DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-163765)

Number of enzymes:	2
Number of disease:	3
Number of reactomes:	7
Number of reactions:	9

Search results (Reactome ID: R-HSA-163765)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0007067	PKLR	P30613	2.7.1.40	R-HSA-163765 R-HSA-163765 Reactome Name: ChREBP activates metabolic gene expression See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome	Metabolism Developmental Biology	R-HSA-163669 ( R-HSA-163765 ) R-HSA-163669 Reaction Name: Transcriptional activation of pyruvate kinase gene by ChREBP:MLX See in Reactome R-HSA-211461 ( R-HSA-210745 ) R-HSA-211461 Reaction Name: HNF1A-dependent synthesis of the L isoform of PKLR protein See in Reactome R-HSA-71670 ( R-HSA-70171 ) R-HSA-71670 Reaction Name: phosphoenolpyruvate + ADP => pyruvate + ATP See in Reactome
MONDO:0009950	PKLR	P30613	2.7.1.40	R-HSA-163765 R-HSA-163765 Reactome Name: ChREBP activates metabolic gene expression See in Reactome R-HSA-210745 R-HSA-210745 Reactome Name: Regulation of gene expression in beta cells See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-186712 R-HSA-186712 Reactome Name: Regulation of beta-cell development See in Reactome	Metabolism Developmental Biology	R-HSA-163669 ( R-HSA-163765 ) R-HSA-163669 Reaction Name: Transcriptional activation of pyruvate kinase gene by ChREBP:MLX See in Reactome R-HSA-211461 ( R-HSA-210745 ) R-HSA-211461 Reaction Name: HNF1A-dependent synthesis of the L isoform of PKLR protein See in Reactome R-HSA-71670 ( R-HSA-70171 ) R-HSA-71670 Reaction Name: phosphoenolpyruvate + ADP => pyruvate + ATP See in Reactome
MONDO:0013493	ACACA	Q13085	6.4.1.2	R-HSA-196780 R-HSA-196780 Reactome Name: Biotin transport and metabolism See in Reactome R-HSA-163765 R-HSA-163765 Reactome Name: ChREBP activates metabolic gene expression See in Reactome R-HSA-200425 R-HSA-200425 Reactome Name: Carnitine metabolism See in Reactome R-HSA-2426168 R-HSA-2426168 Reactome Name: Activation of gene expression by SREBF (SREBP) See in Reactome R-HSA-75105 R-HSA-75105 Reactome Name: Fatty acyl-CoA biosynthesis See in Reactome	R-HSA-1655829 R-HSA-1655829 Reactome Name: Regulation of cholesterol biosynthesis by SREBP (SREBF) See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-8957322 R-HSA-8957322 Reactome Name: Metabolism of steroids See in Reactome	Metabolism	R-HSA-163743 ( R-HSA-163765 ) R-HSA-163743 Reaction Name: Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX See in Reactome R-HSA-1655845 ( R-HSA-2426168 ) R-HSA-1655845 Reaction Name: Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) See in Reactome R-HSA-200555 ( R-HSA-75105 ) R-HSA-200555 Reaction Name: acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate See in Reactome R-HSA-2993814 ( R-HSA-196780 ) R-HSA-2993814 Reaction Name: HLCS biotinylates ACACA:Mn2+ See in Reactome R-HSA-3065958 ( R-HSA-196780 ) R-HSA-3065958 Reaction Name: An unknown protease degrades ACACA See in Reactome R-HSA-75851 ( R-HSA-200425 ) R-HSA-75851 Reaction Name: Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA See in Reactome