DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-1660499)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001056	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0005148	INPPL1	O15357	3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Immune System Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome
MONDO:0005575	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0005595	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0007924	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0007962	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0008021	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0008048	MTMR14	Q8NCE2	3.1.3.-	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism Autophagy	R-HSA-1675994 ( R-HSA-1660499 ) R-HSA-1675994 Reaction Name: PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1676203 ( R-HSA-1660499 ) R-HSA-1676203 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-5679206 ( R-HSA-1632852 ) R-HSA-5679206 Reaction Name: MTMR14, MTMR3 dephosphorylate PI3P See in Reactome
MONDO:0008093	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0008170	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0008170	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0008318	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0008420	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0008903	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0009567	INPP5K	Q9BT40	3.1.3.56 3.1.3.36 3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1676177 ( R-HSA-1660499 ) R-HSA-1676177 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane See in Reactome
MONDO:0009785	INPPL1	O15357	3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Immune System Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome
MONDO:0010013	INPPL1	O15357	3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome	Immune System Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-913374 ( R-HSA-512988; R-HSA-912526 ) R-HSA-913374 Reaction Name: Phosphorylated SHC1 recruits SHIP See in Reactome
MONDO:0010172	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0010359	OCRL	Q01968	3.1.3.56 3.1.3.36 3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-1855183 R-HSA-1855183 Reactome Name: Synthesis of IP2, IP, and Ins in the cytosol See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Signal Transduction Vesicle-mediated transport	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-1675836 ( R-HSA-1660499 ) R-HSA-1675836 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane See in Reactome R-HSA-1675988 ( R-HSA-1660499 ) R-HSA-1675988 Reaction Name: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane See in Reactome R-HSA-1855174 ( R-HSA-1855183 ) R-HSA-1855174 Reaction Name: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol See in Reactome R-HSA-1855213 ( R-HSA-1855204 ) R-HSA-1855213 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421833 ( R-HSA-432722 ) R-HSA-421833 Reaction Name: Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-421836 ( R-HSA-432722 ) R-HSA-421836 Reaction Name: trans-Golgi Network Derived Vesicle Uncoating See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-9017488 ( R-HSA-9013409 ) R-HSA-9017488 Reaction Name: RHOJ GAPs stimulate RHOJ GTPase activity See in Reactome R-HSA-9018806 ( R-HSA-9013423 ) R-HSA-9018806 Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity See in Reactome
MONDO:0010645	OCRL	Q01968	3.1.3.56 3.1.3.36 3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-1855183 R-HSA-1855183 Reactome Name: Synthesis of IP2, IP, and Ins in the cytosol See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome R-HSA-9013409 R-HSA-9013409 Reactome Name: RHOJ GTPase cycle See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Signal Transduction Vesicle-mediated transport	R-HSA-1675824 ( R-HSA-1660514 ) R-HSA-1675824 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane See in Reactome R-HSA-1675836 ( R-HSA-1660499 ) R-HSA-1675836 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane See in Reactome R-HSA-1675988 ( R-HSA-1660499 ) R-HSA-1675988 Reaction Name: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane See in Reactome R-HSA-1855174 ( R-HSA-1855183 ) R-HSA-1855174 Reaction Name: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol See in Reactome R-HSA-1855213 ( R-HSA-1855204 ) R-HSA-1855213 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421833 ( R-HSA-432722 ) R-HSA-421833 Reaction Name: Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-421836 ( R-HSA-432722 ) R-HSA-421836 Reaction Name: trans-Golgi Network Derived Vesicle Uncoating See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome R-HSA-9017488 ( R-HSA-9013409 ) R-HSA-9017488 Reaction Name: RHOJ GAPs stimulate RHOJ GTPase activity See in Reactome R-HSA-9018806 ( R-HSA-9013423 ) R-HSA-9018806 Reaction Name: RAC3 GAPs stimulate RAC3 GTPase activity See in Reactome
