DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-174577)

Number of enzymes:	2
Number of disease:	4
Number of reactomes:	4
Number of reactions:	21

Search results (Reactome ID: R-HSA-174577)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009006	C2	P06681	3.4.21.43	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-166795 ( R-HSA-166663 ) R-HSA-166795 Reaction Name: Formation of Classical C3 convertase (C4b:C2a complex) See in Reactome R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173636 ( R-HSA-174577 ) R-HSA-173636 Reaction Name: Formation of classic pathway C5 convertase See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome R-HSA-981648 ( R-HSA-977606 ) R-HSA-981648 Reaction Name: C4b binding protein binds C4bC2a See in Reactome R-HSA-981680 ( R-HSA-977606 ) R-HSA-981680 Reaction Name: C4b binding protein displaces C2a See in Reactome
MONDO:0013042	CFB	P00751	3.4.21.47	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-173736 R-HSA-173736 Reactome Name: Alternative complement activation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-173740 ( R-HSA-173736 ) R-HSA-173740 Reaction Name: Factor B binds to C3(H2O) See in Reactome R-HSA-173745 ( R-HSA-173736 ) R-HSA-173745 Reaction Name: Factor D cleaves C3(H2O)-bound Factor B See in Reactome R-HSA-173754 ( R-HSA-173736 ) R-HSA-173754 Reaction Name: Properdin stabilizes C3b:Bb bound to cell surfaces See in Reactome R-HSA-174551 ( R-HSA-173736 ) R-HSA-174551 Reaction Name: Formation of alternative pathway C5 convertase See in Reactome R-HSA-183122 ( R-HSA-173736 ) R-HSA-183122 Reaction Name: Factor D cleaves C3b-bound Factor B See in Reactome R-HSA-183126 ( R-HSA-173736 ) R-HSA-183126 Reaction Name: Factor B binds to surface-associated C3b See in Reactome R-HSA-183130 ( R-HSA-173736 ) R-HSA-183130 Reaction Name: C3(H2O):Factor Bb cleaves C3 to C3b and C3a See in Reactome R-HSA-977363 ( R-HSA-977606 ) R-HSA-977363 Reaction Name: Factor H binds to C3bBb See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977605 ( R-HSA-977606 ) R-HSA-977605 Reaction Name: Factor H displaces Bb See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome
MONDO:0014207	CFB	P00751	3.4.21.47	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-173736 R-HSA-173736 Reactome Name: Alternative complement activation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-173740 ( R-HSA-173736 ) R-HSA-173740 Reaction Name: Factor B binds to C3(H2O) See in Reactome R-HSA-173745 ( R-HSA-173736 ) R-HSA-173745 Reaction Name: Factor D cleaves C3(H2O)-bound Factor B See in Reactome R-HSA-173754 ( R-HSA-173736 ) R-HSA-173754 Reaction Name: Properdin stabilizes C3b:Bb bound to cell surfaces See in Reactome R-HSA-174551 ( R-HSA-173736 ) R-HSA-174551 Reaction Name: Formation of alternative pathway C5 convertase See in Reactome R-HSA-183122 ( R-HSA-173736 ) R-HSA-183122 Reaction Name: Factor D cleaves C3b-bound Factor B See in Reactome R-HSA-183126 ( R-HSA-173736 ) R-HSA-183126 Reaction Name: Factor B binds to surface-associated C3b See in Reactome R-HSA-183130 ( R-HSA-173736 ) R-HSA-183130 Reaction Name: C3(H2O):Factor Bb cleaves C3 to C3b and C3a See in Reactome R-HSA-977363 ( R-HSA-977606 ) R-HSA-977363 Reaction Name: Factor H binds to C3bBb See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977605 ( R-HSA-977606 ) R-HSA-977605 Reaction Name: Factor H displaces Bb See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome
MONDO:0014207	C2	P06681	3.4.21.43	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-166795 ( R-HSA-166663 ) R-HSA-166795 Reaction Name: Formation of Classical C3 convertase (C4b:C2a complex) See in Reactome R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173636 ( R-HSA-174577 ) R-HSA-173636 Reaction Name: Formation of classic pathway C5 convertase See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome R-HSA-981648 ( R-HSA-977606 ) R-HSA-981648 Reaction Name: C4b binding protein binds C4bC2a See in Reactome R-HSA-981680 ( R-HSA-977606 ) R-HSA-981680 Reaction Name: C4b binding protein displaces C2a See in Reactome
MONDO:0014255	CFB	P00751	3.4.21.47	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-173736 R-HSA-173736 Reactome Name: Alternative complement activation See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-173740 ( R-HSA-173736 ) R-HSA-173740 Reaction Name: Factor B binds to C3(H2O) See in Reactome R-HSA-173745 ( R-HSA-173736 ) R-HSA-173745 Reaction Name: Factor D cleaves C3(H2O)-bound Factor B See in Reactome R-HSA-173754 ( R-HSA-173736 ) R-HSA-173754 Reaction Name: Properdin stabilizes C3b:Bb bound to cell surfaces See in Reactome R-HSA-174551 ( R-HSA-173736 ) R-HSA-174551 Reaction Name: Formation of alternative pathway C5 convertase See in Reactome R-HSA-183122 ( R-HSA-173736 ) R-HSA-183122 Reaction Name: Factor D cleaves C3b-bound Factor B See in Reactome R-HSA-183126 ( R-HSA-173736 ) R-HSA-183126 Reaction Name: Factor B binds to surface-associated C3b See in Reactome R-HSA-183130 ( R-HSA-173736 ) R-HSA-183130 Reaction Name: C3(H2O):Factor Bb cleaves C3 to C3b and C3a See in Reactome R-HSA-977363 ( R-HSA-977606 ) R-HSA-977363 Reaction Name: Factor H binds to C3bBb See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977605 ( R-HSA-977606 ) R-HSA-977605 Reaction Name: Factor H displaces Bb See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome