DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-168928)

Number of enzymes:	5
Number of disease:	11
Number of reactomes:	18
Number of reactions:	64

Search results (Reactome ID: R-HSA-168928)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007774	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0008328	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome
MONDO:0008922	TKFC	Q3LXA3	2.7.1.28 2.7.1.29 4.6.1.15	R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-70350 R-HSA-70350 Reactome Name: Fructose catabolism See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5652084 R-HSA-5652084 Reactome Name: Fructose metabolism See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Immune System Metabolism	R-HSA-70349 ( R-HSA-70350 ) R-HSA-70349 Reaction Name: DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome
MONDO:0012422	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0013617	RNF135	Q8IUD6	2.3.2.27	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-918224 ( R-HSA-168928 ) R-HSA-918224 Reaction Name: DDX58 is K63 polyubiquitinated See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0014367	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0014575	DDX58	O95786	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-1169408 R-HSA-1169408 Reactome Name: ISG15 antiviral mechanism See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-8983711 R-HSA-8983711 Reactome Name: OAS antiviral response See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1169410 R-HSA-1169410 Reactome Name: Antiviral mechanism by IFN-stimulated genes See in Reactome	Immune System Metabolism of proteins	R-HSA-1169406 ( R-HSA-1169408 ) R-HSA-1169406 Reaction Name: ISGylation of host proteins See in Reactome R-HSA-1678841 ( R-HSA-1169408 ) R-HSA-1678841 Reaction Name: Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 See in Reactome R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-168935 ( R-HSA-168928 ) R-HSA-168935 Reaction Name: viral dsRNA binds DDX58 See in Reactome R-HSA-5690159 ( R-HSA-5689880 ) R-HSA-5690159 Reaction Name: USP21 deubiquitinates RIPK1,DDX58 See in Reactome R-HSA-5696564 ( R-HSA-5689880 ) R-HSA-5696564 Reaction Name: USP25 deubiquitinates DDX58 See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-8985153 ( R-HSA-8983711 ) R-HSA-8985153 Reaction Name: OASL binds DDX58 See in Reactome R-HSA-918224 ( R-HSA-168928 ) R-HSA-918224 Reaction Name: DDX58 is K63 polyubiquitinated See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936390 ( R-HSA-168928; R-HSA-5689880; R-HSA-936440 ) R-HSA-936390 Reaction Name: CYLD mediated deubiquitination of DDX58 (RIG-I) See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-936563 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936563 Reaction Name: ISGylation of DDX58 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0014641	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome
MONDO:0024535	IFIH1	Q9BYX4	3.6.4.13	R-HSA-933542 R-HSA-933542 Reactome Name: TRAF6 mediated NF-kB activation See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins	R-HSA-168909 ( R-HSA-168928 ) R-HSA-168909 Reaction Name: viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS See in Reactome R-HSA-168934 ( R-HSA-168928; R-HSA-933543 ) R-HSA-168934 Reaction Name: MAVS interacts with RIPK1 and FADD See in Reactome R-HSA-5696600 ( R-HSA-5689880 ) R-HSA-5696600 Reaction Name: USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918227 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918227 Reaction Name: Recruitment of TRAF3 to MAVS See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918230 ( R-HSA-168928; R-HSA-933541 ) R-HSA-918230 Reaction Name: Recruitment of TRAF6/TRAF2 to IPS-1 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933523 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933526 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933528 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933528 Reaction Name: Interaction of MEKK1 with TRAF6 See in Reactome R-HSA-933530 ( R-HSA-168928; R-HSA-933542 ) R-HSA-933530 Reaction Name: Activation of IKK by MEKK1 See in Reactome R-HSA-933532 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933537 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933537 Reaction Name: Recruitment of TANK to TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-933539 ( R-HSA-168928; R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-936378 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936378 Reaction Name: Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS See in Reactome R-HSA-936381 ( R-HSA-168928; R-HSA-5689896; R-HSA-936440 ) R-HSA-936381 Reaction Name: OTUD5 deubiquitinates TRAF3 See in Reactome R-HSA-936412 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936412 Reaction Name: RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS See in Reactome R-HSA-936475 ( R-HSA-168928; R-HSA-936440 ) R-HSA-936475 Reaction Name: Negative regulation of DDX58/IFIH1 signaling by RNF216 See in Reactome R-HSA-937343 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937343 Reaction Name: NLRC5 interacts with DDX58/IFIH1 See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-990526 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990526 Reaction Name: Recruitment of ITCH and K48 ubiquitination of MAVS See in Reactome R-HSA-990528 ( R-HSA-168928; R-HSA-936440 ) R-HSA-990528 Reaction Name: Interaction of PCBP2 with MAVS See in Reactome