MONDO:0010683	MTM1	Q13496	3.1.3.64 3.1.3.95	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675795 ( R-HSA-1660517 ) R-HSA-1675795 Reaction Name: PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane See in Reactome R-HSA-1675994 ( R-HSA-1660499 ) R-HSA-1675994 Reaction Name: PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1676065 ( R-HSA-1660517 ) R-HSA-1676065 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane See in Reactome R-HSA-1676105 ( R-HSA-1660516 ) R-HSA-1676105 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane See in Reactome R-HSA-1676141 ( R-HSA-1660516 ) R-HSA-1676141 Reaction Name: PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane See in Reactome R-HSA-1676203 ( R-HSA-1660499 ) R-HSA-1676203 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-6809680 ( R-HSA-1660516 ) R-HSA-6809680 Reaction Name: MTMR12 binds MTM1 See in Reactome R-HSA-6809720 ( R-HSA-1660516 ) R-HSA-6809720 Reaction Name: PI3P is dephosphorylated to PI by MTM1:MTMR12 See in Reactome
MONDO:0011066	MTMR2	Q13614	3.1.3.64 3.1.3.95	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1483248 R-HSA-1483248 Reactome Name: Synthesis of PIPs at the ER membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675795 ( R-HSA-1660517 ) R-HSA-1675795 Reaction Name: PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane See in Reactome R-HSA-1676065 ( R-HSA-1660517 ) R-HSA-1676065 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane See in Reactome R-HSA-1676105 ( R-HSA-1660516 ) R-HSA-1676105 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane See in Reactome R-HSA-1676141 ( R-HSA-1660516 ) R-HSA-1676141 Reaction Name: PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane See in Reactome R-HSA-6809707 ( R-HSA-1660516 ) R-HSA-6809707 Reaction Name: MTMR12 binds MTMR2 See in Reactome R-HSA-6809764 ( R-HSA-1483248 ) R-HSA-6809764 Reaction Name: SBF1 binds MTMR2 See in Reactome R-HSA-6809777 ( R-HSA-1483248 ) R-HSA-6809777 Reaction Name: PI3P is dephosphorylated to PI by MTMR2:SBF1 See in Reactome R-HSA-6809778 ( R-HSA-1483248 ) R-HSA-6809778 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 See in Reactome R-HSA-6809785 ( R-HSA-1660499 ) R-HSA-6809785 Reaction Name: MTMR2 dimerizes See in Reactome R-HSA-6809793 ( R-HSA-1660499 ) R-HSA-6809793 Reaction Name: MTMR2 binds SBF2 See in Reactome R-HSA-6809944 ( R-HSA-1660499 ) R-HSA-6809944 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane See in Reactome R-HSA-6809975 ( R-HSA-1660499 ) R-HSA-6809975 Reaction Name: PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane See in Reactome R-HSA-6810030 ( R-HSA-1660516 ) R-HSA-6810030 Reaction Name: MTMR2 binds MTMR10 See in Reactome
MONDO:0011240	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0011537	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0011738	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0011789	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0011962	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0012656	PIP5K1C	O60331	2.7.1.68	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-399955 R-HSA-399955 Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Signal Transduction Developmental Biology Vesicle-mediated transport	R-HSA-1675773 ( R-HSA-1660499 ) R-HSA-1675773 Reaction Name: PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane See in Reactome R-HSA-1676082 ( R-HSA-1660499; R-HSA-6811558 ) R-HSA-1676082 Reaction Name: PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane See in Reactome R-HSA-1676145 ( R-HSA-1660499 ) R-HSA-1676145 Reaction Name: PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane See in Reactome R-HSA-399936 ( R-HSA-399955 ) R-HSA-399936 Reaction Name: Inhibition of integrin activation by sequestering PIP5KIgamma See in Reactome R-HSA-8868066 ( R-HSA-8856828 ) R-HSA-8868066 Reaction Name: PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 See in Reactome
MONDO:0013038	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0013092	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0013125	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0013226	PIK3CD	O00329	2.7.1.137 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism Signal Transduction Developmental Biology	R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-2045911 ( R-HSA-983695 ) R-HSA-2045911 Reaction Name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2076220 ( R-HSA-983695 ) R-HSA-2076220 Reaction Name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9606160 ( R-HSA-983695 ) R-HSA-9606160 Reaction Name: p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) See in Reactome R-HSA-9606887 ( R-HSA-983695 ) R-HSA-9606887 Reaction Name: p-CD19:VAV binds PI3K and GRB2 See in Reactome
MONDO:0014047	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0014222	PIK3CD	O00329	2.7.1.137 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism Signal Transduction Developmental Biology	R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-2045911 ( R-HSA-983695 ) R-HSA-2045911 Reaction Name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2076220 ( R-HSA-983695 ) R-HSA-2076220 Reaction Name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9606160 ( R-HSA-983695 ) R-HSA-9606160 Reaction Name: p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) See in Reactome R-HSA-9606887 ( R-HSA-983695 ) R-HSA-9606887 Reaction Name: p-CD19:VAV binds PI3K and GRB2 See in Reactome
MONDO:0014233	SYNJ1	O43426	3.1.3.36	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1855183 R-HSA-1855183 Reactome Name: Synthesis of IP2, IP, and Ins in the cytosol See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Vesicle-mediated transport	R-HSA-1675836 ( R-HSA-1660499 ) R-HSA-1675836 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane See in Reactome R-HSA-1675988 ( R-HSA-1660499 ) R-HSA-1675988 Reaction Name: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane See in Reactome R-HSA-1675994 ( R-HSA-1660499 ) R-HSA-1675994 Reaction Name: PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1676177 ( R-HSA-1660499 ) R-HSA-1676177 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane See in Reactome R-HSA-1676203 ( R-HSA-1660499 ) R-HSA-1676203 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1855174 ( R-HSA-1855183 ) R-HSA-1855174 Reaction Name: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome
MONDO:0015293	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0016216	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0016419	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0016642	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0016995	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0016996	PIK3CB	P42338	2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome
MONDO:0017177	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0017564	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0017566	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0017571	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0017812	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0018321	SYNJ1	O43426	3.1.3.36	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1855183 R-HSA-1855183 Reactome Name: Synthesis of IP2, IP, and Ins in the cytosol See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Vesicle-mediated transport	R-HSA-1675836 ( R-HSA-1660499 ) R-HSA-1675836 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane See in Reactome R-HSA-1675988 ( R-HSA-1660499 ) R-HSA-1675988 Reaction Name: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane See in Reactome R-HSA-1675994 ( R-HSA-1660499 ) R-HSA-1675994 Reaction Name: PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1676177 ( R-HSA-1660499 ) R-HSA-1676177 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane See in Reactome R-HSA-1676203 ( R-HSA-1660499 ) R-HSA-1676203 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1855174 ( R-HSA-1855183 ) R-HSA-1855174 Reaction Name: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome
MONDO:0018338	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0018614	SYNJ1	O43426	3.1.3.36	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1855183 R-HSA-1855183 Reactome Name: Synthesis of IP2, IP, and Ins in the cytosol See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Vesicle-mediated transport	R-HSA-1675836 ( R-HSA-1660499 ) R-HSA-1675836 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane See in Reactome R-HSA-1675988 ( R-HSA-1660499 ) R-HSA-1675988 Reaction Name: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane See in Reactome R-HSA-1675994 ( R-HSA-1660499 ) R-HSA-1675994 Reaction Name: PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1676177 ( R-HSA-1660499 ) R-HSA-1676177 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane See in Reactome R-HSA-1676203 ( R-HSA-1660499 ) R-HSA-1676203 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1855174 ( R-HSA-1855183 ) R-HSA-1855174 Reaction Name: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome
MONDO:0018872	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0019002	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0020492	PIK3CA	P42336	2.7.1.137 2.7.11.1 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-1963642 R-HSA-1963642 Reactome Name: PI3K events in ERBB2 signaling See in Reactome R-HSA-9607240 R-HSA-9607240 Reactome Name: FLT3 Signaling See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-180292 R-HSA-180292 Reactome Name: GAB1 signalosome See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654710 R-HSA-5654710 Reactome Name: PI-3K cascade:FGFR3 See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654689 R-HSA-5654689 Reactome Name: PI-3K cascade:FGFR1 See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-5654695 R-HSA-5654695 Reactome Name: PI-3K cascade:FGFR2 See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome R-HSA-8851907 R-HSA-8851907 Reactome Name: MET activates PI3K/AKT signaling See in Reactome R-HSA-1250342 R-HSA-1250342 Reactome Name: PI3K events in ERBB4 signaling See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-9028335 R-HSA-9028335 Reactome Name: Activated NTRK2 signals through PI3K See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-9603381 R-HSA-9603381 Reactome Name: Activated NTRK3 signals through PI3K See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5654687 R-HSA-5654687 Reactome Name: Downstream signaling of activated FGFR1 See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5654708 R-HSA-5654708 Reactome Name: Downstream signaling of activated FGFR3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-9034015 R-HSA-9034015 Reactome Name: Signaling by NTRK3 (TRKC) See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006115 R-HSA-9006115 Reactome Name: Signaling by NTRK2 (TRKB) See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654696 R-HSA-5654696 Reactome Name: Downstream signaling of activated FGFR2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-114542 ( R-HSA-1257604 ) R-HSA-114542 Reaction Name: RAC1,RAC2,RHOG activate PI3K See in Reactome R-HSA-1250189 ( R-HSA-1963642 ) R-HSA-1250189 Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer See in Reactome R-HSA-1250346 ( R-HSA-1963642 ) R-HSA-1250346 Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers See in Reactome R-HSA-1250353 ( R-HSA-1250342 ) R-HSA-1250353 Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250370 ( R-HSA-1250342 ) R-HSA-1250370 Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers See in Reactome R-HSA-1250462 ( R-HSA-1963642 ) R-HSA-1250462 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 See in Reactome R-HSA-1306957 ( R-HSA-1963642 ) R-HSA-1306957 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR See in Reactome R-HSA-1306965 ( R-HSA-1963642 ) R-HSA-1306965 Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. See in Reactome R-HSA-1306979 ( R-HSA-1963642 ) R-HSA-1306979 Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-177927 ( R-HSA-180292 ) R-HSA-177927 Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1 See in Reactome R-HSA-177939 ( R-HSA-180292 ) R-HSA-177939 Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-388830 ( R-HSA-388841 ) R-HSA-388830 Reaction Name: PI3K binds ICOS See in Reactome R-HSA-388832 ( R-HSA-388841; R-HSA-389357 ) R-HSA-388832 Reaction Name: PI3K binds CD28 See in Reactome R-HSA-389158 ( R-HSA-388841; R-HSA-389357 ) R-HSA-389158 Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-416358 ( R-HSA-416476 ) R-HSA-416358 Reaction Name: G alpha (q) inhibits PI3K alpha See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-5654591 ( R-HSA-5654689 ) R-HSA-5654591 Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654596 ( R-HSA-5654689 ) R-HSA-5654596 Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654614 ( R-HSA-5654695 ) R-HSA-5654614 Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654622 ( R-HSA-5654695 ) R-HSA-5654622 Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654640 ( R-HSA-5654710 ) R-HSA-5654640 Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654643 ( R-HSA-5654710 ) R-HSA-5654643 Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654690 ( R-HSA-5654689 ) R-HSA-5654690 Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654692 ( R-HSA-5654689 ) R-HSA-5654692 Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654697 ( R-HSA-5654695 ) R-HSA-5654697 Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654701 ( R-HSA-5654695 ) R-HSA-5654701 Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654705 ( R-HSA-5654710 ) R-HSA-5654705 Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654709 ( R-HSA-5654710 ) R-HSA-5654709 Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8851954 ( R-HSA-8851907 ) R-HSA-8851954 Reaction Name: Phosphorylated GAB1 recruits PI3K to MET See in Reactome R-HSA-8852019 ( R-HSA-8851907 ) R-HSA-8852019 Reaction Name: MET bound PI3K generates PIP3 See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014294 ( R-HSA-9013404 ) R-HSA-9014294 Reaction Name: RAC2 binds effectors at the plasma membrane See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9021660 ( R-HSA-9009391 ) R-HSA-9021660 Reaction Name: PI3K binds membrane-associated estrogen receptors See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-9028505 ( R-HSA-9028335 ) R-HSA-9028505 Reaction Name: Activated NTRK2 recruits PI3K See in Reactome R-HSA-9028519 ( R-HSA-9028335 ) R-HSA-9028519 Reaction Name: NTRK2-activated PI3K generates PIP3 See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9603407 ( R-HSA-9603381 ) R-HSA-9603407 Reaction Name: Activated NTRK3 binds PI3K See in Reactome R-HSA-9603445 ( R-HSA-9603381 ) R-HSA-9603445 Reaction Name: Activated NTRK3 stimulates PI3K activity See in Reactome R-HSA-9632412 ( R-HSA-9009391 ) R-HSA-9632412 Reaction Name: PTK2 is recruited to methylated ESR1 See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome R-HSA-9698170 ( R-HSA-9607240 ) R-HSA-9698170 Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA See in Reactome R-HSA-9706345 ( R-HSA-9607240 ) R-HSA-9706345 Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA See in Reactome
MONDO:0021067	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0021427	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0023122	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0023655	PIK3CD	O00329	2.7.1.137 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome	R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism Signal Transduction Developmental Biology	R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-2045911 ( R-HSA-983695 ) R-HSA-2045911 Reaction Name: BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2076220 ( R-HSA-983695 ) R-HSA-2076220 Reaction Name: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-199418; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9606160 ( R-HSA-983695 ) R-HSA-9606160 Reaction Name: p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) See in Reactome R-HSA-9606887 ( R-HSA-983695 ) R-HSA-9606887 Reaction Name: p-CD19:VAV binds PI3K and GRB2 See in Reactome
MONDO:0024607	INPP5K	Q9BT40	3.1.3.56 3.1.3.36 3.1.3.86	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism	R-HSA-1675949 ( R-HSA-1660499 ) R-HSA-1675949 Reaction Name: PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane See in Reactome R-HSA-1676177 ( R-HSA-1660499 ) R-HSA-1676177 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane See in Reactome
MONDO:0033362	SYNJ1	O43426	3.1.3.36	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1855183 R-HSA-1855183 Reactome Name: Synthesis of IP2, IP, and Ins in the cytosol See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Vesicle-mediated transport	R-HSA-1675836 ( R-HSA-1660499 ) R-HSA-1675836 Reaction Name: PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane See in Reactome R-HSA-1675988 ( R-HSA-1660499 ) R-HSA-1675988 Reaction Name: PI4P is dephosphorylated to PI by SYNJ at the plasma membrane See in Reactome R-HSA-1675994 ( R-HSA-1660499 ) R-HSA-1675994 Reaction Name: PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1676177 ( R-HSA-1660499 ) R-HSA-1676177 Reaction Name: PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane See in Reactome R-HSA-1676203 ( R-HSA-1660499 ) R-HSA-1676203 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1855174 ( R-HSA-1855183 ) R-HSA-1855174 Reaction Name: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol See in Reactome R-HSA-1855218 ( R-HSA-1855204 ) R-HSA-1855218 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol See in Reactome R-HSA-8868648 ( R-HSA-8856828 ) R-HSA-8868648 Reaction Name: SYNJ hydrolyze PI(4,5)P2 to PI(4)P See in Reactome R-HSA-8868651 ( R-HSA-8856828 ) R-HSA-8868651 Reaction Name: Endophilins recruit synaptojanins to the clathrin-coated pit See in Reactome R-HSA-8868658 ( R-HSA-8856828 ) R-HSA-8868658 Reaction Name: HSPA8-mediated ATP hydrolysis promotes vesicle uncoating See in Reactome R-HSA-8868659 ( R-HSA-8856828 ) R-HSA-8868659 Reaction Name: Clathrin recruits auxilins to the clathrin-coated vesicle See in Reactome R-HSA-8868660 ( R-HSA-8856828 ) R-HSA-8868660 Reaction Name: Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle See in Reactome R-HSA-8868661 ( R-HSA-8856828 ) R-HSA-8868661 Reaction Name: Dynamin-mediated GTP hydrolysis promotes vesicle scission See in Reactome R-HSA-8869438 ( R-HSA-8856828 ) R-HSA-8869438 Reaction Name: Dissociation of clathrin-associated proteins See in Reactome R-HSA-8871193 ( R-HSA-8856828 ) R-HSA-8871193 Reaction Name: Dissociation of AAK1 and dephosphorylation of AP-2 mu2 See in Reactome R-HSA-8871194 ( R-HSA-8856828 ) R-HSA-8871194 Reaction Name: RAB5 and GAPVD1 bind AP-2 See in Reactome
MONDO:0034145	PIK3C2A	O00443	2.7.1.137 2.7.1.154 2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-1660514 R-HSA-1660514 Reactome Name: Synthesis of PIPs at the Golgi membrane See in Reactome R-HSA-1660516 R-HSA-1660516 Reactome Name: Synthesis of PIPs at the early endosome membrane See in Reactome R-HSA-1660517 R-HSA-1660517 Reactome Name: Synthesis of PIPs at the late endosome membrane See in Reactome R-HSA-8856828 R-HSA-8856828 Reactome Name: Clathrin-mediated endocytosis See in Reactome R-HSA-432722 R-HSA-432722 Reactome Name: Golgi Associated Vesicle Biogenesis See in Reactome	R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199991 R-HSA-199991 Reactome Name: Membrane Trafficking See in Reactome R-HSA-199992 R-HSA-199992 Reactome Name: trans-Golgi Network Vesicle Budding See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome	Metabolism Vesicle-mediated transport	R-HSA-1675928 ( R-HSA-1660514 ) R-HSA-1675928 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane See in Reactome R-HSA-1675939 ( R-HSA-1660516 ) R-HSA-1675939 Reaction Name: PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane See in Reactome R-HSA-1675961 ( R-HSA-1660514 ) R-HSA-1675961 Reaction Name: PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane See in Reactome R-HSA-1676024 ( R-HSA-1660517 ) R-HSA-1676024 Reaction Name: PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-1676206 ( R-HSA-1660516 ) R-HSA-1676206 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane See in Reactome R-HSA-421831 ( R-HSA-432722 ) R-HSA-421831 Reaction Name: trans-Golgi Network Coat Assembly See in Reactome R-HSA-421833 ( R-HSA-432722 ) R-HSA-421833 Reaction Name: Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture See in Reactome R-HSA-421835 ( R-HSA-432722 ) R-HSA-421835 Reaction Name: trans-Golgi Network Vesicle Scission See in Reactome R-HSA-421836 ( R-HSA-432722 ) R-HSA-421836 Reaction Name: trans-Golgi Network Derived Vesicle Uncoating See in Reactome R-HSA-8867754 ( R-HSA-8856828 ) R-HSA-8867754 Reaction Name: F- and N- BAR domain proteins bind the clathrin-coated pit See in Reactome R-HSA-8868071 ( R-HSA-8856828 ) R-HSA-8868071 Reaction Name: Clathrin recruits PIK3C2A See in Reactome R-HSA-8868072 ( R-HSA-8856828 ) R-HSA-8868072 Reaction Name: Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 See in Reactome
MONDO:0044638	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0044704	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0044705	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome
MONDO:0044740	PTEN	P60484	3.1.3.16 3.1.3.67 3.1.3.48	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-1855204 R-HSA-1855204 Reactome Name: Synthesis of IP3 and IP4 in the cytosol See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-8943723 R-HSA-8943723 Reactome Name: Regulation of PTEN mRNA translation See in Reactome	R-HSA-1483249 R-HSA-1483249 Reactome Name: Inositol phosphate metabolism See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Metabolism of proteins Metabolism Signal Transduction	R-HSA-1676149 ( R-HSA-1660499 ) R-HSA-1676149 Reaction Name: PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane See in Reactome R-HSA-1855205 ( R-HSA-1855204 ) R-HSA-1855205 Reaction Name: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol See in Reactome R-HSA-199456 ( R-HSA-1257604; R-HSA-1660499; R-HSA-199418; R-HSA-202424 ) R-HSA-199456 Reaction Name: PTEN dephosphorylates PIP3 See in Reactome R-HSA-2321904 ( R-HSA-5628897 ) R-HSA-2321904 Reaction Name: PTEN mRNA translation negatively regulated by microRNAs See in Reactome R-HSA-5689950 ( R-HSA-5689880 ) R-HSA-5689950 Reaction Name: USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN See in Reactome R-HSA-6807105 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807105 Reaction Name: Monoubiquitinated PTEN translocates to the nucleus See in Reactome R-HSA-6807106 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807118 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807118 Reaction Name: USP7 deubiquitinates monoubiquitinated PTEN See in Reactome R-HSA-6807126 ( R-HSA-1257604; R-HSA-8948747 ) R-HSA-6807126 Reaction Name: Deubiquitinated PTEN translocates to the cytosol See in Reactome R-HSA-6807134 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-6807206 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-6807206 Reaction Name: USP13 and OTUD3 deubiquitinate PTEN See in Reactome R-HSA-8847968 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847968 Reaction Name: PTEN binds FRK See in Reactome R-HSA-8847977 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8847977 Reaction Name: FRK phosphorylates PTEN See in Reactome R-HSA-8850945 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850945 Reaction Name: Casein kinase II phosphorylates PTEN See in Reactome R-HSA-8850961 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850961 Reaction Name: PREX2 binds PTEN and inhibits it See in Reactome R-HSA-8850992 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850992 Reaction Name: Proteasome degrades polyubiquitinated PTEN See in Reactome R-HSA-8850997 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8850997 Reaction Name: TRIM27 binds PTEN See in Reactome R-HSA-8851011 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8851011 Reaction Name: TRIM27 polyubiquitinates PTEN See in Reactome R-HSA-8873946 ( R-HSA-5689896 ) R-HSA-8873946 Reaction Name: OTUD3 deubiquitinates PTEN See in Reactome R-HSA-8944497 ( R-HSA-1257604; R-HSA-8943723 ) R-HSA-8944497 Reaction Name: PTEN mRNA translation is negatively regulated by microRNAs See in Reactome R-HSA-8948775 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948775 Reaction Name: MKRN1 polyubiquitinates PTEN See in Reactome R-HSA-8948800 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948800 Reaction Name: TNKS and TNKS2 PARylate PTEN See in Reactome R-HSA-8948832 ( R-HSA-1257604; R-HSA-8948751 ) R-HSA-8948832 Reaction Name: RNF146 polyubiquitinates PARylated PTEN See in Reactome R-HSA-9615571 ( R-HSA-8986944 ) R-HSA-9615571 Reaction Name: PTEN mRNA translation is inhibited by miR-137 See in Reactome

Number of enzymes:	13
Number of disease:	62
Number of reactomes:	61
Number of reactions:	166

Search summary (Reactome ID: R-HSA-1660499)

Search results (Reactome ID: R-HSA-1660499)

MONDO:0001056

R-HSA-1660499

R-HSA-198203

R-HSA-4420097

R-HSA-114604

R-HSA-1963642

R-HSA-9607240

R-HSA-186763

R-HSA-180292

R-HSA-8853659

R-HSA-9027276

R-HSA-2730905

R-HSA-912631

R-HSA-1257604

R-HSA-5654710

R-HSA-5654720

R-HSA-5654689

R-HSA-112399

R-HSA-389357

R-HSA-388841

R-HSA-5673001

R-HSA-2029485

R-HSA-202424

R-HSA-912526

R-HSA-1433557

R-HSA-2424491

R-HSA-512988

R-HSA-5654695

R-HSA-9009391

R-HSA-9013149

R-HSA-8851907

R-HSA-1250342

R-HSA-416476

R-HSA-201556

R-HSA-109704

R-HSA-210993

R-HSA-6811558

R-HSA-9028335

R-HSA-9013404

R-HSA-9603381

R-HSA-373753

R-HSA-186797

R-HSA-9012999

R-HSA-2404192

R-HSA-168256

R-HSA-194315

R-HSA-202733

R-HSA-1500931

R-HSA-9006925

R-HSA-2428924

R-HSA-2428928

R-HSA-1236394

R-HSA-74752

R-HSA-1280218

R-HSA-1266738

R-HSA-74751

R-HSA-5654687

R-HSA-5683057

R-HSA-166520

R-HSA-194138

R-HSA-5684996

R-HSA-1430728

R-HSA-449147

R-HSA-1483257

R-HSA-1483255

R-HSA-199418

R-HSA-389356

R-HSA-388396

R-HSA-556833

R-HSA-5654708

R-HSA-109582

R-HSA-202403

R-HSA-5654741

R-HSA-9006335

R-HSA-2029480

R-HSA-190236

R-HSA-2454202

R-HSA-451927