DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-170984)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005012	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0005061	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0005097	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0005575	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0005611	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0007265	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0007958	NTRK1	P04629	2.7.10.1	R-HSA-198745 R-HSA-198745 Reactome Name: Signalling to STAT3 See in Reactome R-HSA-167021 R-HSA-167021 Reactome Name: PLC-gamma1 signalling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-187042 R-HSA-187042 Reactome Name: TRKA activation by NGF See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-166538 ( R-HSA-187042 ) R-HSA-166538 Reaction Name: The bound receptor dimerizes See in Reactome R-HSA-166542 ( R-HSA-187042 ) R-HSA-166542 Reaction Name: beta-NGF dimer binds to TrkA receptor See in Reactome R-HSA-166544 ( R-HSA-187042 ) R-HSA-166544 Reaction Name: TrkA receptor autophosphorylates See in Reactome R-HSA-167019 ( R-HSA-167044 ) R-HSA-167019 Reaction Name: SHC, complexed with TrkA, is tyrosine-phosphorylated See in Reactome R-HSA-167056 ( R-HSA-167044 ) R-HSA-167056 Reaction Name: SHC binds to the activated TrkA receptor See in Reactome R-HSA-167217 ( R-HSA-167044 ) R-HSA-167217 Reaction Name: Phospho-Shc dissociates from the TrkA receptor See in Reactome R-HSA-167674 ( R-HSA-167021 ) R-HSA-167674 Reaction Name: Binding of PLCG1 to active TrkA receptor See in Reactome R-HSA-167683 ( R-HSA-167021 ) R-HSA-167683 Reaction Name: TrkA phosphorylates PLCG1 See in Reactome R-HSA-167684 ( R-HSA-167021 ) R-HSA-167684 Reaction Name: Active PLCG1 dissociates from TrkA receptor See in Reactome R-HSA-169891 ( R-HSA-170984 ) R-HSA-169891 Reaction Name: ARMS:Crk complex binds to active TrkA receptor See in Reactome R-HSA-169895 ( R-HSA-170984 ) R-HSA-169895 Reaction Name: Crk's SH3 domain engages C3G See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-169904 ( R-HSA-170984 ) R-HSA-169904 Reaction Name: C3G stimulates nucleotide exchange on Rap1 See in Reactome R-HSA-169905 ( R-HSA-170984 ) R-HSA-169905 Reaction Name: ARMS is phosphorylated by active TrkA receptor See in Reactome R-HSA-177479 ( R-HSA-177504 ) R-HSA-177479 Reaction Name: Axonal transport of NGF:Trk complexes See in Reactome R-HSA-177491 ( R-HSA-177504 ) R-HSA-177491 Reaction Name: Formation of clathrin-coated vesicle See in Reactome R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-187697 ( R-HSA-187706 ) R-HSA-187697 Reaction Name: TRKA recruits RIT and RIN See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-187746 ( R-HSA-187706 ) R-HSA-187746 Reaction Name: RIT/RIN are activated See in Reactome R-HSA-190065 ( R-HSA-187042 ) R-HSA-190065 Reaction Name: Activated TrkA receptor internalizes to endosomes See in Reactome R-HSA-198211 ( R-HSA-198203 ) R-HSA-198211 Reaction Name: Active TRKA binds IRS1/2 See in Reactome R-HSA-198295 ( R-HSA-198203 ) R-HSA-198295 Reaction Name: TRKA phosphorylates IRS See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-198732 ( R-HSA-198745 ) R-HSA-198732 Reaction Name: STAT3 activation See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome
MONDO:0007963	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0008104	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0009693	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0009746	NTRK1	P04629	2.7.10.1	R-HSA-198745 R-HSA-198745 Reactome Name: Signalling to STAT3 See in Reactome R-HSA-167021 R-HSA-167021 Reactome Name: PLC-gamma1 signalling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-187042 R-HSA-187042 Reactome Name: TRKA activation by NGF See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-167044 R-HSA-167044 Reactome Name: Signalling to RAS See in Reactome R-HSA-177504 R-HSA-177504 Reactome Name: Retrograde neurotrophin signalling See in Reactome R-HSA-187024 R-HSA-187024 Reactome Name: NGF-independant TRKA activation See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-187015 R-HSA-187015 Reactome Name: Activation of TRKA receptors See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome	Signal Transduction	R-HSA-166538 ( R-HSA-187042 ) R-HSA-166538 Reaction Name: The bound receptor dimerizes See in Reactome R-HSA-166542 ( R-HSA-187042 ) R-HSA-166542 Reaction Name: beta-NGF dimer binds to TrkA receptor See in Reactome R-HSA-166544 ( R-HSA-187042 ) R-HSA-166544 Reaction Name: TrkA receptor autophosphorylates See in Reactome R-HSA-167019 ( R-HSA-167044 ) R-HSA-167019 Reaction Name: SHC, complexed with TrkA, is tyrosine-phosphorylated See in Reactome R-HSA-167056 ( R-HSA-167044 ) R-HSA-167056 Reaction Name: SHC binds to the activated TrkA receptor See in Reactome R-HSA-167217 ( R-HSA-167044 ) R-HSA-167217 Reaction Name: Phospho-Shc dissociates from the TrkA receptor See in Reactome R-HSA-167674 ( R-HSA-167021 ) R-HSA-167674 Reaction Name: Binding of PLCG1 to active TrkA receptor See in Reactome R-HSA-167683 ( R-HSA-167021 ) R-HSA-167683 Reaction Name: TrkA phosphorylates PLCG1 See in Reactome R-HSA-167684 ( R-HSA-167021 ) R-HSA-167684 Reaction Name: Active PLCG1 dissociates from TrkA receptor See in Reactome R-HSA-169891 ( R-HSA-170984 ) R-HSA-169891 Reaction Name: ARMS:Crk complex binds to active TrkA receptor See in Reactome R-HSA-169895 ( R-HSA-170984 ) R-HSA-169895 Reaction Name: Crk's SH3 domain engages C3G See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-169904 ( R-HSA-170984 ) R-HSA-169904 Reaction Name: C3G stimulates nucleotide exchange on Rap1 See in Reactome R-HSA-169905 ( R-HSA-170984 ) R-HSA-169905 Reaction Name: ARMS is phosphorylated by active TrkA receptor See in Reactome R-HSA-177479 ( R-HSA-177504 ) R-HSA-177479 Reaction Name: Axonal transport of NGF:Trk complexes See in Reactome R-HSA-177491 ( R-HSA-177504 ) R-HSA-177491 Reaction Name: Formation of clathrin-coated vesicle See in Reactome R-HSA-177501 ( R-HSA-177504 ) R-HSA-177501 Reaction Name: Endocytosis (internalization) of clathrin-coated vesicle See in Reactome R-HSA-187661 ( R-HSA-187024 ) R-HSA-187661 Reaction Name: Ade-Rib binds AODORA2A and NTRK1,2 See in Reactome R-HSA-187678 ( R-HSA-187024 ) R-HSA-187678 Reaction Name: ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 See in Reactome R-HSA-187697 ( R-HSA-187706 ) R-HSA-187697 Reaction Name: TRKA recruits RIT and RIN See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-187746 ( R-HSA-187706 ) R-HSA-187746 Reaction Name: RIT/RIN are activated See in Reactome R-HSA-190065 ( R-HSA-187042 ) R-HSA-190065 Reaction Name: Activated TrkA receptor internalizes to endosomes See in Reactome R-HSA-198211 ( R-HSA-198203 ) R-HSA-198211 Reaction Name: Active TRKA binds IRS1/2 See in Reactome R-HSA-198295 ( R-HSA-198203 ) R-HSA-198295 Reaction Name: TRKA phosphorylates IRS See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-198732 ( R-HSA-198745 ) R-HSA-198732 Reaction Name: STAT3 activation See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9612996 ( R-HSA-187024 ) R-HSA-9612996 Reaction Name: NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates See in Reactome R-HSA-9613023 ( R-HSA-187024 ) R-HSA-9613023 Reaction Name: NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates See in Reactome
MONDO:0010150	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0011508	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0013379	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0013380	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0015447	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0016692	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0018177	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0018310	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0018907	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0018935	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0019392	BRAF	P15056	2.7.11.1	R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-187706 R-HSA-187706 Reactome Name: Signalling to p38 via RIT and RIN See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-170984 R-HSA-170984 Reactome Name: ARMS-mediated activation See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome	R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Signal Transduction	R-HSA-1295604 ( R-HSA-1295596 ) R-HSA-1295604 Reaction Name: B-RAF dissociates from S111/S120 p-SPRY2 See in Reactome R-HSA-1295634 ( R-HSA-1295596 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-169901 ( R-HSA-170984 ) R-HSA-169901 Reaction Name: Rap1-GTP complex binds BRAF complex See in Reactome R-HSA-170965 ( R-HSA-170968 ) R-HSA-170965 Reaction Name: (Frs2)Rap1-GTP binds to and activates B-Raf See in Reactome R-HSA-187698 ( R-HSA-187706 ) R-HSA-187698 Reaction Name: RIT/RIN-GTP binds B-RAF See in Reactome R-HSA-5672950 ( R-HSA-5673000 ) R-HSA-5672950 Reaction Name: "Activator" RAF:YWHAB dimer binds RAS:GTP See in Reactome R-HSA-5672951 ( R-HSA-5673000 ) R-HSA-5672951 Reaction Name: Inactive RAFs bind YWHAB See in Reactome R-HSA-5672960 ( R-HSA-5673000 ) R-HSA-5672960 Reaction Name: YWHAB dimer dissociates from dephosphorylated RAF See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5672961 Reaction Name: PP2A dephosphorylates inactive RAFs See in Reactome R-HSA-5672966 ( R-HSA-5673000 ) R-HSA-5672966 Reaction Name: RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers See in Reactome R-HSA-5672969 ( R-HSA-5673000 ) R-HSA-5672969 Reaction Name: Phosphorylation of RAF See in Reactome R-HSA-5672972 ( R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674140 ( R-HSA-5675221 ) R-HSA-5674140 Reaction Name: PAQR3 binds inactive RAFs See in Reactome R-HSA-5675198 ( R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675417 ( R-HSA-5675221 ) R-HSA-5675417 Reaction Name: PEBP1 binds activated RAF1 See in Reactome R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-5675431 Reaction Name: PP2A dephosphorylates RAF1 See in Reactome R-HSA-5675433 ( R-HSA-5675221 ) R-HSA-5675433 Reaction Name: PP5 dephosphorylates RAF1 S338 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610163 ( R-HSA-170968 ) R-HSA-9610163 Reaction Name: BRAF autophosphorylates downstream of RAP1 and NGF See in Reactome R-HSA-9612980 ( R-HSA-170984 ) R-HSA-9612980 Reaction Name: BRAF in Rap1-GTP complex:BRAF complex autophosphorylates See in Reactome R-HSA-9653108 ( R-HSA-5673000 ) R-HSA-9653108 Reaction Name: Raf dimer inhibitors bind RAF heterodimers See in Reactome R-HSA-9657599 ( R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome

Number of enzymes:	2
Number of disease:	22
Number of reactomes:	15
Number of reactions:	61

Search summary (Reactome ID: R-HSA-170984)

Search results (Reactome ID: R-HSA-170984)

MONDO:0005012

R-HSA-5675221

R-HSA-1295596

R-HSA-187706

R-HSA-170968

R-HSA-5674135

R-HSA-170984

R-HSA-5674499

R-HSA-5673000

R-HSA-169893

R-HSA-5683057

R-HSA-166520

R-HSA-5654738

R-HSA-187687

R-HSA-5654733

R-HSA-5654732

R-HSA-5654726

R-HSA-5654727

R-HSA-9006934

R-HSA-162582

R-HSA-5654736

R-HSA-190236

R-HSA-5654741

R-HSA-5684996

R-HSA-5654743

R-HSA-187037

R-HSA-5673001

R-HSA-1295604

R-HSA-1295634

R-HSA-169901

R-HSA-170965

R-HSA-187698

R-HSA-5672950

R-HSA-5672951

R-HSA-5672960

R-HSA-5672961

R-HSA-5672966

R-HSA-5672969

R-HSA-5672972

R-HSA-5672973

R-HSA-5672978

R-HSA-5672980

R-HSA-5674130

R-HSA-5674132

R-HSA-5674140

R-HSA-5675198

R-HSA-5675417

R-HSA-5675431

R-HSA-5675433

R-HSA-9610152

R-HSA-9610153

R-HSA-9610154

R-HSA-9610156

R-HSA-9610163

R-HSA-9612980

R-HSA-9653108

R-HSA-9657599

R-HSA-9657603

R-HSA-9657606

R-HSA-9657608

R-HSA-9658445

MONDO:0005061

R-HSA-5675221

R-HSA-1295596

R-HSA-187706

R-HSA-170968

R-HSA-5674135

R-HSA-170984

R-HSA-5674499

R-HSA-5673000

R-HSA-169893

R-HSA-5683057

R-HSA-166520

R-HSA-5654738

R-HSA-187687

R-HSA-5654733

R-HSA-5654732

R-HSA-5654726