DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-1650814)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007204	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0008146	P4HB	P07237	5.3.4.1	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-8963888 R-HSA-8963888 Reactome Name: Chylomicron assembly See in Reactome R-HSA-8964041 R-HSA-8964041 Reactome Name: LDL remodeling See in Reactome R-HSA-5358346 R-HSA-5358346 Reactome Name: Hedgehog ligand biogenesis See in Reactome R-HSA-9020933 R-HSA-9020933 Reactome Name: Interleukin-23 signaling See in Reactome R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8866423 R-HSA-8866423 Reactome Name: VLDL assembly See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-8963899 R-HSA-8963899 Reactome Name: Plasma lipoprotein remodeling See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5358351 R-HSA-5358351 Reactome Name: Signaling by Hedgehog See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome	Cellular responses to stimuli Immune System Transport of small molecules Extracellular matrix organization Metabolism of proteins Signal Transduction	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome R-HSA-174741 ( R-HSA-8963888 ) R-HSA-174741 Reaction Name: ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron See in Reactome R-HSA-174786 ( R-HSA-8963888 ) R-HSA-174786 Reaction Name: ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex See in Reactome R-HSA-2002460 ( R-HSA-1650814 ) R-HSA-2002460 Reaction Name: P4HB binds Collagen chains See in Reactome R-HSA-3341296 ( R-HSA-3299685 ) R-HSA-3341296 Reaction Name: GPX7,8 catalyze peroxidation of P4HB (PDI) See in Reactome R-HSA-5358336 ( R-HSA-5358346 ) R-HSA-5358336 Reaction Name: P4HB forms mixed disulphides with Hh precursors See in Reactome R-HSA-5358340 ( R-HSA-5358346 ) R-HSA-5358340 Reaction Name: Autoproteolytic cleavage of Hh precursors See in Reactome R-HSA-8866329 ( R-HSA-8866423 ) R-HSA-8866329 Reaction Name: MTTP lipidates APOB-100, forming a pre-VLDL See in Reactome R-HSA-8948234 ( R-HSA-1650814 ) R-HSA-8948234 Reaction Name: P4HB:4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8950113 ( R-HSA-9020591 ) R-HSA-8950113 Reaction Name: IL12A binds IL12B See in Reactome R-HSA-8950183 ( R-HSA-9020933 ) R-HSA-8950183 Reaction Name: IL12B binds IL23A See in Reactome R-HSA-8950456 ( R-HSA-9020591 ) R-HSA-8950456 Reaction Name: IL12B dimerizes See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9737780 ( R-HSA-8964041 ) R-HSA-9737780 Reaction Name: MTTP binds lomitapide See in Reactome
MONDO:0008147	PPIB	P23284	5.2.1.8	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1980233 ( R-HSA-1650814 ) R-HSA-1980233 Reaction Name: Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen See in Reactome R-HSA-2022073 ( R-HSA-1650814 ) R-HSA-2022073 Reaction Name: Procollagen triple helix formation See in Reactome R-HSA-8948226 ( R-HSA-1650814 ) R-HSA-8948226 Reaction Name: Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8948230 ( R-HSA-1650814 ) R-HSA-8948230 Reaction Name: P3HB binds 4-Hyp-collagen propeptides See in Reactome
MONDO:0008147	P3H1	Q32P28	1.14.11.7	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1980233 ( R-HSA-1650814 ) R-HSA-1980233 Reaction Name: Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen See in Reactome R-HSA-2022073 ( R-HSA-1650814 ) R-HSA-2022073 Reaction Name: Procollagen triple helix formation See in Reactome R-HSA-8948226 ( R-HSA-1650814 ) R-HSA-8948226 Reaction Name: Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8948230 ( R-HSA-1650814 ) R-HSA-8948230 Reaction Name: P3HB binds 4-Hyp-collagen propeptides See in Reactome
MONDO:0008148	PPIB	P23284	5.2.1.8	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1980233 ( R-HSA-1650814 ) R-HSA-1980233 Reaction Name: Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen See in Reactome R-HSA-2022073 ( R-HSA-1650814 ) R-HSA-2022073 Reaction Name: Procollagen triple helix formation See in Reactome R-HSA-8948226 ( R-HSA-1650814 ) R-HSA-8948226 Reaction Name: Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8948230 ( R-HSA-1650814 ) R-HSA-8948230 Reaction Name: P3HB binds 4-Hyp-collagen propeptides See in Reactome
MONDO:0009161	ADAMTS2	O95450	3.4.24.14	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-5173214 R-HSA-5173214 Reactome Name: O-glycosylation of TSR domain-containing proteins See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome	Extracellular matrix organization Metabolism of proteins	R-HSA-2002428 ( R-HSA-1650814 ) R-HSA-2002428 Reaction Name: Removal of fibrillar collagen N-propeptides See in Reactome R-HSA-5173005 ( R-HSA-5173214 ) R-HSA-5173005 Reaction Name: B3GALTL transfers glucose to O-fucosyl-proteins See in Reactome R-HSA-5173192 ( R-HSA-5173214 ) R-HSA-5173192 Reaction Name: POFUT2 transfers fucose to TSR domain-containing proteins See in Reactome
MONDO:0009804	BMP1	P13497	3.4.24.19	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome	Transport of small molecules Extracellular matrix organization	R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-2002428 ( R-HSA-1650814 ) R-HSA-2002428 Reaction Name: Removal of fibrillar collagen N-propeptides See in Reactome R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0009804	PPIB	P23284	5.2.1.8	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1980233 ( R-HSA-1650814 ) R-HSA-1980233 Reaction Name: Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen See in Reactome R-HSA-2022073 ( R-HSA-1650814 ) R-HSA-2022073 Reaction Name: Procollagen triple helix formation See in Reactome R-HSA-8948226 ( R-HSA-1650814 ) R-HSA-8948226 Reaction Name: Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8948230 ( R-HSA-1650814 ) R-HSA-8948230 Reaction Name: P3HB binds 4-Hyp-collagen propeptides See in Reactome