MONDO:0032927	TKFC	Q3LXA3	2.7.1.28 2.7.1.29 4.6.1.15	R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-70350 R-HSA-70350 Reactome Name: Fructose catabolism See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5652084 R-HSA-5652084 Reactome Name: Fructose metabolism See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Immune System Metabolism	R-HSA-70349 ( R-HSA-70350 ) R-HSA-70349 Reaction Name: DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate See in Reactome R-HSA-913725 ( R-HSA-168928 ) R-HSA-913725 Reaction Name: viral dsRNA binds IFIH1:TKFC See in Reactome
MONDO:0054754	TBK1	Q9UHD2	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-933541 R-HSA-933541 Reactome Name: TRAF6 mediated IRF7 activation See in Reactome R-HSA-3134975 R-HSA-3134975 Reactome Name: Regulation of innate immune responses to cytosolic DNA See in Reactome R-HSA-9013973 R-HSA-9013973 Reactome Name: TICAM1-dependent activation of IRF3/IRF7 See in Reactome R-HSA-918233 R-HSA-918233 Reactome Name: TRAF3-dependent IRF activation pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-1606341 R-HSA-1606341 Reactome Name: IRF3 mediated activation of type 1 IFN See in Reactome R-HSA-3249367 R-HSA-3249367 Reactome Name: STAT6-mediated induction of chemokines See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome R-HSA-936964 R-HSA-936964 Reactome Name: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-1606322 R-HSA-1606322 Reactome Name: ZBP1(DAI) mediated induction of type I IFNs See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System	R-HSA-1606324 ( R-HSA-1606341 ) R-HSA-1606324 Reaction Name: Recruitment TBK1 to dsDNA:ZBP1 followed by its activation See in Reactome R-HSA-1606327 ( R-HSA-1606341 ) R-HSA-1606327 Reaction Name: Phosphorylation and release of IRF3 See in Reactome R-HSA-1606345 ( R-HSA-1606341 ) R-HSA-1606345 Reaction Name: Recruitment of IRF3 to activated ZBP1:TBK1 See in Reactome R-HSA-166245 ( R-HSA-936964 ) R-HSA-166245 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex See in Reactome R-HSA-166271 ( R-HSA-936964 ) R-HSA-166271 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 See in Reactome R-HSA-1834939 ( R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-2396002 ( R-HSA-3270619 ) R-HSA-2396002 Reaction Name: TBK1 is phosphorylated within STING:TBK1:IRF3 complex See in Reactome R-HSA-2396007 ( R-HSA-3270619 ) R-HSA-2396007 Reaction Name: IRF3 is phosphorylated by TBK1 See in Reactome R-HSA-3249371 ( R-HSA-3249367 ) R-HSA-3249371 Reaction Name: TBK1 phosphorylates STAT6 at Ser407 See in Reactome R-HSA-3249378 ( R-HSA-3249367 ) R-HSA-3249378 Reaction Name: STING recruits TBK1 and STAT6 See in Reactome R-HSA-3249386 ( R-HSA-3134975 ) R-HSA-3249386 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 See in Reactome R-HSA-3249390 ( R-HSA-3249367 ) R-HSA-3249390 Reaction Name: TBK1 is phosphorylated within STING:TBK1:STAT6 complex See in Reactome R-HSA-3249392 ( R-HSA-3134975 ) R-HSA-3249392 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 See in Reactome R-HSA-8948703 ( R-HSA-3134975 ) R-HSA-8948703 Reaction Name: NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 See in Reactome R-HSA-8948709 ( R-HSA-3134975 ) R-HSA-8948709 Reaction Name: DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 See in Reactome R-HSA-9008684 ( R-HSA-9008059 ) R-HSA-9008684 Reaction Name: TBK1 phosphorylation See in Reactome R-HSA-9013978 ( R-HSA-9013973 ) R-HSA-9013978 Reaction Name: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex See in Reactome R-HSA-9013979 ( R-HSA-9013973 ) R-HSA-9013979 Reaction Name: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 See in Reactome R-HSA-9013986 ( R-HSA-9013973 ) R-HSA-9013986 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation See in Reactome R-HSA-918225 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918225 Reaction Name: TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 See in Reactome R-HSA-918229 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918229 Reaction Name: Phosphorylation and release of IRF3/IRF7 See in Reactome R-HSA-918232 ( R-HSA-168928; R-HSA-918233 ) R-HSA-918232 Reaction Name: Recruitment of IRF3,IRF7 See in Reactome R-HSA-933525 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933525 Reaction Name: Phosphorylation and release of IRF7 See in Reactome R-HSA-933527 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933527 Reaction Name: Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 See in Reactome R-HSA-933538 ( R-HSA-168928; R-HSA-933541 ) R-HSA-933538 Reaction Name: Recruitment of IRF7 to TRAF6 See in Reactome R-HSA-936941 ( R-HSA-936964 ) R-HSA-936941 Reaction Name: Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation See in Reactome R-HSA-937337 ( R-HSA-168928; R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome R-HSA-9679819 ( R-HSA-1606341 ) R-HSA-9679819 Reaction Name: TBK1 binds amlexanox See in Reactome R-HSA-9705137 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705137 Reaction Name: TBK1 or IKBKE forms homodimers See in Reactome R-HSA-9705145 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705145 Reaction Name: TBK1, IKBKE form homodimers See in Reactome R-HSA-9705320 ( R-HSA-168928; R-HSA-918233 ) R-HSA-9705320 Reaction Name: TBK1, IKBKE are autophosphorylated at Ser172 See in Reactome R-HSA-9705323 ( R-HSA-168928; R-HSA-933541 ) R-HSA-9705323 Reaction Name: Phosphorylation of TBK1/IKBKE See in Reactome R-HSA-9709831 ( R-HSA-168928 ) R-HSA-9709831 Reaction Name: HSP90 binds TBK1 and IRF3 See in Reactome R-HSA-9709852 ( R-HSA-168928 ) R-HSA-9709852 Reaction Name: MAVS:TOMM70 recruits HSP90:TBK1:IRF3 See in Reactome