DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-1663150)

Number of enzymes:	7
Number of disease:	11
Number of reactomes:	4
Number of reactions:	9

Search results (Reactome ID: R-HSA-1663150)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009591	ARSB	P15848	3.1.6.12	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1606789 ( R-HSA-2024101 ) R-HSA-1606789 Reaction Name: ARSB hydrolyses DS See in Reactome R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome R-HSA-1793207 ( R-HSA-2024101 ) R-HSA-1793207 Reaction Name: ARSB hydrolyses C4S/C6S chains See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0010088	ARSA	P15289	3.1.6.8	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1606807 ( R-HSA-1660662 ) R-HSA-1606807 Reaction Name: Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside See in Reactome R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome R-HSA-2248891 ( R-HSA-1660662 ) R-HSA-2248891 Reaction Name: Active ARSA translocates to the lysosome See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome
MONDO:0010088	ARSB	P15848	3.1.6.12	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1606789 ( R-HSA-2024101 ) R-HSA-1606789 Reaction Name: ARSB hydrolyses DS See in Reactome R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome R-HSA-1793207 ( R-HSA-2024101 ) R-HSA-1793207 Reaction Name: ARSB hydrolyses C4S/C6S chains See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0010088	SUMF1	Q8NBK3	1.8.3.7	R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Metabolism	R-HSA-1614336 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614336 Reaction Name: SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases See in Reactome R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome
MONDO:0010555	ARSL	P51690	3.1.6.1	R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Metabolism	R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome
MONDO:0010622	STS	P08842	3.1.6.2	R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Metabolism	R-HSA-1606839 ( R-HSA-1660662 ) R-HSA-1606839 Reaction Name: Steryl sulfatase hydrolyses sulfate from steroid sulfates See in Reactome R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome
MONDO:0016485	ARSG	Q96EG1	3.1.6.15 3.1.6.1	R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Metabolism	R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome
MONDO:0017171	ARSB	P15848	3.1.6.12	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1606789 ( R-HSA-2024101 ) R-HSA-1606789 Reaction Name: ARSB hydrolyses DS See in Reactome R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome R-HSA-1793207 ( R-HSA-2024101 ) R-HSA-1793207 Reaction Name: ARSB hydrolyses C4S/C6S chains See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0017172	ARSB	P15848	3.1.6.12	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2024101 R-HSA-2024101 Reactome Name: CS/DS degradation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-1793185 R-HSA-1793185 Reactome Name: Chondroitin sulfate/dermatan sulfate metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1630316 R-HSA-1630316 Reactome Name: Glycosaminoglycan metabolism See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1606789 ( R-HSA-2024101 ) R-HSA-1606789 Reaction Name: ARSB hydrolyses DS See in Reactome R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome R-HSA-1793207 ( R-HSA-2024101 ) R-HSA-1793207 Reaction Name: ARSB hydrolyses C4S/C6S chains See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0017729	ARSA	P15289	3.1.6.8	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1606807 ( R-HSA-1660662 ) R-HSA-1606807 Reaction Name: Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside See in Reactome R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome R-HSA-2248891 ( R-HSA-1660662 ) R-HSA-2248891 Reaction Name: Active ARSA translocates to the lysosome See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome
MONDO:0017730	ARSA	P15289	3.1.6.8	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Immune System Metabolism of proteins Metabolism	R-HSA-1606807 ( R-HSA-1660662 ) R-HSA-1606807 Reaction Name: Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside See in Reactome R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome R-HSA-2248891 ( R-HSA-1660662 ) R-HSA-2248891 Reaction Name: Active ARSA translocates to the lysosome See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome
MONDO:0018418	ARSI	Q5FYB1	3.1.6.-	R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Metabolism	R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome
MONDO:0029141	ARSG	Q96EG1	3.1.6.15 3.1.6.1	R-HSA-1660662 R-HSA-1660662 Reactome Name: Glycosphingolipid metabolism See in Reactome R-HSA-1663150 R-HSA-1663150 Reactome Name: The activation of arylsulfatases See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Metabolism	R-HSA-1614362 ( R-HSA-1660662; R-HSA-1663150 ) R-HSA-1614362 Reaction Name: SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases See in Reactome