MONDO:0009804	P3H1	Q32P28	1.14.11.7	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1980233 ( R-HSA-1650814 ) R-HSA-1980233 Reaction Name: Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen See in Reactome R-HSA-2022073 ( R-HSA-1650814 ) R-HSA-2022073 Reaction Name: Procollagen triple helix formation See in Reactome R-HSA-8948226 ( R-HSA-1650814 ) R-HSA-8948226 Reaction Name: Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8948230 ( R-HSA-1650814 ) R-HSA-8948230 Reaction Name: P3HB binds 4-Hyp-collagen propeptides See in Reactome
MONDO:0009805	PPIB	P23284	5.2.1.8	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1980233 ( R-HSA-1650814 ) R-HSA-1980233 Reaction Name: Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen See in Reactome R-HSA-2022073 ( R-HSA-1650814 ) R-HSA-2022073 Reaction Name: Procollagen triple helix formation See in Reactome R-HSA-8948226 ( R-HSA-1650814 ) R-HSA-8948226 Reaction Name: Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8948230 ( R-HSA-1650814 ) R-HSA-8948230 Reaction Name: P3HB binds 4-Hyp-collagen propeptides See in Reactome
MONDO:0012217	PLOD2	O00469	1.14.11.4	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1981104 ( R-HSA-1650814 ) R-HSA-1981104 Reaction Name: Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines See in Reactome R-HSA-8948232 ( R-HSA-1650814 ) R-HSA-8948232 Reaction Name: Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases See in Reactome
MONDO:0012581	P3H1	Q32P28	1.14.11.7	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1980233 ( R-HSA-1650814 ) R-HSA-1980233 Reaction Name: Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen See in Reactome R-HSA-2022073 ( R-HSA-1650814 ) R-HSA-2022073 Reaction Name: Procollagen triple helix formation See in Reactome R-HSA-8948226 ( R-HSA-1650814 ) R-HSA-8948226 Reaction Name: Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8948230 ( R-HSA-1650814 ) R-HSA-8948230 Reaction Name: P3HB binds 4-Hyp-collagen propeptides See in Reactome
MONDO:0012892	PLOD3	O60568	1.14.11.4 2.4.1.66 2.4.1.50	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1981104 ( R-HSA-1650814 ) R-HSA-1981104 Reaction Name: Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines See in Reactome R-HSA-1981128 ( R-HSA-1650814 ) R-HSA-1981128 Reaction Name: Galactosylation of collagen propeptide hydroxylysines by PLOD3 See in Reactome R-HSA-1981157 ( R-HSA-1650814 ) R-HSA-1981157 Reaction Name: Glucosylation of collagen propeptide hydroxylysines See in Reactome R-HSA-8948219 ( R-HSA-1650814 ) R-HSA-8948219 Reaction Name: PLOD3 binds Lysyl hydroxylated collagen propeptides See in Reactome R-HSA-8948222 ( R-HSA-1650814 ) R-HSA-8948222 Reaction Name: PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates See in Reactome R-HSA-8948224 ( R-HSA-1650814 ) R-HSA-8948224 Reaction Name: PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates See in Reactome R-HSA-8948232 ( R-HSA-1650814 ) R-HSA-8948232 Reaction Name: Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases See in Reactome
MONDO:0013123	TLL1	O43897	3.4.24.-	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0013670	P3H2	Q8IVL5	1.14.11.7	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1980233 ( R-HSA-1650814 ) R-HSA-1980233 Reaction Name: Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen See in Reactome R-HSA-8948226 ( R-HSA-1650814 ) R-HSA-8948226 Reaction Name: Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates See in Reactome R-HSA-8948230 ( R-HSA-1650814 ) R-HSA-8948230 Reaction Name: P3HB binds 4-Hyp-collagen propeptides See in Reactome
MONDO:0013924	BMP1	P13497	3.4.24.19	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome	Transport of small molecules Extracellular matrix organization	R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-2002428 ( R-HSA-1650814 ) R-HSA-2002428 Reaction Name: Removal of fibrillar collagen N-propeptides See in Reactome R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0014982	P4HA2	O15460	1.14.11.2	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1650808 ( R-HSA-1650814 ) R-HSA-1650808 Reaction Name: Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines See in Reactome
MONDO:0016002	PLOD1	Q02809	1.14.11.4	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1981104 ( R-HSA-1650814 ) R-HSA-1981104 Reaction Name: Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines See in Reactome R-HSA-8948232 ( R-HSA-1650814 ) R-HSA-8948232 Reaction Name: Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases See in Reactome
MONDO:0017791	BMP1	P13497	3.4.24.19	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome	Transport of small molecules Extracellular matrix organization	R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-2002428 ( R-HSA-1650814 ) R-HSA-2002428 Reaction Name: Removal of fibrillar collagen N-propeptides See in Reactome R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0020434	TLL1	O43897	3.4.24.-	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0020437	TLL1	O43897	3.4.24.-	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0032564	ADAMTS3	O15072	3.4.24.-	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-5173214 R-HSA-5173214 Reactome Name: O-glycosylation of TSR domain-containing proteins See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome	Extracellular matrix organization Metabolism of proteins	R-HSA-2002428 ( R-HSA-1650814 ) R-HSA-2002428 Reaction Name: Removal of fibrillar collagen N-propeptides See in Reactome R-HSA-5173005 ( R-HSA-5173214 ) R-HSA-5173005 Reaction Name: B3GALTL transfers glucose to O-fucosyl-proteins See in Reactome R-HSA-5173192 ( R-HSA-5173214 ) R-HSA-5173192 Reaction Name: POFUT2 transfers fucose to TSR domain-containing proteins See in Reactome
MONDO:0100105	COLGALT1	Q8NBJ5	2.4.1.50	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1981120 ( R-HSA-1650814 ) R-HSA-1981120 Reaction Name: Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. See in Reactome R-HSA-8948228 ( R-HSA-1650814 ) R-HSA-8948228 Reaction Name: COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides See in Reactome R-HSA-8948231 ( R-HSA-1650814 ) R-HSA-8948231 Reaction Name: COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates See in Reactome

Number of enzymes:	13
Number of disease:	20
Number of reactomes:	15
Number of reactions:	36

Search summary (Reactome ID: R-HSA-1650814)

Search results (Reactome ID: R-HSA-1650814)

MONDO:0007204

R-HSA-381426

R-HSA-9020591

R-HSA-8963888

R-HSA-8964041

R-HSA-5358346

R-HSA-9020933

R-HSA-1650814

R-HSA-3299685

R-HSA-8866423

R-HSA-8957275

R-HSA-8963899

R-HSA-174824

R-HSA-449147

R-HSA-447115

R-HSA-8953897

R-HSA-168256

R-HSA-2262752

R-HSA-382551

R-HSA-1280215

R-HSA-1474290

R-HSA-1474244

R-HSA-8963898

R-HSA-392499

R-HSA-5358351

R-HSA-597592

R-HSA-162582

R-HSA-9711123

R-HSA-1650808

R-HSA-174741

R-HSA-174786

R-HSA-2002460

R-HSA-3341296

R-HSA-5358336

R-HSA-5358340

R-HSA-8866329

R-HSA-8948234

R-HSA-8950113

R-HSA-8950183

R-HSA-8950456

R-HSA-8952289

R-HSA-9737780

MONDO:0008146

R-HSA-381426

R-HSA-9020591

R-HSA-8963888

R-HSA-8964041

R-HSA-5358346

R-HSA-9020933

R-HSA-1650814

R-HSA-3299685

R-HSA-8866423

R-HSA-8957275

R-HSA-8963899

R-HSA-174824

R-HSA-449147

R-HSA-447115

R-HSA-8953897

R-HSA-168256

R-HSA-2262752

R-HSA-382551

R-HSA-1280215

R-HSA-1474290

R-HSA-1474244

R-HSA-8963898

R-HSA-392499

R-HSA-5358351

R-HSA-597592

R-HSA-162582

R-HSA-9711123

R-HSA-1650808

R-HSA-174741

R-HSA-174786

R-HSA-2002460

R-HSA-3341296

R-HSA-5358336

R-HSA-5358340

R-HSA-8866329