DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-174437)

Number of enzymes:	3
Number of disease:	7
Number of reactomes:	27
Number of reactions:	63

Search results (Reactome ID: R-HSA-174437)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005575	WRN	Q14191	3.6.4.12 3.1.-.-	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Metabolism of proteins Cell Cycle	R-HSA-174438 ( R-HSA-174414 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-4568846 ( R-HSA-3108214 ) R-HSA-4568846 Reaction Name: CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome
MONDO:0010196	WRN	Q14191	3.6.4.12 3.1.-.-	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	DNA Repair Gene expression (Transcription) Metabolism of proteins Cell Cycle	R-HSA-174438 ( R-HSA-174414 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-4568846 ( R-HSA-3108214 ) R-HSA-4568846 Reaction Name: CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome
MONDO:0012953	POLD1	P28340	3.1.11.- 2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Cell Cycle DNA Replication DNA Repair Metabolism	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-174438 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174441 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174444 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174444 Reaction Name: Formation of C-strand Okazaki fragments See in Reactome R-HSA-174445 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174445 Reaction Name: RPA binds to the Flap on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-174448 ( R-HSA-174411; R-HSA-174417 ) R-HSA-174448 Reaction Name: Formation of Processive Complex on the C-strand of the telomere See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-174456 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174456 Reaction Name: Joining of adjacent Okazaki fragments of the C-strand See in Reactome R-HSA-176702 ( R-HSA-174417 ) R-HSA-176702 Reaction Name: Disassociation of Processive Complex and Completed Telomere End See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5358579 ( R-HSA-5358565; R-HSA-5358606 ) R-HSA-5358579 Reaction Name: DNA polymerase delta polymerizes DNA across single stranded gap See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome
MONDO:0014062	DNA2	P51530	3.6.4.12 3.1.-.-	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome	Cell Cycle Gene expression (Transcription) DNA Replication DNA Repair	R-HSA-174441 ( R-HSA-174414; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69142 ( R-HSA-69166 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome
MONDO:0014157	POLD1	P28340	3.1.11.- 2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Cell Cycle DNA Replication DNA Repair Metabolism	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-174438 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174441 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174444 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174444 Reaction Name: Formation of C-strand Okazaki fragments See in Reactome R-HSA-174445 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174445 Reaction Name: RPA binds to the Flap on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-174448 ( R-HSA-174411; R-HSA-174417 ) R-HSA-174448 Reaction Name: Formation of Processive Complex on the C-strand of the telomere See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-174456 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174456 Reaction Name: Joining of adjacent Okazaki fragments of the C-strand See in Reactome R-HSA-176702 ( R-HSA-174417 ) R-HSA-176702 Reaction Name: Disassociation of Processive Complex and Completed Telomere End See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5358579 ( R-HSA-5358565; R-HSA-5358606 ) R-HSA-5358579 Reaction Name: DNA polymerase delta polymerizes DNA across single stranded gap See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome
MONDO:0014350	DNA2	P51530	3.6.4.12 3.1.-.-	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome	Cell Cycle Gene expression (Transcription) DNA Replication DNA Repair	R-HSA-174441 ( R-HSA-174414; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69142 ( R-HSA-69166 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome
MONDO:0018653	POLD1	P28340	3.1.11.- 2.7.7.7	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-5358606 R-HSA-5358606 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) See in Reactome R-HSA-5696397 R-HSA-5696397 Reactome Name: Gap-filling DNA repair synthesis and ligation in GG-NER See in Reactome R-HSA-69091 R-HSA-69091 Reactome Name: Polymerase switching See in Reactome R-HSA-110314 R-HSA-110314 Reactome Name: Recognition of DNA damage by PCNA-containing replication complex See in Reactome R-HSA-174414 R-HSA-174414 Reactome Name: Processive synthesis on the C-strand of the telomere See in Reactome R-HSA-174417 R-HSA-174417 Reactome Name: Telomere C-strand (Lagging Strand) Synthesis See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-174411 R-HSA-174411 Reactome Name: Polymerase switching on the C-strand of the telomere See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-174437 R-HSA-174437 Reactome Name: Removal of the Flap Intermediate from the C-strand See in Reactome R-HSA-5358565 R-HSA-5358565 Reactome Name: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) See in Reactome R-HSA-5651801 R-HSA-5651801 Reactome Name: PCNA-Dependent Long Patch Base Excision Repair See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-69166 R-HSA-69166 Reactome Name: Removal of the Flap Intermediate See in