DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-176974)

Number of enzymes:	5
Number of disease:	5
Number of reactomes:	8
Number of reactions:	26

Search results (Reactome ID: R-HSA-176974)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0006065	MCM6	Q14566	3.6.4.12	R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome	DNA Replication Cell Cycle	R-HSA-169468 ( R-HSA-176974 ) R-HSA-169468 Reaction Name: MCM2-7 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-176942 ( R-HSA-176974 ) R-HSA-176942 Reaction Name: Multiple proteins are localized at replication fork See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949; R-HSA-69052 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68954 ( R-HSA-68962 ) R-HSA-68954 Reaction Name: Mcm2-7 is phosphorylated by DDK See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-69019 ( R-HSA-69052 ) R-HSA-69019 Reaction Name: Mcm4,6,7 trimer forms and associates with the replication fork See in Reactome R-HSA-9749253 ( R-HSA-68867 ) R-HSA-9749253 Reaction Name: Formation of MCM2-7 complex See in Reactome R-HSA-9749286 ( R-HSA-68867 ) R-HSA-9749286 Reaction Name: CDT1 binds MCM2-7 See in Reactome R-HSA-9749320 ( R-HSA-68867 ) R-HSA-9749320 Reaction Name: CDT1-mediated loading of MCM2-7 to replication origins See in Reactome R-HSA-9749350 ( R-HSA-68867 ) R-HSA-9749350 Reaction Name: ATP-dependent release of CDT1 from the OCCM complex See in Reactome R-HSA-9749351 ( R-HSA-68867 ) R-HSA-9749351 Reaction Name: CDT1-mediated formation of MCM2-7 double hexamer at the replication origin See in Reactome R-HSA-9757257 ( R-HSA-68867 ) R-HSA-9757257 Reaction Name: MCM4, MCM6 and MCM7 form a heterotrimer See in Reactome R-HSA-9757258 ( R-HSA-68867 ) R-HSA-9757258 Reaction Name: MCM2 binds MCM4:MCM6:MCM7 heterotrimer See in Reactome
MONDO:0012383	MCM4	P33991	3.6.4.12	R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome	DNA Replication Cell Cycle	R-HSA-169468 ( R-HSA-176974 ) R-HSA-169468 Reaction Name: MCM2-7 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-176942 ( R-HSA-176974 ) R-HSA-176942 Reaction Name: Multiple proteins are localized at replication fork See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949; R-HSA-69052 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68954 ( R-HSA-68962 ) R-HSA-68954 Reaction Name: Mcm2-7 is phosphorylated by DDK See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-69019 ( R-HSA-69052 ) R-HSA-69019 Reaction Name: Mcm4,6,7 trimer forms and associates with the replication fork See in Reactome R-HSA-9749253 ( R-HSA-68867 ) R-HSA-9749253 Reaction Name: Formation of MCM2-7 complex See in Reactome R-HSA-9749286 ( R-HSA-68867 ) R-HSA-9749286 Reaction Name: CDT1 binds MCM2-7 See in Reactome R-HSA-9749320 ( R-HSA-68867 ) R-HSA-9749320 Reaction Name: CDT1-mediated loading of MCM2-7 to replication origins See in Reactome R-HSA-9749350 ( R-HSA-68867 ) R-HSA-9749350 Reaction Name: ATP-dependent release of CDT1 from the OCCM complex See in Reactome R-HSA-9749351 ( R-HSA-68867 ) R-HSA-9749351 Reaction Name: CDT1-mediated formation of MCM2-7 double hexamer at the replication origin See in Reactome R-HSA-9757257 ( R-HSA-68867 ) R-HSA-9757257 Reaction Name: MCM4, MCM6 and MCM7 form a heterotrimer See in Reactome R-HSA-9757258 ( R-HSA-68867 ) R-HSA-9757258 Reaction Name: MCM2 binds MCM4:MCM6:MCM7 heterotrimer See in Reactome
MONDO:0014853	MCM2	P49736	3.6.4.12	R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome	DNA Replication Cell Cycle	R-HSA-169468 ( R-HSA-176974 ) R-HSA-169468 Reaction Name: MCM2-7 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-176942 ( R-HSA-176974 ) R-HSA-176942 Reaction Name: Multiple proteins are localized at replication fork See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949; R-HSA-69052 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68954 ( R-HSA-68962 ) R-HSA-68954 Reaction Name: Mcm2-7 is phosphorylated by DDK See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-69019 ( R-HSA-69052 ) R-HSA-69019 Reaction Name: Mcm4,6,7 trimer forms and associates with the replication fork See in Reactome R-HSA-9749253 ( R-HSA-68867 ) R-HSA-9749253 Reaction Name: Formation of MCM2-7 complex See in Reactome R-HSA-9749286 ( R-HSA-68867 ) R-HSA-9749286 Reaction Name: CDT1 binds MCM2-7 See in Reactome R-HSA-9749320 ( R-HSA-68867 ) R-HSA-9749320 Reaction Name: CDT1-mediated loading of MCM2-7 to replication origins See in Reactome R-HSA-9749350 ( R-HSA-68867 ) R-HSA-9749350 Reaction Name: ATP-dependent release of CDT1 from the OCCM complex See in Reactome R-HSA-9749351 ( R-HSA-68867 ) R-HSA-9749351 Reaction Name: CDT1-mediated formation of MCM2-7 double hexamer at the replication origin See in Reactome R-HSA-9757258 ( R-HSA-68867 ) R-HSA-9757258 Reaction Name: MCM2 binds MCM4:MCM6:MCM7 heterotrimer See in Reactome
MONDO:0033046	MCM5	P33992	3.6.4.12	R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome	DNA Replication Cell Cycle	R-HSA-169468 ( R-HSA-176974 ) R-HSA-169468 Reaction Name: MCM2-7 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-176942 ( R-HSA-176974 ) R-HSA-176942 Reaction Name: Multiple proteins are localized at replication fork See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949; R-HSA-69052 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68954 ( R-HSA-68962 ) R-HSA-68954 Reaction Name: Mcm2-7 is phosphorylated by DDK See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-69019 ( R-HSA-69052 ) R-HSA-69019 Reaction Name: Mcm4,6,7 trimer forms and associates with the replication fork See in Reactome R-HSA-9749253 ( R-HSA-68867 ) R-HSA-9749253 Reaction Name: Formation of MCM2-7 complex See in Reactome R-HSA-9749286 ( R-HSA-68867 ) R-HSA-9749286 Reaction Name: CDT1 binds MCM2-7 See in Reactome R-HSA-9749320 ( R-HSA-68867 ) R-HSA-9749320 Reaction Name: CDT1-mediated loading of MCM2-7 to replication origins See in Reactome R-HSA-9749350 ( R-HSA-68867 ) R-HSA-9749350 Reaction Name: ATP-dependent release of CDT1 from the OCCM complex See in Reactome R-HSA-9749351 ( R-HSA-68867 ) R-HSA-9749351 Reaction Name: CDT1-mediated formation of MCM2-7 double hexamer at the replication origin See in Reactome R-HSA-9757256 ( R-HSA-68867 ) R-HSA-9757256 Reaction Name: MCM3 binds MCM5 See in Reactome
MONDO:0044776	MCM8	Q9UJA3	3.6.4.12	R-HSA-68867 R-HSA-68867 Reactome Name: Assembly of the pre-replicative complex See in Reactome R-HSA-176974 R-HSA-176974 Reactome Name: Unwinding of DNA See in Reactome R-HSA-68962 R-HSA-68962 Reactome Name: Activation of the pre-replicative complex See in Reactome R-HSA-68689 R-HSA-68689 Reactome Name: CDC6 association with the ORC:origin complex See in Reactome R-HSA-68949 R-HSA-68949 Reactome Name: Orc1 removal from chromatin See in Reactome R-HSA-176187 R-HSA-176187 Reactome Name: Activation of ATR in response to replication stress See in Reactome R-HSA-113507 R-HSA-113507 Reactome Name: E2F-enabled inhibition of pre-replication complex formation See in Reactome	R-HSA-453279 R-HSA-453279 Reactome Name: Mitotic G1 phase and G1/S transition See in Reactome R-HSA-69052 R-HSA-69052 Reactome Name: Switching of origins to a post-replicative state See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-69206 R-HSA-69206 Reactome Name: G1/S Transition See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-69002 R-HSA-69002 Reactome Name: DNA Replication Pre-Initiation See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-113510 R-HSA-113510 Reactome Name: E2F mediated regulation of DNA replication See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome	DNA Replication Cell Cycle	R-HSA-113638 ( R-HSA-113507 ) R-HSA-113638 Reaction Name: Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation See in Reactome R-HSA-169461 ( R-HSA-176974 ) R-HSA-169461 Reaction Name: MCM8 mediated fork unwinding See in Reactome R-HSA-176298 ( R-HSA-176187 ) R-HSA-176298 Reaction Name: Activation of claspin See in Reactome R-HSA-176318 ( R-HSA-176187 ) R-HSA-176318 Reaction Name: Loading of claspin onto DNA during replication origin firing See in Reactome R-HSA-68688 ( R-HSA-68689; R-HSA-68867 ) R-HSA-68688 Reaction Name: CDC6 association with ORC(1-6) at replication origins See in Reactome R-HSA-68914 ( R-HSA-68962 ) R-HSA-68914 Reaction Name: DNA polymerase alpha:primase binds at the origin See in Reactome R-HSA-68916 ( R-HSA-68962 ) R-HSA-68916 Reaction Name: DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin See in Reactome R-HSA-68917 ( R-HSA-68962 ) R-HSA-68917 Reaction Name: Cdc45 associates with the pre-replicative complex at the origin See in Reactome R-HSA-68918 ( R-HSA-68962 ) R-HSA-68918 Reaction Name: CDK and DDK associate with the Mcm10:pre-replicative complex See in Reactome R-HSA-68919 ( R-HSA-68962 ) R-HSA-68919 Reaction Name: Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 See in Reactome R-HSA-68940 ( R-HSA-68962 ) R-HSA-68940 Reaction Name: Cdt1 is displaced from the pre-replicative complex. See in Reactome R-HSA-68944 ( R-HSA-68949; R-HSA-69052 ) R-HSA-68944 Reaction Name: Orc1 is phosphorylated by cyclin A/CDK2 See in Reactome R-HSA-68960 ( R-HSA-68962 ) R-HSA-68960 Reaction Name: DNA polymerase epsilon binds at the origin See in Reactome R-HSA-9749215 ( R-HSA-68689; R-HSA-68867 ) R-HSA-9749215 Reaction Name: MCM8 binds CDC6 See in Reactome