DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-170822)

Number of enzymes:	2
Number of disease:	7
Number of reactomes:	26
Number of reactions:	55

Search results (Reactome ID: R-HSA-170822)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005148	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0005406	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0007453	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0011236	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0011953	RANBP2	P49792	2.3.2.-	R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-4615885 R-HSA-4615885 Reactome Name: SUMOylation of DNA replication proteins See in Reactome R-HSA-2500257 R-HSA-2500257 Reactome Name: Resolution of Sister Chromatid Cohesion See in Reactome R-HSA-159230 R-HSA-159230 Reactome Name: Transport of the SLBP Dependant Mature mRNA See in Reactome R-HSA-159231 R-HSA-159231 Reactome Name: Transport of Mature mRNA Derived from an Intronless Transcript See in Reactome R-HSA-9648025 R-HSA-9648025 Reactome Name: EML4 and NUDC in mitotic spindle formation See in Reactome R-HSA-3232142 R-HSA-3232142 Reactome Name: SUMOylation of ubiquitinylation proteins See in Reactome R-HSA-4085377 R-HSA-4085377 Reactome Name: SUMOylation of SUMOylation proteins See in Reactome R-HSA-159236 R-HSA-159236 Reactome Name: Transport of Mature mRNA derived from an Intron-Containing Transcript See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-141444 R-HSA-141444 Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal See in Reactome R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-191859 R-HSA-191859 Reactome Name: snRNP Assembly See in Reactome R-HSA-159227 R-HSA-159227 Reactome Name: Transport of the SLBP independent Mature mRNA See in Reactome R-HSA-6784531 R-HSA-6784531 Reactome Name: tRNA processing in the nucleus See in Reactome R-HSA-4570464 R-HSA-4570464 Reactome Name: SUMOylation of RNA binding proteins See in Reactome R-HSA-3108214 R-HSA-3108214 Reactome Name: SUMOylation of DNA damage response and repair proteins See in Reactome R-HSA-5578749 R-HSA-5578749 Reactome Name: Transcriptional regulation by small RNAs See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome R-HSA-3301854 R-HSA-3301854 Reactome Name: Nuclear Pore Complex (NPC) Disassembly See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-72306 R-HSA-72306 Reactome Name: tRNA processing See in Reactome R-HSA-194441 R-HSA-194441 Reactome Name: Metabolism of non-coding RNA See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-159234 R-HSA-159234 Reactome Name: Transport of Mature mRNAs Derived from Intronless Transcripts See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-141424 R-HSA-141424 Reactome Name: Amplification of signal from the kinetochores See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-2980766 R-HSA-2980766 Reactome Name: Nuclear Envelope Breakdown See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-72202 R-HSA-72202 Reactome Name: Transport of Mature Transcript to Cytoplasm See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-69618 R-HSA-69618 Reactome Name: Mitotic Spindle Checkpoint See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome	Immune System Metabolism Cell Cycle Gene expression (Transcription) Cellular responses to stimuli Metabolism of RNA Metabolism of proteins Signal Transduction	R-HSA-111439 ( R-HSA-159227 ) R-HSA-111439 Reaction Name: Docking of Mature Histone mRNA complex:TAP at the NPC See in Reactome R-HSA-1176059 ( R-HSA-1169408 ) R-HSA-1176059 Reaction Name: Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus See in Reactome R-HSA-141409 ( R-HSA-141444 ) R-HSA-141409 Reaction Name: Mad1 binds kinetochore See in Reactome R-HSA-141422 ( R-HSA-141444 ) R-HSA-141422 Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1 See in Reactome R-HSA-141431 ( R-HSA-141444 ) R-HSA-141431 Reaction Name: MAD2 associates with the Mad1 kinetochore complex See in Reactome R-HSA-141439 ( R-HSA-141444 ) R-HSA-141439 Reaction Name: Release of activated MAD2 from kinetochores See in Reactome R-HSA-158441 ( R-HSA-159231 ) R-HSA-158441 Reaction Name: Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC See in Reactome R-HSA-158447 ( R-HSA-159231 ) R-HSA-158447 Reaction Name: Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC See in Reactome R-HSA-158481 ( R-HSA-159227 ) R-HSA-158481 Reaction Name: Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC See in Reactome R-HSA-158484 ( R-HSA-159227 ) R-HSA-158484 Reaction Name: Release of the SLBP independent Histone mRNA from the NPC See in Reactome R-HSA-159046 ( R-HSA-159230 ) R-HSA-159046 Reaction Name: Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC See in Reactome R-HSA-159050 ( R-HSA-159230 ) R-HSA-159050 Reaction Name: Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex See in Reactome R-HSA-1638803 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638803 Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres See in Reactome R-HSA-1638821 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638821 Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin See in Reactome R-HSA-170796 ( R-HSA-170822 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-191825 ( R-HSA-191859 ) R-HSA-191825 Reaction Name: Nuclear export of snRNA transcripts See in Reactome R-HSA-191830 ( R-HSA-191859 ) R-HSA-191830 Reaction Name: snRNP nuclear import and release See in Reactome R-HSA-2467809 ( R-HSA-2467813 ) R-HSA-2467809 Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin See in Reactome R-HSA-2467811 ( R-HSA-2467813 ) R-HSA-2467811 Reaction Name: Separation of sister chromatids See in Reactome R-HSA-2468287 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2468287 Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres See in Reactome R-HSA-2484822 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2484822 Reaction Name: Kinetochore assembly See in Reactome R-HSA-2990880 ( R-HSA-3301854 ) R-HSA-2990880 Reaction Name: NEK6/NEK7 phosphorylates NUP98 See in Reactome R-HSA-2990882 ( R-HSA-3301854 ) R-HSA-2990882 Reaction Name: CDK1 phosphorylates NUP98 See in Reactome R-HSA-3000348 ( R-HSA-3108214 ) R-HSA-3000348 Reaction Name: RANBP2 SUMOylates SP100 with SUMO2 See in Reactome R-HSA-3000399 ( R-HSA-3108214 ) R-HSA-3000399 Reaction Name: RANBP2 SUMOylates SP100 with SUMO1 See in Reactome R-HSA-3000411 ( R-HSA-3108214 ) R-HSA-3000411 Reaction Name: RANBP2 SUMOylates PML with SUMO2 See in Reactome R-HSA-375302 ( R-HSA-68877 ) R-HSA-375302 Reaction Name: Kinetochore capture of astral microtubules See in Reactome R-HSA-4551649 ( R-HSA-4085377 ) R-HSA-4551649 Reaction Name: RANBP2 SUMOylates RANBP2 with SUMO1 See in Reactome R-HSA-4551679 ( R-HSA-4085377 ) R-HSA-4551679 Reaction Name: RANBP2 SUMOylates RANBP2 with SUMO2 See in Reactome R-HSA-4570493 ( R-HSA-4570464 ) R-HSA-4570493 Reaction Name: RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 See in Reactome R-HSA-4615872 ( R-HSA-4551638 ) R-HSA-4615872 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO1 See in Reactome R-HSA-4615987 ( R-HSA-4551638 ) R-HSA-4615987 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO2,3 See in Reactome R-HSA-4655355 ( R-HSA-4615885 ) R-HSA-4655355 Reaction Name: RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) See in Reactome R-HSA-5228508 ( R-HSA-3108214 ) R-HSA-5228508 Reaction Name: RANBP2 SUMOylates PML with SUMO1 See in Reactome R-HSA-5228523 ( R-HSA-3232142 ) R-HSA-5228523 Reaction Name: RANBP2 SUMOylates MDM2 with SUMO1 See in Reactome R-HSA-5228525 ( R-HSA-4615885 ) R-HSA-5228525 Reaction Name: RANBP2 SUMOylates TOP2A with SUMO1 See in Reactome R-HSA-5252041 ( R-HSA-3371453 ) R-HSA-5252041 Reaction Name: NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm See in Reactome R-HSA-5578744 ( R-HSA-5578749 ) R-HSA-5578744 Reaction Name: Importin-8 imports AGO2:miRNA into the nucleus See in Reactome R-HSA-5666129 ( R-HSA-5663220 ) R-HSA-5666129 Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores See in Reactome R-HSA-5666160 ( R-HSA-5663220 ) R-HSA-5666160 Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores See in Reactome R-HSA-5666169 ( R-HSA-5663220 ) R-HSA-5666169 Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 See in Reactome R-HSA-6783483 ( R-HSA-6784531 ) R-HSA-6783483 Reaction Name: tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol See in Reactome R-HSA-75096 ( R-HSA-159236 ) R-HSA-75096 Reaction Name: Docking of the TAP:EJC Complex with the NPC See in Reactome R-HSA-75097 ( R-HSA-159236 ) R-HSA-75097 Reaction Name: Transport of the export-competent mRNP complex through the NPC See in Reactome R-HSA-75098 ( R-HSA-159236 ) R-HSA-75098 Reaction Name: mRNP complex dissociates from cytosolic face of NPC See in Reactome R-HSA-77587 ( R-HSA-159230 ) R-HSA-77587 Reaction Name: Docking of Mature Replication Dependent Histone mRNA with the NPC See in Reactome R-HSA-77594 ( R-HSA-159231 ) R-HSA-77594 Reaction Name: Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC See in Reactome R-HSA-9648114 ( R-HSA-68877; R-HSA-9648025 ) R-HSA-9648114 Reaction Name: EML4 recruits NUDC to mitotic spindle See in Reactome
MONDO:0015967	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome
MONDO:0100165	GCK	P35557	2.7.1.1	R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-9615017 R-HSA-9615017 Reactome Name: FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes See in Reactome R-HSA-170822 R-HSA-170822 Reactome Name: Regulation of Glucokinase by Glucokinase Regulatory Protein See in Reactome	R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome R-HSA-9614085 R-HSA-9614085 Reactome Name: FOXO-mediated transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Gene expression (Transcription) Metabolism Developmental Biology	R-HSA-170796 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170796 Reaction Name: NPC transports GCK1:GKRP from cytosol to nucleoplasm See in Reactome R-HSA-170799 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170799 Reaction Name: cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170810 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170810 Reaction Name: nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) See in Reactome R-HSA-170824 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170824 Reaction Name: glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex See in Reactome R-HSA-170825 ( R-HSA-170822; R-HSA-70171 ) R-HSA-170825 Reaction Name: glucokinase [nucleoplasm] => glucokinase [cytosol] See in Reactome R-HSA-211346 ( R-HSA-210745 ) R-HSA-211346 Reaction Name: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein See in Reactome R-HSA-70420 ( R-HSA-70171 ) R-HSA-70420 Reaction Name: HK1,2,3,GCK phosphorylate Glc to form G6P See in Reactome R-HSA-9625124 ( R-HSA-9615017 ) R-HSA-9625124 Reaction Name: GCK gene expression is inhibited by FOXO1, SIN3A and HDACs See in Reactome