DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-1660661)

Number of enzymes:	15
Number of disease:	18
Number of reactomes:	7
Number of reactions:	20

Search results (Reactome ID: R-HSA-1660661)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002321	SPTLC3	Q9NUV7	2.3.1.50	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428127 ( R-HSA-1660661 ) R-HSA-428127 Reaction Name: palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 See in Reactome
MONDO:0007470	SGMS2	Q8NHU3	2.7.8.27	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-429786 ( R-HSA-1660661 ) R-HSA-429786 Reaction Name: phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2] See in Reactome
MONDO:0008086	SPTLC1	O15269	2.3.1.50	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428127 ( R-HSA-1660661 ) R-HSA-428127 Reaction Name: palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 See in Reactome
MONDO:0010031	ALDH3A2	P51648	1.2.1.3 1.2.1.94	R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome R-HSA-9696270 R-HSA-9696270 Reactome Name: RND2 GTPase cycle See in Reactome R-HSA-9696273 R-HSA-9696273 Reactome Name: RND1 GTPase cycle See in Reactome R-HSA-9609523 R-HSA-9609523 Reactome Name: Insertion of tail-anchored proteins into the endoplasmic reticulum membrane See in Reactome R-HSA-389599 R-HSA-389599 Reactome Name: Alpha-oxidation of phytanate See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Protein localization Metabolism Signal Transduction	R-HSA-9696266 ( R-HSA-9696270 ) R-HSA-9696266 Reaction Name: RND2 binds effectors See in Reactome R-HSA-9696271 ( R-HSA-9696273 ) R-HSA-9696271 Reaction Name: RND1 binds effectors See in Reactome
MONDO:0012866	FA2H	Q7L5A8	1.14.18.-	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-5693761 ( R-HSA-1660661 ) R-HSA-5693761 Reaction Name: FA2H hydroxylates CERA See in Reactome
MONDO:0013337	SPTLC2	O15270	2.3.1.50	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428127 ( R-HSA-1660661 ) R-HSA-428127 Reaction Name: palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 See in Reactome
MONDO:0014010	CERS3	Q8IU89	2.3.1.24 2.3.1.297 2.3.1.298	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428185 ( R-HSA-1660661 ) R-HSA-428185 Reaction Name: sphinganine + stearyl-CoA => dihydroceramide + CoASH See in Reactome
MONDO:0014545	CERS1	P27544	2.3.1.299	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428185 ( R-HSA-1660661 ) R-HSA-428185 Reaction Name: sphinganine + stearyl-CoA => dihydroceramide + CoASH See in Reactome
MONDO:0014599	CERT1	Q9Y5P4	-	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-429683 ( R-HSA-1660661 ) R-HSA-429683 Reaction Name: CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus See in Reactome R-HSA-429694 ( R-HSA-1660661 ) R-HSA-429694 Reaction Name: CERT1-2 dissociates from the endoplasmic reticulum See in Reactome R-HSA-429698 ( R-HSA-1660661 ) R-HSA-429698 Reaction Name: PRKD1 See in Reactome R-HSA-429698 ( R-HSA-1660661 ) R-HSA-429698 Reaction Name: PRKD1,2,3 phosphorylates CERT1-2 See in Reactome R-HSA-429699 ( R-HSA-1660661 ) R-HSA-429699 Reaction Name: CERT1-2 binds ceramide See in Reactome R-HSA-429714 ( R-HSA-1660661 ) R-HSA-429714 Reaction Name: monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP See in Reactome R-HSA-429730 ( R-HSA-1660661 ) R-HSA-429730 Reaction Name: multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate See in Reactome R-HSA-429732 ( R-HSA-1660661 ) R-HSA-429732 Reaction Name: multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B See in Reactome
MONDO:0015626	SPTLC1	O15269	2.3.1.50	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428127 ( R-HSA-1660661 ) R-HSA-428127 Reaction Name: palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 See in Reactome
MONDO:0015626	SPTLC2	O15270	2.3.1.50	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428127 ( R-HSA-1660661 ) R-HSA-428127 Reaction Name: palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 See in Reactome
MONDO:0017167	PRKD1	Q15139	2.7.11.13	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-429698 ( R-HSA-1660661 ) R-HSA-429698 Reaction Name: PRKD1 See in Reactome R-HSA-429698 ( R-HSA-1660661 ) R-HSA-429698 Reaction Name: PRKD1,2,3 phosphorylates CERT1-2 See in Reactome
MONDO:0017999	FA2H	Q7L5A8	1.14.18.-	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-5693761 ( R-HSA-1660661 ) R-HSA-5693761 Reaction Name: FA2H hydroxylates CERA See in Reactome
MONDO:0032730	DEGS1	O15121	1.14.19.17 5.2.1.-	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome	Metabolism Immune System	R-HSA-428259 ( R-HSA-1660661 ) R-HSA-428259 Reaction Name: dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome
MONDO:0032762	SPNS2	Q8IVW8	-	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-9695890 ( R-HSA-1660661 ) R-HSA-9695890 Reaction Name: SPNS2 transports S1P from cytosol to extracellular region See in Reactome
MONDO:0033014	KDSR	Q06136	1.1.1.102	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428123 ( R-HSA-1660661 ) R-HSA-428123 Reaction Name: 3-ketosphinganine + NADPH + H+ => sphinganine + NADP+ See in Reactome
MONDO:0033203	SGPL1	O95470	4.1.2.27	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428676 ( R-HSA-1660661 ) R-HSA-428676 Reaction Name: sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal See in Reactome R-HSA-428681 ( R-HSA-1660661 ) R-HSA-428681 Reaction Name: sphinganine 1-phosphate => phosphoethanolamine + hexadecanal See in Reactome
MONDO:0044303	PRKD1	Q15139	2.7.11.13	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-429698 ( R-HSA-1660661 ) R-HSA-429698 Reaction Name: PRKD1 See in Reactome R-HSA-429698 ( R-HSA-1660661 ) R-HSA-429698 Reaction Name: PRKD1,2,3 phosphorylates CERT1-2 See in Reactome
MONDO:0044718	ACER3	Q9NUN7	3.5.1.23 3.5.1.-	R-HSA-1660661 R-HSA-1660661 Reactome Name: Sphingolipid de novo biosynthesis See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-428157 R-HSA-428157 Reactome Name: Sphingolipid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome	Metabolism	R-HSA-428262 ( R-HSA-1660661 ) R-HSA-428262 Reaction Name: phytoceramide + H2O => stearate + phytosphingosine See in Reactome