Reactome R-HSA-5656169 R-HSA-5656169 Reactome Name: Termination of translesion DNA synthesis See in Reactome R-HSA-69183 R-HSA-69183 Reactome Name: Processive synthesis on the lagging strand See in Reactome	R-HSA-69109 R-HSA-69109 Reactome Name: Leading Strand Synthesis See in Reactome R-HSA-73933 R-HSA-73933 Reactome Name: Resolution of Abasic Sites (AP sites) See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-69242 R-HSA-69242 Reactome Name: S Phase See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-69190 R-HSA-69190 Reactome Name: DNA strand elongation See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-73884 R-HSA-73884 Reactome Name: Base Excision Repair See in Reactome R-HSA-110373 R-HSA-110373 Reactome Name: Resolution of AP sites via the multiple-nucleotide patch replacement pathway See in Reactome R-HSA-69239 R-HSA-69239 Reactome Name: Synthesis of DNA See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-110313 R-HSA-110313 Reactome Name: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template See in Reactome R-HSA-5358508 R-HSA-5358508 Reactome Name: Mismatch Repair See in Reactome R-HSA-180786 R-HSA-180786 Reactome Name: Extension of Telomeres See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-69306 R-HSA-69306 Reactome Name: DNA Replication See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-69186 R-HSA-69186 Reactome Name: Lagging Strand Synthesis See in Reactome R-HSA-73893 R-HSA-73893 Reactome Name: DNA Damage Bypass See in Reactome	Cell Cycle DNA Replication DNA Repair Metabolism	R-HSA-110363 ( R-HSA-5651801 ) R-HSA-110363 Reaction Name: FEN1 bound to PCNA and APEX1 cleaves flap ssDNA See in Reactome R-HSA-110364 ( R-HSA-5651801 ) R-HSA-110364 Reaction Name: PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 See in Reactome R-HSA-110368 ( R-HSA-5651801 ) R-HSA-110368 Reaction Name: POLD,POLE-mediated DNA strand displacement synthesis See in Reactome R-HSA-110371 ( R-HSA-5651801 ) R-HSA-110371 Reaction Name: LIG1 binds APEX1 and PCNA at SSB See in Reactome R-HSA-174438 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174438 Reaction Name: Formation of the Flap Intermediate on the C-strand See in Reactome R-HSA-174441 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174441 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand See in Reactome R-HSA-174444 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174444 Reaction Name: Formation of C-strand Okazaki fragments See in Reactome R-HSA-174445 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174445 Reaction Name: RPA binds to the Flap on the C-strand See in Reactome R-HSA-174446 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174446 Reaction Name: Removal of remaining Flap from the C-strand See in Reactome R-HSA-174448 ( R-HSA-174411; R-HSA-174417 ) R-HSA-174448 Reaction Name: Formation of Processive Complex on the C-strand of the telomere See in Reactome R-HSA-174451 ( R-HSA-174414; R-HSA-174417; R-HSA-174437 ) R-HSA-174451 Reaction Name: Recruitment of DNA2 endonuclease to the C strand See in Reactome R-HSA-174456 ( R-HSA-174414; R-HSA-174417 ) R-HSA-174456 Reaction Name: Joining of adjacent Okazaki fragments of the C-strand See in Reactome R-HSA-176702 ( R-HSA-174417 ) R-HSA-176702 Reaction Name: Disassociation of Processive Complex and Completed Telomere End See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-5358579 ( R-HSA-5358565; R-HSA-5358606 ) R-HSA-5358579 Reaction Name: DNA polymerase delta polymerizes DNA across single stranded gap See in Reactome R-HSA-5651805 ( R-HSA-5651801 ) R-HSA-5651805 Reaction Name: LIG1 bound to APEX1 and PCNA ligates SSB See in Reactome R-HSA-5651809 ( R-HSA-5651801 ) R-HSA-5651809 Reaction Name: LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA See in Reactome R-HSA-5651992 ( R-HSA-110314 ) R-HSA-5651992 Reaction Name: PCNA-containing replication complex binds damaged dsDNA See in Reactome R-HSA-5652005 ( R-HSA-110314 ) R-HSA-5652005 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA See in Reactome R-HSA-5652009 ( R-HSA-110314 ) R-HSA-5652009 Reaction Name: RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA See in Reactome R-HSA-5653838 ( R-HSA-5656169 ) R-HSA-5653838 Reaction Name: POLD,POLE binds deISGylated PCNA after TLS See in Reactome R-HSA-5653840 ( R-HSA-5656169 ) R-HSA-5653840 Reaction Name: POLD,POLE complete replication of damaged DNA after TLS See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690997 ( R-HSA-5696397 ) R-HSA-5690997 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in GG-NER See in Reactome R-HSA-5691001 ( R-HSA-5696397 ) R-HSA-5691001 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-6782208 ( R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-69074 ( R-HSA-69091 ) R-HSA-69074 Reaction Name: Formation of Processive Complex See in Reactome R-HSA-69116 ( R-HSA-69183 ) R-HSA-69116 Reaction Name: Formation of Okazaki fragments See in Reactome R-HSA-69127 ( R-HSA-69183 ) R-HSA-69127 Reaction Name: Formation of the Flap Intermediate See in Reactome R-HSA-69140 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69140 Reaction Name: RPA binds to the Flap See in Reactome R-HSA-69142 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69142 Reaction Name: Recruitment of Dna2 endonuclease See in Reactome R-HSA-69144 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69144 Reaction Name: Removal of RNA primer and dissociation of RPA and Dna2 See in Reactome R-HSA-69152 ( R-HSA-69166; R-HSA-69183 ) R-HSA-69152 Reaction Name: Removal of remaining Flap See in Reactome