DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-1660517)

Number of enzymes:	5
Number of disease:	8
Number of reactomes:	7
Number of reactions:	37

Search results (Reactome ID: R-HSA-1660517)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007376	PIKFYVE	Q9Y2I7	2.7.1.150 2.7.11.1	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675866 ( R-HSA-1660517 ) R-HSA-1675866 Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675910 ( R-HSA-1660517 ) R-HSA-1675910 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675921 ( R-HSA-1660514 ) R-HSA-1675921 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane See in Reactome R-HSA-1676005 ( R-HSA-1660514 ) R-HSA-1676005 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane See in Reactome R-HSA-1676020 ( R-HSA-1660517 ) R-HSA-1676020 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane See in Reactome R-HSA-1676168 ( R-HSA-1660516 ) R-HSA-1676168 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane See in Reactome R-HSA-1676174 ( R-HSA-1660516 ) R-HSA-1676174 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane See in Reactome
MONDO:0008995	FIG4	Q92562	3.1.3.16 3.1.3.- 3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675866 ( R-HSA-1660517 ) R-HSA-1675866 Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675910 ( R-HSA-1660517 ) R-HSA-1675910 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675921 ( R-HSA-1660514 ) R-HSA-1675921 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane See in Reactome R-HSA-1676005 ( R-HSA-1660514 ) R-HSA-1676005 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane See in Reactome R-HSA-1676020 ( R-HSA-1660517 ) R-HSA-1676020 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane See in Reactome R-HSA-1676168 ( R-HSA-1660516 ) R-HSA-1676168 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane See in Reactome R-HSA-1676174 ( R-HSA-1660516 ) R-HSA-1676174 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane See in Reactome
MONDO:0010683	MTM1	Q13496	3.1.3.64 3.1.3.95	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675795 ( R-HSA-1660517 ) R-HSA-1675795 Reaction Name: PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane See in Reactome R-HSA-1675994 ( R-HSA-1660499 ) R-HSA-1675994 Reaction Name: PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1676065 ( R-HSA-1660517 ) R-HSA-1676065 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane See in Reactome R-HSA-1676105 ( R-HSA-1660516 ) R-HSA-1676105 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane See in Reactome R-HSA-1676141 ( R-HSA-1660516 ) R-HSA-1676141 Reaction Name: PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane See in Reactome R-HSA-1676203 ( R-HSA-1660499 ) R-HSA-1676203 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-6809680 ( R-HSA-1660516 ) R-HSA-6809680 Reaction Name: MTMR12 binds MTM1 See in Reactome R-HSA-6809720 ( R-HSA-1660516 ) R-HSA-6809720 Reaction Name: PI3P is dephosphorylated to PI by MTM1:MTMR12 See in Reactome
MONDO:0011066	MTMR2	Q13614	3.1.3.64 3.1.3.95	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1483248 R-HSA-1483248 Reactome Name: Synthesis of PIPs at the ER membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675795 ( R-HSA-1660517 ) R-HSA-1675795 Reaction Name: PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane See in Reactome R-HSA-1676065 ( R-HSA-1660517 ) R-HSA-1676065 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane See in Reactome R-HSA-1676105 ( R-HSA-1660516 ) R-HSA-1676105 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane See in Reactome R-HSA-1676141 ( R-HSA-1660516 ) R-HSA-1676141 Reaction Name: PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane See in Reactome R-HSA-6809707 ( R-HSA-1660516 ) R-HSA-6809707 Reaction Name: MTMR12 binds MTMR2 See in Reactome R-HSA-6809764 ( R-HSA-1483248 ) R-HSA-6809764 Reaction Name: SBF1 binds MTMR2 See in Reactome R-HSA-6809777 ( R-HSA-1483248 ) R-HSA-6809777 Reaction Name: PI3P is dephosphorylated to PI by MTMR2:SBF1 See in Reactome R-HSA-6809778 ( R-HSA-1483248 ) R-HSA-6809778 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 See in Reactome R-HSA-6809785 ( R-HSA-1660499 ) R-HSA-6809785 Reaction Name: MTMR2 dimerizes See in Reactome R-HSA-6809793 ( R-HSA-1660499 ) R-HSA-6809793 Reaction Name: MTMR2 binds SBF2 See in Reactome R-HSA-6809944 ( R-HSA-1660499 ) R-HSA-6809944 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane See in Reactome R-HSA-6809975 ( R-HSA-1660499 ) R-HSA-6809975 Reaction Name: PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane See in Reactome R-HSA-6810030 ( R-HSA-1660516 ) R-HSA-6810030 Reaction Name: MTMR2 binds MTMR10 See in Reactome
MONDO:0012640	FIG4	Q92562	3.1.3.16 3.1.3.- 3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675866 ( R-HSA-1660517 ) R-HSA-1675866 Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675910 ( R-HSA-1660517 ) R-HSA-1675910 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675921 ( R-HSA-1660514 ) R-HSA-1675921 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane See in Reactome R-HSA-1676005 ( R-HSA-1660514 ) R-HSA-1676005 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane See in Reactome R-HSA-1676020 ( R-HSA-1660517 ) R-HSA-1676020 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane See in Reactome R-HSA-1676168 ( R-HSA-1660516 ) R-HSA-1676168 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane See in Reactome R-HSA-1676174 ( R-HSA-1660516 ) R-HSA-1676174 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane See in Reactome
MONDO:0012945	FIG4	Q92562	3.1.3.16 3.1.3.- 3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675866 ( R-HSA-1660517 ) R-HSA-1675866 Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675910 ( R-HSA-1660517 ) R-HSA-1675910 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675921 ( R-HSA-1660514 ) R-HSA-1675921 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane See in Reactome R-HSA-1676005 ( R-HSA-1660514 ) R-HSA-1676005 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane See in Reactome R-HSA-1676020 ( R-HSA-1660517 ) R-HSA-1676020 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane See in Reactome R-HSA-1676168 ( R-HSA-1660516 ) R-HSA-1676168 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane See in Reactome R-HSA-1676174 ( R-HSA-1660516 ) R-HSA-1676174 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane See in Reactome
MONDO:0012986	FIG4	Q92562	3.1.3.16 3.1.3.- 3.1.3.36 3.1.3.86	R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675866 ( R-HSA-1660517 ) R-HSA-1675866 Reaction Name: PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675910 ( R-HSA-1660517 ) R-HSA-1675910 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane See in Reactome R-HSA-1675921 ( R-HSA-1660514 ) R-HSA-1675921 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane See in Reactome R-HSA-1676005 ( R-HSA-1660514 ) R-HSA-1676005 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane See in Reactome R-HSA-1676020 ( R-HSA-1660517 ) R-HSA-1676020 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane See in Reactome R-HSA-1676168 ( R-HSA-1660516 ) R-HSA-1676168 Reaction Name: PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane See in Reactome R-HSA-1676174 ( R-HSA-1660516 ) R-HSA-1676174 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane See in Reactome
MONDO:0034145	PIK3C2A	O00443	2.7.1.137 2.7.1.154 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome	R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Vesicle-mediated transport	R-HSA-1675928 ( R-HSA-1660514 ) R-HSA-1675928 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane See in Reactome R-HSA-1675939 ( R-HSA-1660516 ) R-HSA-1675939 Reaction Name: PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane See in Reactome R-HSA-1675961 ( R-HSA-1660514 ) R-HSA-1675961 Reaction Name: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane See in Reactome R-HSA-1676024 ( R-HSA-1660517 ) R-HSA-1676024 Reaction Name: PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-1676206 ( R-HSA-1660516 ) R-HSA-1676206 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421833 ( R-HSA-432722 ) R-HSA-421833 Reaction Name: Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-421836 ( R-HSA-432722 ) R-HSA-421836 Reaction Name: trans-Golgi Network Derived Vesicle Uncoating See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome