSA-9032500 ) R-HSA-9032601 Reaction Name: FYN-mediated phosphorylation of GRIN2B See in Reactome R-HSA-9032761 ( R-HSA-9032500; R-HSA-9032759 ) R-HSA-9032761 Reaction Name: DOCK3 binds FYN associated with NTRK2 See in Reactome R-HSA-9032798 ( R-HSA-9032500; R-HSA-9032759 ) R-HSA-9032798 Reaction Name: DOCK3 activates RAC1 See in Reactome R-HSA-9032841 ( R-HSA-9032845 ) R-HSA-9032841 Reaction Name: Activated NTRK2 binds CDK5 See in Reactome R-HSA-9032854 ( R-HSA-9032845 ) R-HSA-9032854 Reaction Name: NTRK2 phosphorylates CDK5 See in Reactome R-HSA-9032863 ( R-HSA-9032845 ) R-HSA-9032863 Reaction Name: CDK5 phosphorylates NTRK2 See in Reactome R-HSA-9033276 ( R-HSA-9032845 ) R-HSA-9033276 Reaction Name: NTRK2 binds TIAM1 See in Reactome R-HSA-9033284 ( R-HSA-9032845 ) R-HSA-9033284 Reaction Name: NTRK2 promotes TIAM1 phosphorylation See in Reactome R-HSA-9033292 ( R-HSA-9032845 ) R-HSA-9033292 Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1 See in Reactome R-HSA-9037040 ( R-HSA-9032500 ) R-HSA-9037040 Reaction Name: SRC,FYN phosphorylate NTRK2 See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome