DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-166663)

Number of enzymes:	5
Number of disease:	9
Number of reactomes:	7
Number of reactions:	25

Search results (Reactome ID: R-HSA-166663)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009006	C2	P06681	3.4.21.43	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-166795 ( R-HSA-166663 ) R-HSA-166795 Reaction Name: Formation of Classical C3 convertase (C4b:C2a complex) See in Reactome R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173636 ( R-HSA-174577 ) R-HSA-173636 Reaction Name: Formation of classic pathway C5 convertase See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome R-HSA-981648 ( R-HSA-977606 ) R-HSA-981648 Reaction Name: C4b binding protein binds C4bC2a See in Reactome R-HSA-981680 ( R-HSA-977606 ) R-HSA-981680 Reaction Name: C4b binding protein displaces C2a See in Reactome
MONDO:0009770	MASP1	P48740	3.4.21.-	R-HSA-3000480 R-HSA-3000480 Reactome Name: Scavenging by Class A Receptors See in Reactome R-HSA-2855086 R-HSA-2855086 Reactome Name: Ficolins bind to repetitive carbohydrate structures on the target cell surface See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome R-HSA-166662 R-HSA-166662 Reactome Name: Lectin pathway of complement activation See in Reactome	R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-2173782 R-HSA-2173782 Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Immune System Vesicle-mediated transport	R-HSA-166721 ( R-HSA-166662; R-HSA-166663 ) R-HSA-166721 Reaction Name: MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa See in Reactome R-HSA-166726 ( R-HSA-166662; R-HSA-166663 ) R-HSA-166726 Reaction Name: Activation of MASPs See in Reactome R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-2203480 ( R-HSA-3000480 ) R-HSA-2203480 Reaction Name: COLEC11 binds ligands See in Reactome R-HSA-2855054 ( R-HSA-166662; R-HSA-166663; R-HSA-2855086 ) R-HSA-2855054 Reaction Name: Ficolin-2 binds to molecular patterns on the target cell surface See in Reactome R-HSA-2855077 ( R-HSA-166662; R-HSA-166663; R-HSA-2855086 ) R-HSA-2855077 Reaction Name: Ficolin-3 binds to molecular patterns on the target cell surface See in Reactome R-HSA-2855125 ( R-HSA-166662; R-HSA-166663; R-HSA-2855086 ) R-HSA-2855125 Reaction Name: Ficolin-1 binds to molecular patterns on the target cell surface See in Reactome R-HSA-8852509 ( R-HSA-166662; R-HSA-166663 ) R-HSA-8852509 Reaction Name: CL-LK binds carbohydrates on target cell surface See in Reactome
MONDO:0013419	C1S	P09871	3.4.21.42	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0013423	MASP2	O00187	3.4.21.104	R-HSA-2855086 R-HSA-2855086 Reactome Name: Ficolins bind to repetitive carbohydrate structures on the target cell surface See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome R-HSA-166662 R-HSA-166662 Reactome Name: Lectin pathway of complement activation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166721 ( R-HSA-166662; R-HSA-166663 ) R-HSA-166721 Reaction Name: MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa See in Reactome R-HSA-166726 ( R-HSA-166662; R-HSA-166663 ) R-HSA-166726 Reaction Name: Activation of MASPs See in Reactome R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-2855054 ( R-HSA-166662; R-HSA-166663; R-HSA-2855086 ) R-HSA-2855054 Reaction Name: Ficolin-2 binds to molecular patterns on the target cell surface See in Reactome R-HSA-2855077 ( R-HSA-166662; R-HSA-166663; R-HSA-2855086 ) R-HSA-2855077 Reaction Name: Ficolin-3 binds to molecular patterns on the target cell surface See in Reactome R-HSA-2855125 ( R-HSA-166662; R-HSA-166663; R-HSA-2855086 ) R-HSA-2855125 Reaction Name: Ficolin-1 binds to molecular patterns on the target cell surface See in Reactome R-HSA-8852509 ( R-HSA-166662; R-HSA-166663 ) R-HSA-8852509 Reaction Name: CL-LK binds carbohydrates on target cell surface See in Reactome
MONDO:0013743	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0014207	C2	P06681	3.4.21.43	R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-174577 R-HSA-174577 Reactome Name: Activation of C3 and C5 See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-166795 ( R-HSA-166663 ) R-HSA-166795 Reaction Name: Formation of Classical C3 convertase (C4b:C2a complex) See in Reactome R-HSA-166817 ( R-HSA-174577 ) R-HSA-166817 Reaction Name: Cleavage of C3 by C3 convertases See in Reactome R-HSA-173636 ( R-HSA-174577 ) R-HSA-173636 Reaction Name: Formation of classic pathway C5 convertase See in Reactome R-HSA-173680 ( R-HSA-174577 ) R-HSA-173680 Reaction Name: Activation of C5 See in Reactome R-HSA-977375 ( R-HSA-977606 ) R-HSA-977375 Reaction Name: CR1 binds C3bBb/C4bC2a See in Reactome R-HSA-977619 ( R-HSA-977606 ) R-HSA-977619 Reaction Name: CD55 (DAF) promotes C3bBb/C4bC2a dissociation See in Reactome R-HSA-977629 ( R-HSA-977606 ) R-HSA-977629 Reaction Name: Displacement of C2a/Bb by CR1 See in Reactome R-HSA-981535 ( R-HSA-977606 ) R-HSA-981535 Reaction Name: CD55 (DAF) binds C3bBb, C4bC2a See in Reactome R-HSA-981621 ( R-HSA-977606 ) R-HSA-981621 Reaction Name: C3 convertases spontaneously dissociate See in Reactome R-HSA-981648 ( R-HSA-977606 ) R-HSA-981648 Reaction Name: C4b binding protein binds C4bC2a See in Reactome R-HSA-981680 ( R-HSA-977606 ) R-HSA-981680 Reaction Name: C4b binding protein displaces C2a See in Reactome
MONDO:0014954	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0014954	C1S	P09871	3.4.21.42	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0015699	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0020684	C1R	P00736	3.4.21.41	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome
MONDO:0020684	C1S	P09871	3.4.21.42	R-HSA-173623 R-HSA-173623 Reactome Name: Classical antibody-mediated complement activation See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-166786 R-HSA-166786 Reactome Name: Creation of C4 and C2 activators See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System	R-HSA-166753 ( R-HSA-166663 ) R-HSA-166753 Reaction Name: Conversion of C4 into C4a and C4b See in Reactome R-HSA-166792 ( R-HSA-166663 ) R-HSA-166792 Reaction Name: Conversion of C2 into C2a and C2b See in Reactome R-HSA-173626 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173626 Reaction Name: Activation of C1r See in Reactome R-HSA-173631 ( R-HSA-166663; R-HSA-173623 ) R-HSA-173631 Reaction Name: Activation of C1s See in Reactome R-HSA-8852266 ( R-HSA-977606 ) R-HSA-8852266 Reaction Name: C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s See in Reactome R-HSA-8852481 ( R-HSA-977606 ) R-HSA-8852481 Reaction Name: Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates See in Reactome R-HSA-9021306 ( R-HSA-977606 ) R-HSA-9021306 Reaction Name: C1-Inh binds and inactivates C1r, C1s See in Reactome